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Effect of health education based on information-motivationbehavioral skills model on patients with unilateral vestibular dysfunction

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World Journal of Clinical Cases 2024年第5期12卷 903-912页

作者： qiong shi Ruo-Jun Wu Jiang Liu Department of Neurology Wuahan Fourth HospitalWuhan 430000Hubei ProvinceChina Department of Critical Care Medicine Wuhan No.1 HospitalWuhan 430033Hubei ProvinceChina

BACKGROUND Vestibular dysfunction(VH)is a common concomitant symptom of late peri-pheral vestibular lesions,which can be trauma,poisoning,infection,heredity,and neurodegeneration,but about 50%of the causes are unknown.The study uses the information-motivation-behavioral skills(IMB)model for health education,effectively improve the quality of life,increase their self-confidence,reduce anxiety and depression,and effectively improve the psychological state of patients.AIM To explore the effect of health education based on the IMB model on the degree of vertigo,disability,anxiety and depression in patients with unilateral vestibular hypofunction.METHODS The clinical data of 80 patients with unilateral vestibular hypofunction from January 2019 to December 2021 were selected as the retrospective research objects,and they were divided into the control group and the observation group with 40 cases in each group according to different nursing methods.Among them,the control group was given routine nursing health education and guidance,and the observation group was given health education and guidance based on the IMB model.The changes in self-efficacy,anxiety and depression,and quality of life of patients with unilateral VH were compared between the two groups.RESULTS There was no significant difference in General Self-Efficacy Scale(GSES)scale scores between the two groups of patients before nursing(P>0.05),which was comparable;after nursing,the GSES scale scores of the two groups were higher than those before nursing.The nursing group was higher than the control group,and the difference was statistically significant(P0.05).After nursing,the HADS score,anxiety,and depression subscale scores of the two groups of patients were lower than those before nursing,and the nursing group was lower than the control group,and the difference was statistically

关键词： Information-motivation-behavioral skills model Health education Vestibular function Quality of life Selfefficacy

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Tough Semi-interpenetrating Polyvinylpyrrolidone/Polyacrylamide Hydrogels Enabled by Bioinspired Hydrogen-bonding Induced Phase Separation

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Chinese Journal of Polymer Science 2024年第5期42卷 591-603,I0006页

作者： qiong-Jun Xu Zhao-Yang Yuan Chang-Cheng Wang Hao Liang Yu shi Hai-Tao Wu Hu Xu Jing Zheng Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China

Semi-interpenetrating(semi-IPN)hydrogels formed by the continuous interpenetration of cross-linked polymer network and linear non-crosslinked polymer with multifunctionality are widely used in biomedical and other fields.However,the negative impact of linear polymer on the homogeneity of the cross-linked network often leads to a decrease in the mechanical properties of semi-IPN hydrogels and severely limits their applications.Herein,a bioinspired hydrogen-bonding induced phase separation strategy is presented to construct the tough semi-IPN polyvinylpyrrolidone/polyacrylamide hydrogels(named PVP/PAM hydrogels),including the linear polymer polyvinylpyrrolidone(PVP)and cross-linked polyacrylamide(PAM)network.The resultant PVPx/PAM hydrogels exhibit unique phase separation induced by the hydrogen bonding between PVP and PAM and affected by the amount of substance of PVP.Meanwhile,the phase separation of PVPx/PAM hydrogels results in excellent mechanical properties with a strain of 2590%,tensile strength of 0.28 MPa and toughness of 2.17 MJ/m^(3).More importantly,the hydrogen bonding between PVP and PAM firstly disrupts to dissipate energy under external forces,so the PVPx/PAM hydrogels exhibit good self-recovery properties and outperform chemically cross-linked PAM hydrogels in impact resistance and damping applications.It is believed that the PVPx/PAM hydrogels with hydrogen-bonding induced phase separation possess more potential application prospects.

关键词： Tough Semi-interpenetrating networks Polyvinylpyrrolidone/polyacrylamide Hydrogels Phase separation

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Synergistic anionic/zwitterionic mixed surfactant system with high emulsification efficiency for enhanced oil recovery in low permeability reservoirs

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Petroleum Science 2024年第2期21卷 936-950页

作者： Hai-Rong Wu Rong Tan shi-Ping Hong qiong Zhou Bang-Yu Liu Jia-Wei Chang Tian-Fang Luan Ning Kang Ji-Rui Hou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Gas Production Plant 5 of PetroChina Changqing Oilfield Company PetroChinaXi©an710000ShaanxiChina College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Kazakh-British Technical University Almaty050000Kazakhstan

Emulsification is one of the important mechanisms of surfactant flooding. To improve oil recovery for low permeability reservoirs, a highly efficient emulsification oil flooding system consisting of anionic surfactant sodium alkyl glucosyl hydroxypropyl sulfonate(APGSHS) and zwitterionic surfactant octadecyl betaine(BS-18) is proposed. The performance of APGSHS/BS-18 mixed surfactant system was evaluated in terms of interfacial tension, emulsification capability, emulsion size and distribution, wettability alteration, temperature-resistance and salt-resistance. The emulsification speed was used to evaluate the emulsification ability of surfactant systems, and the results show that mixed surfactant systems can completely emulsify the crude oil into emulsions droplets even under low energy conditions. Meanwhile,the system exhibits good temperature and salt resistance. Finally, the best oil recovery of 25.45% is achieved for low permeability core by the mixed surfactant system with a total concentration of 0.3 wt%while the molar ratio of APGSHS:BS-18 is 4:6. The current study indicates that the anionic/zwitterionic mixed surfactant system can improve the oil flooding efficiency and is potential candidate for application in low permeability reservoirs.

