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An Imbalanced Data Classification Method Based on Hybrid Resampling and Fine Cost Sensitive Support Vector Machine

Computers, Materials & Continua 2024年第6期79卷 3977-3999页

作者： Bo Zhu Xiaona Jing lan qiu Runbo Li College of Mechanical and Electrical Engineering Kunming University of Science&TechnologyKunming650500China

When building a classification model,the scenario where the samples of one class are significantly more than those of the other class is called data *** imbalance causes the trained classification model to be in favor of the majority class(usually defined as the negative class),which may do harm to the accuracy of the minority class(usually defined as the positive class),and then lead to poor overall performance of the model.A method called MSHR-FCSSVM for solving imbalanced data classification is proposed in this article,which is based on a new hybrid resampling approach(MSHR)and a new fine cost-sensitive support vector machine(CS-SVM)classifier(FCSSVM).The MSHR measures the separability of each negative sample through its Silhouette value calculated by Mahalanobis distance between samples,based on which,the so-called pseudo-negative samples are screened out to generate new positive samples(over-sampling step)through linear interpolation and are deleted finally(under-sampling step).This approach replaces pseudo-negative samples with generated new positive samples one by one to clear up the inter-class overlap on the borderline,without changing the overall scale of the *** FCSSVM is an improved version of the traditional *** considers influences of both the imbalance of sample number and the class distribution on classification simultaneously,and through finely tuning the class cost weights by using the efficient optimization algorithm based on the physical phenomenon of rime-ice(RIME)algorithm with cross-validation accuracy as the fitness function to accurately adjust the classification *** verify the effectiveness of the proposed method,a series of experiments are carried out based on 20 imbalanced datasets including both mildly and extremely imbalanced *** experimental results show that the MSHR-FCSSVM method performs better than the methods for comparison in most cases,and both the MSHR and the FCSSVM played significan

关键词： Imbalanced data classification Silhouette value Mahalanobis distance RIME algorithm CS-SVM

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Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

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Infectious Diseases of Poverty 2024年第1期13卷 53-62页

作者： Qing-Nan Shi Hui-Jie Qin Qiao-Shan Lu hu Li Zhong-Fa Tao Meng-Guang Fan Mu-Heta Aishan Zeng-Qiang Kou qiu-lan Chen Wen-Wu Yin Yan-Ping Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionChangbai RoadChangping DistrictBejing 102206China School of Public Health Guangxi Medical UniversityNanningChina Nanning Center for Disease Control and Prevention NanningChina Guizhou Center for Disease Control and Prevention GuiyangChina Inner Mongolia Center for Disease Control and Prevention HohhotChina Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention UrumqiChina Shandong Center for Disease Control and Prevention JinanChina

Background Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of *** A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model *** A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the most prevalent. Complications in other organ systems included the genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Several factors were found to be associated with focal brucellosis. These factors included a long delay in diagnosis [odds ratio (OR) = 3.963, 95% confidence interval(CI): 1.906-8.238 for > 90 days], the presence of underlying disease (OR = 1.675, 95%CI: 1.176-2.384), arthralgia (OR = 3.197, 95%CI: 1.986-5.148), eye bulging pain (OR = 3.482, 95%CI:

关键词： Brucellosis Complications Clinical spectrum Warning signs

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN qiu lan LIU Chang Qing LUO Xiao Yan LU Jia Xi MAO De Qian LI Min YANG Zhen Yu YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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我国新传染病防控的法治路径研究——基于《传染病防治法(修订草案)》的分析

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行政法学研究 2024年第4期 71-82页

作者：刘兰秋首都医科大学医学人文学院北京100069

对病原体未知但病原性较高、需要紧急采取强制防控措施的突发原因不明的传染病建构全周期防控机制,是我国当前公共卫生法治建设面临的重要挑战。《传染病防治法(修订草案)》引入“新发传染病”这一医学术语,容易造成新的混乱;并列规定... 详细信息

对病原体未知但病原性较高、需要紧急采取强制防控措施的突发原因不明的传染病建构全周期防控机制,是我国当前公共卫生法治建设面临的重要挑战。《传染病防治法(修订草案)》引入“新发传染病”这一医学术语,容易造成新的混乱;并列规定“新发”“突发”传染病防控机制缺乏科学性;“新发”“突发”传染病监测、报告及即时防控制度未能充分理解和尊重新传染病的特点,亦未形成闭环防控机制。应基于突发原因不明的传染病的发生发展规律,在《传染病防治法》中直接引入“新传染病”的概念并将其法定传染病化,明确规定新传染病强制性防控措施的具体适用,重构包括新传染病监测、报告、判定、信息发布、紧急处置、应急响应在内的分阶段、全周期的闭环防控机制。

关键词：突发原因不明的传染病法定传染病新发传染病新传染病防控机制

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基于SBERT-Attention-LDA与ML-LSTM特征融合的烟草问句意图识别方法

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农业机械学报 2024年第5期55卷 273-281页

作者：朱波黎魁邱兰黎博昆明理工大学机电工程学院昆明650504 武汉工程大学机电工程学院武汉430205

针对烟草领域中问句意图识别存在的特征稀疏、术语繁多和捕捉文本内部的语义关联困难等问题,提出了一种基于SBERT-Attention-LDA(Sentence-bidirectional encoder representational from transformers-Attention mechanism-Latent dirichlet allocation)与ML-LSTM(Multi layers-Long short term memory)特征融合的问句意图识别方法。该方法首先基于SBERT预训练模型和Attention机制对烟草问句进行动态编码,转换为富含语义信息的特征向量,同时利用LDA模型建模出问句的主题向量,捕捉问句中的主题信息;然后通过更改后的模型级特征融合方法ML-LSTM获得具有更为完整、准确问句语义的联合特征表示;再使用3通道的卷积神经网络(Convolutional neural network,CNN)提取问句混合语义表示中隐藏特征,输入到全连接层和Softmax函数中实现对问句意图的分类。基于烟草行业权威网站上获取的数据集开展了实验验证,实验结果表明,所提方法相比其他几种深度学习结合注意力机制的方法精确率、召回率和F1值上有显著提升,与BERT和ERNIE(Enhanced representation through knowledge integration and embedding)-CNN模型相比提升明显,F1值分别提升2.07、2.88个百分点。

关键词：烟草问句分类自然语言处理特征融合自注意力机制

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Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang qiu-Mei lan Zi-Jun Zhou Yan-Heng Qiao Jie Li Yan-Ru Zhao Ming Pei Bo Yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

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以消毒为导向的集束化管理模式在ICU环境清洁消毒质量管理中的应用效果

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中国感染控制杂志 2024年第6期23卷 742-749页

作者：宋晓陈秋兰付立平聊城市人民医院脑科医院医院感染管理科山东聊城252000

目的探讨以消毒为导向的集束化管理模式在重症监护病房(ICU)环境清洁消毒质量管理中的应用效果。方法运用集束化管理模式对ICU环境清洁消毒工作进行干预,将2022年1—12月设为干预前,2023年1—12月设为干预后。比较干预前后ICU保洁人员... 详细信息

目的探讨以消毒为导向的集束化管理模式在重症监护病房(ICU)环境清洁消毒质量管理中的应用效果。方法运用集束化管理模式对ICU环境清洁消毒工作进行干预,将2022年1—12月设为干预前,2023年1—12月设为干预后。比较干预前后ICU保洁人员消毒知识知晓率、环境卫生学监测结果、患者常见多重耐药菌(MDRO)检出情况及医院感染情况。结果ICU保洁人员消毒知识知晓率、高频接触环境物体表面荧光标记清除率分别由干预前的68.58%、78.45%提升至干预后的88.45%、96.44%,差异均有统计学意义(均P<0.05)。高频接触环境物体表面及医务人员手细菌培养合格率分别由干预前的70.63%、87.90%提升至干预后的88.36%、94.15%,差异均有统计学意义(均P<0.05)。高频接触环境物体表面耐甲氧西林金黄色葡萄球菌(MRSA)、耐碳青霉烯类鲍曼不动杆菌(CRAB)检出率干预前分别为0.49%、1.46%,干预后分别为0、0.27%,干预前后比较差异均有统计学意义(均P<0.05)。干预后ICU患者医院感染发病率(4.97%)、CRAB医院感染发病率(0.77%)较干预前(分别为7.46%、1.62%)低,差异均有统计学意义(均P<0.05)。结论运用集束化管理模式对ICU环境清洁消毒工作进行干预,可有效提升ICU环境清洁消毒效果,增强保洁人员消毒防控意识,降低MRSA、CRAB检出率,降低医院感染风险,保障医疗安全。

关键词：集束化管理消毒清洁环境卫生多重耐药菌医院感染

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不同添加剂处理对水稻秸秆营养成分及发酵品质的影响

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饲料研究 2024年第2期47卷 111-115页

作者：邱亚兰王建林张鑫盐城工学院江苏盐城224051 盐城市丰都米仁厂江苏盐城224051

试验研究不同添加剂处理对水稻秸秆营养成分及发酵品质的影响,旨在提高水稻秸秆的利用率。试验以水稻秸秆为青贮原料,各试验组分别添加1.0 g/kg酶制剂、2.0 g/kg菌制剂及1.0 g/kg酶制剂+2.0 g/kg菌制剂,对照组不添加添加剂,每组设置4个... 详细信息

试验研究不同添加剂处理对水稻秸秆营养成分及发酵品质的影响,旨在提高水稻秸秆的利用率。试验以水稻秸秆为青贮原料,各试验组分别添加1.0 g/kg酶制剂、2.0 g/kg菌制剂及1.0 g/kg酶制剂+2.0 g/kg菌制剂,对照组不添加添加剂,每组设置4个重复。青贮60 d后,取样检测各组水稻秸秆青贮的感官指标、营养成分、发酵品质及瘤胃营养物质降解率。结果表明,对照组水稻秸秆青贮感官总分为13分,为2级尚好,而酶制剂、菌制剂及菌酶制剂处理的水稻秸秆青贮感官评定均较好,达到1级优良。与对照组比较,试验2组和试验3组的水稻秸秆青贮的干物质和总可消化养分含量升高(P<0.05),试验3组水稻秸秆青贮的粗脂肪含量升高(P<0.05),酸性洗涤纤维含量降低(P<0.05);试验1组、试验2组和试验3组水稻秸秆青贮的中性洗涤纤维含量降低(P<0.05),可溶性碳水化合物含量升高(P<0.05),相对饲喂价值增加(P<0.05)。与对照组比较,试验2组和试验3组水稻秸秆青贮的乙酸和总挥发性脂肪酸浓度升高(P<0.05),试验1组、试验2组和试验3组水稻秸秆青贮的pH值降低(P<0.05),试验3组水稻秸秆青贮的氨态氮浓度降低(P<0.05)。与对照组比较,试验1组、试验2组和试验3组水稻秸秆青贮的粗蛋白、中性洗涤纤维及干物质的降解率均得到提高(P<0.05)。研究表明,水稻秸秆经酶制剂、菌制剂、菌酶复合处理后,可以改善青贮饲料的感官评价,增加水稻秸秆青贮的营养成分含量,提高瘤胃营养物质的降解率,菌酶复合处理的效果优于酶制剂和菌制剂处理。

关键词：酶制剂菌制剂水稻秸秆营养成分发酵品质

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Lipids,lipid-lowering drug and sepsis:a Mendelian randomization study

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Medical Data Mining 2024年第2期7卷 17-26页

作者： qiu-lan Mo Rong-Hui Wang qiu-Gui Wei Zu-Lu Liu Department of Critical Medicine the First Affiliated HospitalGuangxi University of Chinese MedicineNanning 530023China

lipid-lowering interventions on the ***:Two-sample Mendelian randomization analyses were conducted to evaluate the associations of high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,triglycerides,apolipoprotein B and apolipoprotein A-I levels with risks for sepsis,and those of low-density lipoprotein cholesterol(HMGCR,PCSK9,NPC1L1),triglycerides(LPL,ANGPTL3,APOC3)and high-density lipoprotein cholesterol(CETP),apolipoprotein A-I(CETP),apolipoprotein B(HMGCR,PCSK9,NPC1L1,LPL,APOC3)with ***:HMGCR-mediated low-density lipoprotein cholesterol and apolipoprotein B were associated with an increased risk of sepsis,with an odds ratio value of 1.4(95%confidence interval(CI):1.06-1.84,P=0.017)and 1.41(95%CI:1.01-1.98,P=0.046).CETP-mediated high-density lipoprotein cholesterol and apolipoprotein A-I were associated with a reduced risk of sepsis,with an odds ratio of 0.87(95%CI:0.82-0.92,P<0.01)respectively and 0.84(95%CI:0.78-0.9,P<0.01).Sensitivity analysis showed that the results were ***:HMG-CoA reductase inhibitors and CETP inhibitors may contribute to the prevention and treatment of sepsis.

关键词： lipid lipid-lowering drug sepsis Mendelian randomization

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从创新思维到创新实践——面向转型的设计学教学探索

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设计 2024年第4期37卷 78-82页

作者：甘伟吴丽多邱岚华中科技大学建筑与城市规划学院光影交互服务技术文化和旅游部重点实验室武汉华中科大建筑规划设计研究院有限公司

创新实践课程是最近这些年来设计学专业本科培养计划内新增加的核心课程之一,顺应了社会发展的需求,是以创新型人才的培育为目的的教学举措。通过环境设计二年级“创新实践课”,以城市公交车站站亭设计竞赛为例。探索了将创新思维培养... 详细信息

创新实践课程是最近这些年来设计学专业本科培养计划内新增加的核心课程之一,顺应了社会发展的需求,是以创新型人才的培育为目的的教学举措。通过环境设计二年级“创新实践课”,以城市公交车站站亭设计竞赛为例。探索了将创新思维培养拓展到创新实践训练的教学全过程。帮助学生从更加宏观的角度,建立系统思维,实现对城市空间与人的行为的关注。

关键词：创新思维创新实践创新设计设计学教育人才培养模式

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