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Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai long qiu Zhenying Diao Lintao Cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

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Electronic and Thermoelectric Properties in SnS-Nanoribbon-Based Heterojunctions

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Chinese Physics Letters 2024年第9期41卷 63-68页

作者： Kai-Bo Zhang Shi-Hua Tan Xiao-Fang Peng Meng-qiu long Hunan Province Key Laboratory of Materials Surface or Interface Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Physics and Electronics Central South UniversityChangsha 410083China

As an earth-abundant and environmentally friendly material,tin sulfide(SnS)is not only a high-performance photovoltaic material,but also a new promising thermoelectric *** extensive research on the thermoelectric properties of this material in recent years,the room-temperature thermoelectric figure of merit(ZT)of SnS has not been broke through 2[2022 *** Mater.651143].In this work,based on a combination of density functional theory and non-equilibrium Green’s function method,the electronic and thermoelectric properties in SnS-nanoribbon-based heterojunctions are *** results show that although SnS nanoribbons(SNSNRs)with zigzag edges(ZSNSNRs)and armchair edges(ASNSNRs)both have semiconductor properties,the bandgaps of ASNSNRs are much wider than those of ZSNSNRs,which induces much wider conductance gaps of𝑁-ASNSNR(N𝑁is the number of tin-sulfide lines across the ribbon width)).In the positive energy region,the ZT peaks of𝐿L-SNS-Au are much larger than those of𝐿L-SNS-GNR(L𝐿represents the number of longitudinal repeating units of SNSNR in the scattering region).While in the positive energy region,the ZT peaks of𝐿-SNSGNR are larger than those of𝐿-*** calculations reveal that the figure of merit will be over 3.7 in L-SNS-Au and 2.2 in𝐿L-SNS-GNR at room temperature,and over 4 in𝐿L-SNS-Au and 2.6 in𝐿L-SNS-GNR at 500 K.

关键词： material. sulfide ribbon

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Alternating spin splitting of electronic and magnon bands in two-dimensional altermagnetic materials

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Chinese Physics B 2024年第9期33卷 194-198页

作者： Qian Wang Da-Wei Wu Guang-Hua Guo Meng-qiu long Yun-Peng Wang School of Physics Central South UniversityChangsha 410083China

Unconventional antiferromagnetism dubbed as altermagnetism was first discovered in rutile structured magnets,which is featured by spin splitting even without the spin–orbital coupling *** interesting phenomenon has been discovered in more altermagnetic *** this work,we explore two-dimensional altermagnetic materials by studying two series of two-dimensional magnets,including MF4 with M covering all 3d and 4d transition metal elements,as well as TS2 with T=V,Cr,Mn,*** the magnetic symmetry operation of RuF4 and MnS2,it is verified that breaking the time inversion is a necessary condition for spin *** on symmetry analysis and first-principles calculations,we find that the electronic bands and magnon dispersion experience alternating spin splitting along the same *** work paves the way for exploring altermagnetism in two-dimensional materials.

关键词： two-dimensional altermagnetic materials altermagnetism spin splitting first-principles calculations

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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken HUANG Yun-ke ZHAO qiu-long HUANG Wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Hybrid pseudocapacitance/co-intercalation mechanisms of TiO2/graphite anodes for rapid sodium-ion storage

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Rare Metals 2024年第10期43卷 5427-5434页

作者： Ze-Rui Yan Da-Fu Tang Bin-Hao Wang Xiao-Juan Huang Xia Zou Si-Cheng Fan Yan Wu Tong Shu qiu-long Wei Department of Materials Science and Engineering College of MaterialsFujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsXiamen University

Developing anode materials with high specific/volumetric capacities,high-rate capability,long-term cycles and low cost is significant for advanced sodium-ion ***,we report the hybrid TiO2/graphite （TiO2/G） anodes for fast （dis）charging sodium-ion *** advantage of the rapid pseudocapacitive surface-redox on anatase TiO2nanoparticles （NPs） and fast[Na（diglyme）x]+co-intercalation into graphite,the hybrid anodes display excellent rate ***,the TiO2NPs are able to fill into the interspaces among graphite flakes and the graphite provides continuous electron pathways,which largely boosts the volumetric capacities and rate *** from the synergistic effects,

