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Simultaneous quantification of fifty-one odor-causing compounds in drinking water using gas chromatography-triple quadrupole tandem mass spectrometry

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Journal of Environmental Sciences 2019年第5期31卷 100-110页

作者： Chunmiao Wang Jianwei Yu Qingyuan Guo Yu Zhao Nan Cao Zhiyong Yu Min Yang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences College of Environmental Science & Engineering Yancheng Institute of Technology Beijing Waterworks Group

A wide range of compounds with various structural features can cause taste and odor(T&O)problems in drinking water. It would be desirable to determine all of these compounds using a simple analytical method. In this paper, a sensitive method combining liquid–liquid extraction(LLE) with gas chromatography-triple quadrupole tandem mass spectrometry(GC–MS/MS)was established to simultaneously analyze 51 odor-causing compounds in drinking water,including organic sulfides, aldehydes, benzenes, phenols, ethers, esters, ketones, nitrogenous heterocyclic compounds, 2-methylisoborneol and geosmin. Three deuterated analogs of target analytes, dimethyl disulfide-d6, benzaldehyde-d6 and o-cresol-3,4,5,6-d4,were used to correct the variations in recovery, and five isotope-labeled internal standards(4-chlorotoluene-d4, 1, 4-dichlorobenzene-d4, naphthalene-d8, acenaphthene-d10, phenanthrene-d10 respectively) were used prior to analysis to correct the variations arising from instrument fluctuations and injection errors. The calibration curves of the target compounds showed good linearity(R2> 0.99, level = 7),and method detection limits(MDLs) below 1/10 of the odor threshold concentrations were achieved for most of the odorants(0.10–20.55 ng/L). The average recoveries of most of the analytes in tap water samples were between 70% and 120%, and the method was reproducible(RSD < 20%, n = 7). Additionally, concentrations of odor-causing compounds in water samples collected from three drinking water treatment plants(DWTPs) were analyzed by this method.According to the results, dimethyl trisulfide, dimethyl disulfide and indole were considered to be the key odorants responsible for the swampy/septic odor. 2-Methylisoborneol and geosmin were detected as the main odor-causing compounds for musty/earthy odor in DWTP B.

关键词： Odor-causing compounds Drinking water GC–MS/MS High-throughput detection

Large-scale simulations of CO_(2) diffusion in metal-organic frameworks with open Cu sites

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Chinese Journal of Chemical Engineering 2022年第2期35卷 1-9页

作者： Tongan Yan Minman Tong qingyuan Yang Dahuan Liu Yandong guo Chongli Zhong State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116China College of Mathematics Science Bohai UniversityJinzhou 121013China State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China

Understanding CO_(2) diffusion behavior in functional nanoporous materials is beneficial for improving the CO_(2) adsorption,separation,and conversion performances.However,it is a great challenge for studying the diffusion process in experiments.Herein,CO_(2) diffusion in 962 metal–organic frameworks(MOFs)with open Cu sites was systematically investigated by theoretical methods in the combination of molecular dynamic simulations and density functional theory(DFT)calculations.A specific force field was derived from DFT-D2 method combined with Grimme’s dispersion-corrected(D2)density functional to well describe the interaction energies between Cu and CO_(2).It is observed that the suitable topology is conductive to CO_(2) diffusion,and 2D-MOFs are more flexible in tuning and balancing the CO_(2) adsorption and diffusion behaviors than 3D-MOFs.In addition,analysis of diffusive trajectories and the residence times on different positions indicate that CO_(2) diffusion is mainly along with the frameworks in these MOFs,jumping from one strong adsorption site to another.It is also influenced by the electrostatic interaction of the frameworks.Therefore,the obtained information may provide useful guidance for the rational design and synthesis of MOFs with enhanced CO_(2) diffusion performance for specific applications.

