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The long-lived partial melting of the Greater Himalayas in southern Tibet, constraints from the Miocene Gyirong anatectic pegmatite and its prospecting potential for rare element minerals

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China Geology 2023年第2期6卷 303-321,I0004-I0015页

作者： Hua-wen Cao qiu-ming pei Xiao Yu Ai-bin Cao Yong Chen Hang Liu Kai Zhang Xin Liu Xiang-fei Zhang Chengdu Center China Geological Survey(Geosciences Innovation Center of Southwest China)Ministry of Natural ResourcesChengdu 610218China College of Earth Sciences Chengdu University of TechnologyChengdu 610059China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China Research Center of Applied Geology China Geological SurveyMinistry of Natural ResourcesChengdu 610036China School of Earth Resources China University of GeosciencesWuhan 430074China

The Cenozoic Himalayan leucogranite-pegmatite belt has been a hotspot for rare metal exploration in recent *** determine the genesis of the pegmatite in the Himalayan region and its relationship with the Greater Himalayan Crystalline Complex(GHC),the Gyirong pegmatite in southern Tibet was chosen for geochronological and geochemical *** dating analyses indicate that the U-Th-Pb ages of zircon,monazite,and xenotime exhibit large variations(38.6‒16.1 Ma),with the weighted average value of the four youngest points is 16.5±0.3 Ma,which indicates that the final stage of crystallization of the melt occurred in the *** age of the muscovite Ar-Ar inverse isochron is 15.2±0.4 Ma,which is slightly later than the intrusion age,showing that a cooling process associated with rapid denudation occurred at 16‒15 ***εHf(t)values of the Cenozoic anatectic zircons cluster between−12 and−9 with an average of−*** Gyirong pegmatite shows high contents of Si,Al,and K,a high Al saturation index,and low contents of Na,Ca,Fe,Mn,P,Mg,and ***,the Gyirong pegmatite is enriched in Rb,Cs,U,K,Th and Pb and depleted in Nb,Ta,Zr,Ti,Eu,Sr,and *** samples show a high 87Sr/86Sr(16 Ma)ratio of ca.0.762 and a lowεNd(16 Ma)value of−*** calculated average initial values of 208Pb/204Pb(16 Ma),207Pb/204Pb(16 Ma)and 206Pb/204Pb(16 Ma)of the whole rock are 39.72,15.79 and 19.56,*** Sr-Nd-Pb-Hf isotopic characteristics of the Gyirong pegmatite are consistent with those of the *** study concludes that the Gyirong pegmatite represents a typical crustal‒derived anatectic pegmatite with low metallogenic potential for rare *** Gyirong pegmatite records the long‒term metamorphism and partial melting process of the GHC,and reflects the crustal thickening caused by thrust compression at 39‒29 Ma and the crustal thinning induced by extensional decompression during 28‒15 Ma.

关键词： Partial melting of magma Anatectic pegmatite Zircon-monazite-xenotime U‒Pb dating Sr-Nd-Pb isotopes Greater Himalayan crystalline complex Mineral exploration engineering Gyirong Tibet

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Notch信号通路异常和肿瘤的生成

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透析与人工器官 2008年第2期19卷 32-36页

作者：裘明哲浦佩玉天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤实验室天津300052

近年研究表明,Notch信号通路与肿瘤发生有关,但Notch对肿瘤的发生、发展可以起着截然相反的作用。在某些组织中Notch单个或多个成员具有显性癌基因作用,而在另一些组织量则发挥着抑癌基因的功能。本文就Notch在肿瘤研究中的研究进展作... 详细信息

近年研究表明,Notch信号通路与肿瘤发生有关,但Notch对肿瘤的发生、发展可以起着截然相反的作用。在某些组织中Notch单个或多个成员具有显性癌基因作用,而在另一些组织量则发挥着抑癌基因的功能。本文就Notch在肿瘤研究中的研究进展作以综述。

关键词：信号通路肿瘤

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Deep-seated large-scale toppling failure in metamorphic rocks：a case study of the Erguxi slope in southwest China

