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Nanograting-Based Dynamic Structural Colors Using Heterogeneous Materials

NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Wang, Jingang Yu, Haibo Zheng, Jianchen Zhang, Yuzhao Guo, Hongji qiu, Ye Wang, Xiaoduo Yang, Yongliang Liu, Lianqing Chinese Acad Sci Shenyang Inst Automat State Key Lab Robot Shenyang 110016 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

A 2.5-dimensional dynamic structural color based on nanogratings of heterogeneous materials was proposed by interweaving a pH-responsive hydrogel with IP-L *** nanogrid structures exhibit brilliant tuneable structural color, high sensitivity, and ultrafast recovery speeds in response to *** 4D printing-based grayscale design approach was proposed for the patterned encoding and array printing of dynamic structural colors, promoting their application in patterned printing, information encryption, and microfluidic chip sensing. Dynamic structural colors can change in response to different environmental stimuli. This ability remains effective even when the size of the species responsible for the structural color is reduced to a few micrometers, providing a promising sensing mechanism for solving microenvironmental sensing problems in micro-robotics and microfluidics. However, the lack of dynamic structural colors that can encode rapidly, easily integrate, and accurately reflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensional dynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogel with an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollen state, resulting in pH-tuned structural colors at a 45 degrees incidence. Moreover, the patterned encoding and array printing of dynamic structural colors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamic structural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive Nanogrid Heterogeneous materials

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Test selection and optimization for PHM based on failure evolution mechanism model

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Journal of Systems Engineering and Electronics 2013年第5期24卷 780-792页

作者： Jing qiu Xiaodong tan Guanjun Liu Kehong L Laboratory of Science and Technology on Integrated Logistics Support College of Mechatronics and AutomationNational University of Defense Technology

The test selection and optimization （TSO） can improve the abilities of fault diagnosis, prognosis and health-state evalua- tion for prognostics and health management （PHM） systems. Traditionally, TSO mainly focuses on fault detection and isolation, but they cannot provide an effective guide for the design for testability （DFT） to improve the PHM performance level. To solve the problem, a model of TSO for PHM systems is proposed. Firstly, through integrating the characteristics of fault severity and propa- gation time, and analyzing the test timing and sensitivity, a testability model based on failure evolution mechanism model （FEMM） for PHM systems is built up. This model describes the fault evolution- test dependency using the fault-symptom parameter matrix and symptom parameter-test matrix. Secondly, a novel method of in- herent testability analysis for PHM systems is developed based on the above information. Having completed the analysis, a TSO model, whose objective is to maximize fault trackability and mini- mize the test cost, is proposed through inherent testability analysis results, and an adaptive simulated annealing genetic algorithm （ASAGA） is introduced to solve the TSO problem. Finally, a case of a centrifugal pump system is used to verify the feasibility and effectiveness of the proposed models and methods. The results show that the proposed technology is important for PHM systems to select and optimize the test set in order to improve their performance level.

关键词： test selection and optimization (TSO) prognostics and health management (PHM) failure evolution mechanism model (FEMM) adaptive simulated annealing genetic algorithm (ASAGA).

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身体还是认知努力的损害?抑郁症努力奖赏动机评估及计算模型应用

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心理科学进展 2025年第1期33卷 107-122页

作者：温秀娟马毓璟谭斯祺李芸刘文华广州医科大学附属脑科医院广州510370 广州医科大学卫生管理学院广州511436

动机损害是抑郁症的常见特征,患者常表现出异常的奖励评估或体验等行为。理解抑郁症患者努力奖赏动机活动中不愿意付出努力的类型——是不愿意付出身体努力还是不愿意付出认知努力,对帮助患者恢复社会功能活动具有重要作用。然而,当前... 详细信息

动机损害是抑郁症的常见特征,患者常表现出异常的奖励评估或体验等行为。理解抑郁症患者努力奖赏动机活动中不愿意付出努力的类型——是不愿意付出身体努力还是不愿意付出认知努力,对帮助患者恢复社会功能活动具有重要作用。然而,当前缺少研究探讨努力类型(身体或认知努力)对研究认识的影响,同时,计算模型方法具有能够精细评估动机相关变量的优势,这一方法在该领域中并未得到普及应用。通过实验方法区分评估抑郁症患者“认知努力”和“身体努力”这两种不同的努力决策,并结合计算模型的数据分析方式,从努力奖赏动机这一角度探索抑郁症动机损害行为,对揭示这一损害潜在的认知神经基础具有促进作用。

关键词：抑郁症快感缺失动机损害身体努力认知努力计算模型

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A study on wrinkling characteristics and dynamic mechanical behavior of membrane

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Acta Mechanica Sinica 2012年第1期28卷 201-210页

作者： Yun-Liang Li Ming-Yu Lu Hui-Feng tan Yi-qiu tan School of Transportation Science and Engineering Harbin Institute of Technology150090 HarbinChina Post-doctoral Research Center in Civil Engineering Harbin Institute of Technology150090 HarbinChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina Center for Composite Materials and Structure Harbin Institute of Technology150001 HarbinChina

An eigenvalue method considering the membrane vibration of wrinkling out-of-plane deformation is introduced, and the stress distributing rule in membrane wrinkled area is analyzed. A dynamic analytical model of rectangular shear wrinkled membrane and its numerical analysis approach are also developed. Results indicate that the stress in wrinkled area is not uniform, i.e. it is larger in wrinkling wave peaks along wrinkles and two ends of wrinkle in vertical direction. Vibration modes of wrinkled membrane are strongly correlated with the wrinkling configurations. The rigidity is larger due to the heavier stress in the part of wrinkling wave peaks. Therefore, wave peaks are always located at the node lines of vibration mode. The vibration frequency obviously increases with the vibration of wave peaks.

