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Ecosystem Health and Sustainability 2020年第1期6卷 299-307,298页

作者： Yong Zhang Hasbagan Ganjurjav Shikui Dong qingzhu gao National Plateau Wetlands Research Center College of WetlandsSouthwest Forestry UniversityKunmingChina Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agriculture SciencesBeijingChina School of Grassland Science Beijing Forestry UniversityBeijingChina

Degradation of meadow ecosystems in the largest alpine region of the world,i.e.,the Qinghai-Tibetan Plateau(QTP),is a crucial ecological issue that has ardently discussed in recent *** factors,such as livestock overgrazing,climate change and overpopulation of small mammals are treated as important factors that cause the degradation of meadow ecosystems in the ***,there are few hypotheses focus on the potential role of plant compensatory growth on meadow *** proposed a compensatory growth-related hypothesis to understand the potential degradation process of meadow ecosystems in the *** discussed that there are two stages of meadow degradation,*** beginning stage of meadow degradation that is triggered by high-strength overcompensation;and the intensification stage of meadow degradation,which are driven by external factors such as climate warming,small mammals and thawing of *** mechanism of meadow degradation driven by plant compensatory growth is the asynchronism of plant consumption and the availability of soil *** hypothesis that plant compensatory growth drives meadow degradation under the overgrazing condition requires re-examination and modification by testing the balance between soil nutrient cycling rates and the strength of plant compensatory growth in alpine regions.

关键词： Compensatory growth overgrazing alpine meadow degradation Qinghai-Tibetan Plateau

Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2

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Genes & Diseases 2020年第4期7卷 551-557页

作者： Jie Hu qingzhu gao Changlong He Ailong Huang Ni Tang Kai Wang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing400010China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative virus of the coronavirus disease 2019(COVID-19)*** establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2,we constructed a codon-optimized,full-length C-terminal mutant spike(S)gene of *** generated a luciferase(Luc)-expressing pseudovirus containing the wild-type or mutant S protein of SARS-CoV-2 in the envelope-defective HIV-1 *** key parameters for this pseudovirus-based assay,including the S mutants and virus incubation time,were *** pseudovirus contains a Luc reporter gene that enabled us to easily quantify virus entry into angiotensin-converting enzyme 2(ACE2)-expressing 293T ***(Cat)B/L inhibitor E64d could significantly block SARS-CoV-2 pseudovirus infection in 293T-ACE2 ***,the SARS-CoV-2 spike pseudotyped virus could be neutralized by sera from convalescent COVID-19 patients or recombinant ACE2 with the fused Fc region of human ***,we developed a pseudovirus-based assay for SARS-CoV-2,which will be valuable for evaluating viral entry inhibitors and neutralizing antibodies against this highly pathogenic virus.

关键词： Antiviral therapeutics Coronavirus Neutralizing antibodies Pseudovirus SARS-CoV-2 Spike protein

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N^(6)-methyladenosine-dependent manner

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1208-1223页

作者： Yang Yang Yu Yan Jiaxin Yin Ni Tang Kai Wang Luyi Huang Jie Hu Zhongqi Feng qingzhu gao Ailong Huang Institute for Viral Hepatitis Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education)Department of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina

Hepatitis B virus(HBV)infection is a major risk factor for hepatocellular carcinoma(HCC),but its pathogenic mechanism remains to be *** RNA N^(6)-methyladenosine(m^(6)A)reader,YTH(YT521-B homology)domain 2(YTHDF2),plays a critical role in the HCC ***,the function and regulatory mechanisms of YTHDF2 in HBV-related HCC remain largely ***,we discovered that YTHDF2 O-GlcNAcylation was markedly increased upon HBV infection.O-GlcNAc transferase(OGT)-mediated O-GlcNAcylation of YTHDF2 on serine 263 enhanced its protein stability and oncogenic activity by inhibiting its ***,YTHDF2 stabilized minichromosome maintenance protein 2(MCM2)and MCM5 transcripts in an m^(6)A-dependent manner,thus promoting cell cycle progression and HBV-related HCC ***,targeting YTHDF2 O-GlcNAcylation by the OGT inhibitor OSMI-1 significantly suppressed HCC *** together,our findings reveal a new regulatory mechanism for YTHDF2 and highlight an essential role of YTHDF2 O-GlcNAcylation in RNA m^(6)A methylation and HCC *** description of the molecular pathway has the potential to yield therapeutic targets for suppression of HCC progression due to HBV infection.