关键词： Titanium dioxide

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Switching On/Off of Guide RNA by Photoinduced Strand Displacement for Functional Control of CRISPR/Cas9

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CCS Chemistry 2024年第5期6卷 1338-1351页

作者： Yang Wang Chao-Qun Wu qiu-long Zhang Ming Shao Yan Liu Liang-Liang Wang Zun-Yun Wang Juan Du Liang Xu Central Laboratory Department of the Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060 MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275 School of Pharmacy and Medical Technology Putian UniversityPutian 351100

Functional control of CRISPR/Cas9 is essential for precise gene *** engineering of guide RNA(gRNA)provides diverse approaches for conditional control of CRISPR/Cas9 function with a variety of chemical reactive ***,previous investigations into chemically engineering gRNA only unidirectionally regulated the CRISPR/Cas9 function via stimuli-induced caging/decaging ***,we propose a combinatory strategy to engineer the dynamics of gRNA in which photocontrolled strand-displacement reactions coupled with sequence designs of gRNA can achieve lightinduced switching-on/off control of CRISPR/Cas9 *** analysis and cellular gene regulation indicate this approach is capable of both activating and deactivating CRISPR/Cas9 activities using light ***,photocontrolled multiplex modulations of gene expression for opposite regulatory effects have also been achieved simultaneously under the same cellular *** work establishes an essential principle for construction of stimuli-induced switching-on/off modulations of gRNA that can greatly enrich the versatility of conditional control for a variety of CRISPR/Cas9-based applications.

关键词： modified oligonucleotides gene manipulation optical control CRISPR/Cas9 strand displacement

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基于无人机测绘图像的大面积地形变化特征提取方法

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北京测绘 2024年第6期38卷 930-935页

作者：邱龙珠海市测绘院广东珠海519000

为了解决大面积地形变化特征提取效果较差的问题,本文提出基于无人机测绘图像的大面积地形变化特征提取方法。利用信息重构法收集无人机拍摄的图像信息,计算地形边缘尺度;利用图像滤波算法预处理大面积图像。测量和计算地形特征参数,利... 详细信息

为了解决大面积地形变化特征提取效果较差的问题,本文提出基于无人机测绘图像的大面积地形变化特征提取方法。利用信息重构法收集无人机拍摄的图像信息,计算地形边缘尺度;利用图像滤波算法预处理大面积图像。测量和计算地形特征参数,利用加权全极化分解地形变化特征,通过特征选择因子与特征判断因子加强特征的区分效果,利用合成孔径雷达(SAR)特征分类方法划分地形特征;通过随机森林和分类器,处理最佳加权SAR特征数据集;根据决策树的投票结果,完成地形变化特征提取。实验证明,应用本文所提方法,大面积地形特征的尺寸与实际值最为匹配,且提取山地与平地区域特征的用时更短;整体特征提取效果好,便于快速调整测绘路径和参数,从而实现地形变化的实时监测。

关键词：特征提取数字高程模型图像滤波算法地形曲率无人机测绘

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混合基础隔震体系优化设计及性能

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振动工程学报 2024年第1期37卷 137-147页

作者：李春祥龙秋雨曹黎媛上海大学力学与工程科学学院土木工程系上海200444

为解决基础隔震结构中隔震层位移需求过大的问题,提出了一种基础隔震结构(Base Isolated Structure,BIS)+串并联调谐质量阻尼器惯容器(Tuned Tandem Mass Damper-Inerter, TTMDI)的混合隔震体系。采用Bouc-Wen滞回模型模拟隔震层的非线... 详细信息

