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美日高校职务成果转化的权利配置及启示

宁夏社会科学 2018年第6期 57-64页

作者：魏琼西南交通大学公共管理与政法学院四川成都610031

美日两国高校职务成果转化的权利配置,兼采普通法与特别法配套的外在形式,以激励创新为内在原则;以约定配置为主,以"雇员优先"的法定配置为补充配置职务成果转化前所涉权利,平衡保护双方利益;注重发明人职务成果转化收益奖酬权的现实性... 详细信息

美日两国高校职务成果转化的权利配置,兼采普通法与特别法配套的外在形式,以激励创新为内在原则;以约定配置为主,以"雇员优先"的法定配置为补充配置职务成果转化前所涉权利,平衡保护双方利益;注重发明人职务成果转化收益奖酬权的现实性,并授予高校对受财政资助职务成果的自主支配权。对高校受财政资助职务成果转化,美国授予政府主管机构法定的介入权,日本未授予政府主管机构介入权,而是结合其国情赋予高校独立行政法人的主体地位,并授予职务成果转化前的选择权及对转化收益的自主支配权,设立专门的技术转移机构,给予资金和人力支持。借鉴美日的成功经验,结合本国国情,中国要完善高校职务成果权利配置的规则,宜兼采普通法与特别法相互配套的立法形式,吸收"职务成果混合所有"改革采用的约定配置方式,注重保障发明人获得职务成果转化收益之奖酬权的现实性,赋予高校独立的法律地位,设立并资助专门的技术转移机构。

关键词：职务成果专利转化权利配置特别立法

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巴比伦商事行为规范论考

华东政法学院学报 2007年第1期 147-153页

作者：魏琼华东政法学院法律学院

古代西亚地区两河流域孕育了世界上最早的文明,催生了古老的私有商业经济,买卖、借贷等商业行为得以发展,并生成了诸多商业习俗与商事规范,奠定了美索不达米亚法系的基础。

关键词：美索不达米亚法系楔形文字法典商事行为规范商事原则契据泥板书巴比伦人

民法的诞生——《乌尔纳姆法典》的民事规范解读

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法学论坛 2006年第5期21卷 139-144页

作者：魏琼华东政法学院上海200042

古代西亚地区的《乌尔纳姆法典》对民事关系有着极为丰富的表述。它既代表了古代西亚地区最早法律文明的昌盛水平,也成为探究民法起源时的首要环节。因此,对《乌尔纳姆法典》颁布之前苏美尔城邦的经济交往关系、《乌尔纳姆法典》的民事... 详细信息

古代西亚地区的《乌尔纳姆法典》对民事关系有着极为丰富的表述。它既代表了古代西亚地区最早法律文明的昌盛水平,也成为探究民法起源时的首要环节。因此,对《乌尔纳姆法典》颁布之前苏美尔城邦的经济交往关系、《乌尔纳姆法典》的民事规范以及对后世的影响进行比较系统的梳理,是十分必要的。

关键词：《乌尔纳姆法典》民事规范民法的诞生

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2970-2983页

作者： Qi Yang Bao Xue Fengjiang Liu Yongzhi Lu Jielin Tang Mengrong Yan qiong Wu Ruyi Chen Anqi Zhou Lijie Liu Junjun Liu Changbin Qu Qingxin Wu Muqing Fu Jiayi Zhong Jianwei Dong Sijie Chen Fan Wang Yuan Zhou Jie Zheng wei Peng Jinsai Shang Xinwen Chen Guangzhou National Laboratory Guangzhou 510005China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou 511436China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China GMUGIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou lnstitute for Advanced StudyUCASHangzhou 310024China

Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the *** are currently no approved RSV-specific therapeutic small molecules *** high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion *** exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral ***-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion *** at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody ***,lonafarnib dose-dependently reduced the replication of RSV in BALB/c ***,lonafarnib could be a potential fusion inhibitor for RSV infection.

