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New Staging Model for Radiation-based Hepatocellular Carcinoma Treatment:A National Multicenter Study

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 341-349页

作者： Ting-Shi Su Shi-Xiong Liang Li-Qing Li qiu-hua liu Xue-Zhang Duan Jing Sun Hai Zeng Hai-Sheng Zhu Jian-Xu Li Xiao-Fei Zhu Hong-Qing Zhuang Ping Liang Yong huang Department of Radiation Oncology Guangxi Medical University Cancer HospitalNanningGuangxiChina Department of Radiation Oncology Ruikang HospitalNanningGuangxiChina Radiation Oncology Department The Fifth Medical Center of PLA General HospitalBeijingChina Department of Oncology First Affiliated Hospital of Yangtze UniversityJingzhouHubeiChina Department of Oncology Sixth Affiliated Hospital of Guangxi Medical UniversityFirst People’s Hospital of YulinYulinGuangxiChina Department of Radiation Oncology Changhai Hospital Affiliated to Navy Medical UniversityShanghaiChina Department of Radiation Oncology Peking University Third HospitalBeijingChina Department of Radiation Oncology Nanning First People’s HospitalNanningGuangxiChina

Background and Aims:The study aimed to create a new staging model for radiotherapy-based treatment for prognostic hepatocellular carcinoma(HCC)***:The training cohort comprised 658 patients receiving stereotactic body radiotherapy and external validation cohort comprised 533 patients receiving three-dimensional conformal radiotherapy and intensity-modulated *** established a modified staging system as follows:stage I,solitary nodule without macrovascular invasion,or 2–3 nodules no more than 3.0 cm apart,and performance status(PS)0–2(Ia:ALBI-1 grade;Ib:ALBI-2 or 3 grade);stage II:2–3 nodules with any one nodule more than 3.0-cm apart,or≥4 nodules,and performance status 0–2(IIa:ALBI-1 grade;IIb:ALBI-2 grade);stage III:macrovascular invasion,regional lymph node metastasis or distant metastasis,and performance status 0–2(IIIa:ALBI-1 grade;IIIb:ALBI-2 grade);stage IV:performance status 3–4,or performance status 0–2 with ALBI-3 *** analyzed longterm overall survival based on different ***:The staging model showed an excellent ability to discriminate patients according to four stages and seven substages with notably different curves in the training and validation *** median survival decreased from stages I to IV with 63.0 months in stage I(not reached in Ia,and 53.0 months in Ib),24.0 months in stage II(28.0 months in IIa,and 22.0 months in IIb),11.0 months in stage III(18.0 months in IIIa,and 9.0 months in IIIb),and less than 9.0 months in stage IV in the training ***:The modified staging model may provide an alternative for clinical radiation oncologists.

关键词： Hepatocellular carcinoma Radiotherapy Stereotactic body radiotherapy Staging system Overall survival

A NEW SERVICE ARCHITECTURE OF FAST LABEL SWITCHING

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Journal of Electronics(China) 2002年第4期19卷 415-419页

作者： You hua qiu Zhiliang liu Zengji (National Key Lab on ISN, Xidian Unviersity, Xi’an 710071) National Key Lab on ISN Xidian University Xi’an

Implementing QoS, one of the eternal research subjects, on Internet has been attracting a lot of attentions although several schemes are already available. This letter proposes a new service architecture-Scalable Tri-tier Service Architecture (STSA) and a fast label switching scheme, which can reduce the overhead of signaling and suit the applications of access demand for a great number of end users with QoS guarantee. Also presented in the letter is an implementation of STSA in MPLS scenario.

关键词： Label switching QoS Service architecture

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi qiu Mingzhu Yang Xiuxiu Jin Jingyang liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang Bo liu Yuanpeng hua qiuyan Li Binhua Tang Jianshu Zhou Yue Xiang Economic and Technology Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China College of Electrical Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable *** methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable *** results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly ***,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.

关键词： Aggregated charging dispatchable capability peak shaving and valley filling the economics of charging demand response

Nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials

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Nano-Micro Letters 2025年第3期17卷 138-151页

作者： Jingang Wang Haibo Yu Jianchen Zheng Yuzhao Zhang Hongji Guo Ye qiu Xiaoduo Wang Yongliang Yang Lianqing liu State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Dynamic structuralcolors can change in response todifferent environmental *** ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and ***, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive Nanogrid Heterogeneous materials

女性盆底功能障碍疾病的诊断及康复治疗效果研究

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按摩与康复医学 2014年第1期5卷 21-22页

作者：邱柳华中山市板芙医院广东中山528459

目的：探讨女性盆底功能障碍疾病的诊断及康复治疗效果。方法：采用仿生物电刺激疗法对585例不同盆底功能障碍性疾病患者进行治疗，并回顾性分析其临床资料。结果：尿失禁总有效率为81.2%，盆腔脏器脱垂总有效率为75.2%，便秘总有效率为... 详细信息

目的：探讨女性盆底功能障碍疾病的诊断及康复治疗效果。方法：采用仿生物电刺激疗法对585例不同盆底功能障碍性疾病患者进行治疗，并回顾性分析其临床资料。结果：尿失禁总有效率为81.2%，盆腔脏器脱垂总有效率为75.2%，便秘总有效率为66.7%，盆底肌力松弛总有效率为88.6%，性功能障碍总有效率为89.5%，慢性盆腔疼痛总有效率为83.5%。结论：仿生物电刺激疗法对女性盆底功能障碍有较好疗效，值得临床推广应用。

关键词：盆底功能障碍仿生物电刺激疗法诊断康复疗效

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai liu Zhe Wang MengXi Shi Willie Soon ShiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

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肾移植术后并发结核感染的观察与护理35例

实用护理杂志 2003年第16期19卷 3-4页

作者：房秋燕刘华郑青南京军区福州总医院结核科

结核是肾移植术后常见的感染性并发症之一,肾移植患者结核的发病率高于普通人群,可高达4.1%～11.8%[1～3],肾移植术后大量免疫抑制剂的使用,极大地降低了以T淋巴细胞为主的细胞免疫系统功能,为结核菌感染和潜伏性结核杆菌(休眠结核菌)... 详细信息

结核是肾移植术后常见的感染性并发症之一,肾移植患者结核的发病率高于普通人群,可高达4.1%～11.8%[1～3],肾移植术后大量免疫抑制剂的使用,极大地降低了以T淋巴细胞为主的细胞免疫系统功能,为结核菌感染和潜伏性结核杆菌(休眠结核菌)的复燃提供了条件和机会[4].

关键词：肾移植结核感染护理