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2013—2023年南京市流感样病例及流感病毒病原学特征分析

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首都公共卫生 2024年第2期18卷 81-86页

作者：胡洋田梦圆周沁易丁松宁吴小清南京市疾病预防控制中心江苏210003

目的了解2013—2023年南京市流感样病例(influenza-like illness, ILI)的流行病学特征及病原学变化趋势,为流行性感冒(以下简称流感)防控提供科学依据。方法通过中国疾病预防控制信息系统收集2013—2023年南京市ILI监测数据、病原学... 详细信息

目的了解2013—2023年南京市流感样病例(influenza-like illness, ILI)的流行病学特征及病原学变化趋势,为流行性感冒(以下简称流感)防控提供科学依据。方法通过中国疾病预防控制信息系统收集2013—2023年南京市ILI监测数据、病原学监测、暴发疫情数据并进行统计分析。结果 2013—2023年南京市哨点医院共报告1 919 187例ILI,ILI百分比(ILI%)为5.85%,总体呈先上升后下降趋势。2018—2019年ILI%最高(11.00%),2016—2017年最低(2.62%)。ILI以0~<5岁年龄组为主,占66.21%。共检测ILI样本45 074份,流感病毒阳性率为11.68%(5 265份),其中甲型H3N2最多(2 206份,占41.90%),其次为乙型Victoria系(1 224份,占23.25%)、甲型H1N1(1 201份,占22.81%)和乙型Yamagata系(599份,占11.38%)。不同监测年度阳性率比较,差异有统计学意义(χ2=1 282.83,P<0.001)。除2020—2021年没有流行高峰,其余9个年份均在冬春季出现了流行高峰,其中2014—2015、2015—2016、2017—2018、2021—2022和2022—2023年还出现了夏季流行高峰。2013—2023年南京市共报告ILI暴发疫情96起,主要发生在中小学校(含托幼机构),共94起(占97.92%)。结论南京市流感流行以冬春季为主,不同监测年度各流感亚型交替流行。0~<15岁儿童是流感防控重点人群,学校是重点防控场所。应持续加强和规范流感监测工作,密切关注南京市流感活动水平和趋势,及时进行预警和预测,科学精准防控流感疫情。

关键词：流行性感冒流感样病例病原学监测哨点监测

Sema3A secreted by sensory nerve induces bone formation under mechanical loads

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International Journal of Oral Science 2024年第1期16卷 62-72页

作者： Hongxiang Mei Zhengzheng Li qinyi Lv Xingjian Li Yumeng Wu Qingchen Feng Zhishen Jiang Yimei zhou Yule Zheng Ziqi Gao Jiawei zhou Chen Jiang Shishu Huang Juan Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduChina

Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A(Sema3A), expressed by sensory nerves, in mechanical loads-induced bone formation and nerve withdrawal using orthodontic tooth movement(OTM) model. Firstly, bone formation was activated after the 3rd day of OTM,coinciding with a decrease in sensory nerves and an increase in pain threshold. Sema3A, rather than nerve growth factor(NGF),highly expressed in both trigeminal ganglion and the axons of periodontal ligament following the 3rd day of OTM. Moreover, in vitro mechanical loads upregulated Sema3A in neurons instead of in human periodontal ligament cells(hPDLCs) within 24 ***, exogenous Sema3A restored the suppressed alveolar bone formation and the osteogenic differentiation of hPDLCs induced by mechanical overload. Mechanistically, Sema3A prevented overstretching of F-actin induced by mechanical overload through ROCK2 pathway, maintaining mitochondrial dynamics as mitochondrial fusion. Therefore, Sema3A exhibits dual therapeutic effects in mechanical loads-induced bone formation, both as a pain-sensitive analgesic and a positive regulator for bone formation.

