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Relationship between somatostatin receptor subtype expression and clinicopathology,Ki-67,Bcl-2 and p53 in colorectal cancer

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World Journal of Gastroenterology 2006年第13期12卷 2011-2015页

作者： Cheng-Zhi qiu Chuan Wang Zhong-Xin Huang shi-Ze Zhu You-Yi Wu Jian-long qiu Department of General Surgery Second Affiliated Hospital of Fujian Medical University Quanzhou 362000 Fujian Province China Department of Oncology Affiliated Union Hospital to Fujian Medical University Fuzhou 350001 Fujian Province China Department of Pathology Second Affiliated Hospital of Fujian Medical University Quanzhou 362000 Fujian Province China

AIM： To study the SSTR1, 2, 3, 4, 5 expression and their relationships with clinico-pathological factors, cell proliferation, Bcl-2 and p53 expression in colorectal cancer cells. METHODS： Immunohistochemical staining of five SSTR subtypes, Ki-67, Bcl-2 and p53 was performed by the standard streptavidin-peroxidase （SP） technique for the paraffin sections of 127 colorectal cancers, and expression of five SSTR subtypes in 40 specimens of normal colorectal mucosae was detected with the same method. RESULTS： Positive staining for five SSTR subtypes was observed in colorectal cancer cells and normal colorectal mucosae. SSTR1 was the most predominant subtype in both colorectal cancer and normal colorectal mucosa, and the second was SSTR5 or SSTR2. As compared with normal colorectal mucosa, SSTR4 was more frequently expressed in colorectal cancer cells （2.5% vs 18.9%, P〈 0.05）; the expression of SSTR2, 4, 5 in moderately to well differentiated colorectal adenocarcinoma was significantly higher than that in poorly differentiated ones （P〈 0.05）, the SSTR1 expression in colorectal cancer with positive lymph node metastasis was significantly higher than that with negative lymph node metastasis （72.2% and 54.5%, P〈 0.05）. In addition, in the ulcerative type of colorectal cancer, SSTR2 expression was obviously decreased （P 〈 0.05）; the correlation did not reach a statistical significance between the five SSTR subtypes expression and Dukes＇stages （P〉 0.05）, but the frequency of SSTR1 expression increased with Dukes＇ stage, while SSTR3 and SSTR5 expression decreased with Dukes＇ stage. Moreover, there was no correlation between expression of the five SSTR subtypes and other clinicopathological factors such as age, sex, tumor site, tumor depth, distant metastasis. The proliferative indexes in colorectal cancer cells with negative expression of SSTR2 and SSTR3 were significantly higher than that with positive expression （P〈0.05）. The Bcl-2 expression in colorectal cancer cells with po

关键词： Somatostatin receptor subtype Cell proliferation Apoptosis, p53, Colorectal cancer Immunohistochemistry

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Corrosion and wear properties of in situ(TiB+TiC)/TA15 composites with a high volume percentage of reinforcement

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China Foundry 2023年第5期20卷 423-431页

作者： Wei-long Wang Kun shi Jun Zhao shi-bing Liu Jiao-jiao Cheng Wei-chen qiu Tian-yu Liu Zhi-yong Zhang Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National Key Laboratory of Advanced Casting Technologies Shenyang 110022China

The in situ(TiC+TiB)/TA15 composites with different volume percentages of reinforcement(10%,15%,20%and 25%)were prepared by water-cooled copper crucible vacuum suspension melting *** structures and compositions of the TA15 alloy and its composites were analyzed by XRD and EDS,and their electrochemical corrosion behaviors in the 3.5%NaCl solution were *** wear testing was conducted using a reciprocating ball-on-disc wear tester under a 10 N *** show that the in situ fibrous TiB phase and the granular TiC phase are uniformly distributed on the composite *** microhardness can reach up to 531 HV as 25vol.%TiC+TiB reinforcement is *** with the TA15 alloy,the volume wear rate decreases from(2.21±0.07)×10^(-4)to(1.75±0.07)×10^(-4)mm^(3)·N^(-1)·m^(-1)by adding 15vol.%TiC+TiB reinforcement,and the wear mechanism is adhesive *** the volume percentage of the reinforcement phase reaches 25%,the volume wear rate increases from(1.75±0.07)×10^(-4)to(2.41±0.07)×10^(-4)mm^(3)·N^(-1)·m^(-1),and the wear mechanism changes into abrasive *** volume loss resulted by the interaction between corrosion and wear accounts for more than 27%of the total wear *** volume loss due to wear-induced corrosion changes from 1.94%to 4.06%with different additions of *** volume loss caused by corrosion-induced wear initially increases from 24.08%to 26.90%as the reinforcement increases from 0 to 15%due to the increase of corrosion potential,and then decreases from 26.90%to 25.68%as the reinforcement increases from 15%to 25%due to the peeling of TiC phase.