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Journal of Mountain Science 2016年第12期13卷 2094-2110页

作者： LIU ming LIU Fang-zhou HUANG Run-qiu pei Xiang-jun State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology Chengdu 610059 China School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

Deep-seated large-scale toppling failure presents unique challenges in the study of natural slope deformation process in mountainous *** active deep-seated toppling process was identified in the Erguxi slope located in southwest China,which affected a large area and damaged critical transportation infrastructure with the volume of the deforming rock mass exceeding 24×10~6 m^*** poses significant risks to the downstream Shiziping Hydropower Station by damming the Zagunao *** investigation and monitoring results indicate that the deformation of the Erguxi slope is in the advanced stage of deep-seated toppling process,with the formation of a disturbed belt but no identifiable master failure *** was postulated that the alternating tensile and shear strength associated with the hard/soft laminated rock strata of metasandstone and phyllite layers preclude the development of either a tensile or shear failure surface,which resulted in the continuous deformation and displacement without a catastrophic mass *** slope movement is in close association with the unfavorable geological conditions of the study area in addition to the construction of transportation infrastructure and the increase of the reservoir *** the basis of the mechanism and intensity of the ongoing toppling deformation,a qualitative grading system was proposed to describe the toppling process and toevaluate the slope *** paper summarized the field observation and monitoring data on the toppling deformation for better characterizing its effect on the stability of the Erguxi *** qualitative grading system intends to provide a basis for quantitative study of large-scale deep-seated toppling process in metamorphic rocks.

关键词： Deep-seated slope deformation Largescale toppling Slope stability Metamorphic rock

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Roles of titanium-rich precipitates as inoculants during solidification in low carbon steel

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International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 276-281页

作者： ming-lin Wang Guo-guang Cheng Sheng-tao qiu pei Zhao Yong Gan The State Key Laboratory for Advanced Steel Process and Products Central Iron and Steel Research Institute Beijing 100081 China National Engineering and Research Center for Continuous Casting Technology Central Iron and Steel Research Institute Beijing 100081 China Metallurgical and Ecological Engineering School University of Science and Technology Beijing Beijing 100083 China

The effect of titanium on the as-cast structure and the growth form of titanium precipitates, and the effect of cooling rate on the size and distribution of titanium precipitates were studied. It is shown that Ti-rich precipitates acting as heterogeneous nucleation sites play an important role in refining the grain size and increasing the equiaxed grain ratio. Cooling rate has a great effect on the size and distribution of precipitates. The number of precipitates increases and the size decreases with the increase of cooling rate. Ti-rich particles acting as het- erogeneous nucleation sites at the onset of solidification are observed in the experiment. This result suggests that TiN nucleated on Ti2O3 is an effective inoculant for δ-ferrite during solidification in low carbon steel.

关键词： precipitate titanium oxide titanium nitride cooling rate solidification

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Simulation of Thermal Insulation of Top-Surface Slag Layers in Continuous Casting Mold

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Journal of Iron and Steel Research International 2011年第10期18卷 29-33页

作者： WANG Qiang WU Ye-ming qiu Sheng-tao ZHAO pei National Engineering Research Center of Continuous Casting Technology Central Iron and Steel Research Institute Beijing 100081 China

A computational model of thermal behavior of the top-surface slag layers in continuous casting mold was applied to interpret the thermal insulation of mold powder. The temperature drop of liquid steel caused by heat re moral at the interface of molten steel and slag in mold was proposed to evaluate the thermal insulation of mold slag. The calculation results show that slag consumption is one of important factor influencing the temperature drop, while the casting speed has no obvious effect on it. With the increase of slag consumption, the temperature drop is increased.

