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Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 652-659页

作者： Lin LU Wen-hui PENG Wei WANG Ling-jie WANG qiu-jing chen Wei-feng SHEN Department of Cardiology Ruoin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Institute of Cardiovascular Diseases School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Objective:Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE).This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat ***:Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks).Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple *** AGEs,RAGE,endogenous secretory RAGE (esRAGE),and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western ***:Mesangial expansion and microalbuminuria were aggravated in diabetic rats,and improved with atorvastatin *** sRAGE levels were lower in diabetic than in normal *** atorvastatin treatment,serum and renal sRAGE levels were up-regulated,while renal RAGE expression was decreased in diabetic rats,associated with a reduction in accumulation of AGEs,though renal esRAGE mRNA expression was not significantly ***:Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation,down-regulating RAGE expression and up-regulating sRAGE in the kidney.

关键词： Receptor for advanced glycation end-product (RAGE) Endogenous secretory RAGE (esRAGE) Soluble RAGE (sRAGE) Diabetic nephropathy Atorvastatin

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Challenges and prospects for room temperature solid-state sodiumsulfur batteries

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Nano Research 2024年第3期17卷 1402-1426页

作者： Yashuang qiu jing Xu Research Center of Grid Energy Storage and Battery Application School of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China

Room temperature sodium-sulfur(Na-S)batteries,known for their high energy density and low cost,are one of the most promising next-generation energy storage ***,the polysulfide shuttling and uncontrollable Na dendrite growth as well as safety issues caused by the use of organic liquid electrolytes in Na-S cells,have severely hindered their ***-state electrolytes instead of liquid electrolytes are considered to be the most direct and effective solution to solve the above ***,its practical application is still greatly challenged due to the poor interfacial compatibility between the all-solid-state electrolytes and the anode/cathode,ionic conductivity,and the shuttle effect caused by the presence of liquid phase in the quasi-solid-state *** paper presents a comprehensive review of solid-state Na-S batteries from the perspective of regulating interfacial compatibility and improving ionic conductivity as well as suppressing polysulfide *** to different components,solid-state electrolytes were divided into five categories:solid inorganic electrolytes,solid polymer electrolytes,polymer/inorganic solid hybrid electrolytes,gel polymer electrolytes,and liquid–solid inorganic hybrid ***,the prospect of developing high performance solid-state electrolytes to improve the cycling stability of room temperature Na-S cells is envisaged.

关键词： sodium-sulfur batteries solid-state electrolytes ionic conductivity polysulfide shuttling interfacial compatibility

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Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

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Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng chen Mao-Mao Zhang Wen-jing Xiao Liang-qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University Wuhan Institute of Photochemistry and Technology State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics (LICP)Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

Chiral α-tertiary amines and related azacycles are commonly found in many natural products, pharmaceuticals and agrochemicals [1]. Copper-catalyzed asymmetric propargylic amination(APA) reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2] and van Maarseveen et al. [3] in 2008.

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Recorded recurrent deep reinforcement learning guidance laws for intercepting endoatmospheric maneuvering missiles

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Defence Technology（防务技术） 2024年第1期31卷 457-470页

作者： Xiaoqi qiu Peng Lai Changsheng Gao Wuxing jing Department of Aerospace Engineering Harbin Institute of TechnologyHarbin150001China Shanghai Electro-Mechanical Engineering Institute Shanghai Academy of Spaceflight TechnologyShanghai201100China

This work proposes a recorded recurrent twin delayed deep deterministic(RRTD3)policy gradient algorithm to solve the challenge of constructing guidance laws for intercepting endoatmospheric maneuvering missiles with uncertainties and observation *** attack-defense engagement scenario is modeled as a partially observable Markov decision process(POMDP).Given the benefits of recurrent neural networks(RNNs)in processing sequence information,an RNN layer is incorporated into the agent’s policy network to alleviate the bottleneck of traditional deep reinforcement learning methods while dealing with *** measurements from the interceptor’s seeker during each guidance cycle are combined into one sequence as the input to the policy network since the detection frequency of an interceptor is usually higher than its guidance *** training,the hidden states of the RNN layer in the policy network are recorded to overcome the partially observable problem that this RNN layer causes inside the *** training curves show that the proposed RRTD3 successfully enhances data efficiency,training speed,and training *** test results confirm the advantages of the RRTD3-based guidance laws over some conventional guidance laws.

关键词： Endoatmospheric interception Missile guidance Reinforcement learning Markov decision process Recurrent neural networks

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Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 705-712页

作者： Zhen SUN Ying SHEN Lin LU Rui-yan ZHANG Li-jin PU Qi ZHANG Zheng-kun YANG Jian HU qiu-jing chen Wei-feng SHEN Department of Cardiology Shanghai Ruijin Hospital Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine

Objective： Coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods： Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results： Low （Rentrop score of 0 or 1） and high （Rentrop score of 2 or 3） coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high coUateralization （for all comparisons, P〈0.05）. In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein （hsCRP） compared with those with high col- lateralization. Multivariate analysis revealed that age of 〉65 years, female gender, diabetes, no history of hypertension dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were inde- pendently associated with low coronary collateralization. Conclusions： Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation.

