检索结果-南通市图书馆

Water Science and Engineering 2017年第4期10卷 311-319页

作者： Hai-bo Yang En-chong Li Yong Zhao qiu-hua liang School of Water Conservancy and Environmental Engineering Zhengzhou University State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower Research School of Civil Engineering and Geosciences Newcastle University

Implementation of the water-sediment regulation(WSR) scheme, mainly focused on solving the sedimentation problems of reservoirs and the lower reaches of the Yellow River, has inevitably influenced the sediment distribution and coastal morphology of the Yellow River *** coastline delineation and suspended sediment concentration(SSC) retrieval methods, this study investigated water and sediment changes,identified detailed inter-annual and intra-annual variations of the coastline and SSC in the normal period(NP: 1986-2001, before and after the flood season) and WSR period(WSRP: 2002-2013, before and after WSR). The results indicate that(1) the sedimentation in the low reaches of the Yellow River turned into erosion from 2002 onward;(2) the inter-annual coastline changes could be divided into an accretion stage(1986-1996), a slow erosion stage(1996-2002), and a slow accretion stage(2002-2013);(3) an intra-annual coastline extension occurred in the river mouth in most years of the WSRP; and(4) the mean intra-annual accretion area was 0.789 km^2 in the NP and 4.73 km2 in the WSRP,and the mean SSC increased from 238 mg/L to 293 mg/L in the NP and from 192 mg/L to 264 mg/L in the WSRP.

关键词： Coastline Suspended sediment concentration Water-sediment regulation Remote sensing Yellow River Estuary

Preface for special section on flood modeling and resilience

在线全文

学校读者我要写书评

暂无评论

Water Science and Engineering 2017年第4期10卷 265-266页

作者： Jing-ming Hou qiu-hua liang Gang Wang Reinhard Hinkelmann Institute of Water Resources and Hydro-Electric Engineering Xi'an University of Technology State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University School of Engineering Newcastle UniversityNewcastle upon TyneNEI 7RUUK Chair of Water Resources Management and Modeling of Hydrosystems Technische Universitt Berlin

Climate change has led to increased frequency, intensity,and duration of extreme weather events, e.g., intense rainfall,heat waves, droughts, and storm surges, worsened byrapid population growth and urbanization at the global *** can be found in the exceptional number of unprecedentedweather extremes and the resulting naturalhazards, especially flooding, as seen in the last few *** example, the UK has experienced numerous storms andsevere floods in the last decade, particularly in 2007, 2012,and 2015, with 2012 being recorded as the second wettest year in the UK and the wettest ever in England. These events have resulted in lives lost and tremendous economic damage. The UK is not alone. Similarly unusual weather events have been reported across the globe. In China,different types of flooding threaten 1/10 of the country's total area, millions of hectares of farmland, and over 100 large cities, making it one of the most vulnerable countries to flooding.

关键词： Climate change has led to increased frequency

An efficient dynamic uniform Cartesian grid system for inundation modeling

在线全文

学校读者我要写书评

暂无评论

Water Science and Engineering 2017年第4期10卷 267-274页

作者： Jing-ming Hou Run Wang Hai-xiao Jing Xia Zhang qiu-hua liang Yan-yan Di Institute of Water Resources and Hydro-Electric Engineering Xi'an University of Technology School of Civil Engineering and Geosciences Newcastle University Hydrology Bureau Yellow River Conservancy Commission

A dynamic uniform Cartesian grid system was developed in order to reduce the computational time in inundation simulation using a Godunov-type finite volume scheme. The reduction is achieved by excluding redundant dry cells, which cannot be effectively avoided with a conventional Cartesian uniform grid system, as the wet area is unknown before computation. The new grid system expands dynamically with wetting, through addition of new cells according to moving wet-dry fronts. The new grid system is straightforward in implementation. Its application in a field-scale flood simulation shows that the new grid system is able to produce the same results as the conventional grid, but the computational efficiency is fairly improved.

