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Principal Component Analysis on Semen Quality among Chinese Young Men

Journal of Reproduction and Contraception 2003年第1期14卷 55-63页

作者： Jun-qingWU Er-shengGAO Jian-guoTAO Cui-lingLIANG WenyingLI qiu-yingyang Kang-shouYAO Wei-qunLU LuCHEN Fudanuniversity Shanghai200032China ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China ZhejiangInstituteofPlannedParenthoodResearch l-langzhou310012China GuizhouInstituteofPlannedParenthoodResearch Guiyang550004China QingdaoInstituteofPlannedParenthoodResearch Qingdao255071China

Objective To understand the current semen quality status among Chinese young men and influential factors in China and to explore its evaluation index. Methods A total of 562 healthy male volunteers were recruited during their premarital examinations in seven provincials and municipal regions' MCH centers; descriptive and principal component analyses were used to analyze data.Results The findings show that semen volume (2. 61± 1. 10 mL), sperm density (64. 47× 34. 59× 106/mL), percentage of sperm forward progression (59. 89%± 17. 11%), percentage of sperm viability (77. 19% ± 11. 87%), and percentage of normal sperm morphology ( 78. 23% ± 9. 15% ). The first principal component function is Z1= -8.512 54 + 0. 001 35X1' + 0. 031 92X2'+0. 043 52X3'+ 0. 039 84X4', which is closely related to percentage of sperm viability (X3), percentage of sperm forward progression (X2), and percentage of normal sperm morphology (X4)The second principal component function is: Z2= 0. 491 92+ 0. 080 80X1- 0. 000 58X2-0. 005 10X3- 0. 018 07X4, which depends on the total sperm count (X1). Conclusion Only 42. 3% subjects meet all the common WHO standard of semen quality. The multiple analysis of Z1 showed that the highest Z1 are among subjects from Guizhou,workers, or town residents. Multiple analysis of Z2 showed that the older age when the subjects had the first sexual impulse, the longer period of sexual abstinence and more quantity of sperm they had; the more sexual activity subjects had, the less amount of sperm they had.

关键词： young men semen quality principal component analysis

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The Canonical Correlation Analysis on Semen Quality and Serum Heavy Metals in Chinese Young Men

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Journal of Reproduction and Contraception 2003年第2期14卷 119-128页

作者： Jun-qingWU Cui-lingLIANG Er-shengGAO Jian-guoTAO qiu-yingyang XiaoXU Wen-juanCAI JianGUO FengTANG JiangZHU Zhan-haiFU Yin-meiDU FudanUniversity shanghai200032China ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China HenanInstituteofPlannedParenthoodResearch Zhengzhou450003China HeibeiInstituteofPlannedParenthoodResearch Shijiazhuang050025China ShanxiInstituteofPlannedParenthoodResearch Xi＇an030006China ZhejiangInstituteofPlannedParenthoodResearch Hangzhou310012China GuizhouInstituteofPlannedParenthoodResearch Guiyang550004China QingdaoInstituteofPlannedParenthoodResearch Qingdao266071China TaiyuanCentersforDiseaseControlandPrevention Taiyuan030001China

Objective To explore the correlation between serum, heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 562 male vomunteers who had undergone premarital physical examination in maternal and children health centers in 7 provinces in China. Results Results from Spearman rank correlation analysis (partial variable: region) show that serum lead and cadmium are negatively related to percentage of morphological normal sperm, but canonical correlation between semen quality and serum heavy metal are not significant. Canonical correlation analysis among the subjects from Guizhou shows cadmium is harmful to sperm morphology. In Henan, furthermore, results show lead and cadmium could negatively affect sperm viability and morphology. Conclusion Among all study subjects, canonical correlation between semen quality and serum heavy metal were not significant; however, results in some region showed serum cadmium and lead might be harmful to sperm quality.

