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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

东江河口典型河段溶解氧时空动态及低氧成因解析

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湖泊科学 2025年第1期37卷 112-121页

作者：黄广灵黄本胜刘达邱静黄国如华南理工大学土木与交通学院广州510640 广东省水利水电科学研究院广州510635 广东省流域水环境治理与水生态修复重点实验室广州510635 华南理工大学亚热带建筑与城市科学全国重点实验室广州510640

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响... 详细信息

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响因子的相关性分析显示,DO与水温呈显著负相关,与盐度呈正相关,而与氨氮和总磷等营养物质呈显著负相关。这些营养物质的增加与DO的降低在空间上呈显著重叠,特别是在夏季。研究结果表明,东江南支流低氧现象受物理、化学和生物因素的共同影响,其中温度升高和营养物质浓度增加使得中下游水体的氧气消耗加快,河道汇流处的断面缩窄和下游水体的透光性差引起DO补给不足,从而导致下游沙田泗盛断面经常性出现氧亏(低氧)现象。

关键词：东江南支流溶解氧低氧营养物珠江

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Design of a terahertz slotted waveguide array antenna based on photonic crystal

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Optoelectronics Letters 2025年

作者： PAN Wu YE Kuan ZHANG Zhen LI Renpu qiu Sen huang Lei College of Photoelectronic Engineering， Chongqing University of Posts and Telecommunications Chongqing Municipal Key Laboratory of Photoelectric Information Sensing and Transmission Technology， Chongqing University of Posts and Telecommunications Laboratory of Quantum Information Technology， Chongqing University of Posts and Telecommunications

In this paper， a terahertz slotted waveguide array antenna is designed based on photonic crystal， which can realize efficient radiation of terahertz waves. The electromagnetic wave is fed from the rectangular waveguide at the bottom of the antenna， coupled to photonic crystal waveguide through photonic crystal cavity， and radiated outward through slots at the top layer of antenna. The simulation results show that the antenna achieves a peak gain of 13.45dBi at 360 GHz， a half-power beamwidth of 10.9o， and a side lobe level of -13.9dB. The antenna based on photonic crystal has the advantages of low profile， low loss， and high radiation efficiency， which can be applied to terahertz wireless communication systems.

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基于非沉浸式虚拟现实技术的设计方法探析

湖北工业大学学报 2006年第3期21卷 154-156页

作者：袁心平唐秋华武汉科技大学艺术与设计学院湖北武汉430081 武汉科技大学机械自动化学院湖北武汉430081

在空间环境设计中运用虚拟现实技术是一种新的尝试,在设计阶段,使人能够在一种虚拟的三维环境中,用动态和交互方式对未来的居住、生活和工作空间或对机械设备等进行操作的空间进行身临其境的全方位的审视,人可以在随意变化的交互控制下... 详细信息

在空间环境设计中运用虚拟现实技术是一种新的尝试,在设计阶段,使人能够在一种虚拟的三维环境中,用动态和交互方式对未来的居住、生活和工作空间或对机械设备等进行操作的空间进行身临其境的全方位的审视,人可以在随意变化的交互控制下感受到场景的动态特性.

关键词：虚拟现实空间环境设计方法人机交互

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

Entire Solutions of Fermat-Type Partial Differential-Difference Equations in■

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Journal of Mathematical Research with Applications 2025年第1期 56-72页

作者： Caoqiang tang Zhigang huang School of Mathematical Sciences Suzhou University of Science and Technology

Abstract In this paper,we mainly investigate the forms of entire solutions for certain Fermattype partial differential-difference equations in ■by using Nevanlinna’s theory of several complex variables.

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Immunological Markers for Central Nervous System Glia

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Neuroscience Bulletin 2023年第3期39卷 379-392页

作者： Hao huang Wanjun He Tao tang Mengsheng qiu Zhejiang Key Laboratory of Organ Development and Regeneration Institute of Life SciencesCollege of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China Department of Anatomy Cell Biology and Physiology Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN 46202USA

Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and *** contribute more than half of the total cells of the CNS,and are essential for neural development and *** on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular ***,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible ***,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression.

关键词： Glial cells Oligodendrocytes Astrocytes Microglia Markers