关键词： Uniform Cartesian grid system Flood simulation Wetting and drying Shallow watere quation Godunov-type finite volume scheme

A graphics processing unit-based robust numerical model for solute transport driven by torrential flow condition

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第10期22卷 835-850页

作者： Jing-ming HOU Bao-shan SHI qiu-hua liang Yu TONG Yong-de KANG Zhao-an ZHANG Gang-gang BAI Xu-jun GAO Xiao YANG State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi’an University of TechnologyXi’an 710048China School of Architecture Building and Civil EngineeringLoughborough UniversityLoughborough LE113TUUK Northwest Engineering Corporation Limited Xi’an 710065China

Solute transport simulations are important in water pollution *** paper introduces a finite volume Godunovtype model for solving a 4×4 matrix form of the hyperbolic conservation laws consisting of 2D shallow water equations and transport *** model adopts the Harten-Lax-van Leer-contact(HLLC)-approximate Riemann solution to calculate the cell interface *** can deal well with the changes in the dry and wet interfaces in an actual complex terrain,and it has a strong shock-wave capturing *** monotonic upstream-centred scheme for conservation laws(MUSCL)linear reconstruction with finite slope and the Runge-Kutta time integration method can achieve second-order *** the same time,the introduction of graphics processing unit(GPU)-accelerated computing technology greatly increases the computing *** model is validated against multiple benchmarks,and the results are in good agreement with analytical solutions and other published numerical *** third test case uses the GPU and central processing unit(CPU)calculation models which take 3.865 s and 13.865 s,respectively,indicating that the GPU calculation model can increase the calculation speed by 3.6 *** the fourth test case,comparing the numerical model calculated by GPU with the traditional numerical model calculated by CPU,the calculation efficiencies of the numerical model calculated by GPU under different resolution grids are 9.8–44.6 times higher than those by ***,it has better potential than previous models for large-scale simulation of solute transport in water pollution *** can provide a reliable theoretical basis and strong data support in the rapid assessment and early warning of water pollution accidents.

关键词： Solute transport Shallow water equations Godunov-type scheme Harten-Lax-van Leer-contact(HLLC)Riemann solver Graphics processing unit(GPU)acceleration technology Torrential flow

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

删失数据下回归函数的加权局部复合分位数回归估计

在线全文

学校读者我要写书评

暂无评论

高校应用数学学报（A辑） 2019年第1期34卷 11-24页

作者：王江峰裘良华张慧增浙江工商大学统计与数学学院浙江杭州310018 杭州师范大学钱江学院浙江杭州310036 杭州师范大学理学院浙江杭州310036

在右删失数据下,研究了误差具有异方差结构的非参数回归模型,利用局部多项式方法构造了回归函数的加权局部复合分位数回归估计,并得到了该估计的渐近正态性结果,最后通过模拟,当误差为重尾分布时,该估计比局部多项式估计以及核估计表现... 详细信息

在右删失数据下,研究了误差具有异方差结构的非参数回归模型,利用局部多项式方法构造了回归函数的加权局部复合分位数回归估计,并得到了该估计的渐近正态性结果,最后通过模拟,当误差为重尾分布时,该估计比局部多项式估计以及核估计表现得更好.

关键词：右删失数据复合分位数回归回归函数渐近正态性

删失相依数据下的分位数核估计的Bahadur型表达

在线全文

学校读者我要写书评

暂无评论

杭州师范大学学报（自然科学版） 2011年第5期10卷 385-392页

作者：王江峰裘良华杭州师范大学理学院浙江杭州310036 杭州师范大学钱江学院浙江杭州310012

该文考虑了在删失相依数据下分位数函数的核估计.在适当条件下,建立了该估计的弱和强Bahadur型表达形式.作为它的应用,导出了该估计的渐近正态性.通过模拟给出了该估计在有限样本下的表现.

关键词：渐近正态性 Bahadur型表达删失数据 α-混合序列分位数函数.