关键词： Anionic/zwitterionic mixed surfactant system Emulsification Synergistic effect Low permeability reservoir Enhanced oil recovery

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PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling

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Genes & Diseases 2022年第6期9卷 1650-1661页

作者： Sicheng Chen Mengjun Bie Xiaowen Wang Mengtian Fan Bin Chen qiong shi Yingjiu Jiang Department of Cardiothoracic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Ministry of Education Key Laboratory of Diagnostic Medicine School of Laboratory MedicineChongqing Medical UniversityChongqing 400016PR China

Progranulin(PGRN)is a growth factor that is involved in the progression of multiple tumors.However,the effects and molecular mechanisms by which PGRN induces lung cancer remain unclear.The expression level of PGRN was analyzed by conducting immunohistochemistry of the histological sections of lung tissues from non-small-cell lung carcinoma(NSCLC)patients.The proliferation,apoptosis,migration,and invasion of NSCLC cells were assessed by the MTT assay,Western blot,degree of wound healing,and Transwell assays.A nude mouse xenograft model was used to validate the role of PGRN in vivo.The expression level of PGRN was higher in male patients with lung adenocarcinoma than in those with lung squamous cell carcinoma;by contrast,no difference was observed in female patients.The overexpression of PGRN promoted the proliferation and anti-apoptosis of H520(derived from lung squamous cell carcinoma)cells,whereas knockdown of PGRN inhibited the proliferation and anti-apoptosis of A549(derived from lung adenocarcinoma)cells.Copanlisib(targeting PI3K)inhibited the increase in the expression of cell anti-apoptosis marker Bcl-2 induced by rhPGRN protein;the PI3K agonist 740 YeP partially reversed the decrease in Bcl-2 expression induced by PGRN deficiency in both A549 and H520 cells.PGRN increased the expression of Ki-67,PCNA,and Bcl-2 in vivo.PGRN inhibited cell apoptosis depending on the PI3K/Akt/Bcl-2 signaling axis;PGRN positivity correlated with lung adenocarcinoma.PGRN is a potential biomarker for the treatment and diagnosis of NSCLC,especially in lung adenocarcinoma.

关键词： Bcl-2 Cell apoptosis NSCLC PGRN PI3K/Akt

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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

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Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU Wei qiong ZHOU Wei Guang ZHOU Guang Wei LIAO Jia Xi shi Jia Xing XIE FengYang LI Shou Heng WANG Yong FENG Xian Hong GU Xiu Li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than conclusive.Here,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer risk.Methods A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were recruited.Genotyping of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger sequencing.Twenty-four eligible studies were included in the meta-analysis.Results After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese population.The meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese population.Conclusion The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

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Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu shi-Qing Yuan Ying Ning shi-Jia Nie Xu-qiong Wang Hong-Yi Jia Xiu-Li Zheng Department of Basic Medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal studies.AIM To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying mechanism.METHODS To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with LGZG.The determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance tests.Using a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic steatosis.It effectively controlled blood glucose and food intake while protecting islet cells.Metabolite analysis revealed significant differences between the HFD and HFDLGZG groups.LGZG intervention reduced branched-chain amino acid levels.Levels of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased significantly.IR may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by qRT-PCR.CONCLUSIONS Our study strongly suggests that LGZG decoction reduces HFD-induced IR.LGZG may activate S6K1 via metabolic pathways.These findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

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基于深度强化学习的可信分簇路由协议

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仪表技术与传感器 2024年第2期 117-126页

作者：段辉石琼师智斌中北大学计算机科学与技术学院

针对分簇路由协议中恶意节点充当簇头的安全性问题以及基于深度强化学习的路由协议存在收敛慢、波动大的难题,提出了一种基于信任机制和深度强化学习算法soft actor-critic(SAC)的分簇路由协议。该协议首先运用改进的标签传播算法对网... 详细信息

