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Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： Hui-Hui LIU Meng ZHANG Yuan-Lin GUO Cheng-Gang ZHU Na-qiong WU Ying GAO Rui-Xia XU Jie QIAN Ke-Fei DOU Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are ***,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with *** In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were *** admission,ABG,SHR,and GG were assessed and all participants were classified according to their ***-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term *** During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were ***-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and *** adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term ***,we observed similar associations of these acute glycemic parameters with 30-day *** Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

采用高精度地球重力场模型计算垂线偏差及隧道贯通误差

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武汉大学学报(信息科学版) 2024年第10期49卷 1922-1930页

作者：李敏李琼苏勇西南石油大学土木工程与测绘学院武汉大学测绘学院湖北珞珈实验室中国科学院精密测量科学与技术创新研究院大地测量与地球动力学国家重点实验室

高精度、高分辨率地球重力场模型可用来获取全球或区域垂线偏差，利用3组最大阶数为2 190阶的超高阶高精度重力场模型(GECO模型、EIGEN-6C4模型和SGG-UGM-2模型)计算了西部重要交通枢纽工程沿线区域尤其是规划站点的垂线偏差，针对重点... 详细信息

高精度、高分辨率地球重力场模型可用来获取全球或区域垂线偏差，利用3组最大阶数为2 190阶的超高阶高精度重力场模型(GECO模型、EIGEN-6C4模型和SGG-UGM-2模型)计算了西部重要交通枢纽工程沿线区域尤其是规划站点的垂线偏差，针对重点隧道区域，计算分析了不同的洞外控制点高度角条件下垂线偏差带来的隧道贯通误差影响。结果表明，采用3组地球重力场模型获取的西部重要交通枢纽工程沿线区域垂线偏差的子午圈分量为20″左右，卯酉圈分量小于1″，且3组模型计算的垂线偏差卯酉圈分量差异小于0.04″，而子午圈分量差异小于0.6″。针对工程中规划的6个重要隧道设计的实验结果表明，当洞外控制点高度角分别为45o、35o、25o、15o时，垂线偏差对横向贯通误差影响值分别约为180、130、100、70 mm。因此，隧道外控制点高度角大小能直接决定垂线偏差对隧道横向贯通误差的影响，在实际施工过程中应尽量保证将隧道外控制点埋设在等高面上，若由于地形条件等影响无法调整控制点间高度角，则必须进行垂线偏差改正，以削弱贯通误差的影响，保证隧道的顺利贯通。

关键词：重力场模型垂线偏差贯通误差西部重要交通枢纽工程

桃李满天下的马克思主义经济学家——宋涛学术成就及影响述评

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中国人民大学学报 2024年第3期38卷 172-175页

作者：李琼中国人民大学经济学院

宋涛是我国卓越的经济学家和杰出的教育家、新中国马克思主义政治经济学学科创始人,也是新中国以马克思主义为指导的理论经济学学科开拓者和奠基者之一。他主持创建并长期领导中国人民大学经济学科教学与研究工作,全国高校从事政治经济... 详细信息

宋涛是我国卓越的经济学家和杰出的教育家、新中国马克思主义政治经济学学科创始人,也是新中国以马克思主义为指导的理论经济学学科开拓者和奠基者之一。他主持创建并长期领导中国人民大学经济学科教学与研究工作,全国高校从事政治经济学教学与研究的人员中有相当多的是宋涛的学生,中国人民大学政治经济学学科成为中国传播、普及和学习研究《资本论》和马克思主义经济学的师资摇篮与大本营。宋涛一生爱党爱国,坚持马克思主义。

关键词：中国人民大学经济学学科学术成就马克思主义政治经济学教学与研究马克思主义经济学教育家

A medium chain fatty acid, 6-hydroxyhexanoic acid (6-HHA), protects against obesity and insulin resistance

