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Chinese Chemical Letters 2022年第1期33卷 11-21页

作者： Binfen Zhao Liyan jiang qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

Over the past few decades,supramolecular chemistry has entered the field of scientific research and attracted extensive *** supramolecular macrocycles,cyclodextrins(CDs)are widely applied in the field of adsorption due to their unique structure and *** review focuses on the important role of cyclodextrin polymers(CDPs)as adsorbents in the adsorption of different *** covers the category of CDPs adsorbents(including crosslinked CDPs,grafted CDPs,CD-based polyrotaxanes/pseudopolyrotaxanes,and imprinted CDPs),their adsorption mechanism and applications in the adsorption of inorganic metal ions,organic pollutants,and ***,the challenges and future perspectives in relative research fields are discussed.

关键词： Cyclodextrin polymer Adsorption Inorganic metal ions Organic pollutants Biomacromolecules Review

Application of magnetic solid phase extraction in separation and enrichment of glycoproteins and glycopeptides

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Chinese Chemical Letters 2021年第9期32卷 2629-2636页

作者： He Qi Liyan jiang qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

The analysis of endogenous glycoproteins and glycopeptides in human body fluids is of great importance for screening and discovering disease biomarkers with clinical ***,the presence of interfering substances makes the direct quantitative detection of low-abundance glycoproteins and glycopeptides in human body fluids one of the great challenges in analytical *** solid phase extraction(MSPE)has the advantages of easy preparation,low cost and good magnetic *** adsorbents are the core of MSPE technology,and magnetic adsorbents based on different functional materials are widely used in the quantitative analysis of glycoproteins and glycopeptides in human body fluids,making it possible to analyze glycoproteins and glycopeptides with low abundance as well as multiple types,which provides a technical platform for screening and evaluating glycoproteins and glycopeptides in body fluids as disease *** this paper,we focus on the recent advances in the application of MSPE technology and magnetic adsorbents for the separation and enrichment of glycoproteins and glycopeptides in human body fluids,and the future trends and application prospects in this field are also presented.

关键词： Glycoproteins Glycopeptides Magnetic solid phase extraction(MSPE) Separation Enrichment Human body fluids

A subspace ensemble regression model based slow feature for soft sensing application

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3061-3069页

作者： qiong jia Jun Cai Xinyi jiang Shaojun Li Key Laboratory of Advanced Control and Optimization for Chemical Processes East China University of Science and TechnologyMinistry of EducationShanghai 200237China

A novel adaptive subspace ensemble slow feature regression model was developed for soft sensing *** to traditional single models and random subspace models,the proposed method is improved in three ***,sub-datasets are constructed through slow feature directions and variables in each subdatasets are selected according to the output related importance ***,an adaptive slow feature regression is presented for ***,a Bayesian inference strategy based on a slow feature analysis process that monitors statistics is developed for probabilistic *** industrial examples were used to evaluate the proposed method.

关键词： Soft sensing Slow feature regression Subspace modeling Ensemble learning

Hydrophilic adamantane derivatives engineered β-cyclodextrin-based self-assembly materials for highly efficient enrichment of glycopeptides

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Chinese Chemical Letters 2023年第3期34卷 283-287页

作者： Ping Li Zheng Li Dawei Zhang qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education College of Life SciencesJilin UniversityChangchun 130012China

β-Cyclodextrin(β-CD) based materials have attracted great attention in the separation of hydrophilic glycopeptides due to the abundant hydroxyl groups in its exterior. However, the current materials based on β-CD generally has complex synthesis process and harsh experimental conditions, on the other hand,the interior cavity of β-CD is hydrophobic and is harmful to capture glycopeptides. Herein, a novel hydrophilic material based on β-CD was engineered via a self-assembly process utilizing L-cysteine(L-Cys)or glutathione(GSH) derived adamantane for highly efficient glycopeptide enrichment. It is the first attempt to make use of the hydrophobic interior cavity of β-CD for hydrophilic glycopeptide capture. Taking advantages of strong hydrophilicity and superparamagnetism, the as-prepared materials possess low detection limit, high selectively, and excellent reusability when employed to glycopeptide enrichment. In addition, the feasibility of the hydrophilic material based on β-CD was verified by enriching glycopeptides from human serum and saliva samples. This study provides a heuristic strategy for the application of β-CD-based self-assembly materials in the enrichment of glycopeptides. Importantly, this strategy certified a possible that the change of glycopeptide enrichment sites through host-guest interaction between β-CD and adamantane derivatives with different functional groups.

