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Synergistic anionic/zwitterionic mixed surfactant system with high emulsification efficiency for enhanced oil recovery in low permeability reservoirs

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Petroleum Science 2024年第2期21卷 936-950页

作者： Hai-Rong Wu Rong Tan Shi-Ping Hong qiong Zhou Bang-Yu Liu Jia-wei Chang Tian-Fang Luan Ning Kang Ji-Rui Hou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Gas Production Plant 5 of PetroChina Changqing Oilfield Company PetroChinaXi'an710000ShaanxiChina College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Kazakh-British Technical University Almaty050000Kazakhstan

Emulsification is one of the important mechanisms of surfactant flooding. To improve oil recovery for low permeability reservoirs, a highly efficient emulsification oil flooding system consisting of anionic surfactant sodium alkyl glucosyl hydroxypropyl sulfonate(APGSHS) and zwitterionic surfactant octadecyl betaine(BS-18) is proposed. The performance of APGSHS/BS-18 mixed surfactant system was evaluated in terms of interfacial tension, emulsification capability, emulsion size and distribution, wettability alteration, temperature-resistance and salt-resistance. The emulsification speed was used to evaluate the emulsification ability of surfactant systems, and the results show that mixed surfactant systems can completely emulsify the crude oil into emulsions droplets even under low energy conditions. Meanwhile,the system exhibits good temperature and salt resistance. Finally, the best oil recovery of 25.45% is achieved for low permeability core by the mixed surfactant system with a total concentration of 0.3 wt%while the molar ratio of APGSHS:BS-18 is 4:6. The current study indicates that the anionic/zwitterionic mixed surfactant system can improve the oil flooding efficiency and is potential candidate for application in low permeability reservoirs.

关键词： Anionic/zwitterionic mixed surfactant system Emulsification Synergistic effect Low permeability reservoir Enhanced oil recovery

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Targeted mutations of BnPAP2 lead to a yellow seed coat in Brassica napus L.

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Journal of Integrative Agriculture 2024年第2期23卷 724-730页

作者： wei Huang Ruyu Jiao Hongtao Cheng Shengli Cai Jia Liu qiong Hu Lili Liu Bao Li Tonghua Wang Mei Li Dawei Zhang Mingli Yan Hunan Research Center of Heterosis Utilization in Rapeseed/Crop Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization/School of Life and Health Science Hunan University of Science and TechnologyXiangtan 411201China Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural Affairs/Oil Crops Research InstituteChinese Academy of Agricultural SciencesWuhan 430062China

The yellow seed trait is preferred by breeders for its potential to improve the seed quality and commercial value of Brassica *** the present study,we produced yellow seed mutants using a CRISPR/Cas9 system when the two BnPAP2 homologs were knocked *** staining of the seed coat demonstrated that proanthocyanidin accumulation was significantly reduced in the pap2 double mutants and decreased specifically in the endothelial and palisade layer cells of the seed *** and metabolite profiling analysis suggested that disruption of the BnPAP2 genes could reduce the expression of structural and regulated genes in the phenylpropanoid and flavonoid biosynthetic *** broad suppression of these genes might hinder proanthocyanidin accumulation during seed development,and thereby causing the yellow seed trait in *** results indicate that BnPAP2 might play a vital role in the regulatory network controlling proanthocyanidin accumulation.

