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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen yan Han Li yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Checklist of marine fishes in the Beibu Gulf:fish classification,resource protection,and biodiversity challenge

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Journal of Oceanology and Limnology 2025年第1期43卷 232-247页

作者： Zhisen LUO Murong YI Xiaodong yang Xiao CHEN Jinxi WANG Changping JIANG Fengming LIU Konglan LUO Xiongbo HE Hung-Du LIN Bin KANG Yunrong yan College of Fisheries Guangdong Ocean UniversityZhanjiang 524088China College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China Fisheries College Ocean University of ChinaQingdao 266003China Guangdong Provincial Engineering and Technology Research Center of Far Sea Fisheries Management and Fishing of South China Sea Guangdong Ocean UniversityZhanjiang 524088China

Marine fish diversity in the Beibu Gulf from 2014 to 2022 was analyzed,using various methods including at-sea fisheries resource surveys,fishing port surveys,underwater survey techniques,and data from literature,books,and databases,from which 1059 fish species across 40 orders,166 families,and 503 genera were *** them,Acanthuriformes displayed the highest diversity,followed by Carangiformes and ***,eight alien species were found in the Beibu *** International Union for Conservation of Nature(IUCN)Red List assessment revealed 51threatened species,primarily cartilaginous *** changes affected 88.70%of species due to classification adjustments,misidentifications,and junior *** study contributed new data of the gulf,including one additional order,six new families,34 new genera,and 81 new species,emphasizing the dynamic nature of marine *** diversity in the gulf was relatively lower than the broader South China Sea,attributed to limited habitats and survey *** survey methods,such as gill nets,trap nets,and underwater cameras,yielded varying *** currents may have transported deep-sea species into the Beibu Gulf,leading to accidental *** gaps exist in unexplored areas,warranting further ***,the Beibu Gulf hosts significant marine biodiversity,but taxonomic challenges and undiscovered species require new research and conservation efforts.

关键词： northwestern South China Sea new record taxonomic change fish diversity survey method

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Unintentional emissions of polychlorinated naphthalenes in China:Sources,composition,and historical trends

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Journal of Environmental Sciences 2025年第2期148卷 221-229页

作者： Ye Huang Lin Huang Ying Li Nazupar Sidikjan Yunshan Zhang yan Chen yangmin Chen Ye Li Wei Du Long Chen yanWu Shanshan Zhang Jing yang Wenjun Meng Guofeng Shen Min Liu Shu Tao Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control Faculty of Environmental Science&EngineeringKunming University of Science&TechnologyKunming 650500China Laboratory of Earth Surface Processes College of Urban and Environmental SciencePeking UniversityBeijing 100871China

Polychlorinated naphthalenes(PCNs)are detrimental to human health and the *** the commercial production of PCNs banned,unintentional releases have emerged as a significant environmental ***,relevant information is still *** this study,provincial emissions for eight PCNs homologues from 37 sources in the Chinese mainland during the period of 1960-2019 were estimated based on a source-specific and time-varying emission factor *** results showed that the total PCNs emissions in 2019 reached 757.0 kg with Hebei ranked at the top among all the provinces and iron&steel industry as the biggest ***-chlorinated PCNs comprised 90%of emissions by mass,while highly chlorinated PCNs dominated in terms of toxicity,highlighting divergent priorities for mitigating emissions and safeguarding human *** emissions showed an overall upward trend from 1960 to 2019 driven by emission increase from iron&steel industry in terms of source,and from North China and East China in terms of geographic ***-capita emissions followed an inverted U-shaped environmental Kuznets curvewhile emission intensities decreased with increasing per-capita Gross Domestic Product(GDP)following a nearly linear pattern when log-transformed.

关键词： PCNs Emission inventory Emission factor Composition profile Emission intensity Chinese mainland

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Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum

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Chinese Journal of Natural Medicines 2025年第2期23卷 245-256页

作者： Jiaocen Guo Li yang Luting Dai Qingyun Ma Jiaoyang yan Qingyi Xie Yougen Wu Haofu Dai Youxing Zhao School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 2 6carbons,ganothenoids A-E（1-5）,and three lanostanoids,ganothenoids F-H（6-8）,along with 24 known ones（9-32）,were isolated from the fruiting bodies of Ganodrma *** structures of the novel compounds were elucidated using comprehensive spectroscopic methods,including electronic circular dichroism（ECD） and nuclear magnetic resonance（NMR） *** 1-32 were assessed for their neuroprotective effects against H2O2-induced damage in human neuroblastoma SH-SY5Y cells,as well as their inhibitory activities against protein tyrosine phosphatase 1B（PTP1B） and α-*** 4demonstrated the most potent neuroprotective activity against H2O2-induced oxidative stress by suppressing G0/G1phase cell cycle arrest,reducing reactive oxygen species（ROS） levels,and inhibiting cell apoptosis through modulation of B-cell lymphoma 2 protein（Bcl-2） and Bcl-2 associated X-protein（Bax） protein *** 26,12,and 28 exhibited PTP1B inhibitory activities with IC50values ranging from 13.92 to 56.94 μmol·L-1,while compound12 alone displayed significant inhibitory effects on α-glucosidase with an IC50value of 43.56μmol·***,enzyme kinetic analyses and molecular docking simulations were conducted for compounds 26 and 12 with PTP1B and α-glucosidase,respectively.