关键词： Metal-organic frameworks Open Cusites Molecular simulations Carbon dioxide Diffusion

Genetic dissection of and genomic selection for seed weight, pod length,and pod width in soybean

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The Crop Journal 2023年第3期11卷 832-841页

作者： Yijie Chen Yajun Xiong Huilong Hong Gang Li Jie Gao Qingyuan Guo Rujian Sun Honglei Ren Fan Zhang Jun Wang Jian Song Lijuan Qiu College of Agriculture Yangtze UniversityJingzhou 434025HubeiChina College of Life Sciences Yangtze UniversityJingzhou 434025HubeiChina National Key Facility for Gene Resources and Genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Soybean Research Institute Heilongjiang Academy of Agricultural SciencesHarbin 150086HeilongjiangChina Engineering Research Center of Ecology and Agricultural Use of Wetland Ministry of EducationJingzhou 434025HubeiChina Hulunbuir Institute of Agriculture and Animal Husbandry Hulunbuir 021000Inner MongoliaChina

A biparental soybean population of 364 recombinant inbred lines(RILs)derived from Zhongdou 41×ZYD02.878 was used to identify quantitative trait loci(QTL)associated with hundred-seed weight(100-SW),pod length(PL),and pod width(PW).100-SW,PL,and PW showed moderate correlations among one another,and 100-SW was correlated most strongly with PW(0.64–0.74).Respectively 74,70,75 and19 QTL accounting for 38.7%–78.8%of total phenotypic variance were identified by inclusive composite interval mapping,restricted two-stage multi-locus genome-wide association analysis,3 variancecomponent multi-locus random-SNP-effect mixed linear model analysis,and conditional genome-wide association analysis.Of these QTL,189 were novel,and 24 were detected by multiple methods.Six loci were associated with 100-SW,PL,and PW and may be pleiotropic loci.A total of 284 candidate genes were identified in colocalizing QTL regions,including the verified gene Seed thickness 1(ST1).Eleven genes with functions involved in pectin biosynthesis,phytohormone,ubiquitin-protein,and photosynthesis pathways were prioritized by examining single nucleotide polymorphism(SNP)variation,calculating genetic differentiation index,and inquiring gene expression.The prediction accuracies of genomic selection(GS)for 100-SW,PL,and PW based on single trait-associated markers reached 0.82,0.76,and 0.86 respectively,but selection index(SI)-assisted GS strategy did not increase GS efficiency and inclusion of trait-associated markers as fixed effects reduced prediction accuracy.These results shed light on the genetic basis of 100-SW,PL,and PW and provide GS models for these traits with potential application in breeding programs.

关键词： Soybean Seed weight Pod size Genetic analysis Genomic selection

Preparation of Novel Silica Nanoparticles with Controllable Fluorescence Intensity from Porphyrin-Bridged Silsesquioxane

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Chinese Journal of Chemistry 2011年第2期29卷 363-368页

作者： guo Ximing guo Bin Sun Xuemei Zhang qingyuan Shi Tongshun School of Materials Science and Engineering Harbin Institute of Technology Harbin Heilongjiang 150001 China The Academy of Science and Technology Harbin Institute of Technology Harbin Heilongjiang 150001 China The Campus Hospitals of Harbin Institute of Technology Harbin Heilongjiang 150001 China Department of Oncology The Affiliated Tumor Hospital of Harbin Medical University Harbin Heilongjiang 150040 China College of Chemistry Jilin University Changchun Jilin 130023 China

为可控制的荧光紧张的一个改进的班的制造的一个方法，高度敏感并且 photostable 卟啉做的硅石 nanoparticles (PDSNP ) 被表明。PDSNP 的荧光紧张能被细微地调节衔接卟啉的 silsesquioxane 的先锋的自我分裂的时间控制。卟啉很好在系... 详细信息