关键词： β-Cyclodextrin Hydrophilic Self-assembly Enrichment Glycopeptides

Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment

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Chinese Chemical Letters 2024年第7期35卷 222-226页

作者： Rui Wang He Qi Haijiao Zheng qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

Metal-organic frameworks(MOFs)combined with specific ligands are highly adaptable smart materials that can respond to external and physiological *** this study,we introduced a pyridinyl zwitterionic ligand with light/pH dual response into magnetic MOF composite(Fe_(3)O_(4)@ZW-MOF)for enrichment of phosphorylated peptides for the first *** introduction of the developed ligand gives MOF material dual response *** stimulation affects the generation/disappearance of free radicals of the pyridine derivative,resulting in a change in the charge gradient of the zwitterion,and zwitterion can also regulate the p H of the solution by adding acid or ***,the reversible capture and release of phosphorylated peptides can be easily achieved by adjusting light and *** established phosphorylated peptide enrichment platform exhibits high sensitivity(detection limit of 1 fmol),high selectivity(β-casein:BSA,1:1000),and good reusability(7 cycles).In addition,the method was applied to the enrichment of phosphorylated peptides in complex systems(non-fat milk and human serum),demonstrating the feasibility of this method for phosphoproteom *** conclusion,the synthesized Fe_(3)O_(4)@ZW-MOF is a promising MOF material,which provides the possibility to advance the application of responsive MOFs materials in proteomics.

关键词： Light pH Dual-response Metal-organic frameworks Phosphorylated peptide

Design and fabrication of highly hydrophilic magnetic material by anchoring L-cysteine onto chitosan for efficient enrichment of glycopeptides

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Chinese Chemical Letters 2023年第3期34卷 148-152页

作者： Binfen Zhao Wenhui Xu Jiutong Ma qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

Hydrophilic interaction liquid chromatography(HILIC) has been recognized as an effective strategy for glycopeptide enrichment. Hydrophilic materials pave the way to solve the limit of low enrichment capacity and poor selectivity. The present study is the first attempt to combine chitosan(CS) and L-cysteine(L-Cys) to design a novel hydrophilic material focusing on glycopeptide enrichment. CS containing a large number of hydrophilic amino and hydroxyl groups has unique chemical properties, which makes it a very attractive biomaterial for glycopeptide enrichment. The excellent hydrophilicity of zwitterionic molecule L-Cys inspires the idea of anchoring L-Cys onto CS to design a novel hydrophilic material(named as Fe_(3)O_(4)@CS@Au-L-Cys) for the capture of low abundance glycopeptides. To be specific, Au nanoparticles(Au NPs) was introduced into CS-coated Fe_(3)O_(4)via electrostatic interaction and served as bridges to anchor L-Cys onto the surface of CS through strong Au-S bond interaction. The prepared Fe_(3)O_(4)@CS@AuL-Cys exhibited strong affinity, low detection limit(0.5 fmol/μL HRP), high selectivity(HRP/BSA with a molar ratio of 1:1000) for glycopeptides. Moreover, successful application of glycopeptide enrichment in human serum and saliva by Fe_(3)O_(4)@CS@Au-L-Cys was achieved. A satisfactory data set indicates that Fe_(3)O_(4)@CS@Au-L-Cys has promising potential in the application of glycopeptide enrichment in real complex bio-samples and for related glycoproteome research.

关键词： Chitosan L-cysteine Hydrophilic material Glycopeptide Enrichment

A one-pot synthesis of a self-included bisester-functionalized copillar[5]arene

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Chinese Chemical Letters 2019年第3期30卷 721-724页

作者： qiong jia Xusheng Du Chunyu Wang Kamel Meguellati International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC) College of Chemistry Jilin University State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University

We report here a one-pot synthetic method for the synthesis of a bisester-functionalized copillar[5]arene(BECP5A) with yield up to 20%. The properties of BECP5A in solution and in solid state were deeply investigated with the aid of 1D and 2D NMR spectra and X-ray diffraction, showing that this molecule has a fully self-included conformation in chloroform and partial self-inclusion in DMSO, and the compound has an asymmetrical structure with only one self-included side in the cavity of pillar[5]arene in the solid state. This compound will be used as the precursor of complex systems such as polymers and mechanically interlocked molecules.

