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Differences in Immune Responses between Children and Adults with COVID-19

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Current Medical Science 2021年第1期41卷 58-61页

作者： Yin YUAN qiu-peng wang Dan SUN Zu-bo WU Hua peng Xin-wen LIU Ya-ling LIU Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China

Over 85590000 individuals have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although there have been an increasing number of reports on coronavirus disease 2019(COVID-19),it is unclear why infected children show milder symptoms than adults.A retrospective case study was performed at two designated hospitals for ***(56 children and 63 adults)with confirmed SARS-CoV-2 infection and mild pneumonia were randomly enrolled in this *** median age of the children was 7.0 years,and 51.79%of them were *** median age of the adults was 57 years,and 47.62%were *** most common symptoms were fever,cough,sputum and *** were no significant differences in symptoms between children and adult *** terms of immunological indices on admission,adult patients displayed typical leukopenia and markedly higher levels of IL-2,IL-4,and IL-6 than child *** elevation of IL-2,IL-4 and IL-6 in adults induced more extensive lung *** effective and non-aggressive immune response successfully resisted SARS-CoV-2 invasion and maintained mild symptoms in child *** correlation of higher IL-2,IL-4,and IL-6 with the lung injury might be evidence that preventing excessive cytokine production can avoid further lung damage in these patients.

关键词： COVID-19 child adult immune response

SIMULTANEOUS ANTERIOR AND POSTERIOR HEMIVERTEBRA RESECTION IN THE TREATMENT OF CONGENITAL KYPHOSCOLIOSIS

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Chinese Medical Sciences Journal 2005年第4期20卷 252-256,页

作者： Li-xiang Ding Gui-xing qiu Yi-peng wang Jian-guo Zhang Department of Orthopedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the efficacy of simultaneous anterior and posterior hemivertebra resection in the treatment of congenital kyphoscoliosis caused by fully-segmented hemivertebra. Methods Twenty-one consecutive cases with congenital kyphoscoliosis, which were 8 males and 13 females, underwent one-stage operation of anterior hemivertebra resection and posterior instrumentation. All of the hemivertebra were fully-segmented. The average age at surgery was 11.4 （range, 1.5-16） years old. Results The average follow-up was 23 （range, 6-50） months. The average Cobb＇s angle of the coronal curve was 51.4° （30°-120°） before surgery, 16.9° （0°-54°） after surgery, and 19.5° at latest follow-up. The angle of segmental kyphosis was 37.1° （0°-95°） before surgery and 16.1° （0°-48°） after surgery, and 18.2° at latest follow-up. Apical translation was improved from 4.7 cm to 1.9 cm. The average fusion segments were 4.8 （range, 2-10） segments. Complication included pressure sore in one case, pedicle cutting by pedicle screw in one case and elongation of the curve in one case. There was no obvious pseudarthrosis, decompensation, and kyohosis deformity aggravation at latest follow-up. Conclusion One-stage hemivortebra resection has a good result in the surgical treatment of congenital kyphoscoliosis caused by fully-segmented hemivertebra, and may shorten fusion levels if performed at an earlier age.

关键词： congenital scoliosis kyphosis hemivertebra resection intemal fixators

VIDEO-ASSISTED THORACOSCOPIC CORRECTION AND FUSION OF SCOLIOSIS

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Chinese Medical Sciences Journal 2007年第3期22卷 144-151页

作者： Bin Yu Jian-guo Zhang Gui-xing qiu Yi-peng wang Xin-yu Yang Department of Orthopedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the operative technique and preliminary results of video-assisted thoracoscopic anterior correction and fusion of scoliosis. Methods Eleven cases underwent thoracoscopic anterior correction and fusion of scoliosis from March 2003 to April 2005 in our hospital were reviewed. They were all females with an average age of 13.1 years old. Of which, 9 cases were idiopathic scoliosis, 1 case was congenital scoliosis, and 1 case was Marian syndrome scoliosis. The coronal Cobb angle and apical vertebral translation before and after surgery as well as at final follow-up were measured. The operation time, blood loss during operation, and peri-operative complications were recorded. The mean operation time was 6. 4 hours, mean instrumented vertebrae were 6.4 segments, and mean blood loss during operation was 364 mU The coronal Cobb angles of the thoracic curve before and after surgery were 45.5° and 15.4° respectively, with an average correction rate of 65.4%. The lumbar curve was corrected from 28.4° to 11.8° , with an average simultaneous correction rate of 57.2%. All of the patients were followed up regularly with an average time of 21.4 months. At the final foUow-up, the coronal Cobb angles of the thoracic and lumbar curves were 19.0° and 20. 1° , with a 3.6° and 8. 3° loss of correction, respectively. The apical vertebral translation was improved from 32. 3 mm to 10.5 mm for the thoracic curve, and from 13.1 mm to 8.2 mm for the lumbar curve. There were 6 cases with peri-opemtive complications, including 1 case of thoracic effusion, 1 case of chylothomx, 1 case of locking plug loosing, 2 cases of aggravation of the unfused lumbar curve （ 1 case also with thoracolumbar kyphosis）, and 1 case with a screw tip causing a contour deformity of the aorta. And 4 of them underwent revision surgery.Conclusions Video-assisted thoracoscopic anterior correction and fusion of scoliosis has good correction capability, less intraoperative bleeding, and favorable

