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The Equivalence Forms of Random Kolmogorov Forward(Backward) Equations

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Wuhan University Journal of Natural Sciences 2005年第5期10卷 808-812页

作者： HU Di-he HU xiao-yu School of Mathematics and Statistics WuhanUniversity Wuhan 430072 HubeiChina Graduate School Chinese Academy of SciencesBeijing 100080 China

The concepts of Markov process in random environment, q-matrix in random environment and q-process in random environment are introduced. Three forms of random Kolmoogrov farward （or backward） equations are introduced and the equivalence of these three forms are also proved. Moreover any conservative q-process in random environment satisfies random Kolmogrov backward equation.

关键词： Markov process in random environment q-matrix in random environment q-process in random enviroment

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采煤塌陷湿地水质与富营养化评价

安徽农学通报 2024年第6期30卷 62-68页

作者：徐力力肖昕韩宝周刘庆峰肖雨成阳江苏贾汪资源枯竭矿区土地修复与生态演替教育部野外科学观测研究站江苏徐州221011 中国矿业大学环境与测绘学院江苏徐州221116 徐州潘安湖湿地公园江苏徐州221137

PAH湿地公园作为采煤沉陷区生态修复而设计的生态湿地公园,其修复后的湖泊水质情况备受关注。本研究于2023年10月在PAH北湖布置13个采样点,研究分析了氧化还原电位、水温、pH、溶解氧、电导率、透明度、五日生化需氧量、亚硝酸盐氮、硝... 详细信息

PAH湿地公园作为采煤沉陷区生态修复而设计的生态湿地公园,其修复后的湖泊水质情况备受关注。本研究于2023年10月在PAH北湖布置13个采样点,研究分析了氧化还原电位、水温、pH、溶解氧、电导率、透明度、五日生化需氧量、亚硝酸盐氮、硝酸盐氮、总氮、氨氮、总磷、叶绿素、化学需氧量和高锰酸盐指数共15项指标,对其水质和富营养化进行评价。结果表明,北湖内梅罗污染指数均值为0.86,其水质处于清洁状态。综合营养水平指数均值为59.98,北湖水体整体上处于轻度富营养化和中度富营养化的临界状态,北湖部分理化指标呈明显空间异质性。

关键词：水质评价富营养化评价综合污染水平指数

Vitamin C exerts anti-cadmium induced fracture functions/targets:bioinformatic and biostructural findings

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Food Science and Human Wellness 2022年第5期11卷 1384-1391页

作者： Rong Li Songzuo yu xiao Liang yu Li Keng Po Lai Laboratory of Environmental Pollution and Integrative Omics Guangxi Key Laboratory of Tumor Immunology and Microenvironmental RegulationGuilin Medical UniversityGuilin 541004China Department of Neurosurgery Guigang City People's HospitalThe Eighth Affi liated Hospital of Guangxi Medical UniversityGuigang 537100China

Background:Epidemiological data indicate an association between cadmium exposure and risk of bone fracture;however,clinical treatment of cadmium-induced fracture is *** vitamin C(VC)reportedly reduces cadmium-induced fracture,its pharmacological mechanism remains ***:Thus,we used a network pharmacology approach and molecular docking analysis to identify core targets,functional processes,and biological pathways involved in the anti-fracture action of ***:Bioinformatics identified 17 intersection targets of VC and cadmium-induced fracture,Nine core targets were characterized,including tumor protein p53,epidermal growth factor receptor,proto-oncogene c,mitogen-activated protein kinase-1(MAPK1),MAPK3,signal transducer and activator of transcription-3,MAPK14,prostaglandin-endoperoxide synthase 2,and estrogen receptor ***,findings of molecular docking analysis indicated that VC exerted effective binding capacity in cadmium-induced ***,biological processes,cell components,molecular functions,and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and ***:Based on these findings,we conclude that VC exhibits its anti-cadmium-induced fracture effects by promoting osteoblastic regeneration and proliferation,and inhibiting inflammatory *** core targets may serve as biomarkers for diagnosing cadmium-induced fractures.

