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Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies

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Neuroscience Bulletin 2019年第2期35卷 253-266页

作者： qiong-Bin zhu Ai-Min Bao Dick Swaab Department of Neurology Sir Run Run Shaw HospitalZhejiang University School of Medicine Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Zhejiang University School of Medicine Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences

Alzheimer's disease(AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased as ‘use it or lose it'. Our hypothesis proposes that(1) during their functioning, neurons are damaged;(2)accumulation of damage that is not repaired is the basis of aging;(3) the vulnerability to AD is determined by the genetic background and the balance between the amount of damage and the efficiency of repair, and(4) by stimulating the brain, repair mechanisms are stimulated and cognitive reserve is increased, resulting in a decreased rate of aging and risk for AD. Environmental stimulating factors such as bilingualism/multilingualism, education, occupation, musical experience, physical exercise, and leisure activities have been reported to reduce the risk of dementia and decrease the rate of cognitive decline, although methodological problems are present.

关键词： Dementia Genes Environmental stimulation Brain activation Cognitive reserve Use it or lose it

Efficacy evaluation of intravitreal ranibizumab therapy for three types of retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 753-759页

作者： qiong Zou Yan-qiong zhu Feng-Jun Zhang Qiu-Ping Liu Affiliated Eye Hospital of Nanchang University NanchangJiangxi ProvinceChina

AIM:To evaluate efficacy of intravitreal ranibizumab(IVR)therapy for aggressive posterior retinopathy of prematurity(ROP),threshold ROP disease and type 1 pre-threshold ***:A retrospective analysis was performed on 40 patients(76 eyes)who had IVR as the primary treatment for ROP from April 2017 to January *** to disease pathogenic features,the 76 eyes were divided into three groups:aggressive posterior ROP(AP-ROP)group(16 eyes),threshold ROP group(28 eyes)and type 1 pre-threshold ROP group(32 eyes).The characteristics of patients and lesions situation before the first intravitreal injection,and posttreatment fundus outcomes determined by wide-angle Ret Cam fundus imaging were ***:The birth weight and postmenstrual age of first IVR treatment in AP-ROP,threshold ROP,and type 1 pre-threshold ROP groups were significant difference(1087.50±246.78,1103.75±168.30,1257.03±210.82 g,P=0.005;34.50±1.46,36.89±2.97,36.50±2.36 wk,P=0.008),while the gestational age was not difference(28.00±2.00,28.54±1.90,28.59±1.43 wk,P=0.510).The retina hemorrhage ratio(with/without:14/2,8/20,5/27),iris neovascularization or vascular engorgement ratio(with/without:12/4,11/17,6/26),and the zone I(inside/outside:16/0,2/26,5/27)in AP-ROP,threshold ROP,and type 1 pre-threshold ROP group were difference significantly(all P<0.05).The regression rates were 37.5%,92.86%,and 100%,and the recurrence rates were 62.5%,7.14%,and 0 in AP-ROP,threshold ROP,and type 1 pre-threshold ROP group,respectively(both P<0.05).The recurrence eyes were cured by secondary IVR or retinal laser ***:IVR is an effective treatment for all types of *** regression of AP-ROP is significantly lower than type 1 pre-threshold and threshold *** weight,retinal hemorrhage,iris neovascularization or vascular engorgement and lesions located in zone I may be associated with AP-ROP recurrence and retreatment,which should be noted in follow-up.

关键词： retinopathy of prematurity ranibizumab intravitreal injection

Properties and feasibility of using cancer stem cells in clinical cancer treatment

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Cancer Biology & Medicine 2016年第4期13卷 489-495页

作者： Xiao-Mei Gao Rui Zhang qiong-zhu Dong Lun-Xiu Qin Institutes of Biomedical Sciences Fudan University Department of General Surgery Huashan Hospital and Cancer Metastasis Institute Fudan University

Cancer treatment failure, drug resistance, or metastatic recurrence are thought to be caused mainly by the existence of a very small number of cancer stem cells(CSCs). The characteristics of this subgroup of cells include self-renewal, tumorigenesis, multiple differentiation and high invasiveness, metastasis, and drug resistance potential. Many studies have demonstrated that CSCs play important roles in tumor growth, spread and metastatic relapse after treatment, and are closely related to the prognosis of *** a therapeutic viewpoint, deep insights into the CSCs biology, development of specific therapeutic strategies for targeting CSCs, and characterization of their microenvironment could be an ideal way to combat cancer.