关键词： thermal insulation temperature distribution heat flux temperature drop

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Elliptical inclusion in an anisotropic plane:non-uniform interface effects

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Applied Mathematics and Mechanics(English Edition) 2022年第5期43卷 667-688页

作者： Pengyu pei ming DAI School of Electrical and Mechanical Engineering Jinling Institute of TechnologyNanjing 211169China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

We study the plane deformation of an elastic composite system made up of an anisotropic elliptical inclusion and an anisotropic foreign matrix surrounding the *** order to capture the influence of interface energy on the local elastic field as the size of the inclusion approaches the nanoscale,we refer to the Gurtin-Murdoch model of interface elasticity to describe the inclusion-matrix interface as an imaginary and extremely stiff but zero-thickness layer of a finite stretching *** opposed to isotropic cases in which the effects of interface elasticity are usually assumed to be uniform(described by a constant interface stretching modulus for the entire interface),the anisotropic case considered here necessitates non-uniform effects of interface elasticity(described by a non-constant interface stretching modulus),because the bulk surrounding the interface is *** this end,we treat the interface stretching modulus of the anisotropic composite system as a variable on the interface curve depending on the specific tangential direction of the *** then devise a unified analytic procedure to determine the full stress field in the inclusion and matrix,which is applicable to the arbitrary orientation and aspect ratio of the inclusion,an arbitrarily variable interface modulus,and an arbitrary uniform external loading applied *** non-uniform interface effects on the external loading-induced stress distribution near the interface are explored via a group of numerical *** is demonstrated that whether the nonuniformity of the interface effects has a significant effect on the stress field around the inclusion mainly depends on the direction of the external loading and the aspect ratio of the inclusion.

关键词： elliptical inclusion anisotropic material interface stress Gurtin-Murdoch model membrane-type interface

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Enhancement of the Neuronal Dynamic Range by Proper Intensities of Channel Noise

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Chinese Physics Letters 2013年第7期30卷 43-46页

作者： WANG Lei ZHANG Pu-ming LIANG pei-Ji qiu Yi-Hong School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240

The capability of a biological neuron to discriminate the intensity of external stimulus is measured in its dynamic *** previous studies,a few factors have been reported to be able to enhance the dynamic range,e.g.,electrical coupling and active *** we numerically show that intrinsic channel noise within neurons has a subtle effect in neuronal dynamic range *** simulation results indicate that for relatively weak noise intensity,the dynamic range of the neuron is enhanced ***,as the noise intensity becomes stronger,the dynamic range of the neuron is *** investigation suggests that sodium channel noise and potassium channel noise play opposite roles in modulating the dynamic ***,the model results suggest a new function of channel noise,that is,a proper value of noise intensity could optimize the dynamic range of neurons.

关键词： channel noise intensity

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Self-Healing Polymeric Materials:On a Winding Road to Success

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Chinese Journal of Polymer Science 2022年第11期40卷 1315-1316页

作者： ming-qiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GD HPPC LabSchool of ChemistrySun Yat-Sen UniversityChina

Self-healing represents a next-generation technology in response to the common demands of polymeric materials for long-term stability and *** mimics the capability of naturally occurring species like living organisms to autonomously recover nonfatal *** damages inevitably generated during fabrication and service are allowed to be unconsciously repaired on a microscopic scale,and would no longer develop into macroscopic failures like the case of conventional materials.

关键词： durability Wind autonomous

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Academician Qi-Yi Xing(Chi-Yi Hsing):pioneer organic chemist of synthetic insulin

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Protein & Cell 2022年第9期13卷 627-630页

作者： ming-Hua qiu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of ScienceKunming650201China

Qi-Yi Xing(Chi-Yi Hsing,November 24th,1911–November 4th,2002)(Fig.1)was one of the remarkable scientist and educators in *** was a pioneer for Chinese Organic Chemistry development,an Academician of the Chinese Academy of Sciences,and a professor at the College of Chemistry and Molecular Engineering in Peking *** was one of the leaders of the synthetic crystalline bovine insulin project in China and a person of outstanding talent in the teaching of organic *** the occasion of 110th anniversary of the establishment of the chemistry department at Peking University,it is also Professor Xing’s 110th birthday,and we pay tribute to his lifelong commitment to the development of organic chemistry,especially protein synthesis,and his teaching style.

关键词： Academician teaching pioneer

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