关键词： hepatocellular markedly DF2

Analysis of LULUCF Accounting Rules after 2012

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Advances in Climate Change Research 2011年第4期2卷 178-186页

作者： Shuo Liu Yu＇e Li qingzhu gao Yunfan Wan Xin Ma Xiaobo Qin Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesJKeyOpening Laboratory of Agricultural Environment and Climate Change of Ministry of Agriculture Beijing 100081 China

Land use, land-use change and forestry （LULUCF） activities can allow Annex I parties in the Kyoto Protocol to decrease their carbon emission reduction pressure, and comparably expanding more emission space for their domestic industries and energy production. The loopholes resulted from LULUCF activity types and specific accounting methods are always argued among the different parties, particularly including harvested wood products, influences of force majeure, threshold values of the reference level, and gross-net or net-net accounting methods. For estimating uncertainties in accounting loopholes, and to avoid that developed countries take advantage of the account{ng loopholes of LULUCF to decrease their emission reduction pressure, the LULUCF data submitted from the main developed countries in Annex I, including EU 27, Canada, Japan, and Russia, were collected. According to the analysis of these data, the loopholes influence the accounting results of LULUCF. The results show that the uncertainty of harvested wood products is excessive. The carbon sink produced by LULUCF activities will increase averagely by at least 30% without force majeure. The threshold values of the reference level of carbon sink should be set to a higher level. The net-net accounting method might be more suitable for LULUCF after 2012.

关键词： LULUCF accounting methods after 2012

Rice re-cultivation in southern China： An option for enhanced climate change resilience in rice production

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Journal of Geographical Sciences 2013年第1期23卷 67-84页

作者： MA Xin WU Shaohong LI Yu'e ZHANG Xueyan gao qingzhu WU Yang Institute of Environment and Sustainable Development in Agriculture CAAS Beijing 100083 China Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China

Rice planted in southern China accounts for 94% of the total in sown acreage and 88% of the total in production, which matters a lot to Chinese food security. However, due to the prolonged conflict between water availability and rice growth in spatial/temporal distribu- tion, rice production suffers from seasonal drought at acreage of 16%-22%, which compro- mises food production capacity and food security. Focusing on the spatial distribution of seasonal drought with rice and the practices to adapt to it, and based on an analysis of bal- anced water supply for and demand by rice at a growing season scale during 1981-2030, this paper assesses the changing seasonal drought in the process of rice production under the changing climate in the future, and identifies general rice re-cultivation options for climate change adaptation. Some conclusions can be drawn as follows. （1） Rice suggests a decline in seasonal drought, with early season rice （early rice hereafter） by 12,500 km2, middle season rice （middle rice） by 80,000 km2, and in particular late season rice （late rice） by 25,000 km2, which accounts for almost 20% of its cultivated acreage. It is indicated that due to climate change, seasonal drought in major rice producing areas tends to alleviate in general, late season rice in particular. （2） Future climate change brings about a significant impact on the spatial/temporal distribution of water resources in rice producing areas in China. Based on ＇pre-designed＇ adaptation actions for rice-re-cultivation, the rice cultivation pattern undergoes a significant alteration between 1981-2000 and 2001-2030. In eastern Guizhou and western Hunan, the pattern of single early plus single dry farming is changed into double cropping. In eastern Hunan, the pattern of dry cropping is changed into single early plus single dry farming In northern Anhui, the pattern of dry farming cropping is changed into middle rice. All this is aimed at a potential adequate availability of water for

关键词： climate change adaptation rice seasonal drought

Grassland degradation in Northern Tibet based on remote sensing data

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Journal of Geographical Sciences 2006年第2期16卷 165-173页

作者： gao qingzhu LI Yu＇e WAN Yunfan LIN Erda XIONG Wei JIANGCUN Wangzha WANG Baoshan LI Wenfu Institute of Environment and Sustainable Development for Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Naqu Agriculture and Animal Husbandry Bureau Tibet Autonomous RegionNaqu 852100China

This study selected vegetation cover as the main evaluation index, calculated the grassland degradation index （GDI） and established the remote sensing monitoring and evaluation system for grassland degradation in Northern Tibet, according to the National Standard （GB19377-2003）, based on the remote sensing data such as NDVI data derived from NOAA/AVHRR with a spatial resolution of 8 km of 1981-2000, from SPOT/VGT with a spatial resolution of 1 km of 2001 and from MODIS with a spatial resolution of 0.25 km of 2002-2004 respectively in this area, in combination with the actual condition of grassland degradation. The grassland degradation processes and their responses to climate change during 1981-2004 were discussed and analyzed in this paper. The result indicated that grassland degradation in Northern Tibet is very serious, and the mean value of GDI in recent 20 years is 2.54 which belongs to the serious degradation grade. From 1981 to 2004, the GDI fluctuated distinctly with great interannual variations in the proportion of degradation degree and GDI but the general tendency turned to severe-grade during this period with the grassland degradation grade changed from light degraded to serious degraded in Northern Tibet. The extremely serious degraded and serious degraded grassland occupied 1.7% and 8.0% of the study area, the moderate and light degraded grassland accounted for 13.2% and 27.9% respectively, and un-degraded grassland occupied 49.2% of the total grassland area in 2004. The grassland degradation was serious, especially in the conjunctive area of Naqu, Biru and Jiali counties, the headstream of the Yangtze River lying in the Galadandong snow mountain and glaciers, the area along the Qinghai-Tibet highway and railway, and areas around the Tanggula and Nianqingtanggula snow mountains and glaciers. So the snow mountains and glaciers as well as their adjacent areas in Northern Tibet were sensitive to climate change and the areas along the vital communication l

关键词： grassland degradation temporal and spatial distribution remote sensing monitoring

