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Combined use of fly ash and silica to prevent the long-term strength retrogression of oil well cement set and cured at HPHT conditions

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Petroleum Science 2024年第2期21卷 1122-1134页

作者： guo-Dong Cheng Xue-Yu Pang Jin-sheng Sun Zheng-Song qiu Chuang-Chuang Wang Jian-Kun Qin Ning Li School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Oil and Gas Engineering Research Institute(Tarim Oilfield Company) China National Petroleum CorporationTarim841000XinjiangChina

The long-term strength retrogression of silica-enriched oil well cement poses a significant threat to wellbore integrity in deep and ultra-deep wells, which is a major obstacle for deep petroleum and geothermal energy development. Previous attempts to address this problem has been unsatisfactory because they can only reduce the strength decline rate. This study presents a new solution to this problem by incorporating fly ash to the traditional silica-cement systems. The influences of fly ash and silica on the strength retrogression behavior of oil well cement systems directly set and cured under the condition of 200°C and 50 MPa are investigated. Test results indicate that the slurries containing only silica or fly ash experience severe strength retrogression from 2 to 30 d curing, while the slurries containing both fly ash and silica experience strength enhancement from 2 to 90 d. The strength test results are corroborated by further evidences from permeability tests as well as microstructure analysis of set cement. Composition of set cement evaluated by quantitative X-ray diffraction analyses with partial or no known crystal structure(PONKCS) method and thermogravimetry analyses revealed that the conversion of amorphous C-(A)-S-H to crystalline phases is the primary cause of long-term strength *** addition of fly ash can reduce the initial amount of C-(A)-S-H in the set cement, and its combined use with silica can prevent the crystallization of C-(A)-S-H, which is believed to be the working mechanism of this new admixture in improving long-term strength stability of oil well cement systems.

关键词： Fly ash Long-term strength retrogression High temperature Quantitative X-ray diffraction(QXRD) Partial or no known crystal structure(PONKCS)

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Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Research 2024年第1期2023卷 315-337页

作者： Chong qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei gu Chengchao Xu qiuyan guo Jigang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic ***,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most *** review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport *** strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/*** the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

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Method for rapid warning and activity concentration estimates in online waterγ-spectrometry systems

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Nuclear Science and Techniques 2024年第3期35卷 1-12页

作者： Meng Wang Yi gu Mao-Lin Xiong Liang-Quan Ge Qing-Xian Zhang guo-Qiang Zeng Heng Lu sheng-Liang guo College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province (Chengdu University of Technology)Chengdu 610059China Chengdu New Ray Technology Co.Ltd Chengdu 610052China

Onlineγ-spectrometry systems for inland waters,most of which extract samples in situ and in real time,are able to produce reliable activity concentration measurements for waterborne radionuclides only when they are distributed relatively uniformly and enter into a steady-state diffusion regime in the measurement *** protect residents’health and ensure the safety of the living environment,better timeliness is required for this measurement *** address this issue,this study established a mathematical model of the online waterγ-spectrometry system so that rapid warning and activity estimates can be obtained for water under non-steady-state(NSS)*** addition,the detection efficiency of the detector for radionuclides during the NSS diffusion process was determined by applying the computational fluid dynamics technique in conjunction with Monte Carlo *** this basis,a method was developed that allowed the online waterγ-spectrometry system to provide rapid warning and activity concentration estimates for radionuclides in *** analysis of the NSS-mode measurements of^(40)K radioactive solutions with different activity concentrations determined the optimum warning threshold and measurement time for producing accurate activity concentration estimates for *** experimental results show that the proposed NSS measurement method is able to give warning and yield accurate activity concentration estimates for radionuclides 55.42 and 69.42 min after the entry of a 10 Bq/L^(40)K radioactive solution into the measurement chamber,*** times are much shorter than the 90 min required by the conventional measurement ***,the NSS measurement method allows the measurement system to give rapid(within approximately 15 min)warning when the activity concentrations of some radionuclides reach their respective limits stipulated in the guidelines for Drinking-water Quality of the WHO,suggesting that this method con