关键词： yellow seed BnPAP2 proanthocyanidins CRISPR/Cas9

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A Limit Problem Involving the *** Square Complementary

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Chinese Quarterly Journal of Mathematics 2010年第2期25卷 168-171页

作者： LIU Miao-hua WANG wei-qiong College of Science Air Force University of Engineering Xi＇an 710051 China College o.f Science Chang＇an University Xi＇an 710064 China

这份报纸的主要目的正在使用基本方法学习包含 *** 方形的互补数字的一个限制问题，并且获得它的限制价值。

关键词：吝啬的价值 asymptotic 公式限制

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乡村非农就业水平的时空格局及动态演进——以青海省为例

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干旱区地理 2023年第12期46卷 2111-2119页

作者：高福鑫赵玲魏琼青海大学财经学院青海西宁810016

为了准确把握县域尺度下青海省乡村非农就业水平的时空格局及动态演进趋势,促进共同富裕的实现,基于2010—2020年青海省43个县域单元的面板数据,借助全局趋势分析、标准差椭圆、Moran’s I指数等方法揭示青海省乡村非农就业水平的时空... 详细信息

为了准确把握县域尺度下青海省乡村非农就业水平的时空格局及动态演进趋势,促进共同富裕的实现,基于2010—2020年青海省43个县域单元的面板数据,借助全局趋势分析、标准差椭圆、Moran’s I指数等方法揭示青海省乡村非农就业水平的时空演变特征,并进一步采用Kernel密度估计、马尔科夫链考察其动态演进趋势。结果表明:(1)青海省乡村非农就业水平总体呈现出波动上升趋势,根据增长速度划分为快速增长阶段和缓慢增长阶段。(2)在空间分布格局上,空间分布整体表现为“东、西部高中部低”“北高南低”,空间格局呈现出由“正东—正西”分布向“偏东北—偏西南”方向偏移趋势。(3)在空间相关性上,乡村非农就业水平存在显著的空间正自相关性,“高-高”集聚和“低-低”集聚的板块特征显著。(4)在分布动态演进上,乡村非农就业水平存在稳定的俱乐部趋同现象,乡村非农就业水平在发展过程中存在“空间溢出”效应。

关键词：乡村非农就业水平共同富裕时空格局动态演进青海省

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Active cell-matrix coupling regulates cellular force landscapes of cohesive epithelial monolayers

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npj Computational Materials 2018年第1期4卷 585-590页

作者： Tiankai Zhao Yao Zhang qiong wei Xuechen Shi Peng Zhao Long-Qing Chen Sulin Zhang Department of Engineering Science and Mechanics Pennsylvania State University University Park PennsylvaniaPA 16802USA Department of Biomedical Engineering Pennsylvania State University University ParkPennsylvaniaPA 16802USA Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPennsylvaniaPA 16802USA

Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic,edge,and interfacial *** we present a molecularly based thermodynamic model,integrating monolayer and substrate elasticity,and force-mediated focal adhesion formation,to elucidate the active biochemical regulation over the cellular force landscapes in cohesive epithelial monolayers,corroborated by microscopy and immunofluorescence *** predicted extracellular traction and intercellular tension are both monolayer size and substrate stiffness dependent,suggestive of cross-talks between intercellular and extracellular *** model sets a firm ground toward a versatile computational framework to uncover the molecular origins of morphogenesis and disease in multicellular epithelia.

关键词： landscape integrating versatile

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai qiong Wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Hemo oxygenase-1 induction in vitro and in vivo can yield pancreas islet xenograft survival and improve islet function

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Chinese Medical Journal 2011年第20期124卷 3378-3385页

作者： CHEN Xi SU Chang ZHANG Zheng-yun ZHANG Ming-jun GU wei-qiong LI Xiao-ying LI Hong-wei ZHOU Guang-wen Department of Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Endocrine and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Surgery Shanghai First Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 China

