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红沿河核电基地一期工程辐射防护与安全管理十年评价(2012—2021年)

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辐射防护通讯 2024年第2期44卷 25-30页

作者：张蔚华张明睿赵延鹏邱文宏杨月郭海峰丁志博生态环境部东北核与辐射安全监督站辽宁大连116001 辽宁红沿河核电有限公司辽宁大连116001 辽宁庄河核电有限公司辽宁大连116001

介绍了红沿河核电厂辐射防护与安全管理体系,对2012—2021年该核电厂一期工程个人剂量监测结果进行了统计和分析,对大修集体剂量占比、集体剂量主要受照人群和工种进行了分析评价,分析了产生辐射防护管理领域异常事件的原因。结果表明:... 详细信息

介绍了红沿河核电厂辐射防护与安全管理体系,对2012—2021年该核电厂一期工程个人剂量监测结果进行了统计和分析,对大修集体剂量占比、集体剂量主要受照人群和工种进行了分析评价,分析了产生辐射防护管理领域异常事件的原因。结果表明:红沿河核电厂在安全稳定运行的同时,职业照射剂量控制满足国家相关标准。年集体剂量最大贡献来自承担辐射照射工作的承包商,主要影响因素为大修工作量。核电厂辐射防护管理工作应重点关注大修期间的承包商的管理。

关键词：辐射防护个人剂量集体剂量大修

Endogenous retrovirus activation: potential for immunology and clinical applications

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National Science Review 2024年第4期11卷 21-23页

作者： Jundan Yu Peishan qiu Jingwen Ai Bo Liu Guan-Zhu Han Fan Zhu wenhong Zhang Jie Cui Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response National Medical Center for Infectious Diseases Huashan Hospital Shanghai Medical College Fudan University CAS Key Laboratory of Molecular Virology &Immunology Shanghai Institute of Immunity and Infection Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Huashen Institute of Microbes and Infections College of Life Sciences Nanjing Normal University State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan University The Institute of Infection and Health Research Fudan University Key Laboratory of Medical Molecular Virology(MOE/MOH) Shanghai Medical CollegeFudan University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Endogenous retroviruses (ERVs), the remnants of ancient retrovirus infections, constitute approximately 8% of the human genome and play important roles in human evolution, development,and diseases. Multiple drugs, such as DNA methyltransferase inhibitors and lysine-specific histone demethylase 1inhibitors, reactivate ERVs, induce viral mimicry and trigger innate immune responses to enhance tumor immunogenicity.

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Injection molding of highly filled microcrystalline cellulose/polycaprolactone composites with the aid of reversible Diels-Alder reaction

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Journal of Materials Science & Technology 2024年第3期170卷 246-254页

作者： Ze Pu Wang wenhong Ruan MinZhi Rong Mingqiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of MOE GD HPPC LabIGCMESchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

To tackle the challenge of producing highly filled polymer composites using the traditional injection molding technique,which is characterized by the fairly high melt viscosity that makes mold filling difficult,the authors propose a solution based on dynamic covalent *** demonstrated by the proof-of-concept experiments,the 4-arm starshaped polycaprolactone(PCL)oligomers and microcrystalline cel-lulose(MCC)are crosslinked by the reversible Diels-Alder(DA)*** flowability of the compounds greatly decreases due to the dissociation of the intercomponent DA bonds at the retro-reaction tempera-ture,and the networked architecture is reconstructed during cooling as a result of the forward DA ***,the high-loading MCC fillers are well distributed in the matrix and covalently bonded to the nearby PCL,forming a striking contrast to the control in which linear PCL acts as the *** DA bonds crosslinked biodegradable PCL composites exhibit decent mechanical strength(20.7 MPa)even at the MCC fraction of 65 wt%,which is superior to those(5-12.2 MPa)of the highly filled PCL composites(with filler contents of 50-63.8 wt%)reported so *** proposed approach has sufficient expansibility for the fabrication of the highly filled polymer composites constructed by other types of matrix and fillers.

关键词： Polymer composites Microcrystalline cellulose Polycaprolactone Injection molding Dynamic reversible chemistry

IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes

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Cellular & Molecular Immunology 2008年第1期5卷 41-46页

作者： Huifen Zhu wenhong qiu Ping Lei Wei Zhou Xue Wen Fengrong He Li Li Hong Dai Guanxin Shen Feili Gong Department of Immunology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Medicine and Life Science College of Jianghan University Wuhan 430056 China These authors contributed equally to this work