关键词： Water radioactivity monitoring Dynamic detection efficiency Rapid warning Activity estimation

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The 2023 M_(w)6.8 Adassil Earthquake(Chichaoua,Morocco)on a steep reverse fault in the deep crust and its geodynamic implications

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Earth and Planetary Physics 2024年第3期8卷 522-534页

作者： Billel Touati WangWang gu SiDao Ni Risheng Chu MinHan sheng QingJie Xue Fouzi Bellalem Said Maouche Habibi Yahyaoui School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Centre de Recherche en Astronomie Astrophysique et Géophysique(CRAAG)BP 63BouzaréahAlgiers 16340Algeria Geography and Territory Planning Natural Hazards and Territory Planning LaboratoryBatna 2 UniversityFesdisBatna 05000Algeria

The Mw 6.8 Adassil earthquake that occurred in the High Atlas on September 8,2023,was a catastrophic event that provided a rare opportunity to study the mechanics of deep crustal *** research aimed to decipher the rupture characteristics of the Adassil earthquake by analyzing teleseismic waveform data in conjunction with interferometric synthetic aperture radar(InSAR)observations from both ascending and descending *** analysis revealed a reverse fault mechanism with a centroid depth of approximately 28 km,exceeding the typical range for crustal *** result suggests the presence of cooler temperatures in the lower crust,which facilitates the accumulation of tectonic *** earthquake exhibited a steep reverse mechanism,dipping at 70°,accompanied by minor strike-slip *** the geotectonic framework of the High Atlas,known for its volcanic legacy and resulting thermal irregularities,we investigated the potential contributions of these factors to the initiation of the Adassil *** seismicity within the lower crust,away from plate boundaries,calls for extensive research to elucidate its implications for regional seismic hazard *** findings highlight the critical importance of studying and preparing for significant seismic events in similar geological settings,which would provide valuable insights into regional seismic hazard assessments and geodynamic paradigms.

关键词： Adassil earthquake seismogenic fault source depth interferometric synthetic aperture radar(InSAR) seismic waveform joint inversion

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An endophytic fungus interacts with the defensinlike protein OsCAL1 to regulate cadmium allocation in rice

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Molecular Plant 2024年第2期17卷 312-324页

作者： Tianyu gu Ziai Qi Yating Wang Siying Chen Jing Yan Huapeng qiu Yanxuan Yu Zjun Fang Junmin Wang Jiming Gong National Key Laboratory of Plant Molecular Genetics Shanghai Center for Plant Stress BiologyCAS Center for Excellence in Molecular Plant SciencesChinese AcademyofSciencesShanghai200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China University of the Chinese Academy of Sciences Beijing 100049China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization College of Life ScienceHunan University of Science and TechnologyXiangtan411201China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Institute of Crops and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesHangzhou 310021China

Defensin-like proteins are conserved in multicellular organisms and contribute to innate immune re-sponses against fungal *** rice,defensins play a novel role in regulating cadmium(Cd)efflux from the ***,whether the antifungal activity of defensins correlates with Cd-efflux function remains *** this study,we isolated an endophytic Fusarium,designed Fo1o,by a comparative mi-crobiome analysis of rice plants grown in a paddy contaminated with ***10 is tolerant to high levels of Cd,but is sensitive to the defensin-like protein OsCAL1,which mediates Cd efflux to the *** found that Fo10 symbiosis in rice is regulated by OsCAL1 dynamics,and Fo10 coordinates multiple plant pro-cesses,including Cd uptake,vacuolar sequestration,efflux to the environment,and formation of Fe pla-ques in the *** processes are dependent on the salicylic acid signaling pathway to keep Cd levels low in the cytosol of rice cells and to decrease Cd levels in rice grains without any yield ***10 also plays a role in Cd tolerance in the poaceous crop maize and wheat,but has no observed effects in the eudicot plants Arabidopsis and *** together,these findings provide insights into the mech-anistic basis underlying how afungal endophyte and host plant interact to control Cd accumulation in host plants by adapting defense responses to promotethe establishment ofa symbiosis that permits adaptation to high-Cd environments.