Background The induced expression of heme oxygenase-1 （HO-1） in donor islets improves allograft survival. Cobalt protoporphyrin （CoPP） could significantly enhance the expression of HO-1 mRNA and protein in rat islet safely. Our work was to study how to protect pancreatic islet xenograft by CoPP-induction. Methods Islet xenografts treated with CoPP-induction and CoPP＋ Zinc protoporphyrin （ZnPP） in vitro and in vivo were randomly transplanted into murine subrenal capsule; then the graft survival time was compared by blood glucose level and pathological examination and meanwhile the interferon ~ （IFN-y）, tumor necrosis factor a （TNF-a）, interleukin 10 （IL-10） and IL-113 level in serum and their mRNA and HO-1 mRNA and protein expression were examined. Results Islets with CoPP-induction under low- and high-glucose stimulation exhibited much higher insulin secretion compared with other three groups. CoPP-induction could increase higher expression of HO-1 （mRNA： 3.33- and 76.09- fold in vitro and in vivo; protein： 2.85- and 58.72-fold）. The normoglycemia time in induction groups （（14.63±1.19） and （16.88±1.64） days） was significantly longer. The pathological examination showed less lymphocyte infiltration in induction groups. The IL-10 level and its mRNA in induction groups were significantly higher. Conclusions The HO-1 induced by CoPP would significantly improve function, prolong normoglycemia time and reduce lymphocyte infiltration. Meanwhile CoPP-induction in vivo had more beneficial effects than in vitro. Its mechanism could be related to immune-modulation of IL-10.

关键词： pancreatic islet transplantation cobalt protoporphyrin xenograft heme oxygenase interleukin 10

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-wei Fan Wan-qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis

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Journal of Geriatric Cardiology 2024年第1期21卷 34-43页

作者： Yong-Gang SUI Cheng YANG Chang-Dong GUAN Yan-Lu XU Na-qiong WU wei-Xian YANG Yong-Jian WU Ke-Fei DOU Yue-Jin YANG Shu-Bin QIAO wei YU Bo XU Sheng-Xian TU Jie QIAN Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for Cardiovascular Diseases BeijingChina

BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fractional flow reserve(FFR)from intravascular ultrasound(IVUS)*** the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)*** This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30%-80%by visual estimation)underwent IVUS and FFR *** independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded *** Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3%diabetes).An acceptable correlation between UFR and FFR was identified(r=0.688,P50%(AUC=0.66,P<0.001)and numerically higher than IVUS-derived MLA(AUC=0.82;P=0.09).Patient level diagnostic accuracy,sensitivity and specificity for UFR to identify FFR≤0.80 was 82.9%(95%CI:70.2-95.7),93.1%(95%CI:82.2-100.0),58.3%(95%CI:26.3-90.4),*** In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard *** present study supports the use of UFR for functional evaluation of intermediate LM stenosis.

关键词： stenosis flow fractional

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On-line Preconcentration and Determination of Trace Metals in Water Samples by Flow Injection Combined with Flame Atomic Absorption Spectrometry via Calix[4]arene Carboxylic Acid Packed Micro-column

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Chemical Research in Chinese Universities 2012年第1期28卷 26-30页

作者： GUO Da-wang, ZHAO Xiao-wei, JIA qiong and ZHOU wei-hong College of Chemistry, Jilin University, Changchun 130012, P. R. China College of Chemistry Jilin University Changchun 130012

An adsorbent calix[4]arene carboxylic acid was employed as the adsorption material for on-line flow in jection（FI） micro-column preconcentration coupled with flame atomic absorption spectrometry（FAAS） determination of trace heavy metals（Cu, Pb, Co, Ni and Cd）. Parameters such as the pH, loading time and flow rate of sample, and the concentration, volume and flow rate of eluent were optimized. The enrichment factors are 50.0, 56.5, 11.6, 12.1 and 19.1 for Cu, Pb, Co, Ni, and Cd, respectively, and a sample throughput of 20 h–1 was obtained. The limits of de tection for Cu, Pb, Co, Ni, and Cd were in a range of 1.56―3.91 μg/L, and the relative standard deviations（RSDs） were less than 2.76%（n=7）. Furthermore, the proposed method was successfully applied to the determination of Cu, Pb, Co, Ni, and Cd in certified reference materials and various water samples.

关键词： Calixarene carboxylic acid Preconcentration Flow injection Metal ion Flame atomic absorptionspectrometry(FAAS)

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