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Emerging roles of ILC2s in antitumor immunity

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Cellular & Molecular Immunology 2022年第11期19卷 1311-1313页

作者： Zhao Li Hanxiao Sun Zhitao Gua ju qiu CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China Department of Blood Transfusion Shanghai Tong Ren HospitalShanghai Jiao Tong University School of MedicineShanghai200336China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Group 2 innate lymphoid cells(ILC2s)are a subset of ILCs that lack T and B-cell antigen receptors[1].ILC2s share similarities with CD4+T helper 2 cells(Th2)in transcription factor GATA3 expression and signature cytoki... 详细信息

关键词： ILC2s GATA3 immunity

Partial embolization as re-treatment of hypersplenism after unsuccessful splenic artery ligation

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World Journal of Gastroenterology 2015年第4期21卷 1365-1370页

作者： Zheng-ju Xu Lian-qiu Zheng Xing-Nan Pan Clinical Liver Center 180~(th) Hospital of the People’s Liberation Army

Ligation of splenic artery(LSA) is used for the treatment of liver cirrhosis with hypersplenism. However, hypersplenism is not significantly improved following LSA treatment in some cases, and there are few reports of retreatment of hypersplenism after LSA. We report the case of a47-year-old man with liver cirrhosis and hypersplenism who underwent LSA treatment, but did not significantly improve. Laboratory tests revealed severe leukocytopeniaand thrombocytopenia. Celiac computed tomography arteriogram and digital subtraction angiography revealed two compensatory arteries connected to the hilar splenic artery from the left gastro-epiploic artery and from the dorsal pancreatic artery. Partial splenic embolization(PSE) was performed through the compensatory arteries. As a result, the patient achieved partial splenic ischemic infarction, and white blood cell and platelet counts rose and remained in the normal range. PSE is an effective therapeutic modality for the retreatment of hypersplenism when other modalities have failed.

关键词： Hypersplenism Partial splenic embolization Splenic

Taking Proactive Action:Introduction to the Prevention and Treatment of COVID-19 with Traditional Chinese Medicine

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Chinese Medicine and Culture 2021年第1期4卷 25-30页

作者： Jian-Nan qiu Hong-Yong deng Shanghai Innovation Center of TCM Health Service Shanghai University of Traditional Chinese MedicineShanghai 201203China

Since the outbreak of coronavirus disease-2019(COVID-19),traditional Chinese medicine(TCM)has fully displayed its strength and specialty and has played an important role in the prevention and treatment of the *** with the unexpected development of the pandemic,the Chinese government has responded quickly and attached great importance to the effect of *** therapy integrating Chinese and Western medicine has achieved remarkable *** summarize and introduce the prevention and treatment of COVID-19 with TCM,this article covers the perspectives of policy guideline issue,clinical diagnosis participation,and scientific research progress.

关键词： COVID-19 integrated Chinese and Western medicine traditional Chinese medicine

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

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Protein & Cell 2016年第5期7卷 362-372页

作者： Yaoting deng Yurika Matsui Wenfei Pan qiu Li Zhi-Chun Lai Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Intercollege Graduate Degree Program in Molecular Cellular and Integrative Biosciences Pennsylvania State University University Park PA 16802 USA Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021 China Department of Biology Pennsylvania State University University Park PA 16802 USA

Mammalian pancreatic β-cells play a pivotal role in development and glucose homeostasis through the production and secretion of insulin. Functional failure or decrease in β-cell number leads to type 2 diabetes （T2D）. Despite the physiological importance of β-cells, the viability of β-cells is often challenged mainly due to its poor ability to adapt to their changing microenvironment. One of the factors that negatively affect β-cell viability is high concentration of free fatty acids （FFAs） such as palmitate. In this work, we demonstrated that Yes-associated protein （Yap1） is activated when β-cells are treated with palmitate. Our loss- and gain-of-function analyses using rodent insulinoma cell lines revealed that Yap1 suppresses palmitate-induced apoptosis in β-cells without regulating their proliferation. We also found that upon palmitate treatment, re-arrangement of F-actin mediates Yap1 activation. Palmitate treatment increases expression of one of the Yap1 target genes, connective tissue growth factor （CTGF）. Our gain-offunction analysis with CTGF suggests CTGF may be the downstream factor of Yap1 in the protective mechanism against FFA-induced apoptosis.