关键词： scoliosis anterior fusion thoracoscopy intemal fixation

Effects of competitive and noncompetitive 5α-reductase inhibitors on serum and intra-prostatic androgens in beagle dogs

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Chinese Medical Journal 2013年第4期126卷 711-715页

作者： ZHAO Xiao-feng YANG Yong wang Wei qiu Zhi ZHANG peng wang Biao Department of Urology Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Background 5a-Reductase inhibitors （5a-RI） act by inhibiting the conversion of testosterone to dihydrotestosterone （DHT）, thereby preventing DHT induced benign prostatic hyperplasia. The existing 5a-RIs can be classified into two types： competitive and noncompetitive. Currently, limited evidence is available concerning the effect differences between the two types of 5a-RI on androgens. The purpose of this study was to assess the effects of competitive and noncompetitive 5a-RIs on serum and intra-prostatic androgens in beagle dogs. Methods Twenty beagles with spontaneous benign prostatic hyperplasia were randomly allocated into two groups： epristeride group （n=10） in which beagles were treated with epristeride at 1 mg/kg once a day for 3 months, and finasteride group （n=10） in which beagles were treated with finasteride at 1 mg/kg once a day for 3 months. The levels of intra-prostatic testosterone and DHT were measured before treatment and on day one after three months medication. Serum levels of testosterone and DHT were measured at the same time points. Changes in androgen levels before and after treatment were analyzed, and comparisons were made within each treatment group and between treatment groups. Results After 3-month treatment, serum and intra-prostatic DHT levels all decreased significantly in both the epristeride and finasteride groups. The change of DHT in serum was significantly higher in the finasteride group （-14% and -43% in epdsteride and finasteride groups respectively, with P〈0.001）; however there was no significant difference in the changes of intra-prostatic DHT between the two groups （-47% and -51% in epristeride and finasteride groups, respectively, P=0.304）. The decreases in DHT levels were accompanied by reciprocal increases in serum and intra-prostatic testosterone levels. Changes of testosterone were significantly higher in finasteride group both in serum （20% and 42% in epristeride and finasteride groups, respectively, P〈0.001） and in pro

关键词： 5a-reductase inhibitor androgen benign prostatic hyperplasia

Posterior Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis Patients:a Comparison of All Pedicle Screws versus Hybrid Instrumentation

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Chinese Medical Sciences Journal 2009年第1期24卷 30-35页

作者： Bin Yu Jian-guo Zhang Gui-xing qiu Yi-peng wang Yu Zhao Jian-xiong Shen Hong Zhao Xin-yu Yang Department of Orthopedic Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100730 China

Objective To analyze the influence of segmental pedicle screws versus hybrid instrumentation on the correction results in adolescent idiopathic scoliosis patients undergoing posterior selective thoracic fusion. Methods By reviewing the medical records and roentgenograms of adolescent idiopathic scoliosis patients who underwent selective thoracic fusion from February 2000 to January 2007 in our hospital, the patients were divided into 2 groups according to different instrumentation fashions： Group A was hook-screw-rod （hybrid） internal fixation type, Group B was screw-rod （all pedicle screws） internal fixation type, and the screws were used in every segment on the concave side of the thoracic curve. The parameters of the scoliosis were measured and the correction results were analyzed. Results Totally, 48 patients （7 males, 41 females） were included, with an average age of 14.4 years old and a mean follow-up time of 12.3 months. Thirty and 18 patients were assigned to group A and group B, respectively. The mean preoperative coronal Cobb angles of the thoracic curve were 48.8° and 47.4°, respectively. After surgery, they were corrected to 13.7° and 6.8°, respectively. At final follow-up, they were 17.0° and 9.5°, with an average correction rate of 64.6% and 79.0%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The mean preoperative coronal Cobb angles of the lumbar curve were 32.6° and 35.2°, respectively. After surgery, they were corrected to 8.6° and 8.3°, respectively. At final follow-up, they were 10.3° and 11.1°, with an average correction rate of 66.8% and 69.9%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The correction loss of the thoracic curve and lumbar curve in the 2 groups were 3.1° and 1.8°, 2.4° and 2.4°, respectively. No significant difference was noted （both P〉0.05）. The decompensation rate at final follow-up in these 2 groups wer

关键词： adolescent idiopathic scoliosis selective thoracic fusion internal fixator pedicle screw decompensation

Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery

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Chinese Medical Sciences Journal 2011年第4期26卷 221-226页

