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BCNU/PLGA microspheres:a promising strategy for the treatment of gliomas in mice

Chinese Journal of Cancer Research 2014年第1期26卷 81-88页

作者： Tongming Zhu Yiwen Shen qisheng tang Luping Chen Huasong Gao Jianhong Zhu Fudan University Huashan Hospital Dept.of Neurosurgery National Key Laboratory for Medical NeurobiologyInstitutes of Brain ScienceShanghai Medical College-Fudan University

Objective：To investigate the effects of BCNU/PLGA microspheres on tumor growth,apoptosis and chemotherapy resistance in a C57BL/6 mice orthotopic brain glioma model using GL261 cell ***：BCNU/PLGA sustained-release microspheres were prepared by the water-in-oil-in-water emulsion ***261 cells were intracranially injected into C57BL/6 mouse by using the stereotactic technology.A total of 60 tumor-bearing mice were randomly and equally divided into three groups：untreated control,PLGA treated,BCNU/PLGA *** resonance imaging （MRI） was taken to evaluate tumor ***/PLGA sustained-release wafers were implanted in the treatment group two weeks after *** time and quality were *** were harvested,and immunohistochemical staining was used to check the expression of Bax,Bcl-2,and O6-methylguanine-DNA methyltransferase （MGMT）.Statistical methods was used for analysis of relevant ***：BCNU/PLGA sustained-release wafers were fabricated and implanted *** is statistical difference of survival time between the BCNU/PLGA treated group and control groups （P＜0.05）.MRIscan showed inhibitory effect of BCNU/PLGA on tumor *** to the group A and B,BCNU/PLGA decreased the expression of apoptosis related gene Bcl-2 （P＜0.05）,but did not elevate the expression level of Bax （P＞0.05）,with the ratio of Bax/Bcl-2 *** MGMT protein expression,no statistically significant change was found in treated group （P＞0.05）.Conclusions：Local implantation of BCNU/PLGA microspheres improved the survival quality and time of GL261 glioma-bearing mice significandy,inhibited the tumor proliferation,induced more cell apoptosis,and did not increase the chemotherapy resistance.

关键词： BCNU/PLGA microspheres glioma interstitial chemotherapy apoptosis

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Current status of cell-mediated regenerative therapies for human spinal cord injury

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Neuroscience Bulletin 2014年第4期30卷 671-682页

作者： Tongming Zhu qisheng tang Huasong Gao Yiwen Shen Luping Chen Jianhong Zhu Department of Neurosurgery Fudan University Huashan Hospital National Key Laboratory of Medical Neurobiology Institutes of Brain ScienceShanghai Medical CollegeFudan University

During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury （SCI）. Positive results have been achieved with different types of cells in various clinical studies of SCI. In this review, we summarize recently-completed clinical trials using cell- mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies published in Chinese journals are included. These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery. However, many obstacles exist, hindering the introduction of a specific clinical therapy, including complications and their causes, selection of the target population, and optimization of transplantation material. Despite these and other challenges, with the collaboration of research groups and strong support from various organizations, cell-mediated regenerative therapies will open new perspectives for SCI treatment.

关键词： cell-mediated regenerative therapy spinal cord injury clinical trials stem cell

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运用队列研究观察抑郁障碍心肾不交型复发率的多中心前瞻性研究

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世界中医药 2024年第7期19卷 1005-1010页

作者：杨歆科唐启盛郑军然刘向哲尹洪娜马良黄世敬王娣北京中医药大学第三附属医院北京100029 北京回龙观医院北京100096 河南中医药大学第一附属医院郑州450099 黑龙江中医药大学附属第二医院哈尔滨150001 北京市朝阳区第三医院北京100025 中国中医科学院广安门医院北京100053 首都医科大学附属北京安定医院北京100088

目的:评价滋阴降火、除烦安神功效中医药治疗方案对心肾不交型抑郁障碍(MDD)2年复发率的疗效。方法:运用队列研究方法,选取2017年1月至2018年12月全国13个分中心的心肾不交型MDD患者,根据患者接受干预方案的不同,自然形成中医、中西医... 详细信息

