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Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1514-1531页

作者： Yong Pan Yi-Ru Zhang Ling-Yun Wang Li-Na Wu Ying-qiu Ma Zhou Fang shi-Bo Li Department of Infectious Disease Zhoushan HospitalWenzhou Medical UniversityZhoushan 316021Zhejiang ProvinceChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in ***,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain *** To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for *** The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal *** expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC *** targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan *** univariate and multivariate analysis were utilized to identify independent prognostic *** CDKN2A was frequently mutated and deleted in *** single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle *** CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully ***5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC *** association between GAS5 expression and methylation,immune infilt-ration was ***,traditional Chinese medicine effective components targeting GAS5 were *** This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and ***,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

关键词： Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker

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Ultra-high-rate Bi anode encapsulated in 3D lignin-derived carbon framework for sodium-ion hybrid capacitors

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Rare Metals 2024年第3期43卷 1037-1047页

作者： Ze-Hua Lin Xue-Qing qiu Xi-Hong Zu Xiao-Shan Zhang Lei Zhong shi-Rong Sun Shu-Hua Hao Ying-Juan Sun Wen-Li Zhang School of Chemical Engineering and Light Industry Guangdong University of Technology(GDUT)Guangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang515200China School of Advanced Manufacturing Institute of Green Chemistry and Advanced MaterialsGuangdong University of TechnologyJieyang515200China

Bismuth(Bi),as an alloy-based anode material,has attracted much atte ntion in the developme nt of sodiumion hybrid capacitors(SIHCs)due to its high theoretical ***,the volume expansion of the Bi-based anode during the sodiation/desodiation process results in limited rate *** the present work,a porous Bi-based composite was constructed by a one-step hydrothermal method,and Bi was encapsulated in ligninderived nitrogen-doped porous carbon(Bi@LNPC)after *** obtained Bi nanoparticles could effectively adapt to the strain and shorten the diffusion distance of Na^(+).In addition,porous carbon skeleton provides a rigid conductive network for electronic ***,the assembled sodium-ion half-cell with Bi@LNPC anode shows ultra-high-rate *** the current density was enhanced from 0.1 to 50 A·g^(-1),the specific capacity decreased slightly from 351.5 to 342.8 mAh·g^(-1).Even at an extremely high current density of 200 A·g^(-1),it retains 81.3%capacity retention when compared to a current density of 1 A·g^(-1).The SIHCs assembled by Bi@LNPC show a high energy density of 63 Wh·kg^(-1).This work provides an effective method for developing high-rate Bi anode materials for sodium-ion hybrid capacitors(SIHCs)and sodium-ion batteries(SIBs).

关键词： Bismuth Lignin Sodium-ion batteries Sodium-ion hybrid capacitors Rate Porous carbon

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Metallaphotoredox-Catalyzed Three-Component Couplings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： Ernest Koranteng Zhen-Cao Shu Yi-Yin Liu Qian Yang Bin shi Qiang-Xian Wu Fen Tan Liang-qiu Lu Wen-Jing Xiao Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries Co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and Technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen ***,it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds,especially unsymmetrical ***,we have disclosed novel and highly efficient three-component coupling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical *** reaction features simple and safe operations,broad substrate scopes,and product *** allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild conditions(27 examples,36%—98%yields).In addition,this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-coupling Nickel Photoredox catalysis Three-component reaction Ureas Carbamates

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Thin-walled and large-sized magnesium alloy die castings for passenger car cockpit:Application,materials,and manufacture

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China Foundry 2024年第5期21卷 525-545页

作者： Lei Zhan Yu-meng Sun Yang Song Chun-hua Kong Kai Ma Bai-xin Dong Hong-yu Yang shi-li Shu Feng qiu School of Automotive Engineering Jilin Communication PolytechnicChangchun 130012China Key Laboratory of Automobile Materials of Ministry of Education School of Materials Science and EngineeringNanling CampusJilin UniversityChangchun 130025China

In order to effectively reduce energy consumption and increase range mile,new energy vehicles represented by Tesla have greatly aroused the application of integrated magnesium(Mg)alloy die casting technology in ***,the application of Mg alloys in automobiles,especially in automotive cockpit components,is quite extensive,while it has almost disappeared for a period of time due to its relatively high cost,causing a certain degree of information loss in the application technology of Mg alloy parts in *** rapid development of automotive technology has led to a higher requirement for the automotive components compared with those traditional ***,whatever the components themselves,or the Mg alloy materials and die casting process have to face an increasing challenge,needing to be *** addition,owing to its high integration characteristics,the application of Mg alloy die casting technology in large-sized and thin-walled automotive parts has inherent advantages and needs to be expanded ***,it necessitates exploring advance Mg alloys and new product structures and optimizing die casting *** article summarizes and analyzes the development status of thin-walled and large-sized die casting Mg alloy parts in passenger car cockpit and corresponding material selection methods,die casting processes as well as mold design ***,this work will aid researchers in establishing a comprehensive understanding of the manufacture of thin-walled and large-sized die casting Mg alloy parts in automobile *** will also assist them in developing new Mg alloys with improved comprehensive performance and new processes to meet the high requirements for die casting automotive components.