关键词： β-cell CTGF F-actin free fatty acid Hipposignaling Yap1

Synthesis,Characterization and Phase Behaviors of Polypeptides Bearing Biphenyl Mesogens and Oligo-Ethylene-Glycol Tails

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Chinese Journal of Polymer Science 2015年第8期33卷 1150-1161页

作者： qiu-lin Yuan Wen-jun Liu Yong deng Ying Ling 唐浩宇 Key Laboratory of Polymeric Materials and Application Technology of Hunan Province Key Laboratory of Advanced Functional Polymer Materials of Colleges and Universities of Hunan ProvinceCollege of ChemistryXiangtan University

A series ofpolypeptides bearing biphenyl mesogenic side-chains and oligo-ethylene-glycol （OEG） tails （PPLGn-g- BPOEGm, n = 26 and 63, m = 2, 3, and 7） has been synthesized via a 1,3-dipolar cycloaddition with quantitative grafting density. FTIR results revealed that the polypeptides adopted highly stable a-helix in the temperature range of 25-200 ℃. DSC, POM and WAXS analysis revealed that PPLGn-g-BPOEGm （m ≤ 3） samples with short OEG tail length showed two main phase transitions including crystal to liquid crystalline （smectie C, SmC） phase transition and the melting transition of crystalline E-phase, while PPLG,-g-BPOEG7 with longer OEG tail length （m = 7） exhibited the melting transitions without the formation of liquid crystalline phase.

关键词： Liquid-crystalline polymers Polypeptides Click chemistry Smectic phases.

Apple Pectin Behavior Separated by Ultrafiltration

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Agricultural Sciences in China 2009年第10期8卷 1193-1202页

作者： qiu Nong-xue TIAN Yu-xia QIAO Shu-tao deng Hong College of Food Engineering and Nutrientional Science Shaanxi Normal University Xi＇an 710062 P.R. China College of Mechanical Instrument Engineering Xi ＇an University of Technology Xi＇an 710048 P.R. China

Separation conditions of ultrafiltration for apple pectin, weights and their structures and properties are studied and relations between apple pectin with different relative molecular Five kinds of ultrafiltration membranes with different molecular weight cut-offs are used to separate apple pectin. FT-IR and HPGC are used individually to determine the structures and monosaccharide composition of apple pectin with different relative molecular weights. In the case of transmembrane pressure difference of 0.08 MPa, material concentration of 1 g·L^-1, and temperature of 50℃, 6 kinds of apple pectins with different molecular weights have been obtained. Molecular weight of apple pectin is correspondingly related to its physicochemical properties. The galacturonic acid contents and esterification and gelatination degrees increase relatively with an increase in molecular weight, and the monosaccharide composition relatively increase much more. And at the same time, the ultrafiltration has a better role to play in decoloring apple pectin solution. Accordingly, this research can be used as a new method for in-depth exploration of apple pectin.

关键词： apple pectin ultrafiltration FT-IR GC

Preparation and properties of dental zirconia ceramics

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Journal of University of Science and Technology Beijing 2008年第6期15卷 764-768页

作者： Xinjie Liang Yuexiu qiu Shaoxiong Zhou Xiaoyang Hu Guangyan Yu Xuliang deng China Iron and Steel Research Institute Group Beijing 100081 China School and Hospital of Stornatology Peking University Beijing 100081 China

Y2O3-stabilized tetragonal zirconia polycrystalline （Y-TZP） ceramics with high-performance were prepared for dental ap- plication by use of the micro-emulsion and two-step sintering method. The crystal phase, morphology, and microstructure of the reaction products were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and transmission electron mi- croscopy （TEM）. XRD results show that the ceramics mainly consist of tetragonal zirconia. Physical and mechanical properties test results show that the bending strength, fracture toughness, and the density of full sintered Y-TZP ceramics are 1150 MPa, 5.53 MPa.m1/2, and 6.08 g/cm3, respectively, which suggest that the material is relatively suitable for dental restoration. The dental base crown machined with this material by CAD/CAM system exhibits a verisimilitude configuration and the material＇s expansion coefficient well matches that of the glaze. These results further indicate that the product can be used as a promising new ceramic material to fabricate dental base crowns and bridges.