Dendritic cells （DCs） have the potency to regulate the outcome of autoimmunity through the modulation of immune responses. The induction of antigen specific tolerance is critical for prevention and treatment of allograft rejection. In the present Study, we transfected IL-10 gene into DCs and investigated their effect on inhibition of lymphocyte activity in vitro and induction of immune tolerance on islet allograft in mice. An IDDM C57BL/6 mouse model was induced by streptozotocin. The islet cells isolated from the BALB/c mice were transplanted into the kidney capules of the model mice followed by injection of IL-10 modified DCs （mDCs）. The results showed that mDCs could significantly inhibit T lymphocyte proliferation mediated by allotype cells and induce its apoptosis, whereas, unmodified DCs （umDCs） could promote the murine lymphocyte proliferation markedly. The injection of mDCs could prolong the survival of allotype islet transplanted IDDM mice. The average plasma glucose （PG） level in mDCs treated mice returned to normal within 3 days and lasted for about 2 weeks. The rejection response in control mice occurred for 5 days after transplantation. The level of IFN-γ was lower while IL-4 was higher in mDCs treated mice than that in umDCs treated mice, which indicated that Thl/Th2 deviation occurred. Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice. Cellular ＆ Molecular Immunology.

关键词： IL-10 dendritic cell IDDM islet transplantation immune tolerance

The coxsackievirus A16 infection suppresses MAVS-induced apoptosis and type Ⅰ interferon activation

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The coxsackievirus A16 infection suppresses MAVS-induced apo...

慢病毒介导的shRNA靶向干扰I2PP2A胃癌稳定细胞株的建立

第十一届全国免疫学学术大会

作者： Shi Yingying Tu Huilin qiu wenhong Huang Lixia Gong Yeli He Xiaohua Liu Wanhong Department of Immunology School of MedicineJianghan University Pathogenic Organism and Infectious Diseases Research Institute School of Basic Medical SciencesWuhan University

Background: Coxsackievirus A16(CA16) is one of the major causative agents of hand, foot and mouth disease(HFMD), which is characterized by herpetic lesions on the hands, feet and oral mucosa in children less than 5 years old. The mitochondrial antiviral signaling protein(MAVS) plays important roles in host defense against viral infection by inducing type I interferon. However, the relationship between CA16 infection and MAVS still remain ***: The aim of this study was to investigate the relationship between CA16 infection and ***: Quantitative real time PCR(qRT-PCR) and western blot were adopted to study the effect of CA16 infection on MAVS expression. Both overexpression and silencing of MAVS expression were employed to detect the effect of MAVS on CA16 replication. In addition, the plasmids over-expressing each viral nonstructural proteins were constructed and transfected into RD cells to investigate the influence of CA16 proteins on the functions of ***: CA16 infection inhibited MAVS expression. MAVS in turn suppressed CA16 replication by both apoptosis induction depending on JNK and ERK signals and type I interferon activation. We further demonstrated that viral protein 2C, 3D downregulated MAVS-induced apoptosis. Meanwhile, 2A and 3C greatly blocked the MAVS mediated activation of IFN-β. Furthermore, MAVS can be cleaved by 3C which is a vital ***: These data provide direct and compelling evidence that CA16 has evolved new strategies by which CA16 evades the host immune system and regulates apoptosis by targeting MAVS, which suggest new targets for anti-HFMD strategies.

关键词： Coxsackievirus A16(CA16) viral protein apoptosis type I interferon

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中国癌症杂志 2015年第5期25卷 352-359页

作者：师海蓉陈莹李长雷邱文洪江汉大学医学院病理学与病理生理学教研室湖北武汉430056 江汉大学医学院免疫学教研室湖北武汉430056 江汉大学医学院实验动物中心湖北武汉430056

背景与目的:蛋白磷酸酶2A抑制剂-2(inhibitor 2 of protein phosphatase 2A,I2PP2A)在包括胃癌的多种肿瘤中过度表达,提示其可能在胃癌的发生中发挥重要作用。为进一步探讨I2PP2A的功能及其在胃癌发生中的作用,建立稳定抑制I2PP2A基因... 详细信息

背景与目的:蛋白磷酸酶2A抑制剂-2(inhibitor 2 of protein phosphatase 2A,I2PP2A)在包括胃癌的多种肿瘤中过度表达,提示其可能在胃癌的发生中发挥重要作用。为进一步探讨I2PP2A的功能及其在胃癌发生中的作用,建立稳定抑制I2PP2A基因表达的人胃癌BGC823细胞株。方法:筛选出I2PP2A基因的RNA干扰(RNA interference,RNAi)有效靶序列,合成靶序列的Oligo DNA并构建p GLV2_sh RNA_I2PP2A慢病毒载体,酶切和测序鉴定正确后,经病毒包装,感染BGC823细胞,经嘌呤霉素筛选稳定表达细胞株,通过实时定量PCR(real-time PCR,RT-PCR)和蛋白[质]印迹法(Western blot)鉴定I2PP2A的表达。结果:重组慢病毒质粒经测序鉴定正确;RT-PCR和Western blot证实干扰I2PP2A后,BGC823细胞株中I2PP2A表达水平明显降低,抑制率约为90%。结论:成功构建了I2PP2A sh RNA慢病毒表达载体,建立了稳定抑制I2PP2A基因表达的人胃癌BGC823细胞株,为进一步研究I2PP2A在胃癌发生中的作用提供了可靠的细胞模型。