关键词： Cadmium Fracture Vitamin C Network pharmacology Mechanism

牡丹茄腐镰刀菌FSH基因组中GATA类转录因子的鉴定与分析

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菏泽学院学报 2024年第2期46卷 110-117页

作者：袁琴琴晏思雨仝笑笑贾媛丹菏泽学院农业与生物工程学院(牡丹学院) 山东菏泽274015

牡丹根腐病主要是由茄腐镰刀菌(Fusarium solani)引起的,对牡丹种植区危害很大.GATA转录因子在病原真菌的定殖和致病过程中发挥重要作用.在牡丹茄腐镰刀菌FSH基因组中共鉴定出6条GATA类转录因子,它们均定位于细胞核中.在这6条GATA类转... 详细信息

牡丹根腐病主要是由茄腐镰刀菌(Fusarium solani)引起的,对牡丹种植区危害很大.GATA转录因子在病原真菌的定殖和致病过程中发挥重要作用.在牡丹茄腐镰刀菌FSH基因组中共鉴定出6条GATA类转录因子,它们均定位于细胞核中.在这6条GATA类转录因子编码的蛋白质中,有4个碱性蛋白(g2237.t1,g4943.t1,g6316.t1和g677.t1),1个酸性蛋白(g3670.t1)和1个中性蛋白(g13425.t1).这6个蛋白质均为亲水性和不稳定蛋白,它们编码的氨基酸数目区间为435~1025.保守结构域分析发现,这6个蛋白质除含有ZnF-GATA结构域外,g13425.t1还编码两个PAC结构域,g13425.t1和g3670.t1编码有PAS结构域;三级结构预测显示这6个蛋白质均无信号肽序列.研究阐述了牡丹茄腐镰刀菌FSH基因组中的GATA类转录因子基因及其生物信息学特征,以期为后期研究该类转录因子的功能提供一定的理论基础.

关键词：牡丹茄腐镰刀菌基因组 GATA转录因子鉴定

Syntheses and Structures of Uwo New Oxalate-bridged Transition-metal Supramolecular Polymers of [M(2-NH_2py)_2(ox)]

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Chemical Research in Chinese Universities 2007年第6期23卷 631-634页

作者： ZHANG xiao YI Zhi-hui XUE Ming XU Yan yu Jie-hui yu xiao-yang XU Ji-qing College of Chemistry State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130021 P. R. China

Two new supramoleeular polymers [ M （2-NH2 py）2 （ox） ] [ M = Co （1）, Ni （2） ; 2-NH2py = 2-aminopyridine; ox = oxalate ] were hydrothermally synthesized and characterized by elemental analyses, IR and single-crystal X-ray diffraction analyses. The isomorphic compounds 1 and 2 both possess one-dimensional zigzag chain structures, which are composed of [ M （2-NH2 py）2 ]^2＋ units bridged by tetradentate oxalate ligands to form three-dimensional supramolecular network v/a the C-H…O hydrogen bonds and π-π stacking interactions. Compound 1 displays antiferromagnetie interaction.

关键词： Crystal structure Oxalate ligand Coordination polymer Supramolecular interaction

子宫内膜癌患者血清脂质运载蛋白-2、内脂素水平变化及临床意义

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慢性病学杂志 2024年第3期 334-338页

作者：周晓宇刘燕龙小平王永周西南医科大学附属中医医院妇科四川泸州646000

目的探讨子宫内膜癌(endometrial cancer)患者的血清脂质运载蛋白-2(lipocalin-2,LCN-2)、内脂素(visfatin)的水平变化及临床意义。方法选取2020年1月至2022年1月西南医科大学附属中医医院妇科收治的子宫内膜癌患者156例(试验组),另选... 详细信息

目的探讨子宫内膜癌(endometrial cancer)患者的血清脂质运载蛋白-2(lipocalin-2,LCN-2)、内脂素(visfatin)的水平变化及临床意义。方法选取2020年1月至2022年1月西南医科大学附属中医医院妇科收治的子宫内膜癌患者156例(试验组),另选健康体检者80名(对照组),采用酶联免疫吸附法检测各组受试者的血清LCN-2、visfatin水平;分析血清LCN-2、visfatin与患者的病理类型、肿瘤直径、国际妇产科联盟国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期、病理分化等病理特征的关系;采用受试者操作特征曲线(receiver operating characteristic,ROC),分析血清LCN-2、visfatin对子宫内膜癌发生的预测价值。结果试验组患者的血清LCN-2、visfatin水平均比对照组高(P<0.05)。子宫内膜癌患者不同体质量指数(body mass index,BMI)、FIGO分期、病理分化、淋巴结转移、血管浸润血清LCN-2、visfatin水平相比,差异有统计学意义(P<0.05)。ROC曲线显示:血清LCN-2、visfatin联合检测预测,子宫内膜癌发生的曲线下面积为0.879,敏感性和特异性为0.893和0.886。多因素logistic回归分析示:血清糖类抗原125(carbohydrate antigen125,CA125)、糖类抗原199(carbohydrate antigen 199,CA199)、LCN-2、visfatin水平变化是患者发生子宫内膜癌的独立危险因素(P<0.05)。结论子宫内膜癌患者血清LCN-2、visfatin水平升高,血清LCN-2、visfatin水平与患者的临床病理特征有关,对预测子宫内膜癌的发生发展有重要的临床意义。

