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Complement factor Ⅰ knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2646-2662页

作者： Yong-Jun Du Yue Jiang yan-Mei Hou Yong-bo Shi Department of Proctology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina School of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Proctology Zigong Hospital of Traditional Chinese MedicineZigong 643000Sichuan ProvinceChina

BACKGROUND Colon cancer(CC)occurrence and progression are considerably influenced by the tumor ***,the exact underlying regulatory mechanisms remain *** To investigate immune infiltration-related differentially expressed genes(DEGs)in CC and specifically explored the role and potential molecular mechanisms of complement factor I(CFI).METHODS Immune infiltration-associated DEGs were screened for CC using *** reverse transcription polymerase chain reaction was used to examine hub DEGs expression in the CC cell *** CFI-knockdown HT29 and HCT116 cell lines were constructed,and the diverse roles of CFI in vitro were assessed using CCK-8,5-ethynyl-2’-deoxyuridine,wound healing,and transwell *** and eosin staining and immunohistochemistry staining were employed to evaluate the influence of CFI on the tumorigenesis of CC xenograft models constructed using BALB/c male nude *** proteins associated with glycolysis and the Wnt pathway were measured using western *** Six key immune infiltration-related DEGs were screened,among which the expression of CFI,complement factor B,lymphoid enhancer binding factor 1,and SRY-related high-mobility-group box 4 was upregulated,whereas that of fatty acid-binding protein 1,and bone morphogenic protein-2 was ***,CFI could be used as a diagnostic biomarker for ***,CFI silencing inhibited CC cell proliferation,migration,invasion,and tumor ***,CFI knockdown downregulated the expression of key glycolysis-related proteins(glucose transporter type 1,hexokinase 2,lactate dehydrogenase A,and pyruvate kinase M2)and the Wnt pathway-related proteins(β-catenin and c-Myc).Further investigation indicated that CFI knockdown inhibited glycolysis in CC by blocking the Wnt/β-catenin/c-Myc *** The findings of the present study demonstrate that CFI plays a crucial role in CC development by influencing g

关键词： Colon cancer Immune infiltration Complement factor I Glycolysis Wnt/β-catenin/c-Myc pathway

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Investigating the causal link between gut microbiota and dry age-related macular degeneration:a bidirectional Mendelian randomization study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1723-1730页

作者： Hai-yan Huang Jing Wang bo Qin Yao Tan Clinical Medical College of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Postdoctoral Station of Clinical Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina The Third Xiangya Hospital Central South UniversityChangsha 410000Hunan ProvinceChina

AIM:To assess the causal link between 211 gut microbiota(GM)taxa and dry age-related macular degeneration(dAMD)***:Mendelian randomization using instrumental factors taken from a genome-wide association study(GWAS)were *** variance weighted(IVW)analysis and sensitivity analysis were performed on the FinnGen project,which included 5095 cases and 222590 ***:The IVW analysis showed substantial genusand family-level relationships between GM taxa and dAMD ***,the family Peptococcaceae(P=0.03),genus Bilophila(P=3.91×10^(-3)),genus Faecalibacterium(P=6.55×10^(-3)),and genus Roseburia(P=0.04)were linked to a higher risk of developing dAMD,while the genus Candidatus Soleaferrea(P=7.75×10^(-4)),genus Desulfovibrio(P=0.04)and genus Eubacterium ventriosum group(P=0.04)exhibited a protective effect against *** significant causal relationships were observed at higher taxonomic ***,in the reverse IVW analysis,no meaningful causal effects of the 7 GM ***:These findings give support for the gutretina axis participation in dAMD and shed light on putative underlying *** on the connection between GM and dAMD have not yet revealed the underlying mechanism.

关键词： dry age-related macular degeneration gut microbiota mendelian randomization gut-retina axis genome-wide association study

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Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

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Neural Regeneration Research 2024年第2期19卷 360-368页

作者： Leyi Huang Wenjie Xiao yan Wang Juan Li Jiaoe Gong Ewen Tu Lili Long bo Xiao Xiaoxin yan Lily Wan Department of Anatomy and Neurobiology Central South University Xiangya Medical SchoolChangshaHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Hunan Children’s HospitalChangshaHunan ProvinceChina Department of Neurology Brain Hospital of Hunan ProvinceChangshaHunan ProvinceChina

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug *** signaling through the excitatory neurotransmitter glutamate is intricately associated with *** glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic *** mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of *** this review,we first introduce the three groups of mGluRs and their associated signaling ***,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in *** addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also *** hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

关键词： antiepileptic drugs epileptogenesis metabotropic glutamate receptors(mGluRs) signal pathways therapeutic potentials

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Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang qiu-Mei Lan Zi-Jun Zhou yan-Heng Qiao Jie Li yan-Ru Zhao Ming Pei bo yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

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Colorimetric detection of α-glucosidase activity using Ni-CeO_(2)nanorods and its application to potential natural inhibitor screening

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Chinese Chemical Letters 2024年第9期35卷 387-391页

作者： Jia Chen Yun Liu Zerong Long yan Li Hongdeng qiu Xinjiang Uygur Autonomous Product Quality Supervision and Inspection Institute Urumqi 830000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

In this work,we established an exceptionally facile method for the preparation of Ni-CeO_(2)nanorods in a kind of deep eutectic solvents(DESs)composed of l-proline and Ce(NO_(3))_(3)·6H_(2)***,Ni-CeO_(2)nanorods were successfully prepared by adding Ni(NO_(3))_(3)·6H_(2)O to ***,we found that Ni-CeO_(2)nanorods prepared in DESs have more prominent oxidase-like activity than pure CeO_(2).The outstanding catalytic activity of Ni-CeO_(2)could be ascribed to its high Ce^(3+)/Ce^(4+)*** a proof-of-concept application,the Ni-CeO_(2)nanorods were successfully acted as a colorimetric platform for the sensitive determination of ascorbic acid andα-glucosidase activity,which displays excellent analytical ***,this sensing platform was applied for screening naturalα-glucosidase inhibitors,such as terpenoids from natural *** results indicated that ursolic acid and oleanolic acid had good inhibitory *** strategy not only provides a new way to construct more kinds of nanomaterials from DESs,but also offers a facile and effective tool to screen theα-glucosidase natural inhibitors as potential anti-diabetic drugs.

