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Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen Qian Yixuan Sun Peishang Shi Xiuman Zhou Qiongqiong Zhang qingyu dong Shengzhe Jin Lu Qiu Xiaoshuang Niu Xiaowen Zhou Wenshan Zhao Yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

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Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy

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Science China(Life Sciences) 2024年第5期67卷 996-1009页

作者： Xiaowen Zhou Yang Li Xiangrui Zhang Beibei Li Shengzhe Jin Menghan Wu Xiuman Zhou qingyu dong Jiangfeng Du Wenjie Zhai Yahong Wu Lu Qiu Guodong Li Yuanming Qi Wenshan Zhao Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The immune checkpoint TIGIT/PVR blockade exhibits significant antitumor effects through activation of NK and CD8^(+)T cell-mediated *** checkpoint blockade(ICB)could induce tumor ferroptosis through IFN-γreleased by immune cells,indicating the synergetic effects of ICB with ferroptosis in inhibiting tumor ***,the development of TIGIT/PVR inhibitors with ferroptosis-inducing effects has not been explored *** this study,the small molecule Hemin that could bind withTIGIT to block TIGIT/PVR interaction was screened by virtual molecular docking and cell-based blocking *** could effectively restore the IL-2 secretion from Jurkat-hTIGIT *** reinvigorated the function of CD8^(+)T cells to secrete IFN-γand the elevated IFN-γcould synergize with Hemin to induce ferroptosis in tumor *** inhibited tumor growth by boosting CD8^(+)T cell immune response and inducing ferroptosis in CT26 tumor *** importantly,Hemin in combination with PD-1/PD-L1 blockade exhibited more effective antitumor efficacy in anti-PD-1 resistant B16 tumor *** summary,our finding indicated that Hemin blocked TIGIT/PVR interaction and induced tumor cell ferroptosis,which provided a new therapeutic strategy to combine immunotherapy and ferroptosis for cancer treatment.

关键词： cancer immunotherapy TIGIT/PVR small molecule Hemin ferroptosis

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Probing the Air Storage Failure Mechanism of Ni-Rich Layered Cathode Materials

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Chinese Physics Letters 2022年第3期39卷 105-108页

作者： qingyu dong Ruowei Yi Jizhen Qi Yanbin Shen Liwei Chen i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China In Situ Center for Physical Sciences School of Chemistry and Chemical EngineeringShanghai Jiaotong UniversityShanghai 200240China

Ni-rich layered oxide cathode materials,such as LiNi_(0.83)Co_(0.12)Mn_(0.05)O_(2)(NCM811),exhibit high specific capacity and low cost,and become cathode material preference of high-energy-density Li-ion ***,these cathode materials are not stable and will form Li-poor reconstructed layers and alkaline compounds(Li_(2)CO_(3),LiOH)on the surface during the storage and processing in humid air,resulting in serious deterioration of electrochemical *** the past two decades,the consensus on the surface instability mechanism during humid air storage has not been *** main controversy focuses on the unstable octahedron mechanism and the Li/H exchange ***,we investigate the instability mechanism in the humid air by conducting scanning electronic microscopy,scanning transmission electron microscopy,and x-ray photoelectron spectroscopy analysis on NCM811 samples stored in designed atmospheres,etc.,and realize that the surface instability of the NCM811 during storage should be mainly originated from Li/H exchange when it contacts with moisture.

关键词： mechanism moisture Storage

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High ceramic content composite solid-state electrolyte films prepared via a scalable solvent-free process

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Nano Research 2023年第3期16卷 3847-3854页

作者： Daiqian Chen Chenji Hu Qi Chen Guoyong Xue Lingfei Tang qingyu dong Bowen Chen Fengrui Zhang Mingwen Gao Jingjing Xu Yanbin Shen Liwei Chen School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Moleculesand in situ Center for Physical SciencesShanghai Jiao Tong UniversityShanghai 200240China Baosheng(Suzhou)Energy Technology Co. LtdSuzhou 215123China

The development of high-performance solid-state electrolyte(SSE)films is critical to the practical application of all-solid-state Li metal batteries(ASSLMBs).However,developing high-performance free-standing electrolyte films remains a challenging *** this work,we demonstrate a novel scalable solvent-free process for fabricating high ceramic content composite solid-state electrolyte(HCCSE)*** speaking,a mixture of ceramic and polymer is dry mixed,fibered,and calendered into a free-standing porous ceramic film,on which polymer precursor is coated and polymerized to bridge the inorganic ceramic particles,resulting in a flexible HCCSE film with a ceramic content of up to 80 wt.%.High ceramic content not only leads to high ionic conductivity but also brings good mechanical properties;while the organic phase enables electrode|electrolyte interfacial *** Li_(10)GeP_(2)S_(12)(LGPS)and polymeric ionic liquid-based solid polymer electrolytes(PIL-SPEs)were used as the inorganic and organic phases,respectively,the room temperature ionic conductivity of the resulted HCCSE reaches 0.91 mS·cm−*** on this HCCSE,Li||Li symmetric battery cycled stably for more than 2,400 h with ultra-low overpotential,and ASSLMBs with different cathodes(LiFePO4 and sulfurized polyacrylonitrile(PAN-S))present small polarization and decent cyclability at room *** work provides a novel scalable solvent-free strategy for preparing high-performance freestanding composite solid-state electrolyte(CSE)film for room temperature ASSLMBs.

关键词： free-standing solid-state electrolyte film composite solid-state electrolyte solid-state battery

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Heat Transfer Performance of a Novel Microchannel Embedded with Connected Grooves

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 362-372页

作者： Ding Yuan Wei Zhou Ting Fu qingyu dong Department of Mechanical and Electrical Engineering Xiamen UniversityXiamen361005China Key Laboratory of Metallurgical Equipment and Control Technology Wuhan University of Science and TechnologyWuhan430081China

To improve the heat transfer performance of microchannels,a novel microchannel embedded with connected grooves crossing two sidewalls and the bottom surface(type A)was designed.A comparative study of heat transfer was conducted regarding the performances of type A microchannels,microchannels embedded with grooves on their bottom(including types B and C),or on the sidewalls(type D)as well as smooth rectangular microchannels(type E)via a three-dimensional numerical simulation and experimental validation(at Reynolds numbers from 118 to 430).Numerical results suggested that the average Nusselt number of types A,B,C,and D microchannels were 106,73.4,50.1,and 12.6%higher than that of type E microchannel,*** smallest synergy angle β and entropy generation number Ns,a were determined for type A microchannels based on field synergy and nondimensional entropy analysis,which indicated that type A exhibited the best heat transfer *** flow analysis indicated that connected grooves induced fluid to flow along two different temperature gradients,which contributed to enhanced heat transfer performance.

关键词： Microchannel Connected grooves Heat transfer enhancement Performance evaluation

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Trimethoxyboroxine as an electrolyte additive to enhance the 4.5V cycling performance of a Ni-rich layered oxide cathode

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eScience 2022年第5期2卷 486-493页

作者： Wei Gu Guoyong Xue qingyu dong Ruowei Yi Yayun Mao Lei Zheng Haikuo Zhang Xiulin Fan Yanbin Shen Liwei Chen I-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China

Ni-rich layered oxides are attractive cathode materials for advanced lithium-ion batteries(LIBs)due to their high energy ***,their large-scale application is seriously hindered by their interfacial instability,especially at a high cut-off ***,we demonstrate that trimethoxyboroxine(TMOBX)is an effective film-forming additive to address the interfacial instability of LiNi0.8Co0.1Mn0.1O_(2)(NCM811)material at a high cut-off voltage of 4.5*** find that TMOBX decomposes before carbonate solvent and forms a thin cathode electrolyte interphase(CEI)layer on the surface of the NCM811 *** TMOBX-formed CEI significantly suppresses electrolyte decomposition at a high potential and inhibits the dissolution of transition metals from NCM811 during *** addition,electron-deficient borate compounds coordinate with anions(PF6^(−),F^(-) etc.)and H2O in the battery,further improving the battery's *** a result,adding 1.0wt%of TMOBX boosts the capacity retention of a Li||NCM811cell from 68.72%to 86.60%after 200 cycles at 0.5C in the range of 2.8–4.5V.

关键词： Ni-rich layered oxides Lithium-ion batteries Interface analysis Electrolyte additives Cathode electrolyte interphase

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Geometric based apple suction strategy for robotic packaging

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 12-20页

作者： Zhong Wang qingyu Wang Mingzhao Lou Fan Wu Yaonan Zhu dong Hu Mingchuan Zhou Yibin Ying College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Micro-Nona Mechanical Science and Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Packaging is one of the least automated steps among all the fruit postharvest processes,which is time-consuming and ***,a robust suction strategy for robotic manipulation needs to be *** this research,a geometric-based apple suction strategy for robotic packaging was studied,including suction cup design,optimal suction region selection algorithm,and robot system *** the first place,on the basis of the geometric features of the spheroid fruit,the structure of the suction cups was designed to provide reliable suction ***,suction force measurement experiments on both acrylic balls and apples were *** on the results,the parameters of the suction cup were finally *** results also indicated that the curvature radius of the suction region is supposed to larger than that of the suction ***,a robust suction region selection algorithm was developed,which involves four steps:RGB-D information acquisition,object detection and point cloud generation,spherical fitting,and suction region ***,the above methods were integrated into a robotic packaging *** addition,on the basis of spatial-frequency domain imaging(SFDI)technology,early stage bruise was detected for *** results showed that,the proposed suction strategy and system is potential for robust robotic apple packaging.

关键词： apple suction cup robotic packaging robotic manipulation point cloud

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Revisiting the capacity-fading mechanism of P2-type sodium layered oxide cathode materials during high-voltage cycling

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Journal of Energy Chemistry 2022年第6期31卷 16-25,I0002页

作者： Meidan Jiang Guannan Qian Xiao-Zhen Liao Zhouhong Ren qingyu dong Dechao Meng Guijia Cui Siqi Yuan Sang-Jun Lee Tian Qin Xi Liu Yanbin Shen Yu-Shi He Liwei Chen Yijin Liu Linsen Li Zi-Feng Ma Department of Chemical Engineering Shanghai Electrochemical Energy Device Research Center(SEED)School of Chemistry and Chemical EngineeringFrontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China Stanford Synchrotron Radiation Lightsource SLAC National Accelerator LaboratoryMenlo ParkCA 94025United States In-Situ Center for Physical Sciences School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Suzhou Institute of Nanotech and Nanobionics(SINANO) Chinese Academy of SciencesSuzhou 215123JiangsuChina Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213SichuanChina

P2-type sodium layered oxide cathode (Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)P2-NNMO) has attracted great attention as a promising cathode material for sodium ion batteries because of its high specific capacity. However, this material suffers from a rapid capacity fade during high-voltage cycling. Several mechanisms have been proposed to explain the capacity fade, including intragranular fracture caused by the P2-O2 phase transion, surface structural change, and irreversible lattice oxygen release. Here we systematically investigated the morphological, structural, and chemical changes of P2-NNMO during high-voltage cycling using a variety of characterization techniques. It was found that the lattice distortion and crystal-plane buckling induced by the P2-O2 phase transition slowed down the Na-ion transport in the bulk and hindered the extraction of the Na ions. The sluggish kinetics was the main reason in reducing the accessible capacity while other interfacial degradation mechanisms played minor roles. Our results not only enabled a more complete understanding of the capacity-fading mechanism of P2-NNMO but also revealed the underlying correlations between lattice doping and the moderately improved cycle performance.

关键词： Phase transition Layered cathode Buckling Capacity fading mechanism Sodium-ion batteries

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Reinforced Lewis covalent bond by twinborn nitride heterostructure for lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第1期88卷 363-372,I0009页

作者： Yaochen Song Pengkai Tang Yanjie Wang Yi Wang Linnan Bi Qi Liang Liang He qingyu Xie Yiyong Zhang Peng dong Yingjie Zhang Yao Yao Jiaxuan Liao Sizhe Wang Yangtze Delta Region Institute(QuZhou) University of Electronic Science and Technology of ChinaQinzhou 324000ZhejiangChina School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093YunnanChina School of Materials Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021ShaanxiChina School of Environmental Science and Engineering North China Electric Power UniversityBaoding 071003HebeiChina

The practical application of lithium-sulfur(Li-S)batteries,as promising next-generation batteries,is hindered by their shuttle effect and the slow redox ***,a tungsten and molybdenum nitride heterostructure functionalized with hollow metal-organic framework-derived carbon(W_(2)N/Mo_(2)N)was proposed as the sulfur *** hollow spherical structure provides storage space for sulfur,enhances electrical conductivity,and inhibits volume *** metal atoms in the nitrides bonded with lithium polysulfides(Li PSs)through Lewis covalent bonds,enhancing the high catalytic activity of the nitrides and effectively reducing the energy barrier of Li PSs redox ***,the high intrinsic conductivity of nitrides and the ability of the heterostructure interface to accelerate electron/ion transport improved the Li+*** leveraging the combined properties of strong adsorption and high catalytic activity,the sulfur host effectively inhibited the shuttle effect and accelerated the redox kinetics of Li ***-efficiency Li+transmission,strong adsorption,and the efficient catalytic conversion activities of Li PSs in the heterostructure were experimentally and theoretically *** results indicate that the W_(2)N/Mo_(2)N cathode provides stable,and long-term cycling(over 2000 cycles)at 3 C with a low attenuation rate of 0.0196%per *** design strategy of a twinborn nitride heterostructure thus provides a functionalized solution for advanced Li-S batteries.

关键词： Heterostructure Adsorption Redox kinetics

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基于Voronoi图的方向区域查询方法

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计算机工程与应用 2022年第8期58卷 83-89页

作者：刘润涛董庆宇吴昊天哈尔滨理工大学信息与科学计算技术研究所哈尔滨150080 哈尔滨理工大学理学院数学系哈尔滨150080

针对空间中方向区域查询效率不高的问题,通过引入Voronoi图,利用其特性对数据空间进行划分,提出了基于Voronoi图的方向区域查询方法。该方法在基于Delaunay三角网生成的Voronoi图索引结构基础上,将首结点与查询对象连线形成有向线段,利... 详细信息

针对空间中方向区域查询效率不高的问题,通过引入Voronoi图,利用其特性对数据空间进行划分,提出了基于Voronoi图的方向区域查询方法。该方法在基于Delaunay三角网生成的Voronoi图索引结构基础上,将首结点与查询对象连线形成有向线段,利用Voronoi图可以通过邻接生成点延展的特点确定查询对象的位置,通过判断空间对象与查询区域的位置关系,将相应关联数据点加入候选集,并判定该数据点是否为正确结果,从而得到查询结果集。理论研究和实验结果表明,该方法在确定查询点位置的过程中有效减少了非必要数据的访问,在过滤阶段大大减少了候选集中点的数量,从而提高了空间数据的方向区域查询效率。

关键词：方向区域查询 Voronoi图 Delaunay三角网索引结构开放区域

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