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Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-Tao Zhang Peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong qiu-shuo ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-Sheng Zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi Shi Willie Soon ShiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

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Physics based circuit compatible model for hybrid antiferroelectric random access memory

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Science China(Information Sciences) 2025年第1期 396-397页

作者： qiuxia WU Yue PENG Wenwu XIAO Wenxuan ma shuo ZHANG Litao SUN Chunfu ZHANG Xiaohua ma Yue HAO School of Microelectronics Xidian University Xi'an Uni IC Semiconductors

Since the discovery of HfO2-based ferroelectric （FE） materials in 2011,considerable advancements have been made in material preparation,mechanism research,and device realization [1].Consequently,these materials are now regarded as leading candidates for embedded non-volatile memory（eNVM）.Beyond eNVM applications,recent studies have demonstrated that memory devices with antiferroelectric（AFE） films can achieve high response speeds,low latency,and reduced power consumption while maintaining excellent endurance characteristics [2,3].Additionally,the typical double hysteresis loops and multiple non-overlapping polarization current peaks of AFE films offer a novel approach to designing multistate ***,in order to further promote the application of high storage density AFE,an AFRAM electronic design automation （EDA） model must be developed,and it has yet to be proposed.

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Prediction and Measurement Techniques for Radiated EMI of Power Converters with Cables

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Chinese Journal of Electrical Engineering 2022年第4期8卷 1-10页

作者： Zhedong ma shuo Wang Power Electronics and Electrical Power Research Lab University of Florida32611 USA

Recently,radiated electromagnetic interference(EMI)has become a research hotspot in power electronics systems,as the switching frequencies of power electronics systems have increased significantly with the adoption of wide-bandgap *** this article,a generalized radiated EMI model for power electronics converters with power cables is first *** radiated EMI model is then developed for a flyback power converter with critical ground impedance *** on the developed model,accurate high-frequency parameter extraction techniques and a radiated EMI prediction technique are developed and experimentally ***,essential measurement techniques are identified and developed to accurately extract parameters for accurate EMI *** effects of the resolution bandwidth of the spectrum analyzer and critical PCB ground impedance on the radiated EMI are experimentally ***’s impact on the common-mode(CM)choke’s impedance and the radiated EMI is further *** for minimizing the undesired near-field couplings in parameter extraction are *** predicted EMI properly agreed with the measured EMI in the range of 30-230 MHz based on the EN550323 m class B standard.

关键词： Radiated electromagnetic interference power converters power cables spectrum analyzer resolution bandwidth

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Hidden policy ciphertext-policy attribute-based encryption with keyword search against keyword guessing attack

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Science China(Information Sciences) 2017年第5期60卷 130-141页

作者： shuo qiu Jiqiang LIU Yanfeng SHI Rui ZHANG School of Computer and Information Technology Beijing Jiaotong University State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of Sciences

Attribute-based encryption with keyword search(ABKS) enables data owners to grant their search capabilities to other users by enforcing an access control policy over the outsourced encrypted data. However,existing ABKS schemes cannot guarantee the privacy of the access structures, which may contain some sensitive private information. Furthermore, resulting from the exposure of the access structures, ABKS schemes are susceptible to an off-line keyword guessing attack if the keyword space has a polynomial size. To solve these problems, we propose a novel primitive named hidden policy ciphertext-policy attribute-based encryption with keyword search(HP-CPABKS). With our primitive, the data user is unable to search on encrypted data and learn any information about the access structure if his/her attribute credentials cannot satisfy the access control policy specified by the data owner. We present a rigorous selective security analysis of the proposed HP-CPABKS scheme, which simultaneously keeps the indistinguishability of the keywords and the access structures. Finally,the performance evaluation verifies that our proposed scheme is efficient and practical.

关键词： earch access structure privacy hidden policy keyword guessing attack

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Land-use zoning in fast developing coastal area with ACO model for scenario decision-making

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Geo-Spatial Information Science 2015年第1期18卷 43-55页

作者： Bin AI Shifa ma shuo WANG School of marine Sciences Sun Yat-sen UniversityGuangzhou 510275China School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China

Potential ecological environment risks have been emerged as the result of land-use change(***)in coastal *** between urban growth and ecological conservation should be brought to the forefront especially in the fast developing coastal *** optimized landscape pattern for land-use planning could reduce the risk at the regional *** cell-based allocation of different land use into the geospace(***-use spatial zoning,LUSZ)to form optimal pattern with planning objectives and constrains could be viewed as a spatial optimization *** study aims to develop a framework incorporated with ant colony algorithm optimization(ACO)to solve LUSZ problem based on the planning guideline of *** planning scenarios(*** focusing on urban growth,development considering ecological conversion,and coordinative development between growth and protection)were devised and analyzed with the study area of Doumen *** analysis with landscape metrics and suitability evaluation indicates that scenario of coordinative development is more available and plausible for land-use change *** study provides a quantitative and feasible procedure to achieve optimal development pattern on given planning ***,it also demonstrates that cell-based spatial optimization model can generate optimal planning scenarios for decision-making.