关键词： Sema3A formation overload

Tailoring the austenite characteristics via dual nanoparticles to synergistically optimize the strength-ductility in cold rolled medium Mn steel

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Journal of Materials Science & Technology 2024年第2期169卷 158-171页

作者： Qizhe Ye Haokai Dong qinyi Guo Yishuang Yu Lijie Qiao Yu Yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In this work,we proposed a novel Cu/θdual nanoparticles strategy to tailor the austenite characteris-tics of a medium Mn steel via a tempering-annealing process to optimize the mechanical *** explored the effects of Cu-rich particles and cementite precipitated in the tempering process on the austenite reversion during the subsequent annealing *** experiments and numerical simula-tions verified that the austenite inherited from cementite had a finer size and a higher Mn enrichment compared with the austenite originating from the tempered martensite *** addition,quantitative evaluations revealed that the pinning effect exerted by the Cu-rich particles could significantly hinder theα/γinterface migration and the recrystallized grain growth,thereby further refining the final *** contributions from the effects of dual nanoprecipitates on the austenite reversion,the heterogeneous austenite grains inherited from varying nucleation sites ensured the sustained and gradual deformation-induced martensite and twinning ***,the Cu-added steels subjected to a tempering-annealing process achieved synergetic enhancement of the tensile strength from 1055 MPa to 1250 MPa and elongation from 33%to 45%.This strategy may provide new guidance for the development and alloy design of high-performance medium Mn steels.

关键词： Dual nanoparticles Medium Mn steel Tempering-annealing process Austenite reversion Mechanical properties

Development and validation of an HPLC–MS/MS method to determine clopidogrel in human plasma

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Acta Pharmaceutica Sinica B 2016年第1期6卷 55-63页

作者： Gangyi Liu Chunxia Dong Weiwei Shen Xiaopei Lu Mengqi Zhang Yuzhou Gui qinyi zhou Chen Yu Central Laboratory Shanghai Clinical CenterChinese Academy of Sciences/Central LaboratoryShanghai Xuhui Central Hospital State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Science

A quantitative method for clopidogrel using online-SPE tandem LC–MS/MS was developed and fully validated according to the well-established FDA *** method achieves adequate sensitivity for pharmacokinetic studies,with lower limit of quantifications(LLOQs)as low as 10 pg/m *** separations were performed on reversed phase columns Kromasil Eternity-2.5-C18-UHPLC for both *** electrospray ionization in multiple reaction monitoring(MRM)mode was employed for signal detection and a deuterated analogue(clopidogrel-d_4)was used as internal standard(IS).Adjustments in sample preparation,including introduction of an online-SPE system proved to be the most effective method to solve the analyte back-conversion in clinical *** clinical samples(two levels)were prepared and successfully used as real-sample quality control(QC)in the validation of back-conversion testing under different *** result showed that the real samples were stable in room temperature for 24 ***,precision,extraction recovery,matrix effect on spiked QC samples and stability tests on both spiked QCs and real sample QCs stored in different conditions met the acceptance *** online-SPE method was successfully applied to a bioequivalence study of75 mg single dose clopidogrel tablets in 48 healthy male subjects.

关键词： Clopidogrel Online-SPE LC–MS/MS Back-conversion Bioequivalence Deuterated analogue Real samples stability FDA guidelines

MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

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Science China Chemistry 2024年第4期67卷 1216-1223页

作者： qinyi Cao Yifan Zhang Yanping Tang Changjin Wu Jizhuang Wang Dan Li College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital)Jinan UniversityHeyuan 517000China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry The University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)hold significant potential as vehicles for drug delivery due to their expansive specific surface area,biocompatibility,and versatile ***,magnetically actuated micro/nano-robots(MNRs)offer distinct advantages,such as untethered and precise *** fusion of these technologies presents a promising avenue for achieving non-invasive targeted drug ***,we report a MOF-based magnetic microrobot swarm(MMRS)for targeted *** approach overcomes limitations associated with a single MNR,including limited drug loading and the risk of loss during *** select Zeolitic Imidazolate Framework-8(ZIF-8)as the drug vehicle for its superior loading potential and p H-sensitive *** design incorporates magnetic responsive components into the one-pot synthesis of Fe@ZIF-8,enabling collective behaviors under *** the yaw angle of alternating magnetic fields and nanoparticles'amount,the MMRSs with controllable size achieve instantaneous transformation among different configurations,including vortex-like swarms,chain-like swarms,and elliptical swarms,facilitating adaptation to environmental *** to the subcutaneous T24 tumor site,the MMRSs with encapsulated doxorubicin(DOX)automatically degrade and release the drug,leading to a dramatic reduction of the tumor in *** investigation signifies a significant advancement in the integration of biodegradable MOFs into microrobot swarms,ushering in new avenues for accurate and non-invasive targeted drug delivery.