关键词：蛋白磷酸酶2A抑制剂-2 胃癌慢病毒稳定细胞株

线上线下混合式教学在医学免疫学教学中的应用与反思

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中国免疫学杂志 2022年第18期38卷 2269-2273页

作者：史颖颖冯凌雁黄丽霞邱文洪(指导) 江汉大学医学院免疫学教研室武汉430056

医学免疫学是基础医学的一个重要分支学科,该学科具有理论概念抽象、逻辑性强与学习难度较高等特点。“混合式”教学突出“以学生为中心”的核心理念,充分融合现代信息技术,在提高教学质量的同时着力培养学生的自主学习能力和综合素质... 详细信息

医学免疫学是基础医学的一个重要分支学科,该学科具有理论概念抽象、逻辑性强与学习难度较高等特点。“混合式”教学突出“以学生为中心”的核心理念,充分融合现代信息技术,在提高教学质量的同时着力培养学生的自主学习能力和综合素质。本研究依托医学免疫学在线资源和超星平台,将线上学生自主学习和线下课堂教学有机结合,构建“以学生为主体”的混合式教学模式。结果表明基于在线课程的混合式教学模式可有效提高教学质量,在向学生传授专业知识的同时,帮助学生培养自主学习习惯,提高学生分析和解决问题的能力。但线上资源的丰富度及教学安排等方面尚需进一步优化和改进。

关键词：混合式教学医学免疫学应用与思考

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河南省新县姚冲钼矿床成因机制研究

南京大学学报（自然科学版） 2016年第4期52卷 567-581页

作者：展恩鹏李红超徐兆文赵增霞邱文洪陈伟内生金属矿床成矿机制研究国家重点实验室南京大学地球科学与工程学院南京210023 河南省有色金属地质勘查总院郑州450052

在详细的野外地质工作基础上,通过含矿石英中的流体包裹体,矿石硫、铅同位素,含矿石英氢、氧同位素等研究,探讨姚冲钼矿床成矿物质来源和形成机制.显微观察表明流体包裹体可分为LH2O+VH2O两相水溶液包裹体(Ⅰ型)、LH2O+LCO2+VCO2三相水... 详细信息

在详细的野外地质工作基础上,通过含矿石英中的流体包裹体,矿石硫、铅同位素,含矿石英氢、氧同位素等研究,探讨姚冲钼矿床成矿物质来源和形成机制.显微观察表明流体包裹体可分为LH2O+VH2O两相水溶液包裹体(Ⅰ型)、LH2O+LCO2+VCO2三相水溶液包裹体(Ⅱ型)和含子矿物的LH2O+LCO2+VCO2+S四相水溶液包裹体(Ⅲ型)三种类型;流体包裹体均一温度介于190℃~384℃(含子晶介于322℃~513℃)之间,盐度介于1.62wt%~13.18wt%NaCl eq之间;流体包裹体激光拉曼组分分析显示:Ⅰ型包裹体主要为H2O并含有少量CO2,Ⅱ型和Ⅲ型包裹体主要为H2O和CO2;计算密度介于0.641~0.965g·cm-3之间,估算最大成矿深度约2km.矿石硫同位素δ34SV-CDT值介于-2.89‰^-0.30‰之间,均值为-1.78‰.矿石铅同位素206 Pb/204 Pb比值介于16.363~17.344之间,均值为16.757;207Pb/204Pb比值介于15.298~15.473之间,均值为15.368;208Pb/204Pb比值介于37.324~37.854之间,均值为37.539.含矿石英的δDSMOW值介于-79.80‰^-64.30‰之间,均值-70.20‰;δ18 OH2O值介于1.24‰~3.08‰之间,均值2.07‰.以上研究表明姚冲钼矿床形成于中高温浅成环境,成矿物质主要来源于下地壳溶融形成的岩浆,可能混有少量的地幔物质;成矿流体以岩浆水为主,混有大气降水,混合作用是矿床形成的主要机制.

关键词：流体包裹体同位素成矿机制姚冲钼矿床河南省新县

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顺应社会需求凝练全科医学办学特色

中国社区医师 2019年第22期35卷 181-182页

作者：付艾妮朱书秀邱文洪舒细记江汉大学医学院

近年来,全科医生资源短缺的问题引起了社会各界的广泛关注,为促进紧缺专科医疗人才培养,学校在全省率先开展了临床医学全科医学生的培养,在教育教学过程中,不断探索全科医学教育模式,完善教学保障体系,培养符合社会需求并全面发展的全... 详细信息

近年来,全科医生资源短缺的问题引起了社会各界的广泛关注,为促进紧缺专科医疗人才培养,学校在全省率先开展了临床医学全科医学生的培养,在教育教学过程中,不断探索全科医学教育模式,完善教学保障体系,培养符合社会需求并全面发展的全科医学人才,以缓解专科医疗人才紧张的局面。

关键词：全科医学培养模式特色服务地方