关键词： defensin-like protein Fusarium oxysporum endophyte cadmium allocation

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Self-healable gels in electrochemical energy storage devices

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Nano Research 2024年第4期17卷 3302-3323页

作者： Yang Li PeiPei Ding Yuzhe gu sheng Qian Yuncong Pang Lele Wang Jiayang Feng Baoguang Liu Qi Wan Ping Li Zhiwei Liu College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Materials Science&Engineering Beijing University of TechnologyBeijing 100124China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Pillar of Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

In the green energy and carbon-neutral technology,electrochemical energy storage devices have received continuously increasing attention ***,due to the unavoidable volume expansion/shrinkage of key materials or irreversible mechanical damages during application,the stability of energy storage and delivery as well as the lifetime of these devices are severely shortened,leading to serious performance degradation or even safety ***,the utilization of self-healable gels into electrochemical energy storage devices,such as electrodes,binders,and electrolytes,is proven as an effective method to realize long-term stable operation of these devices via the self-repairing of mechanical and electrochemical ***,this review first summarizes the feature and fabrication of different gels,paying special attention to hydrogels,organohydrogels,and ***,basic concepts and figure of merit of self-healable gels are analyzed with a detailed discussion at the healing mechanisms,from reversible dynamic bonds to physical molecular diffusion,and to external healing *** we introduce all the important parts of electrochemical energy storage devices,which could be replaced by healable gels to enhance the durability,including electrodes,binders,and ***,the critical challenges and future perspectives regarding the future development of healable gels based high-performance electrochemical energy storage devices or electronics are provided.

关键词： self-healable gels healing mechanisms electrodes binders gel electrolytes

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ThyroidNet:A Deep Learning Network for Localization and Classification of Thyroid Nodules

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 361-382页

作者： Lu Chen Huaqiang Chen Zhikai Pan sheng Xu guangsheng Lai Shuwen Chen Shuihua Wang Xiaodong gu Yudong Zhang Ultrasonic Department Zhongda Hospital Affiliated to Southeast UniversityNanjing210009China School of Physics and Information Engineering Jiangsu Second Normal UniversityNanjing211200China School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia State Key Laboratory of MillimeterWaves Southeast UniversityNanjing210096China Jiangsu Province Engineering Research Center of Basic Education Big Data Application Jiangsu Second Normal UniversityNanjing211200China School of Software Engineering Quanzhou Normal UniversityQuanzhou362000China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215123China

Aim:This study aims to establish an artificial intelligence model,ThyroidNet,to diagnose thyroid nodules using deep learning techniques ***:A novel method,ThyroidNet,is introduced and evaluated based on deep learning for the localization and classification of thyroid ***,we propose the multitask TransUnet,which combines the TransUnet encoder and decoder with multitask ***,we propose the DualLoss function,tailored to the thyroid nodule localization and classification *** balances the learning of the localization and classification tasks to help improve the model’s generalization ***,we introduce strategies for augmenting the ***,we submit a novel deep learning model,ThyroidNet,to accurately detect thyroid ***:ThyroidNet was evaluated on private datasets and was comparable to other existing methods,including U-Net and *** results show that ThyroidNet outperformed these methods in localizing and classifying thyroid *** achieved improved accuracy of 3.9%and 1.5%,***:ThyroidNet significantly improves the clinical diagnosis of thyroid nodules and supports medical image analysis *** research directions include optimization of the model structure,expansion of the dataset size,reduction of computational complexity and memory requirements,and exploration of additional applications of ThyroidNet in medical image analysis.