关键词： magnetic microrobot swarm MOF nanoparticles magnetic propulsion pH-responsive drug release targeted drug delivery

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Promising real-time fruit and vegetable quality detection technologies applicable to manipulator picking process

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INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING 2024年第2期17卷 14-26页

作者： Feng, Jintao Yang, qinyi Tian, Hao Wang, Zhipeng Tian, Shijie Xu, Huirong Zhejiang Univ Coll Biosyst Engn & Food Sci Hangzhou 310058 Peoples R China Key Lab Intelligent Equipment & Robot Agr Zhejiang Hangzhou 310058 Peoples R China

In recent years, worldwide research on fruit and vegetable quality detection technology includes machine vision, spectroscopy, acoustic vibration, tactile sensors, etc. These technologies have also been gradually applied to fruit and vegetable grading and sorting lines in recent years, greatly improving the income of farmers. There have been numerous reviews of these techniques. Most of the published research on fruit and vegetable quality detection technology is still carried out in the laboratory. The emphases have been on quality feature extraction, model establishment and experimental verification. The successful application in the fruit and vegetable sorting production line proves that these studies have high application potential and value, and we look forward to the performance of these sensing technologies in the fruit and vegetable picking field. Therefore, in this paper, based on the future highly automated fruit and vegetable picking mode, we will focus on three kinds of fruit and vegetable quality detection technologies including machine vision, tactile sensor and spectroscopy, to provide some reference for future research. Since there are currently limited cases of detecting quality during the fruit and vegetable picking, experiments performed on prototypes of manipulator, or devices such as Nanocilia sensors, portable spectrometers, etc., which are compact and convenient to mount on manipulator will be reviewed. Several tables and mosaics showing the performance of the three technologies in the detection of fruit and vegetable quality over the past five years have been listed. The performance of each sensing technology was relatively satisfactory in the laboratory in general. However, in the picking scenario, there are still many challenges to be solved. Different from industrial environments, agricultural scenarios are complex and changeable. Fragile and vulnerable agricultural products pose another challenge. The development of portable devices and n

关键词： fruit and vegetable quality detection machine vision spectroscopy tactile sensors picking scenario STRAWBERRY-HARVESTING ROBOT SOLUBLE SOLIDS CONTENT IN-FIELD TACTILE SENSOR MATURITY CLASSIFICATION SPECTROMETER SPECTROSCOPY RIPENESS FEATURES

The Application Progress of Skin Imaging Technology in Psoriasis

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Advances in Bioscience and Biotechnology 2024年第7期15卷 397-405页

作者： qinyi Wang Jin Gong Department of Dermatology The First Affiliated Hospital of Yangtze University Jingzhou China

Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can improve clinical diagnosis rate, and its non-invasiveness and repeatability make it occupy an irreplaceable position in clinical diagnosis. With the “booming development” of medical technology, skin imaging technology can improve clinical diagnosis rate. Researchers have made significant advances in assisting clinical diagnosis, prediction, and treatment of disease. This article reviews the application and progress of skin imaging in the diagnosis of psoriasis.