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1892-1894页

作者： Sara C.Sebag Meihua Hao Qingwen Qian Chawin Upara qiong Ding Min Zhu Jeffrey A.Banas Huojun Cao Liu Hong Ling Yang Department of Anatomy and Cell Biology University of Iowa Carver College of MedicineIowa CityIA 52242USA Fraternal Order of Eagles Diabetes Research Center University of Iowa Carver College of MedicineIowa CityIA 52242USA Pappajohn Biomedical Institute University of Iowa Carver College of MedicineIowa CityIA 52242USA Iowa Institute for Oral Health Research University of Iowa College of DentistryIowa CityIA 52242USA

To the Editor,Obesity,one of the most serious health concerns worldwide,exacerbates periodontitis pathogenesis and reduces the effectiveness of ***,periodontitis-associated inflammation disrupts systemic lipid and glucose homeostasis,the major risk factors for developing obesity-associated *** studies have demonstrated that certain supplemental dietary lipids such as dietary polyunsaturated fatty acids,have beneficial outcomes for diabetic and obese *** addition to dietary lipid supply,the oral and gut microbiota produce fatty acids(FAs)which provide the host with essential nutrients and aid in defense against *** medium chain FAs(MCFAs;6–12 carbons)are bacterial-derived lipids shown to have anti-inflammatory and insulin sensitization effects in diverse cell types such as ***,whether and to what extent oral microbiota-produced MCFAs may ameliorate obesity-associated metabolic dysfunction are largely unknown.

关键词： obesity dietary lipids

吸入制剂生物等效性试验中受试者管理的关键要素

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中国临床药理学杂志 2024年第9期40卷 1360-1362页

作者：王晶晶张菁魏琼曹钰然复旦大学附属华山医院临床药理研究中心上海200040

经口吸入制剂由于自身的特殊性和给药复杂性,其仿制药生物等效性试验在临床实施过程中比一般的口服给药难度大,尤其体现在受试者自主进行吸入给药过程中可能产生的偏差。因此在经口吸入制剂临床试验中受试者的管理尤为重要。本文基于研... 详细信息

经口吸入制剂由于自身的特殊性和给药复杂性,其仿制药生物等效性试验在临床实施过程中比一般的口服给药难度大,尤其体现在受试者自主进行吸入给药过程中可能产生的偏差。因此在经口吸入制剂临床试验中受试者的管理尤为重要。本文基于研究团队完成的经口吸入制剂生物等效性试验经验,探讨做好临床试验中受试者管理的关键要素及措施,旨在提高吸入制剂仿制药一致性评价中研究者的临床实施能力,确保临床试验质量。

关键词：经口吸入制剂生物等效性试验受试者管理

Cretaceous crown male ant reveals the rise of modern lineages

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Zoological Research 2024年第5期45卷 983-989页

作者： qiong Wu Alexander G.Radchenko Michael S.Engel Xiao-Qin Li Hong-Ru Yang Xing-Ru Li Chung-Kun Shih Dong Ren Tai-Ping Gao College of Life Sciences Capital Normal UniversityBeijing 100048China I.I.Schmalhausen Institute of Zoology NAS of UkraineKiev 01054Ukraine Division of Invertebrate Zoology American Museum of Natural HistoryNew York 10024-5192USA Facultad de Ciencias Biológicas Universidad Nacional Mayor de San MarcosLima 11-0058Perú Departamento de Entomología Museo de Historia NaturalUniversidad Nacional Mayor de San MarcosLima 15072Perú Department of Chemistry Analytical and Testing CenterCapital Normal UniversityBeijing 100048China Department of Paleobiology National Museum of Natural HistorySmithsonian InstitutionWashington DC 20013-7012USA

