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4D label-free proteomic analysis of vitreous from patients with rhegmatogenous retinal detachment

International Journal of Ophthalmology(English edition) 2023年第4期16卷 523-531页

作者： qiu-yi huo Meng-Chao Zhu Wen-Chao Yang yi-Peng Wang Song Chen Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Anyang Eye Hospital Anyang 455000Henan ProvinceChina Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceNankai University Affiliated Eye HospitalTianjin 300020China

AIM:To identify metabolites,proteins,and related pathways involved in the etiology of rhegmatogenous retinal detachment(RRD)for use as biomarkers in diagnosing and treating ***:Vitreous specimens were collected and liquid chromatography-tandem mass spectrometry analysis was per formed using the four-dimensional label-free *** significant differentially expressed proteins,gene ontology(GO)terms,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway representations,and protein interactions were ***:Nine specimens were subjected to proteomic *** total,161 proteins were identified as differentially expressed proteins(DEPs),including 53 upregulated proteins and 108 downregulated *** functional analysis revealed that some DEPs were enriched in neuron-related terms and membrane protein ***,KEGG analysis indicated that the cell adhesion molecule metabolic pathway was associated with the greatest number of ***,the evaluation of protein-protein interaction network revealed that DEPs were clustered in neuronal adhesion,apoptosis,inflammation and immune responses,correct protein folding,and ***:Proteomic profiling is useful for the exploration of molecular mechanisms that underlie *** study reveals increased expression levels of proteins related to heat shock protein content,glycolysis,and inflammatory responses in *** regarding biomarkers of RRD pathogenesis may help to prevent the occurrence of RRD in the future.

关键词： vitreous rhegmatogenous retinal detachment proteome 4D label-free

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Asymmetric dark matter and Sommerfeld enhancement

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Communications in Theoretical Physics 2024年第8期76卷 118-123页

作者： Sujuan qiu Hoernisa Iminniyaz Wensheng huo School of Physics Science and Technology Xinjiang UniversityUrumqi 830017China

We study the relic density of asymmetric dark matter with long-range interactions by considering the Sommerfeld effect. We find that the annihilation cross section of asymmetric dark matter is enhanced by the Sommerfeld effect and thus the relic density is decreased. Then we use the Planck data to constrain the asymmetry factor, coupling, and to derive the upper bounds on the dark matter mass in s-wave and p-wave annihilation cases.

关键词： asymmetric dark matter relic density Sommerfeld enhancement

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Elastic three-dimensional phononic topological insulators with Dirac hierarchy

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 54-62页

作者： Shao-Yong huo qiu-Shuang Yang Jiu-Jiu Chen Hong-Kang Li Long-Chao Yao Fu-Chun He Chun-Ming Fu College of Mechanical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

Three-dimensional(3D)phononic topological insulators(TIs)featuring two-dimensional(2D)surface states and one-dimensional(1D)hinge states have opened up a new route for multi-dimensional robust wave transport,providing unprecedented methods for integrated acoustic sensors and energy harvesting ***,aiming at the elastic 3D phononic TI with gapless surface states and hinge states,the realization of elastic 3D phononic TIs with gapless surface states and hinge states is a significant challenge due to the complicated multi-mode polarization of elastic waves in 3D *** this study,we demonstrate an elastic 3D phononic TI with a Dirac hierarchy by elaborately operating the corresponding spatial symmetries of the chiral honeycomb ***,a 3D double Dirac cone of elastic wave can be achieved by doubling the lattice along the outof-plane direction to fold two iso-frequency Weyl *** topological phase transitions and 2D gapless two-fold Dirac surface states of elastic wave are realized by breaking the half-lattice spatial translation ***,based on the Brillouin zone folding along the in-plane direction,the 2D gapless two-fold surface Dirac cones are folded into four-fold surface Dirac ***,by inducing the relative radius of adjacent holes to break the in-plane spatial inversion symmetry,the fourfold surface Dirac cones are gapped and associated with a surface state inversion,in which the gapless 1D hinge Dirac dispersion is *** research offers a route for engineering the hierarchies of TIs in 3D elastic wave systems and provides new possibilities for designing 3D ultrasonic devices with unconventional functions.

关键词： Dirac topological hierarchy

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Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability

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Science China(Information Sciences) 2024年第2期67卷 335-336页

作者： Kui DANG Zhilin qiu Shudong huo Peng ZHAN Huining LIU Yachao ZHANG Jing NING Hong ZHOU Jincheng ZHANG Key Lab of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Guangzhou Wide Bandgap Semiconductor Innovation Center Guangzhou Institute of TechnologyXidian University

Microwave power transmission(MPT) could realize the point-to-point long-distance transfer of energy without any wires, which makes it attractive for solar-powered satellites,drones, and implantable medical devices, and has aroused enormous attention [1]. Microwave rectifiers could convert RF(radio frequency) energy into DC(direct current) power,

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Structural transition,electric transport,and electronic structures in the compressed trilayer nickelate La_(4)Ni_(3)O_(10)

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 9-15页

作者： Jingyuan Li Cui-Qun Chen Chaoxin Huang yifeng Han Mengwu huo Xing Huang Peiyue Ma Zhengyang qiu Junfeng Chen Xunwu Hu Lan Chen Tao Xie Bing Shen Hualei Sun Dao-Xin Yao Meng Wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China Center for Materials of the Universe School of Molecular SciencesArizona State UniversityTempe 85287USA School of Sciences Sun Yat-sen UniversityShenzhen 518107China

Atomic structure and electronic band structure are fundamental properties for understanding the mechanism of superconductivity. Motivated by the discovery of pressure-induced high-temperature superconductivity at 80 K in the bilayer Ruddlesden-Popper nickelate La_(3)Ni_(2)O_(7), the atomic structure and electronic band structure of the trilayer nickelate La_(4)Ni_(3)O_(10) under pressure up to 44.3 GPa are investigated. A structural transition from the monoclinic P2_(1)/a space group to the tetragonal I4/mmm around 12.6-13.4 GPa is identified, accompanied by a drop of resistance below 7 K. Density functional theory calculations suggest that the bonding state of Ni 3d_(z^(2)) orbital rises and crosses the Fermi level at high pressures, which may give rise to possible superconductivity observed in resistance under pressure in La_(4)Ni_(3)O_(10). The trilayer nickelate La_(4)Ni_(3)O_(10) shows some similarities with the bilayer La_(3)Ni_(2)O_(7) and has unique properties, providing a new platform to investigate the underlying mechanism of superconductivity in nickelates.

关键词： La_(4)Ni_(3)O_(10) high pressure synchrotron X-ray diffraction structural transition DFT calculations

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Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin yi-Juan Liu Shao-Wei Lin Yan-Feng Shao Feng qiu Qing-Wu qiu Zhang-Kun Xu Jin-Xian Chen Liang-huo Chen Zhen-Qun Lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang Zhong-Qin Xiao Xian-Xing Cheng Xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing Lin Yong-Fu Wang Fu-Jin Lai Long-Qun Chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

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大数据时代智慧农业实验室管理创新策略研究

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山东农业大学学报（自然科学版） 2024年第3期55卷 427-432页

作者：韩勇费攀锋霍迎秋西北农林科技大学信息工程学院陕西杨凌712100

大数据时代背景下,高校智慧农业实验室作为农业教育与科研的关键平台,面临管理革新需求。当前,这些实验室普遍采用的传统管理系统与智慧农业的快速发展不相匹配,限制了其潜能发挥。本文针对性地分析了智慧农业实验室的管理现状,并依托... 详细信息