目的:评价滋阴降火、除烦安神功效中医药治疗方案对心肾不交型抑郁障碍(MDD)2年复发率的疗效。方法:运用队列研究方法,选取2017年1月至2018年12月全国13个分中心的心肾不交型MDD患者,根据患者接受干预方案的不同,自然形成中医、中西医结合及西医队列,比较3个队列复发率。并根据患者接受中医药方案干预时间的不同,将中医和中西医结合队列分为低、中、高3个暴露水平,比较3种暴露水平的复发率,以评价中医药方案降低心肾不交型MDD远期复发率的疗效。结果:共纳入506例患者,其中中医队列172例、中西医结合队列166例、西医队列168例。2年复发率方面,中医队列25.6%、中西医结合队列21.1%、西医队列35.1%。复发风险方面,中医队列中水平暴露比低水平暴露低63.0%(HR=0.370,95%CI为0.170~0.808,P<0.05),高水平暴露比低水平暴露低94.5%(HR=0.055,95%CI为0.016~0.192,P<0.01);中西医结合队列中水平暴露比低水平暴露低72.3%(HR=0.277,95%CI为0.111~0.689,P<0.01),高水平暴露比低水平暴露低83.9%(HR=0.161,95%CI为0.058~0.446,P<0.01)。结论:滋阴降火、除烦安神治法的中医药综合方案能有效降低心肾不交型MDD远期复发率,同时随接受中医药干预时间的增加,MDD复发率亦有逐渐下降趋势。

关键词：抑郁障碍复发率心肾不交型前瞻性队列研究云数据多中心中西医结合暴露水平

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Input and influence to YSFRI by the“Bei Dou”Project

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海洋水产研究 2001年第4期22卷 7-9页

作者： tang qisheng 中国水产科学黄海水产所山东青岛 2 660 71

The research parts of the project operated by YSFRI YSFRI is involved in 5 sub-projects of the “Bei Dou” Fisheries Research and Management Project, 1997/1998-2000. About 20 scientists at YSFRI worked in the project. From the Norwegian side, the scientists taking part in the work were Svein A. Iversen, ivind Strand, Einar Lied and Anders Aksnes. The Chinese and Norwegi an scientists work together to achieve the objectives of the project.

关键词：北斗项目黄海水产研究所影响

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Intraoperative ultrasound assistance in resection of intracranial meningiomas

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Chinese Journal of Cancer Research 2013年第3期25卷 339-345页

作者： Hailiang tang Huaping Sun Liqian Xie qisheng tang Ye Gong Ying Mao Qing Xie Mingzhe Zheng Daijun Wang Hongda Zhu Jianhong Zhu Xiaoyuan Feng Zhenwei Yao Xiancheng Chen Liangfu Zhou Neurosurgery Department of Huashan Hospital Radiology Department of Huashan Hospital

Objective： Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It＇s essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods： Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results： The border of the rneningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions： Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information （such as the tumor supplying vessels） that helps to improve surgical resection and therefore might reduce the postoperative morbidity.

关键词： Intraoperative ultrasonography intracranial meningioma

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常染色体显性遗传2型多囊肾病基因参与精子尾部组装的作用研究

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空军军医大学学报 2024年第6期45卷 639-644,649页

作者：高婷刘博熊明祥李田田续功权唐启胜李臻空军军医大学基础医学院人体解剖与组织胚胎学教研室陕西西安710032 解放军中部战区空军医院泌尿外科山西大同037000 空军军医大学唐都医院泌尿外科陕西西安710038

目的研究常染色体显性遗传2型多囊肾病基因(PKD2)在精子尾部组装过程中的作用。方法回顾分析1例携带PKD2基因突变的非梗阻性无精症(NOA)患者的临床资料,Sanger测序验证该基因突变,对睾丸组织进行HE和免疫荧光染色;通过对正常人精子涂片... 详细信息

目的研究常染色体显性遗传2型多囊肾病基因(PKD2)在精子尾部组装过程中的作用。方法回顾分析1例携带PKD2基因突变的非梗阻性无精症(NOA)患者的临床资料,Sanger测序验证该基因突变,对睾丸组织进行HE和免疫荧光染色;通过对正常人精子涂片进行免疫荧光染色观察PKD2在精子的定位,利用人视网膜色素上皮(hRPE)细胞检测PKD2在纤毛发育过程中的定位。结果该NOA患者PKD2基因存在c.1571T>A(P.I524N)杂合突变,其精子细胞尾部发育缺陷;PKD2主要定位于精子鞭毛起始部,与参与精子尾部组装及发育的重要蛋白Ac-Tubulin及γ-Tubulin存在共定位,在hRPE细胞纤毛发育过程中PKD2主要定位于纤毛的基体。结论本研究报道了1例全新的PKD2杂合突变的NOA患者病例,结果提示PKD2可能参与精子尾部的起始组装,为进一步研究精子鞭毛组装的机制提供了基础,PKD2基因c.1571T>A(P.I524N)杂合突变可能是无精症诊疗的新靶点。

关键词：多囊肾病非梗阻性无精症基因突变精子鞭毛

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ESTIMATION OF FISHING MORTALITY AND ABUNDANCE OF PACIFIC HERRING IN THE HUANGHAI SEA BY COHORT ANALYSIS (VPA)

