检索结果-南通市图书馆

Aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo:a pilot study in rats

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第5期25卷 637-642页

作者： Yuan-Yuan Huang Dang-Wei Peng qiu-shi Liu Hui Jiang Xian-sheng Zhang Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Urology Peking University First HospitalBeijing 100000China Andrology Center Peking University First HospitalBeijing 100000China Institute of Urology Peking UniversityBeijing 100000China

Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and behaviors.The aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors,as well as to make a preliminary assessment of aerobic exercise as a complementary strategy to dapoxetine treatment in rapid ejaculators.Copulatory tests of rats and a treadmill training protocol were performed in this study.In total,12 rapid ejaculators were selected on the basis of ejaculation distribution theory and randomly assigned to 4 groups:control(Ctrol)group,aerobic exercise(Ex)group,dapoxetine(Dapo)group,and Ex+Dapo group.We evaluated the changes in ejaculatory parameters in the 4 groups.Variations in biological markers,including serum corticosterone,serotonin(5-HT),and brain-derived neurotrophic factor(BDNF)of the raphe nucleus,were determined by enzyme-linked immunosorbent assay(ELISA).The primary finding of our study was that both aerobic exercise and acute dapoxetine could enhance ejaculation control and prolong ejaculation latency in rapid ejaculator rats.The ejaculation delay effect of aerobic exercise was nearly equivalent to that of acute dapoxetine.In addition,both aerobic exercise and dapoxetine treatment could lead to increased expression of BDNF and 5-HT in the raphe nucleus of rapid ejaculators.Moreover,the two interventions,when applied together,may further upregulate the expression of BDNF-5-HT duo in a complementary manner.This study highlights the positive effects of aerobic exercise on ejaculation control.Regular aerobic exercise might be a promising complementary treatment to dapoxetine in rats.

关键词： aerobic exercise animal model brain-derived neurotrophic factor premature ejaculation raphe nucleus serotonin

Contrast-enhanced ultrasound as a valuable imaging modality for characterizing testicular lesions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第2期24卷 201-206页

作者： Jie Yu Xin-Hui Jiang Lian-Fang Du Min Bai Zhao-Jun Li Qiu-sheng shi Qi Jiang Fan Li Department of Ultrasound Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Medical Ultrasound Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western MedicineShanghai 201999China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Contrast-enhanced ultrasound(CEUS)is a new form of ultrasound(US)that can dynamically display microvessels in a highly sensitive manner.The purpose of this study was to investigate the efficacy of CEUS for characterizing testicular lesions in comparison with conventional US.Forty-seven patients with testicular lesions were enrolled.The histopathology results revealed that 31 cases were neoplastic(11 cases of seminomas,8 nonseminomatous germ cell tumors,8 lymphomas,2 Leydig cell tumors,and 2 nonspecific tumors),and 16 cases were nonneoplastic(8 cases of infarctions,3 epidermoid cysts,and 5 inflammation).The indicators of shallow lobulated morphology and cystic-solid echogenicity on conventional US were suggestive of germ cell tumors.More indicators on CEUS were found to be useful for characterizing testicular lesions.All the neoplastic lesions showed hyperenhancement on CEUS.Moreover,germ cell tumors presented with heterogeneous enhancement(73.7%,14/19),a twisted blood vessel pattern,rapid wash-in and wash-out,and peripheral rim hyperenhancement signs.Lymphoma was characterized by nonbranching linear vessel patterns(87.5%,7/8),rapid wash-in and slow wash-out.In nonneoplastic lesions,infarction and epidermoid cysts showed no enhancement,and abscesses were observed with marginal irregular enhancement.The sensitivity,specificity,and accuracy of CEUS for differentiating between neoplastic and nonneoplastic lesions were 100%,93.8%,and 97.9%,respectively,and these values were higher than those for conventional US(90.3%,62.5%,and 80.9%,respectively).CEUS can sensitively reflect the microvascular perfusion in testicular lesions and offers high accuracy for characterizing them.

关键词： characterization contrast-enhanced ultrasound diagnosis testicular neoplasms ultrasound

Lightweight epoxy-based abradable seal coating with high bonding strength

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第10期69卷 129-137页

作者： Yun-Qi Tong Qiu-sheng shi Mei-Jun Liu Guang-Rong Li Chang-Jiu Li Guan-Jun Yang State Key Laboratory for Mechanical Behavior o f Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an710049China

To gain high efficiency and low fuel consumption, aluminum-based abradable seal coatings had been widely used in the compressor casing of aero engines or gas turbines owing to the low elastic modulus. However, the adhesive transfer phenomenon frequently occurs when the radial rubbing generates between titanium alloy blade tips and aluminum-based coating. It tends to increase scratch force and results in blades vibration and even engine jam. To eliminate this problem, a new lightweight epoxy-based abradable seal coating with high bonding strength was developed by an effective and porosity controllable mixing process that distributes spherical pores uniformly in the continuous matrix. A lightweight coating of 63% porosity with a hardness of 33.1(HR15 Y) can be reached when the content of hollow microspheres is 31 wt.%. The coating density is 0.5 g/cm3 and the bonding strength is as high as 18 MPa.The performance of the epoxy-based coating is comprehensively better than aluminum-based coatings in five essential indices. This study is expected to provide a new technical path for obtaining high-quality abradable seal coatings to guarantee the efficient and safe operation of compressors.

关键词： Epoxy-based seal coating Porosity HR15Y Lightweight High bonding strength

Comparative study of galectin-3 and B-type natriuretic peptide as biomarkers for the diagnosis of heart failure

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2014年第1期11卷 79-82页

作者： qiu-sheng YIN Bing shi Lan Dong Lei BI Department of Geriatric Cardiology General Hospital of Be~jing Command of PLA Beijing 100700 China

BackgroundHeart 失败(HF ) 是有复杂 pathophysiological 原因的普通疾病。HF 的诊断通常依靠病历和症状的全面分析，并且源于 echocardiography 和生物化学的测试。Galectin-3，在 HF 的相对新的 biomarker，被 US 食物药品管理局为 ... 详细信息

BackgroundHeart 失败(HF ) 是有复杂 pathophysiological 原因的普通疾病。HF 的诊断通常依靠病历和症状的全面分析，并且源于 echocardiography 和生物化学的测试。Galectin-3，在 HF 的相对新的 biomarker，被 US 食物药品管理局为 HF 在风险的层化作为一个标记在 2010 同意。我们与保存喷射部分(pEF ) 在病人为 HF 诊断作为 biomarker 估计了 galectin-3 并且把它的性能与 B 类型 natriuretic 的作比较肽(BNP ).MethodsThirty -- 有 HF (HFpEF 组) 的五个 pEF 病人和没有 HF (控制组) 的 43 个 pEF 病人被注册。在 HFpEF 和控制题目的 galectin-3 和 BNP 的血浆层次是坚定的。象为 HF 诊断的标记的 galectin-3 和 BNP 的敏感，特性，预兆的价值，和精确性被计算， galectin-3 和 BNP 的 compared.ResultsLevels 是 23.09 ±；6.97 ng/mL 和 270.46 ±；在 HFpEF 组的 330.41 pg/mL，和 16.74 ±；2.75 ng/mL 和 59.94 ±；在控制组的 29.93 pg/mL 分别地。在在二个组之间的 galectin-3 和 BNP 的层次的差别是重要的(P <；0.01 ) 。作为为在学习题目的 HF 诊断的 biomarker，分别地， galectin-3 在 17.8 ng/mL 的截止价值显示出 94.3% 和 65.1% 的敏感和特性。分别地， BNP 在 100 pg/mL 的截止价值显示出 77.1% 和 90.7% 的敏感和特性。Galectin-3 是一显著地更敏感(P <；0.05 ) 但是不太特定(P <；0.01 ) biomarker 与 BNP 相比。在在 galectin-3 和 BNP 标记之间的积极预兆的价值，否定预兆的价值，和精确性的差别不是重要的(P >；0.05 ) 。在操作典型曲线(95% 信心间隔) 的接收装置下面的区域是 0.891 (0.808-0.974 ) 并且(0.809-0.984 ) 分别地， 0.896 没有二之间的重要差别为 galectin-3 和 BNP 珍视(P >；0.05 ) galectin-3 的 .ConclusionsThe 水平显著地与 HF 在病人被提高。Galectin-3 和 BNP 是为在有 pEF 的病人的 HF 的诊断的有用 biomarkers。