关键词： Mg alloys thin wall large size automotive part die casting

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Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing qiu Wei Li Thanh Nguyen Shouchun Wang Huaizhang shi Ming Wei Feng Wang Di Li Hui-Sheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention Department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom *** size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke *** Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre *** AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:*** experimental group will be treated with intra-arterial infusion of TNK during *** control group will be treated with standard *** The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 *** primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial *** The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK

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Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： Juan Sun Jin-Xiu Zhang Meng-shi Li Meng-Bin Qin Ruo-Xi Cheng Qing-Ru Wu qiu-Ling Chen Dan Yang Cun Liao shi-Quan Liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

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Neurotrophins and neural stem cells in posttraumatic brain injury repair

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Animal Models and Experimental Medicine 2024年第1期7卷 12-23页

作者： Wenwen Guo Ke Liu Yinghua Wang Xu ge Yifan Ma Jing Qin Caiqin Zhang Ya Zhao Changhong shi Laboratory Animal Center Fourth Military Medical UniversityXi'anP.R.China Gansu University of Traditional Chinese Medicine LanzhouP.R.China Medical College of Yan'an University Yan'anP.R.China

Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising *** different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains *** have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory *** factors are instrumental in alleviating neu-roinflammation and promoting *** addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular ***,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after *** this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with *** endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.

关键词： mutual effect neural stem cells neurological function neurotrophins traumatic brain injury

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丙酮盐酸混合液提取土壤腐殖质组分的光谱学特征

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光谱学与光谱分析 2024年第2期44卷 474-479页

作者：宋鸽孔祥仕黑龙江大学中俄学院黑龙江哈尔滨150080 Institute of Earth Sciences St.Petersburg State UniversitySt.Petersburg 199034Russia 吉首大学旅游学院湖南吉首416000

采用丙酮盐酸混合液提取土壤胡敏酸(HA)和胡敏素(HU)组分,利用元素分析、紫外-可见漫反射光谱和红外光谱进行结构表征。元素分析表明,HA中C、H、N和S含量均高于HU,O含量低于HU。原子比分析表明HA的缩合度相对较高,分子结构相对复杂,HU... 详细信息

采用丙酮盐酸混合液提取土壤胡敏酸(HA)和胡敏素(HU)组分,利用元素分析、紫外-可见漫反射光谱和红外光谱进行结构表征。元素分析表明,HA中C、H、N和S含量均高于HU,O含量低于HU。原子比分析表明HA的缩合度相对较高,分子结构相对复杂,HU的缩合度相对较低,分子结构相对简单。紫外-可见漫反射光谱分析表明,由于腐殖质(HS)的组成复杂,多种官能团互相干扰,HA和HU紫外-可见漫反射光谱无明显特征峰,吸光度值随着波长的增加呈下降趋势,且HA包含的吸光有机成分较多,化学组成较复杂。HA和HU紫外特征参数SUV254和E4/E6比较分析表明,与HU相比,HA芳香性较大,腐殖化程度较高。红外光谱分析表明,HA和HU具有相似的红外光谱,各研究对象特征吸收峰的吸收强度不同,其中开垦黑土20~40 cm和未开垦灰土18~37 cm土层HA的振动幅度较大,说明其包含的酚类化合物、含羟基化合物、脂肪族化合物和羧酸,以及含羰基的醛、酮、醚等化合物的含量较多。开垦黑土10~20 cm土层和未开垦灰土18~37 cm土层HU在各特征吸收峰振动幅度较大,说明其包含的酚类化合物、羧酸、脂肪烃和糖类化合物含量较多。红外光谱各吸收峰强度比较分析表明,开垦后黑土HA和HU酚类化合物、羟基官能团和脂肪族化合物等含量增加,而开垦后灰土HA和HU酚类化合物、羧酸和脂肪族化合物含量下降,表明开垦对黑土土壤有机质影响相对较小,并且在一定程度上增加了土壤有机质含量,而促进了灰土土壤有机质的分解。综上所述,丙酮盐酸混合液提取法为HS生物化学和生理活性的研究提供了新的技术手段,为合理利用土壤资源提供理论依据。

关键词：胡敏酸胡敏素元素分析紫外-可见漫反射光谱近红外光谱

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Revisit of geV Gamma-Ray Emission from Orion B with the Fermi Large Area Telescope

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Research in Astronomy and Astrophysics 2024年第9期24卷 128-135页

作者： Wei Zeng Xiao-Na Sun Rui-Zhi Yang Jia-Chun He Zhao-Dong shi Ting-Ting ge Yun-Feng Liang En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physics Science and TechnologyGuangxi UniversityNanning 530004China Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Key Labrotory for Research in Galaxies and Cosmology University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China

We revisit the γ-ray emission above 300 Me V towards the massive star-forming region of Orion B by adopting14 yr observations with the Fermi Large Area Telescope and utilizing the updated software *** extended γ-ray emission region around Orion B is resolved into two components(region Ⅰ and region Ⅱ).The γ-ray spectrum of region I agrees with the predicted γ-ray spectrum assuming the cosmic ray(CR)density is the same as that of Alpha Magnetic Spectrometer(AMS-02)measured ***γ-ray emissivity of region II appears to be deficit at low energy band(EgeV).Through modeling we find that CR densities exhibit a significant deficit below 20 ge V,which may be caused by a slow diffusion inside the dense *** is probably caused by an increased magnetic field whose strength increases with the gas density.

关键词： (ISM:)cosmic rays gamma-rays:ISM (Galaxy:)open clusters and associations:individual(NGC 2023 NGC 2024 NGC 2068 and NGC 2071)

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Reinforcement Technology for Soft Soil Roadbed in the Widened Section of Expressway Expansion

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Journal of World Architecture 2024年第2期8卷 25-30页

作者： Zhiqiang qiu Yun shi Lei Jiang China Merchants Chongqing Communications Technology Research&Design Institute Co. LTD.Chongqing 400067China

This article examines the soft soil roadbed reinforcement technology for widened sections of highways in a specific *** provides an overview of the project,the principles of soft soil roadbed reinforcement technology for wide sections,and its practical *** analysis aims to offer guidance on applying soft soil roadbed wide section reinforcement technology and enhancing the overall quality of similar projects.

关键词： Expressway Expansion project Widened section Soft soil roadbed Reinforcement treatment

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