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Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4072-4078页

作者： Zhi-Rong Zhang Ai-Xia Dou Yan Liu hong-Bo Zhu Hai-Peng Jia qiu-hong kong Li-Kun Sun Ai-Qiong Qin Department of Haematology The Second Affiliated Hospital of Shandong First Medical UniversityTa’an 271000Shandong ProvinceChina Department of Haematology The Second Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Cadres Medical Care/Gerontology Geriatric The Second Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina

BACKGROUND Angioimmunoblastic T-cell lymphoma(AITL), a unique subtype of peripheral Tcell lymphoma, has relatively poor outcomes. High-dose chemotherapy with autologous stem cell transplantation(ASCT) can achieve complete remission and improve outcomes. Unfortunately, subsequent T-cell lymphoma-triggered hemophagocytic lymphohistiocytosis(HLH) has a worse prognosis than B-cell lymphoma-triggered *** SUMMARY We here report a 50-year-old woman with AITL who achieved a favorable outcome after developing HLH 2 mo after receiving high-dose chemotherapy/ASCT. The patient was initially admitted to our hospital because of multiple enlarged lymph nodes. The final pathologic diagnosis, made on biopsy of a left axillary lymph node was AITL(Stage Ⅳ, Group A). Four cycles of the following chemotherapy regimen were administered: Cyclophosphamide 1.3 g, doxorubicin 86 mg, and vincristine 2 mg on day 1;prednisone 100 mg on days 1-5;and lenalidomide 25 mg on days 1-14. The interval between each cycle was 21 d. The patient received a conditioning regimen(busulfan, cyclophosphamide, and etoposide) followed by peripheral blood stem cell infusion. Unfortunately, she developed sustained fever and a low platelet count 17 d after ACST, leading to a diagnosis of HLH after ASCT. During treatment, she experienced thrombocytopenia and Pneumocystis carinii pneumonia. The patient was successfully treated with etoposide and *** It is possible that development of HLH is related to immune reconstitution after ASCT.

关键词： Angioimmunoblastic T-cell lymphoma Autologous stem cell transplantation Hemophagocytic lymphohistiocytosis Complication Outcome Immune reconstitution Case report

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Numerical manifold method for steady-state nonlinear heat conduction using Kirchhoff transformation

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Science China(Technological Sciences) 2024年第4期67卷 992-1006页

作者： ZHANG LiMei kong Heng ZHENG hong Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Municipal Construction Co. Ltd.Beijing 100048China

The numerical manifold method(NMM)introduces the mathematical and physical cover to solve both continuum and discontinuum problems in a unified *** this study,the NMM for solving steady-state nonlinear heat conduction problems is presented,and heat conduction problems consider both convection and radiation boundary ***,the nonlinear governing equation of thermal conductivity,which is dependent on temperature,is transformed into the Laplace equation by introducing the Kirchhoff *** transformation reserves linearity of both the Dirichlet and the Neumann boundary conditions,but the Robin and radiation boundary conditions remain ***,the NMM is employed to solve the Laplace equation using a simple iteration procedure because the nonlinearity focuses on parts of the problem domain ***,the temperature field is retrieved through the inverse Kirchhoff *** examples are analyzed,demonstrating the advantages of the Kirchhoff transformation over the direct solution of nonlinear equations using the NewtonRaphson *** study provides a new method for calculating nonlinear heat conduction.

关键词： numerical manifold method nonlinear heat conduction temperature-dependent thermal conductivity Kirchhoff transformation convection and radiation boundary conditions

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Progress of additives for morphology control in organic photovoltaics

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Chinese Chemical Letters 2024年第6期35卷 38-46页

作者： Zhongjie Li Xiangyue kong Yuhao Liu Huayu qiu Lingling Zhan Shouchun Yin Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China

The microstructure of the active layer in organic photovoltaics(OPVs),such as the size of phase separation,purity of the phases,and molecular packing within each phase,plays a crucial role in influencing the behavior of excitons and charge carriers within the active *** is also a key determinant of the photovoltaic performance of the *** the optimization of OPV devices,the use of additives has been demonstrated to be an effective strategy in microstructure control,leading to enhanced ***,the quest for stable and efficient novel additives,along with an exploration and summarization of the mechanisms underlying additive-induced microstructure control,is essential for a better understanding of the developmental trends of high-performance *** this review,we categorize additives based on their chemical structures and discuss their effects on the microstructure of the active layer from both thermodynamic and kinetic ***,we elaborate on the working mechanisms and their impact on the photovoltaic performance of the *** review provides an overview of recent advances in additives for OPVs,offering potential guidance for the future development of additives and further optimization of the active layer in photovoltaic devices.

关键词： Organic photovoltaics Additives Active layer morphology Mechanisms Photovoltaic performances

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Dietary Supplementation ofβ-Carotene Reveals miRNAs Involved in the Regulation of Carotenoid Metabolism in Crassostrea gigas

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Journal of Ocean University of China 2024年第4期23卷 1045-1053页

作者： SUN Dongfang WAN Sai YU hong kong Lingfeng LI Qi Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China

Carotenoids play crucial physiological roles in animals.A comprehensive investigation into the mechanism of carotenoid metabolism in oysters will establish a theoretical foundation for further development of its carotenoid-rich ***,the information on the function of miRNA inβ-carotene metabolism in oysters is *** elucidate the mechanisms underlying miRNA regulation of carotenoid metabolism in oysters,we compared the expressions of miRNA in digestive gland tissues of Pacific oyster(Crassostrea gigas)fed with aβ-carotene supplemented diet and a normal diet,respectively.A total of 690 candidate miRNAs in the Pacific oyster digestive gland tissues were identified,including 590 known miRNAs and 111 unknown *** differentially expressed miRNAs were obtained in the carotenoid-fed and normal groups,associated to 137 differentially expressed target ***,the GO enrichment analysis revealed that the differentially expressed target genes were mainly involved in transmembrane transport *** enrichment showed that the differentially expressed target genes were involved in ABC *** of the mRNA-miRNA network revealed that novel0025 played a central role in carotenoid metabolism,and it was negatively correlated with the expression of 46 *** addition,down-regulated expression of novel0025 upregulated the expression of the lipoprotein gene LOC105342186,suggesting a potential regulatory role in carotenoid *** results provide useful information for elucidating the miRNA regulation mechanism during carotenoids metabolism in the Pacific oyster.

关键词： Crassostrea gigas β-carotene microRNA carotenoid metabolism

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An electromagnetic semi-active dynamic vibration absorber for thin-walled workpiece vibration suppression in mirror milling

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1315-1334页

作者： Jianghua kong Bei DING Wei WANG Zhixia WANG Juliang XIAO hongyun qiu School of Mechanical Engineering Tianjin University Tianjin Key Laboratory of Nonlinear Dynamics and Control Key Laboratory of Modern Mechanisms and Equipment Design of the State Ministry of Education Tianjin University

As critical components of aircraft skins and rocket fuel storage tank shells,large thin-walled workpieces are susceptible to vibration and deformation during machining due to their weak local stiffness. To address these challenges, we propose a novel tunable electromagnetic semi-active dynamic vibration absorber(ESADVA), which integrates with a magnetic suction follower to form a followed ESADVA(follow-ESADVA)for mirror milling. This system combines a tunable magnet oscillator with a follower,enabling real-time vibration absorption and condition feedback throughout the milling process. Additionally, the device supports self-sensing and frequency adjustment by providing feedback to a linear actuator, which alters the distance between magnets. This resolves the traditional issue of being unable to directly monitor vibration at the machining point due to space constraints and tool interference. The frequency shift characteristics and vibration absorption performance are comprehensively investigated. Theoretical and experimental results demonstrate that the prototyped follow-ESADVA achieves frequency synchronization with the milling tool, resulting in a vibration suppression rate of approximately 47.57%. Moreover, the roughness of the machined surface decreases by18.95%, significantly enhancing the surface quality. The results of this work pave the way for higher-quality machined surfaces and a more stable mirror milling process.

关键词： 70J35 mirror milling O326 self-sensing semi-active dynamic vibration absorber (SADVA) thin-walled workpiece vibration absorption tuning

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NbB_(2)Modified Al-Cu Alloys Fabricated by Freeze-Ablation Casting under High Cooling Rate Solidification

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 921-938页

作者： Xiang kong Yu Wang hong Xu Haotian Fan Yuewu Zheng Beibei Xie School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

At present,improving the properties of aluminum alloys is generally achieved by increasing the cooling rate of the melt and adding micro-nano *** the cooling rate of the melt to improve the refining effect of grain refiner is still a difficult problem in the aluminum alloy casting *** innovative and environmentally friendly casting process,known as freeze ablation,was introduced during the preparation of an Al–NbB_(2) intermediate *** process significantly enhanced the cooling rate of the *** results indicated that the Al–NbB_(2) intermediate alloy produced under high cooling rates had a noticeable refining effect on Al–Cu alloys,with smaller NbB2 particles demonstrating superior refining *** average grain size of the refined Al–Cu alloy decreased from 154 to 69μm,the tensile strength increased by 12%,the fluidity increased by 18.4%,and the hot tearing index decreased from 144 to *** matching degree between NbB_(2) andα-Al was calculated using high-resolution transmission electron microscopy and the edge-to-edge *** was found that the atomic interplanar spacing and the interatomic spacing mismatch between NbB_(2)’splane and Al were both less than 10%,which further proved that NbB2 could serve as an effective nucleation site forα-Al grains to achieve grain refinement.

关键词： Grain refinement Freeze ablation Particle size control Mechanical properties Process properties

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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： Chen qiu Yu-Kai Xiang Xuan-Bo Da hong-Lei Zhang Xiang-Yu kong Nian-Zong Hou Cheng Zhang Fu-Zhou Tian Yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface ***,these enzymes play a significant role in the development of diverse *** To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression *** study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and *** Set Enrichment Analysis was utilized to pinpoint associated ***,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was *** PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy *** expression of PLA2G2A was correlated with poorer overall survival in CCA ***,the study delineated pathways and miRNAs associated with these *** Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for *** increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

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Prominent removal of trace lead(Ⅱ)ions from polluted water by terephthalic acid reformed Al/Zn metal organic nanoflakes

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Particuology 2024年第1期84卷 81-88页

作者： Junhua Li Lingshu Gao Junmao hong Xiaofeng Shi Sifang kong Jingyu Wang Hassan Algadi Benbin Xu Zhanhu Guo School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China School of Traffic&Environment Shenzhen Institute of Information TechnologyShenzhen518172China Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran11001Saudi Arabia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon TyneNE18STUK

Terephthalic acid reformed Al/Zn metal organic nanoflake was prepared and functionalized with trie-thylamine(T-AlZn).Without adding terephthalic acid,there was no product of metal organic nanoflake.T-AlZn has a remarkable performance in removing trace lead(Ⅱ)ions(Pb^(2+)).The adsorption equipoise with the removal rate≥97%was reached within 35 *** removal rates of T-AlZn for Pb^(2+)declined by only 16.73%after four *** adsorption of T-AlZn for Pb^(2+)follows the Langmuir isotherms model and pseudo-second-order dynamics *** utmost adsorption competence was calculated as 215.27 mg g^(-1).The T-AlZn adsorbent exhibits a bright prospect in the adsorption for Pb^(2+)and is a considerable candidate in the disposal of industrial sewage.

关键词： Metal organic complex Nanoflake Trace level Pb^(2+) Adsorption

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New strategy for boosting cathodic performance of low temperature solid oxide fuel cells via chlorine doping

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Nano Research 2024年第9期17卷 8086-8094页

作者： ShaoHua Xu Hao qiu Shanshan Jiang Jingjing Jiang Wei Wang Xiaomin Xu Wei kong Tanaka Dennis Chivurugwi Arkadii Proskurin Daifen Chen Chao Su School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA6102Australia Admiral Makarov National University of Shipbuilding Heroiv Ukrainy av.9Mykolaiv54025Ukraine

To enhance the performance and widespread use of solid oxide fuel cells(SOFCs),addressing the low-temperature(<650℃)electrochemical performance and operational stability issues of cathode materials is ***,we propose an innovative approach to enhance oxygen ion mobility and electrochemical performance of perovskite oxide by substituting some oxygen sites with chlorine *** designed SrTa_(0.1)Fe_(0.9)O_(3-δ-x)Clx(x=0.05 and 0.10)exhibits improved performance compared to SrTa_(0.1)Fe_(0.9)O_(3-δ)(STF).SrTa_(0.1)Fe_(0.9)O_(2.95-δ)Cl_(0.05)(STFCl0.05)shows the lowest area-specific resistance(ASR)value on Sm0.2Ce0.8O1.9(SDC)*** 600℃,STFCl0.05 achieves an ASR value of 0.084Ω·cm^(2),and a single cell with STFCl0.05 reaches a higher peak power density(PPD)value(1143 mW·cm^(-2))than that with STF(672 mW·cm^(-2)).Additionally,besides exhibiting excellent oxygen reduction reaction(ORR)activity at lower temperatures,the STFCl0.05 cathode demonstrates good CO_(2)tolerance and operational *** cell operation lasts for 150 h,and single cell operation endures for 720 h without significant performance *** chlorine doping approach effectively enhances ORR activity and stability,making STFCl0.05 a promising cathode material for low-temperature SOFCs.

关键词： low-temperature solid oxide fuel cells(LT-SOFCs) oxygen reduction reaction(ORR) CO_(2)tolerance chlorine doping

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Flat jet electrochemical milling of TC4 alloy with tailoring backward parallel flow

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Chinese Journal of Aeronautics 2024年第4期37卷 574-592页

作者： Huanghai kong Ningsong QU College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In flat jet electrochemical milling, the electrolyte forms a backward parallel flow after impacting the workpiece, resulting in a weak current density distribution on the workpiece. Poor surface quality usually occurs on the machined titanium alloy surface because it inevitably suffers from the weak current density. In this study, a method of flat jet electrochemical milling with tailoring the backward parallel flow was proposed to eliminate the negative effects caused by the weak current density. Multiphysics simulations are carried out to comprehend the mechanism of flat jetEC milling with tailoring backward parallel flow and better construct the novel tool *** on flat jet electrochemical milling of TC4 alloy with and without tailoring backward parallel flow are conducted. The results reveal that, compared with flat jet electrochemical milling without tailoring backward parallel flow, the recommended tool reduces the surface roughness by86% to 93%, and improves the material removal rate by 93% to 163% with different feed ***, the recommended tool is more conducive to maintaining the inherent hardness of the material. Finally, a surface with low Sa of 0.37 μm is obtained.

关键词： Flat jet electrochemical milling TC4 alloy Surface roughness Micro-hardness Material removal rate

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