关键词： Ni-CeO_(2) Ascorbic acid α-Glucosidase Inhibitor screening Nanozyme

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Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

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Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-Ming Wei yang Xia yan Jin Xu-yang Guo Jing-Yu Zi Kai-Xuan qiu Si-Yuan Chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

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Highly Transparent Fire-resistant Coatings with Intumescent Three-source Integration

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Chinese Journal of Polymer Science 2024年第7期42卷 907-915,I0005页

作者： Xiao-Liang Zeng Xin-Sheng Lan yan Wang Lin Zhang De-Ming Guo Hai-bo Zhao State Grid Sichuan Electric Power Research Institute Chengdu610041China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(Ministry of Education) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

Wood,a readily available and sustainable natural resource,has found widespread use in construction and ***,its inherent flammability poses a potential fire *** intumescent fire-retardant coatings effectively mitigate this risk,achieving high transparency in such coatings presents a significant *** our approach,we employed a cross-linked network of phytic acid anion and N-[3-(trimethoxysilyl)propyl]-N,N,N-trimethylammonium cation to create a transparent"three-in-one"intumescent *** collaborative P/N/Si flame-retardant effect markedly improved the intumescent char-forming capability,preventing the wood from rapid *** resulted in a substantial reduction in heat release(13.9%decrease in THR)and an increased limiting oxygen index(LOI)value of 35.5%.Crucially,the high transparency of the coating ensured minimal impact on the wood's appearance,allowing the natural wood grains to remain clearly *** innovative approach provides a straightforward method for developing transparent intumescent flame-retardant coatings suitable for wooden *** potential applications extend to preserving ancient buildings and heritage conservation efforts.

关键词： Fire-resistant coating Flame retardancy Wood Transparency

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Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun yang-yang Wang Lin Wan qiu-Hong Wang Qian Lu Xiao-yan yang Qi Zhang Hui-Min Chen Lu-Peng qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

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MoS_2/g-C_3N_4复合材料的制备及可见光催化性能

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无机化学学报 2017年第3期33卷 389-395页

作者：徐梦秋柴波闫俊涛汪海波任占冬武汉轻工大学化学与环境工程学院武汉430023

首先在N-甲基吡咯烷酮溶液中超声剥离得到少层的MoS_2,将其与石墨相氮化碳(g-C_3N_4)复合,制得MoS_2/g-C_3N_4复合材料。采用X射线衍射(XRD),扫描电镜(SEM),X射线光电子能谱(XPS),傅里叶变换红外光谱(FTIR),Raman光谱,紫外-可见漫反射... 详细信息

首先在N-甲基吡咯烷酮溶液中超声剥离得到少层的MoS_2,将其与石墨相氮化碳(g-C_3N_4)复合,制得MoS_2/g-C_3N_4复合材料。采用X射线衍射(XRD),扫描电镜(SEM),X射线光电子能谱(XPS),傅里叶变换红外光谱(FTIR),Raman光谱,紫外-可见漫反射吸收光谱(DRS)和光致荧光(PL)技术对复合材料进行表征。可见光下考察MoS_2/g-C_3N_4复合材料光催化降解罗丹明B(Rh B)的活性,结果表明:将少量MoS_2与g-C_3N_4复合可明显提高光催化活性,且1%(w/w)MoS_2/g-C_3N_4复合物的光催化活性最高,可能的原因是MoS_2和g-C_3N_4匹配的能带结构,增大了界面间电荷的传输,降低了光生电子-空穴的复合,进而提高了光催化活性。

关键词： MoS2/g-C3N4复合材料光催化降解罗丹明B

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Application of artificial synapse based on all-inorganic perovskite memristor in neuromorphic computing

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Nano Materials Science 2024年第1期6卷 68-76页

作者： Fang Luo Wen-Min Zhong Xin-Gui Tang Jia-Ying Chen yan-Ping Jiang qiu-Xiang Liu School of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China

Artificial synapse inspired by the biological brain has great potential in the field of neuromorphic computing and artificial *** memristor is an ideal artificial synaptic device with fast operation and good ***,we have prepared a memristor device with Au/CsPbBr_(3)/ITO *** memristor device exhibits resistance switching behavior,the high and low resistance states no obvious decline after 400 switching *** memristor device is stimulated by voltage pulses to simulate biological synaptic plasticity,such as long-term potentiation,long-term depression,pair-pulse facilitation,short-term depression,and short-term *** transformation from short-term memory to long-term memory is achieved by changing the stimulation *** addition,a convolutional neural network was constructed to train/recognize MNIST handwritten data sets;a distinguished recognition accuracy of~96.7%on the digital image was obtained in 100 epochs,which is more accurate than other memristor-based neural *** results show that the memristor device based on CsPbBr3 has immense potential in the neuromorphic computing system.

关键词： Memristor CsPbBr_(3) Resistive switching Artificial synapse Neuromorphic computing

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