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Acta Oceanologica Sinica 1987年第1期6卷 132-141页

作者：唐启升 Yellow Sea Fisheries Research Institute Qingdao

In this paper Cohort Analysis (VPA) with the data on catch in number by age and year is used to estimate independently fishing mortality, abundance and actual number of spawning stock of the Pacific herring in the Huanghai Sea. The results show that catch rate of the fishery is very high, and that the fishing mortality of the dominant age group aged 2-4 was 0.87-2.97 during the years 1971-1984. The size of year class has been decreased since 1982 although the variability for this species in the Huanghai Sea is frequent. This results in reducing the recruitment of the fishery, the abundance and the actual number of spawning stock. Therefore, an urgent management measure should be *** magnitude of several sources of errors in Cohort Analysis (VPA) are examined, and the precision of the estimates is mainly dependent on an accurate natural mortality.

关键词： VPA ESTIMATION OF FISHING MORTALITY AND ABUNDANCE OF PACIFIC HERRING IN THE HUANGHAI SEA BY COHORT ANALYSIS SSN

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Genetic Variation Among White Croaker Populations

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Journal of Ocean University of China 2008年第1期7卷 72-76页

作者： HAN Zhiqiang GAO Tianxiang ZHUANG Zhimeng tang qisheng Key Laboratory of Mariculture of Chinese Ministry of Education Ocean University of China Qingdao 266003 P. R. China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 P. R. China

To investigate the genetic structures and differentiation of different wild populations of white croaker （Pennahia argentara）, horizontal starch gel electrophoresis was performed on 133 individuals collected from five different locations in China and Japan. The eleven enzyme systems revealed 15 loci, of which eleven were polymorphic. The percentage ofpolymorphic loci of white croaker populations varied from 6.67% to 53.3.3%; the mean observed and expected heterozygosity ranged from 0.0033 to 0.0133 and 0.0032 to 0.0191, respectively. The expected heterozygosity revealed a low genetic variability for white croaker in comparison with other marine fishes. The genetic distances between populations ranged from 0.00005 to 0.00026. A weak differentiation was observed within each clade and between clades; and no significant differences in gene frequencies among populations were observed in white croaker. Among the five populations, three Chinese populations showed more genetic diversity than that in Japanese populations.

关键词： Pennahia argentata white croaker allozyme genetic variation population

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抑郁障碍中西医研究进展述评

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北京中医药大学学报 2022年第9期45卷 871-877页

作者：唐启盛北京中医药大学第三附属医院北京100029

通过对抑郁障碍(MDD)流行病学、发病机制、诊断筛查、治疗、患者生活质量、中医药证候研究及中医药减少自杀和降低复发方面的总结及评价,提出了中西医研究的热点及误区。指出未来中西医研究的共同方向,包括继续探讨发病机制、不断更新... 详细信息

通过对抑郁障碍(MDD)流行病学、发病机制、诊断筛查、治疗、患者生活质量、中医药证候研究及中医药减少自杀和降低复发方面的总结及评价,提出了中西医研究的热点及误区。指出未来中西医研究的共同方向,包括继续探讨发病机制、不断更新临床诊断标准、开发疗效确切的抗抑郁药物,而中医学研究方向尤其应当重视对MDD新理论、新认识的规范与深化,对MDD特征性症状进行中医机制分析和具有中医特色的治疗,实现在提高疗效基础上降低自杀风险和复发率的目的。

关键词：抑郁中医药脑功能环路复发率自杀风险特征性症状

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以科技创新驱动引领山东高质量发展

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科技导报 2020年第14期38卷 1-2页

作者：唐启升中国水产科学研究院黄海水产研究所青岛266071 农业农村部科技委

惟改革者进,惟创新者强,惟改革创新者胜。仲夏时节,美丽的岛城即将迎来一场以"改革开放,创新引领——科技赋能,合作发展"为主题的全国科技界盛会——第二十二届中国科协年会。多年来,中国科协年会作为我国科技领域高层次、高水平、高规... 详细信息

惟改革者进,惟创新者强,惟改革创新者胜。仲夏时节,美丽的岛城即将迎来一场以"改革开放,创新引领——科技赋能,合作发展"为主题的全国科技界盛会——第二十二届中国科协年会。多年来,中国科协年会作为我国科技领域高层次、高水平、高规格、大规模的科技盛会,为促进学术交流、推动科技进步、服务地方发展发挥了重要作用。

关键词：科技进步中国科协创新者学术交流创新引领服务地方发展科技创新驱动高质量发展

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