关键词： ThyroidNet deep learning TransUnet multitask learning medical image analysis

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Enhanced recovery after surgery in elderly patients with non-small cell lung cancer who underwent video-assisted thoracic surgery

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World Journal of Clinical Cases 2024年第12期12卷 2040-2049页

作者： Mei-Hua Sun Liu-sheng Wu Ying-Yang qiu Jun Yan Xiao-Qiang Li Department of Thoracic Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China Yong Loo Lin School of Medicine National University of SingaporeSingapore 119077Singapore

BACKGROUND This study was designed to investigate the clinical outcomes of enhanced recovery after surgery(ERAS)in the perioperative period in elderly patients with nonsmall cell lung cancer(NSCLC).AIM To investigate the potential enhancement of video-assisted thoracic surgery(VATS)in postoperative recovery in elderly patients with *** We retrospectively analysed the clinical data of 85 elderly NSCLC patients who underwent ERAS(the ERAS group)and 327 elderly NSCLC patients who received routine care(the control group)after VATS at the Department of Thoracic Surgery of Peking University Shenzhen Hospital between May 2015 and April *** propensity score matching of baseline data,we analysed the postoperative stay,total hospital expenses,postoperative 48-h pain score,and postoperative complication rate for the 2 groups of patients who underwent lobectomy or sublobar *** After propensity score matching,ERAS significantly reduced the postoperative hospital stay(6.96±4.16 vs 8.48±4.18 d,P=0.001)and total hospital expenses(48875.27±18437.5 vs 55497.64±21168.63 CNY,P=0.014)and improved the satisfaction score(79.8±7.55 vs 77.35±7.72,P=0.029)relative to those for routine *** significant between-group difference was observed in postoperative 48-h pain score(4.68±1.69 vs 5.28±2.1,P=0.090)or postoperative complication rate(21.2%vs 27.1%,P=0.371).Subgroup analysis showed that ERAS significantly reduced the postoperative hospital stay and total hospital expenses and increased the satisfaction score of patients who underwent lobectomy but not of patients who underwent sublobar *** ERAS effectively reduced the postoperative hospital stay and total hospital expenses and improved the satisfaction score in the perioperative period for elderly NSCLC patients who underwent lobectomy but not for patients who underwent sublobar resection.

关键词： Enhanced recovery after surgery Non-small cell lung cancer Perioperative care Propensity score Video-assisted thoracic surgery

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Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu Wei qiu-Man Xu Wei Shang Qing Li Jing-sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

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Microeukaryotic plankton community dynamics under ecological water replenishment:Insights from eDNA metabarcoding

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Environmental Science and Ecotechnology 2024年第4期20卷 278-290页

作者： Shuping Wang Songsong gu Yaqun Zhang Ye Deng Wenhui qiu Qianhang Sun Tianxu Zhang Pengyuan Wang Zhenguang Yan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China CAS Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Key Laboratory of Aquatic Genomics Ministry of Agriculture and Rural AffairsBeijing Key Laboratory of Fishery BiotechnologyChinese Academy of Fishery SciencesBeijing100141China College of Resources and Environment University of Chinese Academy of SciencesBeijing100190China guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen518055China

Ecological water replenishment(EWR)is an important strategy for river restoration globally,but timely evaluation of its ecological effects at a large spatiotemporal scale to further adjust the EWR schemes is of great ***,we examine the impact of EWR on microeukaryotic plankton communities in three distinct river ecosystems through environmental DNA(eDNA)*** three ecosystems include a long-term cut-off river,a short-term connected river after EWR,and long-term connected *** analyzed community stability by investigating species composition,stochastic and deterministic dynamics interplay,and ecological network *** found that EWR markedly reduced the diversity and complexity of microeukaryotic plankton,altered their community dynamics,and lessened the variation within the ***,EWR disrupted the deterministic patterns of community organization,favoring dispersal constraints,and aligning with trends observed in naturally connected *** shift from an isolated to a temporarily connected river appeared to transition community structuring mechanisms from deterministic to stochastic dominance,whereas,in permanently connected rivers,both forces concurrently influenced community *** ecological network in temporarily connected rivers post-EWR demonstrated significantly greater stability and intricacy compared to other river *** shift markedly bolstered the resilience of the ecological *** eDNA metabarcoding insights offer a novel understanding of ecosystem resilience under EWR interventions,which could be critical in assessing the effects of river restoration projects throughout their life cycle.

关键词： Ecological water replenishment Community stability Succession Community assembly mechanism Ecological network

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