关键词： Stable angina Coronary collateral circulation Risk factors Angiography Chronic total coronary occlusion

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The First Five Years of a Phase Theory for Complex Systems and Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1728-1743页

作者： Dan Wang Wei chen Li qiu Division of Decision and Control Systems KTH Royal Institute of TechnologyStockholm 10044Sweden Department of Mechanics and Engineering Science&the State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China Hong Kong University of Science and Technology Hong KongChinaand also with the Southern University of Science and TechnologyShenzhen 518055China

In this paper,we review the development of a phase theory for systems and networks in its first five years,represented by a trilogy:Matrix phases and their properties;The MIMO LTI system phase response,its physical interpretations,the small phase theorem,and the sectored real lemma;The synchronization of a multi-agent network using phase *** the end,we also summarize a list of ongoing research on the phase theory and speculate what will happen in the next five years.

关键词： Consensus and synchronization matrix phases multi-agent systems phase theory sectored real lemma small phase theorem.

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Kerr black hole shadows cast by extraordinary light rays with Weyl corrections

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 18-26页

作者： Songbai chen Jiliang jing Department of Physics Institute of Interdisciplinary StudiesKey Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China

We investigate the equation of motion for photons with Weyl corrections in a Kerr black hole spacetime in a small coupling *** results show that Weyl corrections yield phenomena of *** light rays propagating in the spacetime are separated into the ordinary rays and the extraordinary rays,and the propagation of the latter depends on the *** probe the effects of Weyl corrections on the Kerr black hole shadows casted by the extraordinary rays and find that such corrections result in a weak stretching or squeezing in the vertical direction for the black hole ***,we also study the change of the length of the Near-Horizon Extremal Kerr line(NHEK line)with Weyl *** features could help us to understand the electrodynamics with Weyl corrections from black hole shadows.

关键词： correction light stretching

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Gravitational wave fluxes on generic orbits in near-extreme Kerr spacetime:Higher spin and large eccentricity

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Science China(Physics,Mechanics & Astronomy) 2024年第11期Mechanics & Astronomy) .卷 20-32页

作者： Changkai chen Jiliang jing Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and Applications Hunan Normal University

To accurately obtain the waveform template of gravitational waves, substantial computational resources and extremely high precision are often required. In a previous study, we employed the confluent Heun function to obtain an exact solution to the Teukolsky equation. This approach allowed us to efficiently and accurately calculate the gravitational wave flux for a particle in circular orbits around a Schwarzschild black hole. Building on this method, we now extend its application to calculate the asymptotic gravitational wave fluxes from a particle in generic orbits around a near-extreme Kerr black hole. Our extended method proves particularly effective in handling computational challenges associated with large eccentricities(e = 0.9), higher spins(a = 0.999), higher harmonic modes, and strong-field regions. The results we obtained significantly outperform those derived from the numerical integration method based on the Mano-Suzuki-Takasugi method.

关键词： gravitational wave fluxes exact solution Teukolsky equation near-extreme Kerr black hole

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Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species

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Chinese Journal of Natural Medicines 2024年第4期22卷 375-384页

作者： ZENG Zhen ZHANG chen HU Jiadong WANG Feiyan WU Ziding WANG jing ZHANG Jun YANG Shuda chen Junfeng LI Mingming TONG Qi qiu Shi chen Wansheng The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Second Affiliated Hospital of Navy Medical UniversityShanghai 200003China Kunming Plant Classification Biotechnology Co. Ltd.Kunming 650500China School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing100700China

The aerial parts of Mosla chinensis *** Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as ***,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and *** challenge in distinguishing between these genera arises from their similar morphological and metabolic *** address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based *** detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203 identified compounds,as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia *** methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal *** findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants.

关键词： Genus Elsholtzia Genus Mosla Traditional Chinese medicine Xiang-ru Non-volatile phenolic compounds Liquid chromatography-mass spectrometry

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Cybersecurity Landscape on Remote State Estimation:A Comprehensive Review

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 851-865页

作者： jing Zhou Jun Shang Tongwen chen the Department of Electrical and Computer Engineering University of AlbertaEdmonton AB T6G 1H9Canada the Department of Control Science and Engineering and Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China

Cyber-physical systems(CPSs)have emerged as an essential area of research in the last decade,providing a new paradigm for the integration of computational and physical units in modern control *** state estimation(RSE)is an indispensable functional module of ***,it has been demonstrated that malicious agents can manipulate data packets transmitted through unreliable channels of RSE,leading to severe estimation performance *** paper aims to present an overview of recent advances in cyber-attacks and defensive countermeasures,with a specific focus on integrity attacks against ***,two representative frameworks for the synthesis of optimal deception attacks with various performance metrics and stealthiness constraints are discussed,which provide a deeper insight into the vulnerabilities of ***,a detailed review of typical attack detection and resilient estimation algorithms is included,illustrating the latest defensive measures safeguarding RSE from ***,some prevalent attacks impairing the confidentiality and data availability of RSE are examined from both attackers'and defenders'***,several challenges and open problems are presented to inspire further exploration and future research in this field.

关键词： Cyber-attacks Kalman filtering remote state estimation unreliable transmission channels

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