Most described Mesozoic ants belong to stem groups that existed only during the Cretaceous ***,the earliest known crown ants were dated to the Turonian(Late Cretaceous,ca.94-90 million years ago(Ma))deposits found in the USA,Kazakhstan,and ***,the recent discovery of an alate male ant in Kachin amber from the earliest Cenomanian(ca.99 Ma),representing a new genus and species,Antiquiformica alata,revises the narrative on ant *** can be distinctly differentiated from all known male stem ants by its geniculate antennae with elongated scape,extending far beyond the occipital margin of the head and half the length of the funiculus,as well as its partly reduced forewing ***,the combination of a one-segmented waist with a well-developed node,elongated scape extending beyond the occipital margin,and reduced forewing venation,particularly the completely reduced m-cu and rs-m crossveins and absence of rm and mcu closed cells,firmly places the fossil within the extant subfamily *** transform infrared spectroscopy(FTIR)confirmed that the amber containing Antiquiformica alata originated from the Kachin mines in *** discovery significantly revises our understanding of the early evolution of *** presence of Antiquiformica in Cenomanian amber indicates that the subfamily Formicinae emerged at least by the start of the Late Cretaceous,with crown ants likely originating earlier during the earliest Cretaceous or possibly the Late Jurassic,although paleontological evidence is lacking to support the latter hypothesis.

关键词： Formicidae Formicinae Morphology Taxonomy Antiquiformica alata Paleontology Kachin amber

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

Ternary-phase layered cathodes toward ultra-stable and highrate sodium ion storage

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Rare Metals 2024年第4期43卷 1589-1598页

作者： Wen-Ji Yin Pei-Dan Su Qi Lu Xiao-qiong Li Ji-Ming Peng Teng-Fei Zhou Ge-Meng Liang Yu-Liang Cao Hong-Qiang Wang Qing-Yu Li Si-Jiang Hu Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin541004China Institutes of Physical Science and Information Technology Anhui UniversityHefei230601China Department of Chemistry and Pharmaceutical Sciences Guilin Normal CollegeGuilin541199China College of Chemistry and Chemical Engineering Huanggang Normal UniversityHuanggang438000China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide5005Australia Engineering Research Center of Organosilicon Compounds and Materials of Ministry of Education College of Chemistry and Molecular SciencesWuhan UniversityWuhan430072China

With the shortage of lithium resources,sodiumion batteries(SIBs)are considered one of the most promising candidates for lithium-ion batteries.P2-type and O3-type layered oxides are one of the few cathodes that can access high energy ***,they usually exhibit structural change,capacity decay,and slow Na ion ***,we present layered ternary-phase cathodes with P2,P3 and O3 phases by a lattice doping strategy,which is demonstrated by X-ray diffraction(XRD)*** the characteristics of P2,P3 and O3 phases,the layered composites show performance improvement during long-term battery *** particular,Na_(0.7)Li_(0.1)Co_(0.3-)Fe_(0.3)Mn_(0.3)O_(2)(NLCFM)delivers a reversible capacity of120.1 mAh·g^(-1)at 0.1C(1.0C=175 mA·g^(-1))with a superior capacity retention of 72.5%after 1000 cycles *** work offers insights into the development of advanced cathode materials for SIBs.

关键词： Sodium-ion battery Cathode material Layered oxides Lattice doping Mixed phase

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生物育种新品种市场推广策略与消费者接受度

分子植物育种 2024年第13期22卷 4492-4499页

作者：闫琼河南工业贸易职业学院工商管理学院郑州451191

生物育种新品种是推动农业可持续发展、保障全球粮食安全的关键因素。本研究对生物育种新品种的消费者接受度与市场推广策略进行了深入研究,系统介绍了生物育种新品种的发展背景和消费者接受度与市场推广的重要性,并从消费者接受度和市... 详细信息

生物育种新品种是推动农业可持续发展、保障全球粮食安全的关键因素。本研究对生物育种新品种的消费者接受度与市场推广策略进行了深入研究,系统介绍了生物育种新品种的发展背景和消费者接受度与市场推广的重要性,并从消费者接受度和市场推广策略两个方面进行了详细阐述,分析了影响消费者接受度的主要因素,并提出了提高消费者接受度的策略。同时,本研究还探讨了市场推广的基本概念、原则、手段、方式以及针对生物育种新品种的推广策略,并对市场推广效果进行了评价与优化;通过理论分析和实证研究,不仅丰富了相关领域的理论体系,还为实际操作提供了有益的指导,以期为生物新品种推广、企业战略规划、政府决策和学术研究提供参考。

关键词：生物育种新品种消费者接受度市场推广影响因素