关键词： semen quality heavy metal canonical correlation serum lead serum cadmium

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Effect of air-conditioner exposure on semen quality

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Asian Journal of Andrology 2004年第4期6卷 354-354页

作者： Min-LiLu Jun-QingWu qiu-yingyang Wei-JinZhou Er-ShengGao DepartmentofEpidemiology SchoolofPublicHealthShanghaiMedicalSchoolofFudanUniversityShanghai200032China ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China

Aim: To investigate the effect of air-conditioner exposure on semen quality. Methods: The data came from the healthy male volunteers, aged 22 to 30 years, who went to centers for maternity and children health for premarital physical examination in Shanghai, Henan, Zhejiang and Hebei from December 1998 to February 2000. The sampling size is 304. Results: Among the subjects, 90 (29.6 %) had air-conditioner at home and the rest did not. X2-test and multiple logistic regression analyses showed that, the difference between the exposure and control groups was statistically significant in semen volume, sperm density and proportion of sperm with normal morphology. The three indexes were lower in the exposure group. Conclusion: Air-conditioner exposure possibly influences the semen quality.

关键词： semen quality air-conditioner influencing factors

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7075铝合金偏心薄壁件高速车削加工应用方法研究

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机械工程师 2019年第8期 173-175,180页

作者：骆仕斌李爱娜黄松福邱英洋阳江职业技术学院广东阳江529566 阳江市睿精模塑有限公司广东阳江529500

针对偏心薄壁件的高速车削加工方法开展了相关研究,设计了高精度的专用偏心夹具,实现了对偏心薄壁件提供均匀的夹持力,提高了工件的偏心精度和装夹效率。以PCD刀具为切削工具,7075铝合金为切削对象,通过设计正交试验法,验证了在高速切... 详细信息

针对偏心薄壁件的高速车削加工方法开展了相关研究,设计了高精度的专用偏心夹具,实现了对偏心薄壁件提供均匀的夹持力,提高了工件的偏心精度和装夹效率。以PCD刀具为切削工具,7075铝合金为切削对象,通过设计正交试验法,验证了在高速切削环境下,合理的进给量对表面质量的提升至关重要,进给量和背吃刀量是增加切削力的主要因素,切削速度对切削力和表面粗糙度影响较小,适当提高刀尖圆角半径可降低工件的粗糙度。

关键词：偏心薄壁件高速车削正交试验进给速度

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Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells' growth in vitro and in vivo

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World Journal of Gastroenterology 2005年第16期11卷 2491-2496页

作者： yingyang qiu-JunLv Qing-YouDu Bing-HuYang Ru-XianLin Sheng-QiWang BeijingInstitutionofRadiationMedicine Beijing100850China BeijingInstitutionofRadiationMedicine Beijing100850China//DepartmentofBiochemistryNationalInstitutefortheControlofPharmaceuticalandBiologicalProductBeijing100050China

AIM: To investigate the combination effect of hTERT antisense oligonucleotide 'Cantide' and three chemotherapeutic drugs (cisplatin, 5-fluorouracil (5-FU) and adriamycin (ADM)) on inhibiting the proliferation of HepG2, BGC and A549 cell lines in vitro, and to investigate the efficacy of Cantide used in combination with cisplatin (DDP) in vivo. METHODS: Cantide was transfected into these tumor cells by Lipofectin, and cell growth activity was calculated by microcytotoxicity assay. In vivo study, cells of HepG2 were implanted in Balb/c nude mice for 4 d. Then Cantide, DDP and Cantide+DDP were given intra peritonea Ily for 24 d respectively. The body weights of the tumor-bearing animals and their tumor mass were measured later to assess the effect of combination therapy in the nude mice. To evaluate the interaction of Cantide and these chemotherapeutic drugs, SAS software and Jin Zhengjun method were used. RESULTS: Combination treatments with 0.1μmol/L Cantide reduced the IC50 of DDP, 5-FU and ADM from 1.07, 4.15 and 0.29 μg/mL to 0.25,1.52 and 0.12 μg/mL respectively. The inhibition ability of DDP, 5-FU and ADM respectively in combination with Cantide in these tumor cells was higher than that of these drugs alone (P<0.0001). And synergism (Q≥1.15)was observed at the lower concentration of DDP (≤1μg/mL) and ADM (≤0.1 μg/mL) with combination of Cantide. In vivo, combination treatment with Cantide and DDP produced the greater growth inhibition of human liver carcinoma cells HepG2 in nude mice (0.65±0.19 g tumor) compared with that when only one of these drugs was used (Cantide group: 1.05±0.16 g tumor, P= 0.0009<0.001; DDP group: 1.13±0.09 g tumor, P= 0.0001<0.001). CONCLUSION: These findings indicate that Cantide may enhance therapeutic effectiveness of chemotherapeutic drugs over a wide range of tumor cells in vitro, and the combination use of Cantide and DDP can produce much higher inhibition rates, as compared with when either of these drugs was used only in vivo.