关键词： land-use planning urban growth spatial optimization coastal area

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Neuroprotective mechanisms ofε-viniferin in a rotenone-induced cell model of Parkinson's disease:significance of SIRT3-mediated FOXO3 deacetylation

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Neural Regeneration Research 2020年第11期15卷 2143-2153页

作者： shuo Zhang Yan ma Juan Feng Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Ultrasound Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Trans-(-)-ε-viniferin(ε-viniferin)has antioxidative and anti-inflammatory *** also has neuroprotective effects in Huntington's disease by activating the SIRT3/LKB1/AMPK signaling pathway;however,it remains unknown whetherε-viniferin also has a neuroprotective role in Parkinson's disease.A Parkinson's disease cell model was induced by exposing SH-SY5 Y cells to 3.0μM rotenone for 24 hours,and cells were then treated with 1.0μMε-viniferin for 24 *** withε-viniferin upregulated SIRT3 expression,which promoted FOXO3 deacetylation and nuclear localization.ε-Viniferin also increased ATP production and decreased reactive oxygen species ***,ε-viniferin treatment alleviated rotenone-induced mitochondrial depolarization and reduced cell apoptosis,and restored the expression of mitochondrial homeostasis-related ***,when cells were transfected with SIRT3 or FOXO3 shRNA prior to rotenone andε-viniferin treatment,these changes were *** results from the present study indicate thatε-viniferin enhances SIRT3-mediated FOXO3 deacetylation,reduces oxidative stress,and maintains mitochondrial homeostasis,thus inhibiting rotenone-induced cell apoptosis.ε-Viniferin may therefore be a promising treatment strategy for Parkinson's disease.

关键词： deacetylation FOXO3 mitochondrial homeostasis mitophagy oxidative stress Parkinson's disease SIRT3 ε-viniferin

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Status of Research on Application of High Purity Rare Earth Oxides in Solid Oxide Fuel Cells

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Journal of Rare Earths 2004年第z1期22卷 287-294页

作者： ma Zhihong qiu Jufeng Baotou Hengyitong Rare Earth Co. Ltd Baotou 014060 China Baotou Research Institute of Rare EarthsBaotou 014010 China

The solid oxide fuel cell (SOFC) is a high-efficient and environmentally friendly power generation *** rare earth oxide materials are used extensively in the manufacturing of SOFC *** particular, the CeO2doped with Gd2O3 or Sm2O3, lanthanide perovskite oxides are indispensable and key materials for developing the intermediate temperature *** research and development status of application of high purity rare earth oxides in SOFC was *** rare earth oxide-based and -doped materials were discussed for the SOFC *** the rare earth oxides applicable to SOFC, several topics were also pointed out for further researching and developing.

关键词： inorganic materials chemistry oxide ceramics solid oxide fuel cell component materials rare earths

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Ultrathin and Flexible CNTs/MXene/Cellulose Nanofibrils Composite Paper for Electromagnetic Interference Shielding

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Nano-Micro Letters 2019年第4期11卷 276-292页

作者： Wentao Cao Chang ma shuo Tan Mingguo ma Pengbo Wan Feng Chen Department of Orthopedics Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072People’s Republic of China Engineering Research Center of Forestry Biomass materials and Bioenergy Beijing Key Laboratory of Lignocellulosic ChemistryCollege of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China Center of Advanced Elastomer materials State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

As the rapid development of portable and wearable devices,different electromagnetic interference(EMI)shielding materials with high efficiency have been desired to eliminate the resulting radiation ***,limited EMI shielding materials are successfully used in practical applications,due to the heavy thickness and absence of sufficient strength or ***,an ultrathin and flexible carbon nanotubes/MXene/cellulose nanofibrils composite paper with gradient and sandwich structure is constructed for EMI shielding application via a facile alternating vacuum-assisted filtration *** composite paper exhibits outstanding mechanical properties with a tensile strength of 97.9±5.0 MPa and a fracture strain of 4.6±0.2%.Particularly,the paper shows a high electrical conductivity of 2506.6 S m?1 and EMI shielding effectiveness(EMI SE)of 38.4 dB due to the sandwich structure in improving EMI SE,and the gradient structure on regulating the contributions from reflection and *** strategy is of great significance in fabricating ultrathin and flexible composite paper for highly efficient EMI shielding performance and in broadening the practical applications of MXene-based composite materials.

关键词： MXene Carbon nanotubes Cellulose nanofibrils Mechanical property Electromagnetic interference shielding

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