关键词：半乳糖凝集素生物标志物心力衰竭利钠肽诊断心脏精度指标 BNP

Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2022年第2期28卷 153-161页

作者： BU Yu LI Wen-shuang LIN Ji WEI Yu-wei SUN qiu-ying ZHU shi-jie TANG Zhong-sheng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Department of Hematology the Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(550025)China

Objective:To investigate whether electroacupuncture(EA)alleviates cognitive impairment by suppressing the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)signaling pathway,which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia(VaD).Methods:The experiments were conducted in 3 parts and in total the Sprague-Dawley rats were randomly divided into 8 groups by a random number table,including sham,four-vessel occlusion(4-VO),4-VO+EA,4-VO+non-EA,sham+EA,4-VO+lipopolysaccharide(LPS),4-VO+LPS+EA,and 4-VO+TAK-242 groups.The VaD model was established by the 4-VO method.Seven days later,rats were treated with EA at 5 acupoints of Baihui(DV 20),Danzhong(RN 17),Geshu(BL 17),Qihai(RN 6)and Sanyinjiao(SP 6),once per day for 3 consecutive weeks.Lymphocyte subsets,lymphocyte transformation rates,and inflammatory cytokines interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were measured to assess immune function and inflammation in VaD rats.Transmission electron microscopy was used to observe the ultrastructure of nerve cells in the hippocampus.The levels of TLR4,MyD88,IL-6,and TNF-αwere detected after EA treatment.TLR4/MyD88 signaling and cognitive function were also assessed after intracerebroventricular injection of TLR4 antagonist TAK-242 or TLR4 agonist LPS with or without EA.Results:Compared with the 4-VO group,EA notably improved immune function of rats in the 4-VO+EA group,inhibited the protein and mRNA expressions of TLR4 and MyD88 in the hippocampus of rats,reduced the expressions of serum IL-6 and TNF-α(all P0.05).Conclusions:EA attenuated cognitive impairment associated with immune inflammation by inhibition of the TLR4/MyD88 signaling pathway.Thus,EA may be a promising alternative therapy for the treatment of VaD.

关键词： electroacupuncture vascular dementia immune-inflammation toll-like receptor 4/myeloid differentiation factor 88 signaling pathway

Microstructure stability of γ’+β Ni-Al coated single-crystal superalloy N5 annealed at 1100℃

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2021年第3期40卷 693-700页

作者： Jing-Yong Sun Liang-Liang Wei qiu-shi Li sheng-Kai Gong Hong-Bo Guo School of Energy and Power Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structural Materials and Coatings Technology Ministry of Industry and Information TechnologyBeijing 100191China

γ’+β Binary-phase Ni-Al coatings were prepared on second-generation single-crystal superalloy Rene N5(N5) substrates by electron beam physical vapor deposition.Inter-diffusion behavior between coatings and substrates at 1100℃ and its effects on microstructure stability of the substrates were investigated.A 3-μm-thick substrate diffusion zone(SDZ) layer forms beneath the coating/substrate interface after 5-h heat treatment.The SDZ layer is composed of γ’-Ni_(3) Al phases and needle-like precipitates growing along(100)(110) or(100) direction.After100-h annealing,the thickness of the SDZ layer increases to~17 μm,much lower than that of the single β-NiAl-coated substrate,while keeping single-crystal microstructure.