关键词：子宫内膜癌脂质运载蛋白-2 内脂素

Hf0.5Zr0.5O2 1T–1C FeRAM arrays with excellent endurance performance for embedded memory

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Science China(Information Sciences) 2023年第4期66卷 303-304页

作者： Wenwu xiao yue PENG Yan LIU Huifu DUAN Fujun BAI Bing yu Qiwei REN xiao yu Genquan HAN School of Microelectronics Xidian University Xi'an UniIC Semiconductors Research Center for Intelligent Chips Zhejiang Lab Hangzhou Institute of Technology Xidian University

Since the initial report of HfO2-based ferroelectric films in 2011, great attention has been paid to ferroelectric field-effect transistors and ferroelectric random-access memories(FeRAMs)[1–3]. Up to now, many efforts have been devoted to realizing the industrialization of HfO2-based FE films. However, the limited fatigue performance has always been the main problem to be resolved.

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挤压螺杆转速对碎米重组米中淀粉多层级结构的影响

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食品科学 2024年第12期45卷 212-219页

作者：王可心王丽爽霍金杰于小帅岳喜庆马小淇段玉敏肖志刚沈阳农业大学食品学院辽宁沈阳110866 沈阳师范大学粮食学院辽宁沈阳110034 沈阳师范大学实验教学中心辽宁沈阳110034

以碎米粉为原料,调整挤压螺杆转速,通过扫描电子显微镜图、小角X射线衍射图、X射线衍射图及傅里叶变换红外光谱对重组米的微观结构、淀粉糊体系亚微观结构和分形结构、长程有序、短程有序结构进行对比。研究发现:挤压处理后大米淀粉的... 详细信息

以碎米粉为原料,调整挤压螺杆转速,通过扫描电子显微镜图、小角X射线衍射图、X射线衍射图及傅里叶变换红外光谱对重组米的微观结构、淀粉糊体系亚微观结构和分形结构、长程有序、短程有序结构进行对比。研究发现:挤压处理后大米淀粉的螺旋构象发生变化,其表面孔隙变多,结晶结构发生明显改变。随着挤压螺杆转速逐渐降低,大米淀粉的分形维数、相对结晶度和双螺旋程度均逐渐下降,体系呈现疏松无序的状态。将直链淀粉和支链淀粉进行分离后发现,挤压处理可能导致直链淀粉与脂质形成少量复合物,支链淀粉的粒径最大达到1000μm以上,挤压使得颗粒表面更加粗糙。本研究对大米副产物的重构利用有着重要借鉴意义。

关键词：挤压处理长程有序精细结构直链淀粉支链淀粉

TRIM22 Inhibits the TRAF6-stimulated NF-κB Pathway by Targeting TAB2 for Degradation

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Virologica Sinica 2013年第4期28卷 209-215页

作者： Hui qiu Fang Huang Han xiao Binlian Sun Rongge Yang Research Group of HIV Molecular Epidemiology and Virology Center for Emerging Infectious Diseases The State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences

Tripartite motif containing 22 （TRIM22）, a member of the TRIM/RBCC family, has been reported to activate the nuclear factor-kappa B （NF-kB） pathway in unstimulated macrophage cell lines, but the detailed mechanisms governing this activation remains unclear. We investigated this mechanism in HEK293T cells. We found that overexpression of TRIM22 could activate the NF-kB pathway and conversely, could inhibit the tumor necrosis factor receptor-associated factor 6 （TRAF6）-stimulated NF-kB pathway in HEK293T cells. Further experiments showed that TRIM22 could decrease the self-ubiquitination of TRAF6, and interact with and degrade transforming growth factor-13 activated kinase 1 binding protein 2 （TAB2）, and that these effects could be partially rescued by a TRIM22 RING domain deletion mutant. Collectively, our data indicate that overexpression of TRIM22 may negatively regulate the TRAF6-stimulated NF-rd3 pathway by interacting with and degrading TAB2.

关键词： TRIM22 NF-kB pathway TRAF6 TAB2