作者： Zhi-jian Sun Yu Zhao Giu-xing qiu Yi-peng wang Xi-sheng Weng Hong Zhao Jian-xiong Shen Yu Jiang Ye Li Xiang Li Department of Orthopedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the efficacy and safety of low molecular weight heparin (LMWH) prophylaxis for venous thromboembolism (VTE) after lumbar decompression surgery. Methods Patients at high or the highest risk of VTE who underwent lumbar spine surgery in Peking Union Medical College Hospital from January 2004 to April 2011 were included in the present study. All the patients received a half dose of LMWH 6 hours after surgery followed by a full dose LMWH once per day until discharge. We recorded incidences of deep venous thrombosis (DVT), pulmonary embolism (PE), bleeding complications, and medication side effects. Results Seventy-eight consecutive patients were eligible and enrolled in this study. The mean hospital stat was 8.5±4.5 days. No symptomatic DVT, PE, or major bleeding events were observed. One patient developed wound ecchymosis, another developed wound bleeding, four had mild hepatic aminotransferase level elevation, and one developed a suspicious allergic reaction. Conclusion LMWH may be applied as an effective and safe prophylaxis for VTE in high-risk patients undergoing lumbar decompression surgery.

关键词： venous thromboembolism prophylaxis low molecular weight heparin lumbar decompression surgery

A mathematical model for simulating the phase-based transmissibility of a novel coronavirus

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Infectious Diseases of Poverty 2020年第1期9卷 18-25页

作者： Tian-Mu Chen Jia Rui qiu-peng wang Ze-Yu Zhao Jing-An Cui Ling Yin State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen University4221-117 South Xiang’an RoadXiang’an DistrictXiamenFujian ProvincePeople’s Republic of China Department of Mathematics School of ScienceBeijing University of Civil Engineering and ArchitectureBeijingPeople’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong ProvincePeople’s Republic of China

Background:As reported by the World Health Organization,a novel coronavirus(2019-nCoV)was identified as the causative virus of Wuhan pneumonia of unknown etiology by Chinese authorities on 7 January,*** virus was named as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by International Committee on Taxonomy of Viruses on 11 February,*** study aimed to develop a mathematical model for calculating the transmissibility of the ***:In this study,we developed a Bats-Hosts-Reservoir-People transmission network model for simulating the potential transmission from the infection source(probably be bats)to the human *** the Bats-HostsReservoir network was hard to explore clearly and public concerns were focusing on the transmission from Huanan Seafood Wholesale Market(reservoir)to people,we simplified the model as Reservoir-People(RP)transmission network *** next generation matrix approach was adopted to calculate the basic reproduction number(R0)from the RP model to assess the transmissibility of the ***:The value of R0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was ***:Our model showed that the transmissibility of SARS-CoV-2 was higher than the Middle East respiratory syndrome in the Middle East countries,similar to severe acute respiratory syndrome,but lower than MERS in the Republic of Korea.

关键词： Novel coronavirus Mathematical model Basic reproduction number Next generation matrix Transmissibility

Effect and mechanism of EOP on diabetic mice induced by alloxan

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Effect and mechanism of EOP on diabetic mice induced by allo...

α1,3Fucosyltransferase-Ⅶ Modulates the Function,Signaling of Insulin Receptor and the Cell Cycle

中国药理学会第十次全国学术会议

作者： XIN Xiao-ming,qiu Li-peng,wang Hao,Gao Yun-sheng (Pharmaceutical college,Taishan Medical College,Taian 271016,China)

Aim In order to investigate the hypoglycemic effect of the eucommia ulmoides oliv polysaccharides on diabetes mellitus mices caused by Alloxan,in order to provide the basis theory for eucommia’s further development and the *** Hyperglycemic model of mice was made by intraperitoneal injection of alloxan(250 mg·kg),which destroys their pancreatic islet *** the blood glucose of the mice with blood glucose monitoring,blood glucose levels higher than 10.0 mmol·L were the successful diabetic *** mice were randomly divided into 6 teams by weights,and each group has 8 *** dose of physiological saline, xiao ke wan,low dose(100 mg·kg),medium dose(200 mg·kg) and high dose(400 mg·kg) were given to mice orally by weight(ig),administered orally for ten *** the end of the fasting administration the mice can not help but water 3 *** the blood glucose levels and weight again,after taken the blood from eyeball,the mice were sacrificed for thymus and spleen,then calculated their ***,measuring the index of MDA,SOD in blood,and NO,NOS in the *** the above indexs,observate weather the Eucommia ulmoides oliv polysaccharides have the hypoglycemic effect on diabetes mellitus mices caused by *** Eucommia ulmoides oliv polysaccharides can be effective decrase the blood glucose of diabetes mellitus mice caused by *** with the model group,Eucommia the polysaccharide group of blood glucose and weight loss reduction,thymus index and the index spleen have been increased,MDA,NO lower,and SOD,NOS increased. Conclusion Eucommia ulmoides oliv polysaccharides can decrase the blood glucose of diabetes mellitus mice caused by Alloxan on certen degree.

关键词： Eucommia ulmoides oliv polysaccharides(EOP) Alloxan Hypoglycemic Effect

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α1,3Fucosyltransferase-Ⅶ Modulates the Function,Signaling ...