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Computed tomography-based nomogram of Siewert type Ⅱ/Ⅲ adenocarcinoma of esophagogastric junction to predict response to docetaxel, oxaliplatin and S-1

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World Journal of Radiology 2024年第1期16卷 9-19页

作者： Chuan-qinyuan Zhou Dan Gao Yan gui Ning-Pu Li Wen-Wen Guo Hai-Ying Zhou Rui Li Jing Chen Xiao-Ming Zhang Tian-Wu Chen Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Radiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Neoadjuvant chemotherapy(NAC)has become the standard care for advanced adenocarcinoma of esophagogastric junction(AEG),although a part of the patients cannot benefit from *** are no models based on baseline computed tomography(CT)to predict response of Siewert type II or III AEG to NAC with docetaxel,oxaliplatin and S-1(DOS).AIM To develop a CT-based nomogram to predict response of Siewert type II/III AEG to NAC with *** One hundred and twenty-eight consecutive patients with confirmed Siewert type II/III AEG underwent CT before and after three cycles of NAC with DOS,and were randomly and consecutively assigned to the training cohort(TC)(n=94)and the validation cohort(VC)(n=34).Therapeutic effect was assessed by disease-control rate and progressive disease according to the Response Evaluation Criteria in Solid Tumors(version 1.1)*** prognostic factors associated with responses after DOS treatment including Siewert classification,gross tumor volume(GTV),and cT and cN stages were evaluated using pretherapeutic CT data in addition to sex and *** and multivariate analyses of CT and clinical features in the TC were performed to determine independent factors associated with response to DOS.A nomogram was established based on independent factors to predict the *** predictive performance of the nomogram was evaluated by Concordance index(C-index),calibration and receiver operating characteristics curve in the TC and *** Univariate analysis showed that Siewert type(52/55 vs 29/39,P=0.005),pretherapeutic cT stage(57/62 vs 24/32,P=0.028),GTV(47.3±27.4 vs 73.2±54.3,P=0.040)were significantly associated with response to DOS in the *** analysis of the TC also showed that the pretherapeutic cT stage,GTV and Siewert type were independent predictive factors related to response to DOS(odds ratio=4.631,1.027 and 7.639,respectively;all P<0.05).The nomogram developed with these independent factors showed an exc

关键词： Esophagogastric junction Adenocarcinoma Neoadjuvant chemotherapy Response Tomography,X-ray computed Predictor

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耳鸣的中西医临床研究进展

光明中医 2019年第5期34卷 809-812页

作者：陈潇张勉桂雄斌李艺高阳郑琴媛广西中医药大学第一附属医院耳鼻喉科广西南宁530023

广泛查阅国内外中西医耳鸣相关文献资料,从发病机制、药物治疗、物理治疗及病因病机、中医中药、中医外治等方面进行阐述,总结中西医关于对耳鸣的认识及相关治疗,为临床诊疗工作提供参考。中西医对耳鸣的干预及诊治需进一步探索研究,以... 详细信息

广泛查阅国内外中西医耳鸣相关文献资料,从发病机制、药物治疗、物理治疗及病因病机、中医中药、中医外治等方面进行阐述,总结中西医关于对耳鸣的认识及相关治疗,为临床诊疗工作提供参考。中西医对耳鸣的干预及诊治需进一步探索研究,以更好提高耳鸣的临床疗效。

关键词：耳鸣中西医结合综述

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沁水盆地南部地应力特征及高产区带预测

天然气地球科学 2007年第6期18卷 885-890页

作者：刘洪林王勃王烽李贵中秦勇中国石油勘探开发科学研究院廊坊分院河北廊坊065007 中国矿业大学(徐州)资环学院江苏徐州221008

地应力是渗透率的重要控制因素,高产井主要分布在最小主应力相对较小的区域,因此地应力特征对高产区带的预测具有重要意义。分析了泌水盆地南部地区现代构造应力场对煤储层物性的控制机理,指出主应力差增大,渗透率呈指数形式急剧增高,... 详细信息

地应力是渗透率的重要控制因素,高产井主要分布在最小主应力相对较小的区域,因此地应力特征对高产区带的预测具有重要意义。分析了泌水盆地南部地区现代构造应力场对煤储层物性的控制机理,指出主应力差增大,渗透率呈指数形式急剧增高,而储层压力呈对数形式上升;试井地应力梯度尽管与渗透率、储层压力之间存在相关关系,但离散性较大。预测了3种有利的煤层气成藏类型,即大宁—潘庄—樊庄区带高主应力差—滞流封闭—浅埋型煤层气藏、沁水—郑庄—樊庄北和沁源—安泽区带中主应力差—缓流封闭—中埋型煤层气藏、郑庄北和沁源东—安泽东区带中主应力差—缓流封闭—深埋型煤层气藏。

关键词：沁水盆地煤层气地应力渗透率区带

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含硬煤夹层厚煤层综放面矿压显现规律研究

山西焦煤科技 2010年第9期34卷 43-46页

作者：邢桂新项国徐腾飞孙英天颜丙双中国矿业大学

通过对秦源煤矿S204工作面现场矿山压力观测,研究了含硬煤夹层厚煤层综放面的矿压显现规律。研究结果表明:由于硬煤夹层的影响,与不含硬煤夹层综放工作面相比,其周期来压步距、平均动压系数都有不同程度的增大;工作面支架性能完全能够... 详细信息

通过对秦源煤矿S204工作面现场矿山压力观测,研究了含硬煤夹层厚煤层综放面的矿压显现规律。研究结果表明:由于硬煤夹层的影响,与不含硬煤夹层综放工作面相比,其周期来压步距、平均动压系数都有不同程度的增大;工作面支架性能完全能够满足工作面支护强度的要求;由于硬煤夹层的存在,工作面超前支承压力分布呈现出较硬煤层的特征,即超前支承压力的分布范围和峰值点距煤壁的距离并不大。

关键词：硬煤夹层矿压显现支承压力规律研究