关键词： titanium matrix composites high volume percentage corrosion wear wear mechanism

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Effect of Bi/Si Ratio of BiBSi Glass on Its Structure, Properties and Laser Sealing Shear Strength for Vacuum Glazing

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 13-24页

作者： LIU Wei JIAO Jinxu LUO Dusha ZHOU Junjie shi Lifen WANG Weiwei LI Changqing WANG Peng XIONG Dehua LI Hong State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Silica-Based Materials Laboratory of Anhui Province CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China State Key Laboratory of Advanced Technology for Float Glass CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China

The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum *** the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was *** addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were *** results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal *** laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting *** absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper *** greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser *** shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.

关键词： Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi) Bi/Si ratio low-melting glass laser sealing vacuum glazing

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu Xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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A highly ionic conductive succinonitrile-based composite solid electrolyte for lithium metal batteries

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Nano Research 2022年第6期15卷 5153-5160页

作者： Genrui qiu Yapeng shi Bolong Huang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Solid-state Li metal batteries with solid electrolytes have built a potential way to solve the safety and low energy density problems of current commercial Li-ion batteries with liquid *** a key component of solid-state Li metal batteries,solid electrolytes require high ionic conductivities and good mechanical *** have designed a composite solid electrolyte(CSE)consisting of poly(vinylidene fluoride-hexafluoropropylene)(PVDF-HFP)-Li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZTO)-succinonitrile(SN)and Li bis(trifluoromethylsulphonyl)imide(LiTFSI).The PVDF-HFP-based porous matrix made by electrospinning ensures good mechanical properties of the electrolyte membrane,and the large proportion of SN filling material makes the electrolyte membrane have an ionic conductivity of 1.11 mS·cm^(–1)without the addition of liquid *** symmetric battery assembled with CSE can be cycled stably for more than 600 h,and the LiFePO4|CSE|Li full battery can also be cycled stably for more than 200 *** addition to Li metal batteries,Li-O_(2)and Li-CO_(2)batteries that use CSE as electrolytes also have good performances,reflecting the universality of *** does not only guarantee good mechanical properties but also obtain a high ionic *** design provides a new idea for the commercial application of polymer-based solid batteries.

关键词： Li metal batteries composite solid-state electrolyte succinonitrile ionic conductivity mechanical strength

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Concurrent multi-task pre-processing method for LEO mega-constellation based on dynamic spatio-temporal grids

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Chinese Journal of Aeronautics 2023年第11期36卷 233-248页

作者： Xibin CAO Ning LI shi qiu Research Center of Satellite Technology Harbin Institute of TechnologyHarbin 150080China

The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple ***,the complexity of resource allocation is increased because of the large number of tasks and ***,the primary problem of implementing concurrent multiple tasks via LEO mega-constellation is to pre-process tasks and observation *** address the challenge,we propose a pre-processing algorithm for the mega-constellation based on highly Dynamic Spatio-Temporal Grids(DSTG).In the first stage,this paper describes the management model of mega-constellation and the multiple ***,the coding method of DSTG is proposed,based on which the description of complex mega-constellation observation resources is *** the third part,the DSTG algorithm is used to realize the processing of concurrent multiple tasks at multiple levels,such as task space attribute,time attribute and grid task importance ***,the simulation result of the proposed method in the case of constellation has been given to verify the effectiveness of concurrent multi-task pre-processing based on *** autonomous processing process of task decomposition and task fusion and mapping to grids,and the convenient indexing process of time window are verified.

关键词： LEO mega-constellation Concurrent multiple tasks Tasks pre-processing Highly dynamic spatiotemporal grids Multi-task fusion merging Importance evaluation

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Effect of Modulus Heterogeneity on the Equilibrium Shape and Stress Field ofαPrecipitate in Ti-6Al-4V

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1017-1028页

作者： Di qiu Rongpei shi Materials Genome Institute Shanghai UniversityShanghai200444China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen518055China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai200444China Zhejiang Laboratory Hangzhou311100China

For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the *** stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving *** study develops a phase-field model concerningmodulus *** effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is ***αprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial *** calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is *** addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied *** stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβ*** study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.