为可控制的荧光紧张的一个改进的班的制造的一个方法，高度敏感并且 photostable 卟啉做的硅石 nanoparticles (PDSNP ) 被表明。PDSNP 的荧光紧张能被细微地调节衔接卟啉的 silsesquioxane 的先锋的自我分裂的时间控制。卟啉很好在系统由于共有原子价附件被驱散进硅石矩阵，完全因此避免熄灭的卟啉漏和荧光完成。有一个狭窄的尺寸分布式的区域和常规球形的结构的结果的 PDSNP 能被达到。

关键词：纳米二氧化硅倍半硅氧烷荧光强度可控制备卟啉二氧化硅纳米粒子制备方法调节控制

Efficacy of verbascoside,echinacoside,crenatoside on altitudeinduced fatigue in rats and possible mechanism

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中医杂志:英文版 2023年第5期43卷 934-943页

作者： guo Ziliang QIAN qingyuan LI Xiaolin ZHU Yuting REN Jun LI Maoxing College of Pharmacy Lanzhou UniversityLanzhou 730030China Department of Pharmacy the 940th Hospital of Joint Logistic Support Force of Chinese of the People's Liberation ArmyLanzhou 730050China Department of Pharmacy 3201 HospitalHanzhong 723000China

OBJECTIVE:To study the efficacy and mechanism of three phenylethanoid glycosides(PhG s)(verbascoside,echinacoside,and crenatoside)on altitude-induced fatigue in rats.METHODS:Altitude-induced fatigue model rats were established in a large hypobaric chamber.Swimming time,energy storage substances,metabolic enzymes,and metabolites were used to evaluate the anti-fatigue activities and mechanism of three PhG s(verbascoside,echinacoside,and crenatoside)(150 mg/kg,intragastric administration)in the hypoxic environment.RESULTS:The three PhGs,especially verbascoside,could prolong the swimming time of rats,ameliorate the edema and inflammatory infiltration of liver and skeletal muscle,increase the level of energy storage substances,reduce the decomposition of proteins,and exhibit positive effects on the metabolism-related enzyme activity and metabolites.CONCLUSIONS:The PhG s,especially verbascoside,are very potential with anti-fatigue activity in hypoxia.The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress.

关键词： phenylethanoid glycosides verbascoside hypoxia fatigue energy metabolism

Evaluating the safety of early surgery for ruptured intracranial aneurysms in patients with long-term aspirin use: a propensity score matching study

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中华神经外科杂志(英文) 2021年第1期07卷 13-18页

作者： Li Maogui Yang Shuzhe Liu qingyuan guo Rui Wu Jun Cao Yong Wang Shuo Fengtai District Capital Medical University Department of Neurosurgery Beijing Tiantan Hospital Beijing 100070 119 South Fourth Ring Road West ChinaDepartment of Neurosurgery

Background: Early microsurgical clipping is recommended for ruptured intracranial aneurysms to prevent rebleeding. However, dilemma frequently occurs when managing patients with current acetylsalicylic acid (aspirin) use. This study aimed to examine whether aspirin use was associated with worse outcomes after early surgery for aneurysmal subarachnoid hemorrhage (aSAH).Methods: We retrieved a consecutive series of 215 patients undergoing early microsurgical clipping within 72 h after aneurysmal rupture from 2012 to 2018 in the neurosurgery department of Beijing Tiantan Hospital. The medical records of each case were reviewed. Twenty-one patients had a history of long-term aspirin use before the onset of aSAH, and 194 patients did not. To reduce confounding bias, propensity score matching (PSM) was performed to balance some characteristics of the two groups. The intraoperative blood loss, postoperative hemorrhagic events, postoperative hospital stay, and functional outcome at discharge were compared between aspirin and non-aspirin group.Results: We matched all the 21 patients in aspirin group with 42 patients in non-aspirin group (1:2). Potential confounding factors were corrected between the two groups by PSM. No hospital mortality occurred after surgery. No significant differences were found in intraoperative blood loss (P = 0.540), postoperative hemorrhagic events (P > 0.999), postoperative hospital stay (P = 0.715), as well as functional outcome at discharge (P = 0.332) between the two groups.Conclusions: Our preliminary results showed that long-term low-dose aspirin use was not associated with worse outcomes. Early surgery can be safe for ruptured intracranial aneurysms in patients with long-term aspirin use.