关键词： Psoriasis Skin Imaging Technology High Frequency Ultrasound Optical Coherence Tomography

Typhoon-and pollution-driven enhancement of reactive bromine in the mid-latitude marine boundary layer

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National Science Review 2024年第4期11卷 93-101页

作者： Shanshan Wang qinyi Li Ruifeng Zhang Anoop Sharad Mahajan Swaleha Inamdar Nuria Benavent Sanbao Zhang Ruibin Xue Jian Zhu Chenji Jin Yan Zhang Xiao Fu Alba Badia Rafael P.Fernandez Carlos A.Cuevas Tao Wang Bin zhou Alfonso Saiz-Lopez Institute for Interdisciplinary Science (ICB) National Research Council (CONICET) Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3) Department of Environmental Science and Engineering Fudan University Institute of Eco-Chongming(IEC) Department of Atmospheric Chemistry and Climate Institute of Physical Chemistry Blas CabreraCSIC Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Environment Research Institute Shandong University Centre for Climate Change Research Indian Institute of Tropical MeteorologyMinistry of Earth Sciences Department of Chemistry University of Colorado Boulder Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua University Sostenipra Research Group Institute of Environmental Science and Technology(ICTA)Universitat Autonoma de Barcelona(UAB)

Tropospheric reactive bromine is important for atmospheric chemistry,regional air pollution,and global *** studies have reported measurements of atmospheric reactive bromine species in different environments,and proposed their main sources,***-salt aerosol（SSA）,oceanic biogenic activity,polar snow/ice,and *** and other strong cyclonic activities（***） induce abrupt changes in different earth system processes,causing widespread destructive ***,the role of typhoons in regulating reactive bromine abundance and sources remains ***,we report field observations of bromine oxide（BrO）,a critical indicator of reactive bromine,on the Huaniao Island（HNI）in the East China Sea in July *** observed high levels of BrO below 500 m with a daytime average of9.7±4.2 pptv and a peak value of ～26 pptv under the influence of a *** field measurements,supported by model simulations,suggest that the typhoon-induced drastic increase in wind speed amplifies the emission of SSA,significantly enhancing the activation of reactive bromine from SSA *** also detected enhanced BrO mixing ratios under high NOxconditions（ppbv level） suggesting a potential pollution-induced mechanism of bromine release from *** elevated levels of atmospheric bromine noticeably increase ozone destruction by as much as ～40% across the East China *** the high frequency of cyclonic activity in the northern hemisphere,reactive bromine chemistry is expected to play a more important role than previously thought in affecting coastal air quality and atmospheric oxidation *** suggest that models need to consider the hitherto overlooked typhoon-and pollution-mediated increase in reactive bromine levels when assessing the synergic effects of cyclonic activities on the earth system.

关键词： reactive bromine atmospheric chemistry marine boundary layer atmospheric oxidation capacity marine emission

Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit

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Advanced Photonics 2024年第1期6卷 106-114页

作者： Haozong Zhong Yong Zheng Jiacheng Sun Zhizhang Wang Rongbo Wu Ling-en Zhang Youting Liang qinyi Hua Minghao Ning Jitao Ji Bin Fang Lin Li Tao Li Ya Cheng Shining Zhu East China Normal University School of Physics and Electronic ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Nanjing University College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjingChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina Chinese Academy of Sciences(CAS) Shanghai Institute of Optics and Fine Mechanics(SIOM)State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser ScienceShanghaiChina

Achieving spatiotemporal control of light at high speeds presents immense possibilities for various applications in communication,computation,metrology,and *** integration of subwavelength metasurfaces and optical waveguides offers a promising approach to manipulate light across multiple degrees of freedom at high speed in compact photonic integrated circuit(PIC)***,we demonstrate a gigahertz-rate-switchable wavefront shaping by integrating metasurface,lithium niobate on insulator photonic waveguides,and electrodes within a PIC *** proofs of concept,we showcase the generation of a focus beam with reconfigurable arbitrary polarizations,switchable focusing with lateral focal positions and focal length,orbital angular momentum light beams as well as Bessel *** measurements indicate modulation speeds of up to the gigahertz *** integrated platform offers a versatile and efficient means of controlling the light field at high speed within a compact system,paving the way for potential applications in optical communication,computation,sensing,and imaging.

关键词： metasurface photonic integrated circuit lithium niobate on insulator high-speed modulation