关键词： Elastic heterogeneity habit plane stress field titanium phase-field simulation

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Covalent coupling of DNA bases with graphene nanoribbon electrodes: Negative differential resistance, rectifying, and thermoelectric performance

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Chinese Physics B 2020年第10期29卷 418-427页

作者： Peng-Peng Zhang shi-Hua Tan Xiao-Fang Peng Meng-qiu long Hunan Provincial Key Laboratory of Materials Surface or Interface Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Physics and Electronics Central South UniversityChangsha 410083China

By applying nonequilibrium Green's functions in combination with the density-functional theory, we investigate the electronic, thermal, and thermoelectric properties of four kinds of bases in DNA perpendicularly coupling between two ZGNR electrodes. The results show that the electron transport is highly sensitive to different base-ZGNR coupling geometries, and the system can present large rectifying and negative differential resistance effects. Moreover, the fluctuations of electronic transmission and super-low thermal conductance result in significant enhancement of the thermoelectric figure of merit (ZT): the ZT will be over 1.4 at room temperature, and over 1.6 at 200 K. The results show that the base-ZGNR coupling devices can present large rectifying, negative differential resistance, and enhanced thermoelectric effects.

关键词： DNA bases graphene electron transport phonon transport thermoelectric performance

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Electronic and Thermoelectric Properties in SnS-Nanoribbon-Based Heterojunctions

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Chinese Physics Letters 2024年第9期41卷 63-68页

作者： Kai-Bo Zhang shi-Hua Tan Xiao-Fang Peng Meng-qiu long Hunan Province Key Laboratory of Materials Surface or Interface Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Physics and Electronics Central South UniversityChangsha 410083China

As an earth-abundant and environmentally friendly material,tin sulfide(SnS)is not only a high-performance photovoltaic material,but also a new promising thermoelectric *** extensive research on the thermoelectric properties of this material in recent years,the room-temperature thermoelectric figure of merit(ZT)of SnS has not been broke through 2[2022 *** Mater.651143].In this work,based on a combination of density functional theory and non-equilibrium Green’s function method,the electronic and thermoelectric properties in SnS-nanoribbon-based heterojunctions are *** results show that although SnS nanoribbons(SNSNRs)with zigzag edges(ZSNSNRs)and armchair edges(ASNSNRs)both have semiconductor properties,the bandgaps of ASNSNRs are much wider than those of ZSNSNRs,which induces much wider conductance gaps of𝑁N-ASNSNR(N is the number of tin-sulfide lines across the ribbon width)).In the positive energy region,the ZT peaks of𝐿L-SNS-Au are much larger than those of𝐿L-SNS-GNR(L represents the number of longitudinal repeating units of SNSNR in the scattering region).While in the positive energy region,the ZT peaks of L-SNSGNR are larger than those of *** calculations reveal that the figure of merit will be over 3.7 in L-SNS-Au and 2.2 in L-SNS-GNR at room temperature,and over 4 in L-SNS-Au and 2.6 in L-SNS-GNR at 500 K.

关键词： material sulfide ribbon

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工业园区光伏发电系统运行与优化配置研究

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环境技术 2021年第5期39卷 199-205页

作者：周汝祥张紫凡胡子安丘世隆梁炜政刘玉就广州城市理工学院广州510800 广东电网有限责任公司韶关供电局韶关512000

随着光伏发电技术日益成熟,作为可再生能源越来越多的光伏发电设备作为本地电源为耗电量较大的工业园区提供电能。光伏发电受环境影响具有一定的随机性且光伏电源需经变流器并入电网,在发电的同时产生一定的谐波污染。光伏并网系统的控... 详细信息

随着光伏发电技术日益成熟,作为可再生能源越来越多的光伏发电设备作为本地电源为耗电量较大的工业园区提供电能。光伏发电受环境影响具有一定的随机性且光伏电源需经变流器并入电网,在发电的同时产生一定的谐波污染。光伏并网系统的控制方式以及并网系统的设备参数选择对光伏并网系统的技术参数有较大的影响,基于PSCAD仿真平台建立了光伏并网仿真模型,研究了光照及温度变化对光伏发电功率的影响,分析了LC并网滤波器的参数选择方法。最后,以100 kW工业园区光伏接入系统为例分析了不同并网模式的经济性。

关键词：光伏并网系统 LC滤波器仿真建模经济效益

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