关键词： Pillararene One-pot reaction Ester group Supramolecular chemistry X-ray crystal structure

Facile preparation of hydrophilic glutathione modified magnetic nanomaterials for specific enrichment of glycopeptides

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Chinese Chemical Letters 2019年第12期30卷 2181-2185页

作者： He Qi Zheng Li Haijiao Zheng Li Fu qiong jia College of Chemistry Jilin UniversityChangchun 130012China The Second Hospital of Jilin University Changchun 130041China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

Investigations of glycosylated proteins or peptides and their related biological pathways provide new possibilities for illuminating the physiological and pathological mechanisms of glycosylation ***,open-ended and in-depth analysis of glycoproteomics is usually subjected to the low-abundance of glycopeptides,heterogeneous glycans,and a variety of interference *** order to alleviate the influence of these obstacles,effective preconcentration of glycopeptides are ***,we employed a hydrophilic interaction liquid chromatography(HILIC)-based method to universally capture *** modified magnetic nanoparticles(Fe304@AuGSH) were synthesized through a simple process and exploited to enrich glycopeptides from complex *** prepared materials showed excellent ability to trap glycopeptides from standard glycoproteins digests,low detection limit(10 fmol/p L),and good selectivity(HRP:BSA=1:100).These results indicated that glutathione-based magnetic nanoparticles synthesized in this work had great potential for glycopeptides enrichment.

关键词： Hydrophilic Glutathione Magnetic Enrichment Glycopeptides

Preparation of Cerium Dioxide Functionalized Magnetic Layered Double Hydroxides for High-efficiency Phosphopeptide Enrichment

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Chemical Research in Chinese Universities 2023年第2期39卷 253-259页

作者： jiaNG Dandan QI Ruixue LYU Siqi WANG Wei LIU Jinghai jia qiong College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Carbon NanomaterialsInner Mongolia Minzu UniversityTongliao028000P.R.China College of Chemistry Jilin UniversityChangchun130012P.R.China

In this work,we prepared a material with magnetic nanoparticles(Fe_(3)O_(4))as core,layered double hydroxides(LDHs)as affinity shell,and cerium dioxide(CeO_(2))as functional molecules(denoted as Fe_(3)O_(4)@LDH-CeO_(2)).On the basis of combined immobilized metal ion affinity chromatography(IMAC)and metal oxide affinity chromatography(MOAC),Fe_(3)O_(4)@LDH-CeO_(2) was used to enrich phosphopeptides with high *** material exhibited high selectivity(α-casein:β-casein:BSA=1:1:5000,mass ratio),high recovery(95.87%),and good reusability of 10 times adsorption-desorption *** feasibility of Fe_(3)O_(4)@LDH-CeO_(2) was further investigated by extracting phosphopeptides from biological samples(nonfat milk,serum,saliva,and A549 cell lysate).

关键词： Layered double hydroxide Cerium dioxide Magnetic Phosphopeptide enrichment

Carbon emission reduction: Contribution of geothermal energy and practice in China

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China Geology 2024年第1期7卷 161-164页

作者： Liang Wang Li-qiong jia Natural Resources Integrated Survey Command Center China Geological SurveyMinistry of Natural ResourcesBeijing 100055China Development and Research Center China Geological SurveyMinistry of Natural ResourcesBeijing 100037China

As a kind of natural energy from the earth’s interior,geothermal energy is characterized by large reserve,wide distribution,good stability,high utilization coefficient,and positive effects of energy-saving and *** is of great significance for promoting green and low-carbon energy transition,reducing greenhouse gas emission,and achieving global climate goals and sustainable economic ***,it has been highly recognized and valued by lots of countries around the world,and has become one of the most important clean energy sources that countries are accelerating to develop and *** potential of the global geothermal energy resource is estimated to be 1.25×1027 J,equivalent to 4.27×10^(16) t of standard coal,among which the geothermal resource between 0 km and 5 km is 1.45×10^(26) J,equivalent to 4.95×1015 t of standard coal(China Geological Survey,2018).

关键词： energy utilize interior