为解决基础隔震结构中隔震层位移需求过大的问题,提出了一种基础隔震结构(Base Isolated Structure,BIS)+串并联调谐质量阻尼器惯容器(Tuned Tandem Mass Damper-Inerter, TTMDI)的混合隔震体系。采用Bouc-Wen滞回模型模拟隔震层的非线性力-变形行为,基于随机等效线性化和模式搜索优化算法并考虑地震动模型,在频域内建立了BIS+TTMDI体系的优化设计框架。分别从鲁棒性、有效性、刚度和阻尼系数、冲程及对地震频率敏感性方面对BIS+TTMDI体系的性能进行评估,并与BIS+调谐质量阻尼器(Tuned Mass Damper, TMD)、串并联调谐质量阻尼器(TunedTandemMassDamper,TTMD)和调谐质量阻尼器惯容器(TunedMass Damper-Inerter, TMDI)进行比较。通过对近场地震动下某七层混合基础隔震结构(包括BIS+TTMDI和BIS+TMDI体系)的动力弹塑性分析,评价了其减/隔震性能。结果表明:BIS+TTMDI体系具有最好的减/隔震性能和强鲁棒性;而且在BIS+TTMDI体系中TTMDI的总阻尼需求不到BIS+TMDI体系中TMDI的一半,因而更为经济实用。

关键词：混合基础隔震结构振动控制优化设计等效线性化动力弹塑性分析

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Investigation on vehicle occupant dummy applicability for under-foot impactloading conditions

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Chinese Journal of Traumatology 2024年第4期27卷 235-241页

作者： Teng-Fei Tian Fu-Hao Mo Hao-Yang Su Can Huang Hui Zhao Jun Liu Bo Shang Kui Li Jin-long qiu State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityChangsha410082China Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Zhongzheng Judicial Expert Center Chongqing400020China NIO Limited Liability Company Shanghai200050China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China

Purpose:Under-foot impact loadings can cause serious lower limb injuries in many activities,such asautomobile collisions and underbody explosions to military *** present study aims to comparethe biomechanical responses of the mainstream vehicle occupant dummies with the human body lowerlimb model and analyze their robustness and applicability for assessing lower limb injury risk in underfoot impact loading ***:The Hybrid III model,the test device for human occupant restraint(THOR)model,and a hybridhuman body model with the human active lower limb model were adopted for under-foot impactanalysis regarding different impact velocities and initial lower limb ***:The results show that the 2 dummy models have larger peak tibial axial force and highersensitivity to the impact velocities and initial postures than the human lower limb *** particular,the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lowerlimb *** the case of minimal difference in tibial axial force,Hybrid III's tibial axial force(7.5 KN)isstill 312.5%that of human active lower limb's(2.4 KN).Even with closer peak tibial axial force values,thebiomechanical response curve shapes of the THOR model show significant differences from the humanlower limb ***:Based on the present results,the Hybrid III dummy cannot be used to evaluate the lowerlimb injury risk in under-foot loading *** contrast,potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for betterapplicability.

关键词： Lower limb Under-foot impact Human body model Dummy Finite element model

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基于TBM掘进参数的地质风险监测方法

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建筑机械 2024年第7期 118-121,129页

作者：丘武龙中交天和机械设备制造有限公司南京分公司江苏南京211800

鉴于TBM施工中地质灾害对工程的进度、成本、安全影响巨大,因此实时监测地质变化并对可能出现的风险进行报警是非常必要的。为此,文章分析了TBM的掘进数据,发现其一阶差分的分布符合正态分布。据此提出了基于TBM掘进参数的地质风险监测... 详细信息

鉴于TBM施工中地质灾害对工程的进度、成本、安全影响巨大,因此实时监测地质变化并对可能出现的风险进行报警是非常必要的。为此,文章分析了TBM的掘进数据,发现其一阶差分的分布符合正态分布。据此提出了基于TBM掘进参数的地质风险监测方法,收集最近3环的正常掘进数据计算均值和方差,采用3倍方差原则判断异常地质,同时设计报警阈值和出警计数过滤掉不构成风险的短暂波动。实验结果误警率为0%,漏警率为16.67%。文章提出的方法简单高效,能自适应地质,不需要事先收集大量不同地质中的掘进信息训练模型,具有较大的实用价值。

关键词： TBM 盾构掘进参数风险监测围岩

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