甲磺酸阿帕替尼片联合卡培他滨片和奥沙利铂注射剂治疗晚期结直肠癌的临床研究

在线全文

学校读者我要写书评

暂无评论

中国临床药理学杂志 2019年第15期35卷 1565-1567页

作者：包久铭高艳梅邱华凉周秀敏福建省南平市人民医院肿瘤内科

目的观察甲磺酸阿帕替尼片联合卡培他滨片和奥沙利铂注射剂治疗晚期结直肠癌的临床疗效及安全性。方法将66例晚期结肠癌患者随机分为对照组和试验组,每组33例。对照组予以135 mg·m^-2奥沙利铂,静脉滴注,每3周重复1次+1250 mg·m^-2卡... 详细信息

目的观察甲磺酸阿帕替尼片联合卡培他滨片和奥沙利铂注射剂治疗晚期结直肠癌的临床疗效及安全性。方法将66例晚期结肠癌患者随机分为对照组和试验组,每组33例。对照组予以135 mg·m^-2奥沙利铂,静脉滴注,每3周重复1次+1250 mg·m^-2卡培他滨片,bid,口服,给药2周停药1周;试验组在对照组治疗的基础上,予以甲磺酸阿帕替尼片每次0. 5 g,qd,口服。2组患者均治疗6周。比较2组患者的临床疗效、生存期,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的客观缓解率分别为69. 70%(23例/33例)和36. 36%(12例/33例),疾病控制率分别为96. 97%(32例/33例)和75. 76%(25例/33例),总生存期分别为(5. 14±0. 14)和(2. 22±0. 15)年,无进展生存期分别为(4. 16±0. 15)和(1. 41±0. 09)年,差异均有统计学意义(均P 0. 05)。结论甲磺酸阿帕替尼片联合卡培他滨片和奥沙利铂注射剂治疗晚期结直肠癌的临床疗效较好,且不增加药物不良反应的发生率。

关键词：甲磺酸阿帕替尼片卡培他滨片奥沙利铂注射剂晚期结直肠癌安全性评估

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Assessing healthcare workers’knowledge and confidence in the diagnosis,management and prevention of Monkeypox

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第1期13卷 38-47页

作者： Epipode Ntawuyamara Thierry Ingabire Innocent Yandemye Polycarpe Ndayikeza Bina Bhandari Yan-hua liang Department of Dermatology Cosmetology and VenereologyShenzhen Hospital of Southern Medical UniversityShenzhen 518101Guangdong ProvinceChina Department of Dermatology and Venereology Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi Department of Infectious Diseases Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi General Directorate of Healthcare Supply Modern and Traditional MedicineNutrition and RegistrationMinistry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi Department of Epidemiology National Institute of Public HealthBujumbura 350Burundi General Directorate of Planification Ministry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi

BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central *** To assess Burundi healthcare workers(HCWs)s’level of knowledge and confidence in the diagnosis and management of *** We conducted a cross-sectional study via an online survey designed mainly from the World Health Organization course distributed among Burundi HCWs from June-July *** questionnaire comprises 8 socioprofessional-related questions,22 questions about Mpox disease knowledge,and 3 questions to assess confidence in Mpox diagnosis and *** data were analyzed via SPSS software version 25.0.A P value<0.05 was considered to indicate statistical *** The study sample comprised 471 HCWs who were mainly medical doctors(63.9%)and nurses(30.1%).None of the 22 questions concerning Mpox knowledge had at least 50%correct responses.A very low number of HCWs(17.4%)knew that Mpox has a *** confidence level to diagnose(21.20%),treat(18.00%)or prevent(23.30%)Mpox was low among *** confidence level in the diagnosis of Mpox was associated with the HCWs’age(P value=0.009),sex(P value<0.001),work experience(P value=0.002),and residence(P value<0.001).The confidence level to treat Mpox was significantly associated with the HCWs’age(P value=0.050),sex(P value<0.001),education(P value=0.033)and occupation(P value=0.005).The confidence level to prevent Mpox was associated with the HCWs’education(P value<0.001),work experience(P value=0.002),residence(P value<0.001)and type of work institution(P value=0.003).CONCLUSION This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose,treat or prevent *** is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi *** encourage future researchers to assess potential hesitancy toward Mpox vaccination and its asso

关键词： Monkeypox Public health emergency of international concern Healthcare workers Epidemic Preparedness Knowledge Confidence