针对分簇路由协议中恶意节点充当簇头的安全性问题以及基于深度强化学习的路由协议存在收敛慢、波动大的难题,提出了一种基于信任机制和深度强化学习算法soft actor-critic(SAC)的分簇路由协议。该协议首先运用改进的标签传播算法对网络进行分簇。然后采用基于信任的簇头选举机制从簇内选出可信簇头,并采取主-从簇头机制防止簇头“叛变”成为恶意节点。最后利用SAC算法,将簇头作为智能体,实现动态路由决策。实验结果表明:该协议相较于RTRPT、SCR-TBE以及基于DQN、D3QN、PPO的路由协议,具有更优的性能和更好的收敛性。其丢包率、平均时延和网络吞吐量指标均为最优。在多个测试场景下,相较于PPO方案性能最小提升3.97%,最大提升22.39%。

关键词：无线传感器网络分簇路由协议网络安全深度强化学习信任机制

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高等教育推进“三融”的路径依赖与改革路向

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中国高教研究 2024年第5期 55-60页

作者：史秋衡陈琼厦门大学教育研究院福建厦门361005 池州学院艺术与教育学院安徽池州247000

推进职普融通、产教融合、科教融汇既是高等教育勇担强国使命的应有之义,也是实现自身高质量发展的必由之路。然而,对高等教育推进“三融”进行客观审视后发现,实践中面临着制度性、资源性、主体性上的三重路径依赖。联动融通中“通而... 详细信息

推进职普融通、产教融合、科教融汇既是高等教育勇担强国使命的应有之义,也是实现自身高质量发展的必由之路。然而,对高等教育推进“三融”进行客观审视后发现,实践中面临着制度性、资源性、主体性上的三重路径依赖。联动融通中“通而不畅”“合而不深”“融而不创”等梗阻问题尚未得到根本解决。未来,可从完善面向现代产业体系建设的人才供需联动机制、加速教育链人才链与产业链创新链共生衔接、构建以技术进步为核心的高等教育创新生态系统等方面出发,积极探索高等教育推进“三融”的改革路向。

关键词：高等教育高职教育联动三融

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Genomic selection of orange-spotted grouper(Epinephelus coioides)based on multiplex PCR enrichment capture sequencing

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Aquaculture and Fisheries 2023年第6期8卷 681-688页

作者： Xinxin Shan Xinhui Zhang Zhiqiang Ruan Jieming Chen qiong shi Junmin Xu Xinxin You Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineBGIShenzhen518083China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) State Key Laboratory of BiocontrolSchool of Marine SciencesSun Yat-Sen UniversityGuangzhou510275China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

Orange spotted grouper(Epinephelus coioides)is an important mariculture fish,and genomic breeding of this grouper species has been hindered due to lack of efficient genotyping tools.Here,we developed a single nucleotide polymorphism(SNP)genotyping technology based on multiplex PCR enrichment capture sequencing,which mainly aims at target area for high-throughput sequencing,and 741 SNPs were designed for genomic selection(GS)of growth and ammonia tolerance traits at the same time.The multiplex PCR enrichment capture sequencing assay showed that the genotyping efficiency was more than 99%in the orange-spotted grouper and the predictive accuracy of body weight and ammonia tolerance traits was 82%and 96%,respectively.More importantly,the average identity of the sequences with these SNPs aligned to the genomes of giant grouper(E.lanceolatus)and brown-marbled grouper(E.fuscoguttatus)were both over 96%.Test data showed that the SNP genotyping efficiency was more than 94%in both giant grouper and brown-marbled grouper.In summary,these results indicated that the development of SNP loci and genotyping approach based on the multiple PCR enrichment capture sequencing are suitable for GS of growth and ammonia tolerance traits in various grouper species,and it would provide technical support for practical grouper breeding.

关键词： Grouper SNP genotyping Approach Multiple PCR enrichment Capture sequencing Genomic selection

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High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development

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BioDesign Research 2022年第1期2022卷 38-51页

作者： Bingmiao Gao Yu Huang Chao Peng Bo Lin Yanling Liao Chao Bian Jiaan Yang qiong shi Key Laboratory of Tropical Translational Medicine of Ministry of Education School of PharmacyHainan Medical UniversityHaikouHainan 570102China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China BGI-Marine Research Institute for Biomedical Technology Shenzhen Huahong Marine Biomedicine Co.Ltd.ShenzhenGuangdong 518119China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical UniversityHaikouHainan 570102China Research and Development Department Micro Pharmtech Ltd.WuhanHubei 430075China

Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to theirpharmacological applications in development of marine drugs for treatment of various human diseases. To date, around 800Conus species are recorded, and each of them produces over 1,000 venom peptides (termed as conopeptides or conotoxins).This reflects the high diversity and complexity of cone snails, although most of their venoms are still uncharacterized.Advanced multiomics (such as genomics, transcriptomics, and proteomics) approaches have been recently developed to minediverse Conus venom samples, with the main aim to predict and identify potentially interesting conopeptides in an efficientway. Some bioinformatics techniques have been applied to predict and design novel conopeptide sequences, related targets, andtheir binding modes. This review provides an overview of current knowledge on the high diversity of conopeptides andmultiomics advances in high-throughput prediction of novel conopeptide sequences, as well as molecular modeling and designof potential drugs based on the predicted or validated interactions between these toxins and their molecular targets.

关键词： drugs Con prediction

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