关键词： Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B α-Glucosidase

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Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism,FGF23,and Klotho

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World Journal of Diabetes 2025年第1期16卷 49-57页

作者： Fan yang yan Wu Wei Zhang Department of Endocrinology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina Department of Nephrology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina

BACKGROUND The progression of diabetic kidney disease(DKD)affects the patient’s kidney glomeruli and tubules,whose normal functioning is essential for maintaining normal calcium(Ca)and phosphorus(P)metabolism in the *** risk of developing osteoporosis(OP)in patients with DKD increases with the aggravation of the disease,including a higher risk of fractures,which not only affects the quality of life of patients but also increases the risk of *** To analyze the risk factors for the development of OP in patients with DKD and their correlation with Ca-P metabolic indices,fibroblast growth factor 23(FGF23),and *** One hundred and fifty-eight patients with DKD who were admitted into the Wuhu Second People’s Hospital from September 2019 to May 2021 were selected and divided into an OP group(n=103)and a normal bone mass group(n=55)according to their X-ray bone densitometry *** data and differences in Ca-P biochemical indices,FGF23,and Klotho were *** correlation of Ca-P metabolic indices with FGF23 and Klotho was discussed,and the related factors affecting OP in patients with DKD were examined by multivariate logistic regression *** The OP group had a higher proportion of females,an older age,and a longer diabetes mellitus duration than the normal group(all P<0.05).Patients in the OP group exhibited significantly higher levels of intact parathyroid hormone(iPTH),blood P,Ca-P product(Ca×P),fractional excretion of phosphate(FeP),and FGF23,as well as lower estimated glomerular filtration rate,blood Ca,24-hour urinary phosphate excretion(24-hour UPE),and Klotho levels(all P<0.05).In the OP group,25-(OH)-D3,blood Ca,and 24-hour UPE were negatively correlated with FGF23 and positively correlated with *** contrast,iPTH,blood Ca,Ca×P,and FeP exhibited a positive correlation with FGF23 and an inverse association with Klotho(all P<0.05).Moreover,25-(OH)-D3,iPTH,blood Ca,FePO4,FGF23,Klotho,age,and female gender were key fa

关键词： Diabetic kidney disease Osteoporosis Calcium-phosphorus metabolism FGF23 Klotho

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基于STIRPAT和CNN-LSTM组合模型的福建省碳达峰预测

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环境科学 2025年第1期46卷 10-18页

作者：连艳琼苏墩煌施生旭福建农林大学公共管理与法学院福州350002

碳达峰对中国实现“双碳”目标、推动经济社会绿色转型具有重要意义.基于改进的STIRPAT模型分析影响福建省碳排放的主要因素,设置3种情景方案,利用CNN-LSTM神经网络混合模型对福建省2022~2035年碳排放量进行预测.结果表明:①人口、人均... 详细信息

碳达峰对中国实现“双碳”目标、推动经济社会绿色转型具有重要意义.基于改进的STIRPAT模型分析影响福建省碳排放的主要因素,设置3种情景方案,利用CNN-LSTM神经网络混合模型对福建省2022~2035年碳排放量进行预测.结果表明:①人口、人均GDP和产业结构对福建省碳排放有正向驱动作用,能源强度、能源结构和对外贸易度则起负向驱动作用;②基准情景下于2033年实现碳达峰,达峰值为361.1079 Mt,低碳情景和优化情景可以提早1 a达峰且达峰值均有不同程度下降,分别为333.0284 Mt和301.7483 Mt;③对比优化情景和低碳情景,调整产业和能源结构能够控制福建省碳峰值降低10.37%,加快推动能源和产业结构优化转型是解绑碳排放与经济发展之间束缚的关键所在.最后,结合福建省当前政策规划和发展现状,从能源减排、产业结构和制度体系等角度提出低碳发展建议.

关键词：碳排放碳达峰 STIRPAT模型 CNN-LSTM模型政策

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An efficient conversion model between acceleration and pseudo-acceleration response spectra considering effects of magnitude,distance,and site class

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 15-30页

作者： Liu Zheng Zhao yan-Gang Zhang Haizhong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China Faculty of Agriculture Yamagata University1-23Wakaba-machiTsuruoka-shiYamagata 997-8555Japan

Both acceleration and pseudo-acceleration response spectra play important roles in structural seismic ***,only one of them is generally provided in most seismic ***,many studies have attempted to develop conversion models between the acceleration response spectrum(SA)and the pseudo-acceleration response spectrum(PSA).Our previous studies found that the relationship between SA and PSA is affected by magnitude,distance,and site ***,we developed an SA/PSA model incorporating these ***,this model is suitable for cases with small and moderate magnitudes and its accuracy is not good enough for cases with large *** paper aims to develop an efficient SA/PSA model by considering influences of magnitude,distance,and site class,which can be applied to cases not only with small or moderate magnitudes but also with large *** this purpose,regression analyses were conducted using 16,660 horizontal seismic records with a wider range of *** magnitude of these seismic records varies from 4 to 9 and the distances vary from 10 to 200 *** ground motions were recorded at 338 stations covering four site *** comparing them with existing models,it was found that the proposed model shows better accuracy for cases with any magnitudes,distances,and site classes considered in this study.

关键词： acceleration response spectrum pseudo-acceleration response spectrum magnitude distance site class

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An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： yan Dong Wenzheng An Zihu Wang Dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan yang Xinxin yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian Cancer Institute Handan 056500China Linzhou Cancer Hospital Linzhou 456550China Center for Disease Control and Prevention of Sheyang County Yancheng 224499China Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for Disease Control and Prevention Xinyang 464299China Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

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