关键词： Space membrane structure Wrinkle Vibration

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Microstructures and mechanical properties of low carbon fishplate materials

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Acta Metallurgica Sinica(English Letters) 2010年第3期23卷 176-184页

作者： Fumin XU Kai wen Yi tan School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China

Two kinds of low carbon bainite materials were developed for fishplate *** microstructures and mechanical properties were measured in *** results showed that one material was composed of fine granular bainite with the yield strength of 722 MPa at room temperature and 738 MPa at-55℃, and elongation percentages of 60.7% and 41.7%, *** other one had a meta-bainite microstructure with corresponding strengths of 568.5 MPa and 700 MPa, elongation percentages of 63.5% and 67.1%, *** values are all superior to the home-made B7 steel and the fishplate materials made in *** major strengthening mechanisms were discussed and attributed to the solid solution, complex phases, fine grain and dislocation strengthening.

关键词： Fishplate Microstructure Mechanical property Strengthening

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A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility

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Asian Journal of Andrology 2023年第5期25卷 643-645页

作者： Si-Yi Zhao Lan-Lan Meng Zhao-Li Du Yue-qiu tan wen-Bin He Xiong Wang The First Clinical College of Guangzhou Medical University Guangzhou 511436China National Engineering and Research Center of Human Stem Cells and Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya and Clinical Research Center For Reproduction and Genetics in Hunan Province Changsha 410008China Yinfeng Gene Technology Co. Ltd.Jinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

Male infertility is a major reproductive disorder,which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or *** date,five male patients with biallelic loss-of-function(LOF)variants of PARN-like ribonuclease domain-containing exonuclease 1(PNLDC1)have been reported to experience infertility with nonobstructive *** aim of this study was to identify the genetic cause of male infertility with oligo-astheno-teratozoospermia(OAT)in a patient from a Chinese Han ***-exome and Sanger sequencing analyses identified a homozygous LOF variant(NM_173516.2,c.l42C>T,***48Ter)in *** and eosin staining revealed that the spermatozoa of the patient with OAT had an irregular head phenotype,including microcephaly,head tapering,and ***,peanut agglutinin staining of the spermatozoa revealed a complete or partial loss of the ***,the disomy rate of chromosomes in the patient’s spermatozoa was significantly increased compared with that of a fertile control *** reported an LOF variant of the PNLDC1 gene responsible for OAT.

关键词： loss-of-function variant male infertility oligo-astheno-teratozoospermia PARN-like ribonuclease domain-containing exonuclease 1

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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有为政府与有效市场下的我国职业教育治理:理论逻辑与实践路径

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高校教育管理 2025年第1期19卷 62-73页

作者：李政邱懿华东师范大学职业教育与成人教育研究所上海200062 中华人民共和国教育部职业教育与成人教育司北京100816 北京大学教育学院北京100871

政府与市场的关系是职业教育内外部治理关系的核心,先后经历了政府主导论、市场基础论、有为政府与有效市场论的演变。在有为政府与有效市场的关系形塑下,职业教育治理改革应实现三大转变,即政府治理方式应从事后响应转变为事前布局,职... 详细信息

政府与市场的关系是职业教育内外部治理关系的核心,先后经历了政府主导论、市场基础论、有为政府与有效市场论的演变。在有为政府与有效市场的关系形塑下,职业教育治理改革应实现三大转变,即政府治理方式应从事后响应转变为事前布局,职业院校治理角色应从代理主体转变为改革先锋,市场主体参与治理的动机应从短期利益转变为战略投资。政府、职业院校和市场的关系应由单向的“影响回应”关系转变为双向的“并行互动”关系。当前,我国政府参与职业教育治理的权责边界不清,职业院校办学自主权无法满足发展需求,市场主体参与职业教育缺乏战略自觉。为此,我国应加强各级政府的政策协作,提升政府政策的精准度和前瞻性;优化职业院校组织定位和内部治理模式,提升学校治理的灵活性和有效性;深度分析企业发展的外部条件和内部需求,提升企业发展的积极性和适应性。

关键词：职业教育治理有为政府有效市场全面深化改革办学自主权

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Quantitative reconstruction of formation paleo-pressure in sedimentary basins and case studies

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Science China Earth Sciences 2020年第6期63卷 808-821页

作者： Nansheng qiu Yifeng LIU wen LIU Jingkun JIA State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China College of Ocean Zhejiang UniversityZhoushan 316021China Institute of Geomechanics Chinese Academy of Geological ScienceBeijing 100081China

Paleo-pressure reconstruction in sedimentary basins is one of the most important aspects of hydrocarbon accumulation *** view of the advantages and disadvantages of the current methods for paleo-pressure research,a new method to reconstruct the paleo-pressure is presented in this *** to the geological background,quantitative analyses of the factors that might control overpressure were first conducted to clarify the contributions of each mechanism during different geological *** evolution was reconstructed by fluid-compaction modelling with constraints imposed by the paleo-pressures obtained from fluid inclusions or differential stress *** the mechanisms responsible for overpressures during geological history is the basic prerequisite for paleo-pressure ***,quantitative studies were conducted of the contributions of disequilibrium compaction,gas charging,oil cracking,temperature reduction,and tectonic uplift and subsidence to *** case studies of paleo-pressure reconstruction were performed for the Sinian strata in the Sichuan Basin,Ordovician strata in the north uplift in the Tarim Basin and the Permian strata in the Sulige Gas Field in the Ordos Basin,where these three study sites are normally pressured,weakly over-pressured and abnormally low pressured at present,*** new method developed in this paper is very important for the practical reconstruction of the paleopressure in marine strata and ancient strata in deep basins.

关键词： Formation pressure Fluid inclusion Differential stress Basin modelling Overpressure Marine basin

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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