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吸收能力与创新绩效:文献综述与研究展望

四川职业技术学院学报 2018年第6期28卷 44-50页

作者：高庆祝河南师范大学商学院河南新乡453000

持续创新是创新驱动发展战略环境下企业获取动态竞争优势以实现商业化的重要源泉,其中吸收能力被认为是企业创新赖以成功的关键。然而现有研究很少回答吸收能力是否对创新绩效产生影响、如何产生影响以及产生怎样的影响。文章首先系统... 详细信息

持续创新是创新驱动发展战略环境下企业获取动态竞争优势以实现商业化的重要源泉,其中吸收能力被认为是企业创新赖以成功的关键。然而现有研究很少回答吸收能力是否对创新绩效产生影响、如何产生影响以及产生怎样的影响。文章首先系统梳理吸收能力的内涵;其次从国家层面、行业层面和企业层面归纳出吸收能力与创新绩效关系的三种表现形式;再次重点阐述吸收能力直接作用、间接作用创新绩效的过程;最后在剖析现有研究不足基础上聚焦未来研究方向。文章丰富了吸收能力与创新绩效关系理论研究,为企业增强吸收能力促进创新绩效,进而为提升动态竞争力提供理论参考。

关键词：吸收能力创新绩效表现形式作用过程

95后大学生消费行为分析——基于新乡市高校调查数据

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河南科技学院学报（社会科学版） 2018年第12期38卷 41-46页

作者：高庆祝河南师范大学商学院河南新乡453007

基于河南省新乡市部分高校316份95后大学生的问卷数据,从消费水平、消费来源、消费内容、消费观念四个方面分析95后大学生的消费现状,总结其在消费过程中存在的问题,提出了消费观念重塑、消费情感强化、消费行为培育的合理化建议,以期... 详细信息

基于河南省新乡市部分高校316份95后大学生的问卷数据,从消费水平、消费来源、消费内容、消费观念四个方面分析95后大学生的消费现状,总结其在消费过程中存在的问题,提出了消费观念重塑、消费情感强化、消费行为培育的合理化建议,以期提升高校思想政治教育工作成效,推动95后大学生绿色消费、健康消费、和谐消费。

关键词： 95后大学生消费行为

IPCC第五次评估报告关于适应气候变化与可持续发展的新认知

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气候变化研究进展 2014年第3期10卷 197-202页

作者：段居琦徐新武高清竹中国气象局国家气候中心/中国气象局气候研究开放实验室北京100081 中国气象局科技与气候变化司北京100081 中国农业科学院农业环境与可持续发展研究所北京100081

IPCC发布的《气候变化2014:影响、适应和脆弱性》进一步提升了国际社会对于适应气候变化和可持续发展的认识水平,主要表现在:适应气候变化的研究视角从自然生态脆弱性转向更为广泛的社会经济脆弱性及人类的响应能力;阐明了气候风险与社... 详细信息

IPCC发布的《气候变化2014:影响、适应和脆弱性》进一步提升了国际社会对于适应气候变化和可持续发展的认识水平,主要表现在:适应气候变化的研究视角从自然生态脆弱性转向更为广泛的社会经济脆弱性及人类的响应能力;阐明了气候风险与社会发展的关系,明确了适应在气候灾害风险管理中的积极作用;提出了减少脆弱性和暴露度及增加气候恢复能力的有效适应原则;提出了适应极限的概念,指出这一概念对于适应气候变化的政策含义;提出了保障社会可持续发展的气候恢复能力路径;强调要注重适应与减缓的协同作用和综合效应,指出转型适应是应对气候变化影响的必要选择。报告认为,气候变化、影响、适应及社会经济过程不再是一个简单的单向线性关系,需要纳入统一的系统框架下予以认识和理解。

关键词：气候变化影响适应风险可持续发展

高管过度自信、研发投入跳跃与企业绩效——来自中国上市公司的经验证据

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科技进步与对策 2020年第12期37卷 136-145页

作者：海本禄高庆祝尹西明杨君笑河南师范大学商学院河南新乡453007 中国科学院创新发展研究中心北京100049 北京理工大学管理与经济学院北京100081

基于间断平衡理论和高阶梯队理论,以2007-2017年中国沪深两市902家制造企业为样本,实证分析研发投入跳跃对企业绩效的影响以及高管过度自信的调节作用。结果显示:研发投入正向跳跃和负向跳跃均有助于提升企业绩效,高管过度自信正向调节... 详细信息

基于间断平衡理论和高阶梯队理论,以2007-2017年中国沪深两市902家制造企业为样本,实证分析研发投入跳跃对企业绩效的影响以及高管过度自信的调节作用。结果显示:研发投入正向跳跃和负向跳跃均有助于提升企业绩效,高管过度自信正向调节研发投入跳跃与企业绩效间的关系。引入高管过度自信这一重要高管特征作为调节变量,有助于重新认识管理者心理偏差对企业创新行为和绩效的影响,较好地弥补了研发投入跳跃对企业绩效影响机制的研究空缺,丰富了创新间断平衡理论研究。研究表明,企业应重视高管心理特征的影响并结合自身实际情况,合理选择研发投入策略以改善企业绩效。

关键词：高管过度自信研发投入跳跃企业绩效间断平衡