关键词： Cancer stem cells cancers treatment failure metastasis cancer therapy

Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

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World Journal of Gastroenterology 2016年第10期22卷 3038-3051页

作者： Zheng Wang Yuan-Yuan Sheng qiong-zhu Dong Lun-Xiu Qin Department of Surgery Huashan HospitalFudan University Institute of Biomedical Sciences Fudan University

AIM: To identify the prognostic value of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections in patients with intrahepatic ***: A search was performed for relevant publications in Pub Med, EMBASE and Web of Science databases. The pooled effects were calculated from the available information to identify the relationship between HBV or HCV infection and the prognosis and clinicopathological features. The χ2 and I2 tests were used to evaluate heterogeneity between studies. Pooled hazard ratios(HRs) with 95% confidence intervals(CIs) were calculated by a fixed-effects model, if no heterogeneity existed. If there was heterogeneity, a random-effects model was ***: In total, 14 studies involving 2842 cases were enrolled in this meta-analysis. The patients with HBV infection presented better overall and diseasefree survival, and the pooled HRs were significant at 0.76(95%CI: 0.70-0.83) and 0.78(95%CI: 0.66-0.94), respectively. Additionally, our study revealed that HCV infection was correlated with shortened overall survival in comparison with the control group(HR = 2.64, 95%CI: 1.77-3.93). We also found that HBV infection occurred more frequently in male patients [odds ratio(OR) = 1.91, 95%CI: 1.06-3.44] and was correlated with higher levels of serum aspartate transaminase(AST) and alpha-fetoprotein(AFP)(OR = 1.93, 95%CI: 1.11-3.35; OR = 3.86, 95%CI: 2.58-5.78) and a lower level of serum carbohydrate antigen 19-9(CA19-9)(OR = 0.47, 95%CI: 0.34-0.65). Moreover, HBV infection was associated with cirrhosis(OR = 6.44, 95%CI: 4.33-9.56), a higher proportion of capsule formation(OR = 6.04, 95%CI: 3.56-10.26), and a lower rate of lymph node metastasis(OR = 0.39, 95%CI: 0.25-0.58). No significant publication bias was seen in any of the enrolled ***: HBV infection may indicate a favorable prognosis in patients with intrahepatic cholangiocarcinoma, while HCV infection suggests a poor prognosis.

关键词： Hepatitis B virus Hepatitis C virus Clinical features Intrahepatic cholangiocarcinoma Prognosis

CALPHAD modeling of molar volume

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Chinese Science Bulletin 2014年第15期59卷 1646-1651页

作者： Yan-Lin He Xiao-Gang Lu Na-qiong zhu Bo Sundman School of Materials Science and Engineering Shanghai University CEA Saclay INSTN Gif-sur-Yvette 91191 France

Databases concerning basic physical properties of materials,such as molar volume,density,thermal expansion coefficient,elastic constants,thermal conductivity,etc.,are essential parts of the underlying knowledge for materials *** thermodynamic databases provide chemical driving forces and phase equilibrium data,physical property databases provide essential physical parameters,such as volume,lattice constant,lattice misfit,elastic energy,interfacial energy,etc.,for phase transformation and microstructure *** with thermodynamic databases,physical property databases established on the basis of the calculation of phase diagram(CALPHAD)method can be used to calculate physical properties together with phase equilibria,phase fractions,phase compositions,and thermodynamic properties for multi-component and multi-phase material systems and for the constituent *** this paper,we will discuss in detail various volume models based on the CALPHAD method which are capable of describing experimental data in a wide range from cryogenic temperatures to melting points,from the atmospheric pressure to high pressures for pure substances as well as multi-component and multiphase materials.

关键词：计算模型摩尔体积相图计算热力学数据库相平衡数据属性数据库物理性质材料设计

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo

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Military Medical Research 2022年第3期9卷 331-350页

作者： Ying He Xun-Hu Dong qiong zhu Ya-Li Xu Ming-Liang Chen Zheng Liu Department of Ultrasound Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing400037China Department of Chemical Defense Medicine School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Toxicology School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Background:Ultrasound-triggered microbubble destruction(UTMD) is a widely used noninvasive technology in both military and civilian medicine,which could enhance radiosensitivity of various ***,little information is available regarding the effects of UTMD on radiotherapy for glioblastoma or the underlying *** study aimed to delineate the effect of UTMD on the radiosensitivity of glioblastoma and the potential involvement of ***:GL261,U251 cells and orthotopic glioblastoma-bearing mice were treated with ionizing radiation(IR) or IR plus *** was observed by confocal microscopy and transmission electron *** blotting and immunofluorescence analysis were used to detect progesterone receptor membrane component 1(PGRMC1),light chain 3 beta 2(LC3B2) and sequestosome 1(SQSTM1/p62) *** vectors or siRNAs transfection,and fluorescent probes staining were used to explore the underlying ***:UTMD enhanced the radiosensitivity of glioblastoma in vitro and in vivo(P0.05).Furthermore,UTMD inhibited PGRMC1expression and binding with LC3B2 in IR-exposed glioblastoma cells(P<0.01).PGRMC1 inhibitor AG-205 or PGRMC1siRNA pretreatment enhanced UTMD-induced LC3B2 and p62 accumulation in IR-exposed glioblastoma cells,thereby promoting UTMD-mediated radiosensitization(P<0.05).Moreover,PGRMC1 overexpression abolished UTMD-caused blockade of autophagic degradation,subsequently inhibiting UTMD-induced radiosensitization of glioblastoma ***,compared with IR plus UTMD group