关键词： hTERT Antisense oligonucleotide Tumor Chemotherapeutic drugs

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多因素作用下单裂缝铺砂规律CFD数值模拟

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西安石油大学学报（自然科学版） 2019年第5期34卷 86-90页

作者：刘平礼雷飞云李骏罗应扬曾然邱礼彬西南石油大学石油与天然气工程学院四川成都610500 中国石油西南油气田公司页岩气研究院四川成都610512 川庆钻探工程井下作业公司四川成都610213

为研究压裂过程单裂缝中入口速度(排量)、粒径等因素对支撑剂铺置运移影响规律,运用CFD数值模拟软件,建立简化二维模型,鉴于以往模型出口设置引起支撑剂回流铺置,设计模型出口为全开出口。模拟结果表明:随着排量的增大,支撑剂主要沉降... 详细信息

为研究压裂过程单裂缝中入口速度(排量)、粒径等因素对支撑剂铺置运移影响规律,运用CFD数值模拟软件,建立简化二维模型,鉴于以往模型出口设置引起支撑剂回流铺置,设计模型出口为全开出口。模拟结果表明:随着排量的增大,支撑剂主要沉降区向裂缝深处移动,同时,入口处湍流效应增加,近井筒区域支撑剂空缺带变大,降低支撑剂铺置效果;增加砂比到一定值,其对砂堤形态的影响逐渐减小;高排量、高砂比时,在一段时间内,砂堤高度先逐渐增高再降低达到平衡高度,砂堤形态非均匀性先增大再减小。

关键词：水力压裂支撑剂铺置运移数值模拟入口速度

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基于数据挖掘与优选的薄层河道砂体地震预测——以松辽盆地北部卫星油田扶Ⅰ油层组为例

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成都理工大学学报（自然科学版） 2023年第4期50卷 385-400页

作者：王文红崔云华吴勇邓强周路刘全稳秦应洋邱泽华中国石油大庆油田第八采油厂黑龙江大庆163514 西南石油大学地球科学与技术学院成都610500 广东石油化工学院石油工程学院广东茂名525000

针对卫星油田扶Ⅰ油层组小规模河道及薄层砂体平面展布认识不清的油藏开发难点,通过多种地震数据挖掘与多项预测方法优选,分别筛选出优势地震数据体和优势预测方法对薄层河道砂体进行了有效预测。研究结果表明:①基于叠后三维地震频率... 详细信息

针对卫星油田扶Ⅰ油层组小规模河道及薄层砂体平面展布认识不清的油藏开发难点,通过多种地震数据挖掘与多项预测方法优选,分别筛选出优势地震数据体和优势预测方法对薄层河道砂体进行了有效预测。研究结果表明:①基于叠后三维地震频率域和子波域多尺度分解与重构数据体的对比,55 Hz地震分频体、导航金字塔2级分级数据体、不同频率或不同分级数据体重构形成的优势数据体均可不同程度识别出薄层河道砂体;②波形指示深侧向电阻率模拟方法相较于其它反演方法在识别3~6 m薄层砂体与刻画窄河道边界方面效果突出;③研究区主力产层F I42小层具有网状河道分布特征,主河道沿近NE-SW向分布,河道宽度窄,河道内砂体发育,分支河道数量多,砂体厚度薄,呈断续窄条带状分布,主河道控制了溢岸砂的分布。基于优势地震数据,并利用优选出来的地震岩性反演方法可有效预测薄层河道砂体的分布。

关键词：卫星油田扶余油层河道砂体小波变换导航金字塔储层预测波形指示模拟

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