关键词： Ni-Al coating EB-PVD Single-crystal superalloy Inter-diffusion Microstructure stability

Thermally Conductive Poly(lactic acid) Composites with Superior Electromagnetic shielding Performances via 3D Printing Technology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第3期40卷 248-255,I0006页

作者： Teng-Bo Ma Hao Ma Kun-Peng Ruan Xue-Tao shi Hua qiu sheng-Yuan Gao Jun-Wei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China

This work proposes a facile fabrication strategy for thermally conductive graphite nanosheets/poly(lactic acid) sheets with ordered GNPs(o-GNPs/PLA) via fused deposition modeling(FDM) 3 D printing technology.Further combinations of o-GNPs/PLA with Ti_(3) C_(2) T_(x) films prepared by vacuum-assisted filtration were carried out by "layer-by-layer stacking-hot pressing" to be the thermally conductive Ti_(3) C_(2) T_(x)/(oGNPs/PLA) composites with superior electromagnetic interference shielding effectiveness(EMI SE).When the content of GNPs was 18.60 wt%and 4 layers of Ti_(3) C_(2) T_(x)(6.98 wt%) films were embedded,the in-plane thermal conductivity coefficient(λ_(Ⅱ)) and EMI SE(EMI SE_(Ⅱ)) values of the thermally conductive Ti_(3) C_(2) T_(x)/(o-GNPs/P LA) composites significantly increa sed to 3.44 W·m^(-1)·K^(-1) and 65 d B(3.00 mm),increased by 1223.1% and2066.7%,respectively,compared with λ_(Ⅱ)(0.26 W·m^(-1)·K^(-1)) and EMI SE_(Ⅱ)(3 d B) of neat PLA matrix.This work offers a novel and easily route for designing and manufacturing highly thermally conductive polymer composites with superior EMI SE for broader application.

关键词： Polymer-matrix composites(PMCs) Ti_(3)C_(2)T_(x) 3D printing Thermal conductivity Electromagnetic interference(EMI)

In situ construction of a favorable cathode electrolyte interphase through a fluorosilane additive for high-performance Li-rich cathode materials

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第11期41卷 3630-3638页

作者： Yuan-Yuan Pan Chang-Ding qiu shi-Jie Qin Zuo-Fei Wang Jing-Song Yang Heng-Jiang Cong Fu-sheng Ke Sauvage Center for Molecular Sciences College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Li-rich manganese-based oxides (LRMO) with high capacities are attractive cathode materials for next-generation lithium-ion batteries.However,poor cycling stability is one of the key issues impeding their commercialization.Here,for the first time,we employed trimethoxy(3,3,3-trifluoropropyl)silane (TMTFS) as a multifunctional electrolyte additive to stabilize the LRMO cathode interphase and elevate its cycling performance.The LRMO electrode delivered a high reversible capacity of 250.4 mAh·g^(-1) with a stable capacity retention of 91% after 200 cycles.

关键词： electrolyte cycling additive

A non-invasive diagnostic method of cavity detuning based on a convolutional neural network

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2022年第7期33卷 25-35页

作者： Liu-Yuan Zhou Hao Zha Jia-Ru shi Jia-Qi qiu Chuan-Jing Wang Yun-sheng Han Huai-Bi Chen Department of Engineering Physics Tsinghua UniversityBeijing100084China Key Laboratory of Particle and Radiation Imaging Tsinghua UniversityBeijing100084China

As modern accelerator technologies advance toward more compact sizes,conventional invasive diagnostic methods of cavity detuning introduce negligible interference in measurements and run the risk of harming structural surfaces.To overcome these difficulties,this study developed a non-invasive diagnostic method using knowledge of scattering parameters with a convolutional neural network and the interior point method.Meticulous construction and training of the neural network led to remarkable results on three typical acceleration structures:a 13-cell S-band standing-wave linac,a 12-cell X-band traveling-wave linac,and a 3-cell X-band RF gun.The trained networks significantly reduced the burden of the tuning process,freed researchers from tedious tuning tasks,and provided a new perspective for the tuning of side-coupling,semi-enclosed,and total-enclosed structures.

关键词： Cavity detuning Convolutional neural network Equivalent circuit