关键词： zirconia ceramic crown property

Permeability and Sedimentation Characteristics of Pleistocene Fluvio-glacial Deposits in the Dadu River Valley,Southwest China

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Journal of Mountain Science 2013年第3期10卷 482-493页

作者： TU Guo-xiang HUANG Run-qiu deng Hui LI Yan-rong State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection Chengdu University of Technology Department of Earth Sciences The University of Hong Kong

There exist many fluvio-glacial deposits in the valley of Dadu River, Southwest China, which dates back to the Pleistocene. As some of the deposits are located within the seasonal water fluctuation zone of reservoirs, the seepage of groundwater acts as one of the key factors influencing their stability. Investigation into the sediment properties and permeability is, therefore, crucial for evaluating the sediment stability. In this study, in-situ permeability and sieving tests have been carried out to determine grain size distribution, correlations of permeability and hydraulic gradients, and relations between permeability and sedimentation properties. Test results indicate that the deposits are composed mostly of sands, gravels, cobbles and boulders, and the percentage of fines is less than 5%. The sediments have high densities, low porosities and natural moisture contents. At low hydraulic gradients, the seepage velocity obeys the Darcy＇s law, while a non- Darcy permeability is observed with hydraulic gradient exceeding a certain value （about 0.5 - 0.7）. The linear permeability coefficient ranges from 0.003 to 0.009 cm/s. Seepage failure occurs above a threshold between 1.1 and 1.5. The test data fit well with the non-linear permeability equations suggested by Forchheimer and Izbash. The non-Darcy permeability proves to be in accordance with the seepage equation suggested by Izbash with the power ＇m＇ of about 0.6 - 0.7. The characteristic grain sizes of the studied deposits are found in a narrow range between 0.024 and o.o31 mm, which is much lowerthan the effective grain size （dlo）.

关键词： Fluvio-glacial deposits Grain sizedistribution Linear and non-linear permeability Seepage failure

Low-noise,low-power-consumption seafloor vector magnetometer

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Journal of Oceanology and Limnology 2023年第2期41卷 804-815页

作者： Xiaochen LI Xianhu LUO Ming deng Ning qiu Zhen SUN Kai CHEN China University of Geosciences Beijing 100083China Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 511458Chinaa SCSIO Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

The seafloor vector magnetometer is an effective tool for marine geomagnetic surveys and seafloor magnetotelluric(MT)***,the noise,power consumption,cost,and volume characteristics of existing seafloor vector magnetometers are insufficient for practical ***,a low-noise,low-power-consumption seafloor vector magnetometer that can be used for data acquisition of deep-ocean geomagnetic vector components is developed and presented.A seafloor vector magnetometer mainly consists of a fluxgate sensor,data acquisition module,acoustic release module,glass sphere,frame,burn-wire release,and anchor.A new low-noise data acquisition module and a fluxgate sensor greatly reduce power ***,compact size is achieved by integrating an acoustic telemetry module and replacing the acoustic release with an external burn-wire *** new design and magnetometer characteristics reduce the volume of the instrument and the cost of hardware considerably,thereby improving the integrity and deployment efficiency of the ***,it can operate for 90 days underwater at a maximum depth of 6000 *** seafloor vector magnetometer was tested in the South China Sea and the Philippine Sea and obtained high-quality geomagnetic *** deep-water environment facilitates magnetic field data measurements,and the magnetometer has an approximate noise level of 10 pT/rt(Hz)@1 Hz,a peak-to-peak value error of 0.2 nT,and approximate power consumption of 200 *** fluxgate sensor can measure the magnetic field in the lower frequency band and realize geomagnetic field measurements over prolonged periods.

关键词： seafloor vector magnetometer low noise low power consumption