关键词： Ultrasound-triggered microbubble destruction Radiosensitization Progesterone receptor membrane component 1 Autophagy Glioblastoma

IDENTIFICATION OF INPAINTED IMAGES AND NATURAL IMAGES FOR DIGITAL FORENSICS

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Journal of Electronics(China) 2009年第3期26卷 341-345页

作者： Wu qiong Sun Shaojie zhu Wei Li Guohui College of Information System and Management National University of Defense Technology Changsha 410073 China

Image forensics is a form of image analysis for finding out the condition of an image in the complete absence of any digital watermark or *** can be used to authenticate digital images and identify their *** the technology of exemplar-based inpainting provides an approach to remove objects from an image and play visual *** this paper, as a first attempt, a method based on zero-connectivity feature and fuzzy membership is proposed to discriminate natural images from inpainted ***, zero-connectivity labeling is applied on block pairs to yield matching degree feature of all blocks in the region of suspicious, then the fuzzy memberships are computed and the tampered regions are identified by a cut *** results demonstrate the effectiveness of our method in detecting inpainted images.

关键词： Image authentication Image inpainting Fuzzy membership

Microstructures and mechanical properties of ferrite-based lightweight steel with different compositions

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Journal of Iron and Steel Research International 2017年第7期24卷 737-742页

作者： Reng-chong Xu Yan-lin He Hu Jiang Hua Wang Na-qiong zhu Xiao-gang Lu Lin Li School of Materials Science and Engineering Shanghai University State Key Laboratory of Advanced Special Steel Shanghai University Instrumental Analysis & Research Center Shanghai University Materials Genome Institute Shanghai University

The microstructures and mechanical properties of ferrite-based lightweight steel with different compositions were investigated by tensile test,scanning electron microscopy（SEM）,transmission electron microscopy（TEM）,X-ray diffraction（XRD）and thermodynamic calculation（TC）.It was shown that the ferrite-based lightweight steels with 5wt.%or 8wt.%Al were basically composed of ferrite,austenite andκ-*** the annealing temperature increased,the content of the austenite in the steel gradually increased,while theκ-carbide gradually decomposed and finally *** mechanical properties of the steel with 5wt.%Al and 2wt.%Cr,composed of ferrite and Cr7C3carbide at different annealing temperatures,were significantly inferior to those of *** steel containing 5wt.%Al,annealed at 820°C for 50sthen rapidly cooled to 400°C and held for 180s,can obtain the best product of strength and elongation（PSE）of 31242MPa·%.The austenite stability of the steel is better,and its PSE is *** addition,the steel with higher PSE has a more stable instantaneous strain hardening exponent（n value）,which is mainly caused by the effect of transformation induced plasticity（TRIP）.When theκ-carbide or Cr7C3carbide existed in the microstructure of the steel,there was an obvious yield plateau in the tensile curve,while its PSE decreased significantly.

关键词： Ferrite-based lightweight steel Microstructure Mechanical property Transformation induced plasticity effect κ-carbide

Exosomes derived from human induced pluripotent stem cell-derived neural progenitor cells protect neuronal function under ischemic conditions

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Neural Regeneration Research 2021年第10期16卷 2064-2070页

作者： Wen-Yu Li qiong-Bin zhu Lu-Ya Jin Yi Yang Xiao-Yan Xu Xing-Yue Hu Department of Neurology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Brain Research Institute Zhejiang UniversityHangzhouZhejiang ProvinceChina

Compared with other stem cells,human induced pluripotent stem cells-derived neural progenitor cells(iPSC-NPCs)are more similar to cortical neurons in morphology and ***,they have greater potential for promoting the survival and growth of neurons and alleviating the proliferation of *** of stem cell exosomes and stem cells themselves have both been shown to effectively repair nerve ***,there is no study on the protective effects of exosomes derived from iPSC-NPCs on oxygen and glucose deprived *** this study,we established an oxygen-glucose deprivation model in embryonic cortical neurons of the rat by culturing the neurons in an atmosphere of 95%N2 and 5%CO2 for 1 hour and then treated them with iPSC-NPC-derived exosomes for 30 *** results showed that iPSC-NPC-derived exosomes increased the survival of oxygen-and glucose-deprived neurons and the level of brain-derived neurotrophic factor in the culture ***,it attenuated oxygen and glucose deprivation-induced changes in the expression of the PTEN/AKT signaling pathway as well as synaptic plasticity-related proteins in the ***,it increased the length of the longest neurite in the oxygen-and glucose-deprived *** findings validate the hypothesis that exosomes from iPSCNPCs exhibit a neuroprotective effect on oxygen-and glucose-deprived neurons by regulating the PTEN/AKT signaling pathway and neurite *** study was approved by the Animal Ethics Committee of Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,China(approval ***20191010)on October 10,2019.

关键词： AKT cortical neurons exosome ischemia neural progenitor cells neuronal protection oxygen and glucose deprivation pluripotent stem cells PTEN signaling pathway