大数据时代背景下,高校智慧农业实验室作为农业教育与科研的关键平台,面临管理革新需求。当前,这些实验室普遍采用的传统管理系统与智慧农业的快速发展不相匹配,限制了其潜能发挥。本文针对性地分析了智慧农业实验室的管理现状,并依托大数据技术,探索创新管理模式,旨在通过信息技术、智慧化及移动管理工具集成,优化资源配置与提升管理效率。提出的策略旨在最大化实验室资源效用,加速智慧农业教育与研究进程,推动该领域的持续创新与进步。

关键词：智慧农业计算机实验室大数据管理创新信息技术

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基于矿物溶解理论的砂岩化学损伤动态模型

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材料导报 2024年第8期38卷 159-165页

作者：梁艳玲霍润科宋战平穆彦虎秋添宋子羿西安建筑科技大学土木工程学院西安710055 西安建筑科技大学陕西省岩土与地下空间工程重点实验室西安710055 中国科学院西北生态环境资源研究院冻土工程国家重点实验室兰州730050

酸腐蚀环境下岩石物理力学性质的劣化本质上由岩石矿物的溶解引发的孔隙微裂隙的扩展贯通所致。为研究酸性环境下砂岩矿物的溶解特性,选择pH=1、3的盐酸溶液为腐蚀环境,借助X射线衍射试验鉴定砂岩矿物成分及含量,测试不同浸泡周期下溶液... 详细信息

酸腐蚀环境下岩石物理力学性质的劣化本质上由岩石矿物的溶解引发的孔隙微裂隙的扩展贯通所致。为研究酸性环境下砂岩矿物的溶解特性,选择pH=1、3的盐酸溶液为腐蚀环境,借助X射线衍射试验鉴定砂岩矿物成分及含量,测试不同浸泡周期下溶液的pH值、阳离子浓度、岩样的质量及其纵波波速,并通过矿物溶解理论与化学动力学原理,建立反映整个腐蚀过程的砂岩化学损伤动态模型。研究结果表明:酸性环境下砂岩的损伤主要由长石和方解石的溶解所致,矿物溶解反应分为界面吸附、界面交换、解吸附三个步骤,且步骤最慢者对整个反应起控制作用。矿物溶解速率与H+浓度的n次幂成正比,且0

关键词：砂岩矿物溶解化学损伤模型孔隙度纵波波速

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Maturity assessment model for aircraft collaborative design software solution

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Journal of Systems Engineering and Electronics 2018年第6期29卷 1228-1236页

作者： huo ying qiu Peng ZHAI Jiyou School of Computer Engineering Nanjing Institute of Technology

In order to assure quality and control process in the development of the aircraft collaborative design software, a maturity assessment model is proposed. The requirements designing—house of quality is designed to evaluate the maturity degree of the solution, and the evaluation results can help to manage and control the development process. Furthermore, a fuzzy evaluation method based on the minimum deviation is proposed to deal with the fuzzy information. The quantitative evaluation result of the maturity degree can be calculated by optimizing the semantic discount factor aim for the minimum deviation. Finally, this model is illustrated and analyzed by an example study of the aircraft collaborative design software.

关键词： aircraft collaborative design software development process quality function deployment fuzzy evaluation method

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Local existence and uniqueness of the incompressible Navier-Stokes-Landau-Lifshitz equations with the Dzyaloshinskii-Moriya interaction and V-flow term

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广州大学学报（自然科学版） 2024年第3期23卷 44-57页

作者： HUANG Gui-huo WANG Guang-wu YE Ting-ting qiu Zhen School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006China

In this paper,we prove that there exists a unique local solution for the Cauchy problem of a system of the incompressible Navier-Stokes-Landau-Lifshitz equations with the Dzyaloshinskii-Moriya interaction and V-flow term inR^(2) and R^(3).Our methods rely upon approximating the system with a perturbed parabolic system and parallel transport.

关键词： incompressible Navier-Stokes-Landau-Lifshitz equations Dzyaloshinskii-Moriya interac-tion local solution

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