关键词： neutral metastable approved

A case of multiple system atrophy： onset with the cold hands sign

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Chinese Medical Journal 2011年第11期124卷 1719-1719页

作者： WANG Zhen-fu WANG qiong WU wei-ping Department of Geriatric Neurology. People's Liberation Army General Hospital.Beijing 100853 China

To the Editor： The cold hands sign （CHS） presents a distinct feature in some multiple system atrophy （MSA） patients, but it is receiving little consideration. To our knowledge, there are few reported cases of MS... 详细信息

关键词： multiple system atrophy onset with cold hands sign

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论龙冈四规与龙场悟道及阳明心学的关系

贵阳学院学报（社会科学版） 2022年第5期17卷 84-90页

作者：刘妮曹维琼贵州人民出版社贵州贵阳550081

龙场悟道,是王阳明人生中的大事件,是阳明心学建构的大事件,也是中国思想发展史上的大事件。然而,龙场悟道悟出了什么?却没有一个相对全面、相对完整的答案。以王阳明在贵州龙场龙冈书院发布的龙冈四规为切入点,探究其主旨,探讨其与龙... 详细信息

龙场悟道,是王阳明人生中的大事件,是阳明心学建构的大事件,也是中国思想发展史上的大事件。然而,龙场悟道悟出了什么?却没有一个相对全面、相对完整的答案。以王阳明在贵州龙场龙冈书院发布的龙冈四规为切入点,探究其主旨,探讨其与龙场悟道、与阳明心学的关系,可以由此而得出,龙场悟道,王阳明取得:两个成果:其一,悟出了做人之道,确立了人生三观,实现了人生转折;其二,悟出了做人之学,以人生三论为基础,建构起阳明心学。龙冈四规与龙场悟道的两个成果密不可分,既是阳明三观的重要支柱,又是阳明心学的重要内容,值得认真研习。

关键词：龙冈四规龙场悟道阳明心学研究

XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping Wang Wen-wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-Jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

基于网络药理学研究枸杞提取液对肠道致病菌的影响

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食品工业科技 2024年第2期45卷 12-20页

作者：李倩廖嘉宁魏媛王贞香安琼河西学院医学院甘肃省河西走廊特色资源利用重点实验室甘肃张掖734000

目的:采用网络药理学分析方法研究枸杞的抑菌作用机制,并进行体外抑菌实验验证。方法:用中药系统药理学在线分析数据库TCMSP筛选出枸杞活性成分及其作用靶点。以“抑菌”为关键词在GeneCards、DisGeNET数据库检索相关靶点。通过Venny平... 详细信息

目的:采用网络药理学分析方法研究枸杞的抑菌作用机制,并进行体外抑菌实验验证。方法:用中药系统药理学在线分析数据库TCMSP筛选出枸杞活性成分及其作用靶点。以“抑菌”为关键词在GeneCards、DisGeNET数据库检索相关靶点。通过Venny平台获取枸杞和抑菌的交集靶点。使用STRING数据库结合Cytoscape软件构建PPI网络并筛选关键靶点。运用Metascape数据库进行GO功能富集和KEGG通路富集分析。枸杞经过80%乙醇提取,浓缩至浸膏,分别用石油醚、二氯甲烷、乙酸乙酯和正丁醇萃取,得到枸杞的不同极性部位,用滤纸片法测定枸杞不同极性部位的抑菌作用。结果:共筛选到活性成分26个,药物潜在靶点368个,抑菌靶点2212个,药物与抑菌作用交集靶点73个。蛋白互作网络分析显示TNF、AKT1、EGFR、HSP90AA1、PTGS2、PPARG等69个蛋白可能是枸杞抑菌作用的关键靶点。GO富集分析显示枸杞抑菌主要通过对外源性刺激的反应、基因表达正调控、一氧化氮生物合成过程的正向调控等。KEGG分析表明枸杞的抑菌可能与癌症信号通路、C型凝集素受体信号通路、脂质与动脉粥样硬化等信号通路有关。体外抑菌实验结果显示,枸杞提取物的不同极性部位对金黄色葡萄球菌和大肠杆菌均有抑制作用,乙酸乙酯部位对大肠杆菌的抑制作用最强,正丁醇部位对金黄色葡萄球菌的抑制作用最强。乙酸乙酯部位对大肠杆菌的最低抑菌浓度为0.125 mg/mL,正丁醇部位对金黄色葡萄球菌的最低抑菌浓度为0.25 mg/mL。结论:枸杞提取液对金黄色葡萄球菌和大肠大肠杆菌有抑制作用。枸杞可以通过多成分、多靶点、多通路的作用机制发挥抑菌作用。

关键词：枸杞网络药理学不同极性部位抑菌活性

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Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-qiong Zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu Shuo-Hua Chen Jost B Jonas Wen-Bin wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination