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Weekly taxane-anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer:a randomized controlled trial

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Chinese Journal of Cancer 2017年第6期36卷 274-281页

作者： qiu-wen tan Ting Luo Hong Zheng Ting-Lun Tian Ping He Jie Chen He-Lin Zeng Qing Lv Department of Breast Surgery West China HospitalSichuan University Department of Medical Oncology West China HospitalSichuan University

Background:Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast ***,few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast *** study was to compare the efficacy and safety of a weekly taxaneanthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast ***:Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide(FEC) regimen or weekly paclitaxel-epirubicin(PE) *** primary endpoint was the pathologic complete response(pCR) *** endpoints included the clinical tumor response,breast-conserving surgery rate,and adverse ***:Between March 2010 and September 2013,293 patients were randomized to the FEC(n=151) and PE(n=142) *** overall clinical response rate was significantly higher in the PE arm than in the FEC arm(76.06%vs.59.95%,P=0.001).Consistently,the post-chemotherapy pathologic T and N stages were significantly lower in the PE arm than in the FEC arm(P<0.001).However,the pCR rate was similar in the two arms(10.61%vs.12.31%,P=0.665).Overall,36(27.27%) patients in the FEC arm and 6(35.28%) in the PE arm were qualified for breast-conserving *** adverse events were comparable in both arms,with more severe neutropenia in the PE arm than in the FEC arm(11.97%vs.5.96%,P=0.031).Conclusions:In patients with locally advanced breast cancer,weekly PE was not superior to FEC in terms of ***,weekly PE has a higher response rate and superior down-staging *** this account,the PE regimen may be considered an alternative option for locally advanced breast ***-term follow-up data are needed to confirm the efficacy of this regimen on locally advanced breast *** registration Chinese clinical trial registry,Ch

关键词：随机对照试验治疗方案乳腺癌紫杉烷晚期环类药物蒽

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Increased pathologic complete response are expected in HER2-positive and triple-negative locally advanced breast cancers

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Chinese Journal of Cancer 2017年第6期36卷 282-283页

作者： Kadri Altundag qiu-wen tan Ting Luo Hong Zheng Ting-Lun Tian Ping He Jie Chen He-Lin Zeng Qing Lv MKA Breast Cancer Clinic Tepe Prime Cankaya 06800 Ankara Turkey Department of Breast Surgery West China Hospi-tal Sichuan University Chengdu Sichuan 610041 P. R. China Department of Medical Oncology West China Hospi-tal Sichuan University Chengdu Sichuan 610041 P. R. China

To The Editor I want to congratulate *** and colleagues for their article entitled'Weekly taxane-anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer:a randomized controlled trial'[1].The pathologic complete response(pCR)rate was similar in the two arms(10.61%vs.12.31%,P=0.665).However,the

关键词：乳腺癌晚期病理阳性阴性治疗方案 tan PCR

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每周一次的紫杉烷–蒽环类联合方案与3周一次的以蒽环类为基础方案治疗局部晚期乳腺癌的随机对照研究

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癌症 2018年第2期37卷 65-72页

作者： qiu-wen tan Ting Luo Hong Zheng Ting-Lun Tian Ping He Jie Chen He-Lin Zeng Qing Lv 四川大学华西医院乳腺外科四川大学华西医院肿瘤科

背景与目的已有大量研究证实了紫杉烷与蒽环类联合化疗治疗乳腺癌的疗效。然而,很少有研究评价每周一次紫杉烷–蒽环类治疗方案对局部晚期乳腺癌的疗效。本研究旨在比较每周一次紫杉烷–蒽环类治疗方案和3周一次以蒽环类为基础的治疗方... 详细信息

背景与目的已有大量研究证实了紫杉烷与蒽环类联合化疗治疗乳腺癌的疗效。然而,很少有研究评价每周一次紫杉烷–蒽环类治疗方案对局部晚期乳腺癌的疗效。本研究旨在比较每周一次紫杉烷–蒽环类治疗方案和3周一次以蒽环类为基础的治疗方案在治疗局部晚期乳腺癌上的疗效和安全性。方法局部晚期乳腺癌患者随机分组,接受4–6周期的3周一次的5-氟尿嘧啶–表柔比星–环磷酰胺(5-fluorouracil–epirubicin–cyclophosphamide,FEC)或每周一次的紫杉醇–表柔比星(paclitaxel–epirubicin,PE)的新辅助化疗方案。主要终点是病理完全缓解(pathologic complete response,pCR)率。其他终点包括临床肿瘤反应、保乳手术率和不良事件。结果从2010年3月至2013年9月,293例患者被随机分为FEC(n=151)组和PE(n=142)组。PE组的总临床反应率显著高于FEC组(76.06%vs. 59.95%,P=0.001)。一致的是,PE组化疗后病理性T和N分期显著低于FEC组(P <0.001)。但两组的pCR率是相似的(10.61%vs. 12.31%,P=0.665)。总体而言,FEC组36例(27.27%)和PE组6例(35.28%)适合进行保乳手术。两个治疗组中患者的大多数不良事件相似,其中PE组患者的中性粒细胞减少症比FEC组更严重(11.97%vs. 5.96%,P=0.031)。结论:在局部晚期乳腺癌患者中,每周一次PE方案在pCR方面并不优于每3周一次FEC方案。然而,每周一次PE方案具有较高的应答率和较好的肿瘤降级效果。因此,PE方案可能为治疗局部晚期乳腺癌的可选方案。还需要长期随访数据来证实这种方案对治疗局部晚期乳腺癌患者的疗效。

关键词：局部晚期乳腺癌新辅助化疗随机临床试验紫杉烷蒽环类化疗

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Effect of Tetramethylpyrazine on Large-conductance Calcium-activated Potassium Channels of Human Mesenteric Artery Smooth Muscle Cells

Effect of Tetramethylpyrazine on Large-conductance Calcium-a...

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中国生理学会第九届全国青年生理学工作者学术会议

作者： Jun Cheng,Xiao-rong Zeng,Peng-yun Li,wen-jun Huang,Xiao-qiu tan,wen Zhou,Yan Yang~* (Department of Electrophysiology,Institute of Cardiovasology,Luzhou Medical College,Luzhou, 646000,China)

Objective:To investigate the effect of lingustrazine on Large-conductance Calcium-activated Potassium Channels(BK) of human mesenteric artery smooth muscle ***:Enzymatically isolate human mesentery artery smooth muscle cells and study the effect of lingustrazine on BK currents and spontaneous transient outward currents(STOCs) using perforate whole cell patch ***:At 0.73 and 3.67mmol/L,tetramethylpyrazine obviously actives BK on human mesenteric artery smooth muscle *** the dose is 0.73 mmol/L,and membrane potential from -50 to +60mV,tetramethylpyrazine obviously increase current density of BKfrom 0.25±0.03 pA/pF (-50 mV)and 8.37±1.75 pA/pF(+60 mV) to 0.34±0.039 pA/pF(-50 mV,P<0.01,n=12) and to 14.12±2.66 pA/pF(+60 mV,P<0.01,n=12).When 3.67 mmol/L is used,and membrane potential from 0 to +60 mV,Tetramethylpyrazine obviously increase current density of BKfrom 1.25±0.23 pA/pF(0 mV) and 10.57±3.61 pA/pF(+60 mV) to 1.90±0.31pA/pF(0 mV,P<0.05,n=7) and 20.32±4.68pA/pF(+60 mV,P<0.05,n=7).Otherwise,when the dose is up to 8.07 mmol/L, Tetramethylpyrazine significantly reduce current density of BK from -60 to +*** 8.07 mmol/L Tetramethylpyrazine,-60 and +60mV membrane potential,current density of BK respectively reduce from 0.28±0.02pA/pF(-60mV) and 10.49±0.44pA/pF(+60mV) to 0.15±0.04pA/pF(-60mV,P<0.01,n=6) and 1.83±0.68pA/pF(+60mV,P<0.01,n=6).Conclusion:Tetramethylpyrazine can markedly active BK in HMASMC at lower concentration,but significantly inhibit BK in HMASMC at higher *** differentiation will provide the basis of clinical therapy for tetramethylpyrazine reasonable utility.

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi tan Chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第1期 10-11页

作者： Zhoumei tan Kun Xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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几种土壤铁锰结核对Cr(Ⅲ)的氧化特性ⅡpH、离子强度、温度等因素的影响

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土壤学报 2003年第6期40卷 852-857页

作者：刘桂秋谭文峰冯雄汉刘凡华中农业大学资源与环境学院

以我国几种土壤中铁锰结核为材料 ,研究了不同pH、离子强度和温度条件下氧化锰矿物对Cr(Ⅲ )的氧化。结果表明 :随着体系pH的降低、离子强度的增加以及温度的升高 ,供试铁锰结核对Cr(Ⅲ )的氧化量增加 ,这除了与其氧化还原反应本身消耗H... 详细信息

以我国几种土壤中铁锰结核为材料 ,研究了不同pH、离子强度和温度条件下氧化锰矿物对Cr(Ⅲ )的氧化。结果表明 :随着体系pH的降低、离子强度的增加以及温度的升高 ,供试铁锰结核对Cr(Ⅲ )的氧化量增加 ,这除了与其氧化还原反应本身消耗H+有关外 ,还与氧化锰矿物表面电荷性质和电位变化、共存的氧化铁矿物有关。而上述因素的变化导致N2 1、N4 1号样氧化Cr(Ⅲ )的增幅比N5 1号样的大 ,则可能与氧化锰矿物的结晶程度、晶体构造和铁锰结核中Mn(Ⅳ )

关键词：土壤铁锰结核 Cr 氧化特性 pH值离子强度温度影响因素

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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辽宁省稻田土壤供钾状况研究

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土壤通报 2003年第4期34卷 302-307页

作者：邱卫文谭成君雷永振王祥珍赵凯沈阳农业大学土地资源与环境学院辽宁沈阳110161 辽宁省农科院土肥所辽宁沈阳110161

据测定,辽宁省水稻土速效钾、缓效钾的平均含量均以盘锦、营口地区的盐渍型水稻土为最高,其次是东港地区盐渍型、淹育型和潜育型水稻土以及铁岭地区淹育型水稻土,最低的是沈阳地区淹育型水稻土。各地区水稻土的供钾强度(Ⅰ)、供钾容量(Q... 详细信息

据测定,辽宁省水稻土速效钾、缓效钾的平均含量均以盘锦、营口地区的盐渍型水稻土为最高,其次是东港地区盐渍型、淹育型和潜育型水稻土以及铁岭地区淹育型水稻土,最低的是沈阳地区淹育型水稻土。各地区水稻土的供钾强度(Ⅰ)、供钾容量(Q)以及供钾缓冲力(Q/I),均按上述地区顺序依次递减。出现这些差异,是由于土壤成土母质、粘土矿物类型、钾肥用量、灌溉水水质以及土壤基本性质,诸如粘粒含量、阳离子交换量、pH值等因素不同而造成的。盘锦、营口稻区水稻土在这几方面都占优势。

关键词：辽宁稻田土壤钾素供应盐渍型水稻土淹育型潜育型供钾强度容量缓冲力

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