关键词： Intracranial aneurysm Subarachnoid hemorrhage Early surgery Aspirin Antiplatelet

Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study

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Chinese Medical Journal 2022年第4期135卷 433-440页

作者： Xiaonan Hong Yuqin Song Yuankai Shi qingyuan Zhang Wei guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Hematology The First Hospital of Jilin UniversityChangchunJilin 130015China Department of Medical Oncology Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430023China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Oncology Jiangsu Cancer HospitalNanjing Medical University Affiliated Cancer HospitalNanjingJiangsu 210009China Consultant to F.Hoffmann-La Roche Ltd BaselSwitzerlandvia GCE Solutions-an IQVIA businessSwitzerland Product Development Oncology F.Hoffmann-La Roche LtdBaselSwitzerland Department of Medical Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South Chinaand Collaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510075China

Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968.

关键词： Chinese Follicular lymphoma GALLIUM Obinutuzumab Rituximab

数字化背景下家庭体育在儿童身心健康发展中的契机、价值和路径研究

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体育科技文献通报 2024年第4期32卷 128-129,146页

作者：郭庆媛淮北师范大学安徽淮北235000

本文运用文献资料法、逻辑分析法等研究方法,在分析数字化背景下家庭体育在儿童身心发展中的契机基础上,探讨了数字化背景下家庭体育在儿童身心发展中的价值,并提出了数字化背景下家庭体育在儿童身心发展中的路径:建立完善家庭体育平台... 详细信息

本文运用文献资料法、逻辑分析法等研究方法,在分析数字化背景下家庭体育在儿童身心发展中的契机基础上,探讨了数字化背景下家庭体育在儿童身心发展中的价值,并提出了数字化背景下家庭体育在儿童身心发展中的路径:建立完善家庭体育平台、树立正确数字化融入家庭体育意识、提供健全的家庭体育服务等。

关键词：数字化家庭体育儿童身心健康

An effective strategy for preparing transparent ceramics using nanorod powders based on pressure-assisted particle fracture and rearrangement

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Journal of Advanced Ceramics 2022年第12期11卷 1976-1987页

作者： Zhangyi HUANG Yang SHI Yutong ZHANG Mao DENG Yi guo Qingquan KONG Jianqi QI Benyuan MA qingyuan WANG Haomin WANG Institute for Advanced Study Chengdu UniversityChengdu 610106China School of Mechanical Engineering Chengdu UniversityChengdu 610106China College of Physics Sichuan UniversityChengdu 610064China Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices Huizhou UniversityHuizhou 516001China

Achieving full densification of some ceramic materials,such as Y_(2)O_(3),without sintering aids by spark plasma sintering(SPS)is a great challenge when plastic deformation contributes limitedly to the densification as the yield stress of the material at an elevated temperature is higher than the applied sintering pressure.Herein,we demonstrate that particle fracture and rearrangement is an effective strategy to promote the densification during the pressure-assisted sintering process.Specifically,Y_(2)O_(3) nanocrystalline powders composed of nanorod and near-spherical particles were synthesized and sintered at various temperatures by the SPS.The results show that the relative density of the ceramics prepared by the nanorod powders is higher than the density of the ceramics from the near-spherical powders after 600℃ due to the fracture and rearrangement of the nanorods at low temperatures,which leads to the decrease of particle size and the increase of density and homogeneity.Based on this novel densification mechanism,ultrafine-grained Y_(2)O_(3) transparent ceramics with good optical and mechanical properties were fabricated successfully from the nanorod powders.

关键词： transparent ceramics nanorods fracture and rearrangement Y_(2)O_(3) spark plasma sintering(SPS)