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Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe Zhang Xiaoying Tian qingyu cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang Department of Nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

Chinese dwarf cherry [Cerasus humilis(Bge.) Sok.] polyphenol extract promotes osteoblastic differentiation in MC3T3-E1 cells and reduce ovariectomy-induced bone loss in rats via the calcium/AMPK signaling pathway

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Food Science and Human Wellness 2024年

作者： Yushi Zhang qingyu cui Lixin Wang Xiaoxue Wang Shupeng Liu Rong Zeng Weidong Li School of Chinese Materia Medica Beijing University of Chinese Medicine Qingdao Histep Health Technology Ltd. Department of Cardiology Beijing Anzhen Hospital Capital Medical University

Chinese dwarf cherry (Cerasus humilis) is a fruit unique to China， which is considered to have osteoprotective effects. However， no systematic experimental characterization was available. In this study， the osteoprotective activity and mechanism of Chinese dwarf cherry polyphenol extract (OPE) was studied. In vitro， OPE stimulated the alkaline phosphatase activity in the early differentiation stage， increased the osteocalcin level in the middle differentiation stage， and induced the formation of more bone-mineralized nodules in the late osteogenic stage. In vivo， OPE improved cancellous bone structure and maximum load of the femur in ovariectomized (OVX) rats. The balance between bone formation and resorption was regulated. Oxidative stress levels in the peripheral blood， liver and femur were reduced. OPE alleviated the disturbance in energy metabolism， muscle development， and muscle regulation-related signaling pathways caused by OVX and activated the calcium/adenosine monophosphate-activated protein kinase signaling pathway. Therefore， OPE is a potential dietary supplement for the prevention and treatment of osteoporosis.

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New sensor technologies in quality evaluation of Chinese materia medica:2010–2015

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Acta Pharmaceutica Sinica B 2017年第2期7卷 137-145页

作者： Xiaosu Miao qingyu cui Honghui Wu Yanjiang Qiao Yanfei Zheng Zhisheng Wu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100102China

New sensor technologies play an important role in quality evaluation of Chinese materia medica(CMM) and include near-infrared spectroscopy,chemical imaging,electronic nose and electronic tongue.This review on quality evaluation of CMM and the application of the new sensors in this assessment is based on studies from 2010 to 2015,with prospects and opportunities for future research.

关键词： Chinese materia medica Quality evaluation Sensors Near-infrared Electronic nose Electronic tongue Chemical imaging

露天煤矿环境下基于LiDAR/IMU的紧耦合SLAM算法研究

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煤炭科学技术 2024年第3期52卷 236-244页

作者：马宝良崔丽珍李敏超张清宇内蒙古科技大学信息工程学院内蒙古包头014010

随着人工智能和无人驾驶等相关学科的快速发展,煤矿装备的智能化和无人化成为了新的趋势。智能设备的应用将大幅提高煤矿作业的生产力以及人员安全性。露天煤矿地形复杂,与城市环境相比无明显的几何特征,具有分段相似性,利用现有以激光... 详细信息

随着人工智能和无人驾驶等相关学科的快速发展,煤矿装备的智能化和无人化成为了新的趋势。智能设备的应用将大幅提高煤矿作业的生产力以及人员安全性。露天煤矿地形复杂,与城市环境相比无明显的几何特征,具有分段相似性,利用现有以激光雷达为主的同时定位与建图(Simultaneous Localization and Mapping,SLAM)方案在该环境下易出现定位漂移和建图误差较大等现象。针对上述问题,提出了一种基于激光雷达(Light Detection and Ranging,LiDAR)和惯导(Inertial Measurement Unit,IMU)紧耦合的SLAM算法,该算法使用LiDAR和IMU两种传感器作为数据输入,对数据进行预处理,前端利用迭代扩展卡尔曼滤波器将预处理后的LiDAR特征点与IMU数据相融合,并使用后向传播来矫正雷达运动畸变,后端利用雷达相对位姿因子将LiDAR帧间配准结果作为约束因子与回环因子共同完成全局因子图优化。利用开源数据集和露天煤矿实地数据集验证了算法的鲁棒性和精确性。试验结果表明在城市结构化环境中文中所提算法与当前激光SLAM算法精度保持一致,而针对长达两千多米的露天煤矿实地环境,所提算法较FAST-LIO2、LIO-SAM紧耦合算法在定位精度上分别提高了46.00%和23.15%,且具有更高的鲁棒性。

关键词：露天煤矿同时定位与地图构建激光雷达惯性导航因子图

Metabolite acetyl-L-carnitine participates in Bif. Animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NFκB pathway

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Food Science and Human Wellness 2023年

作者： Xi Liang Zhe Zhang Xiaoying Tian qingyu cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang College of Food Science and Engineering， Ocean University of China Department of Nutrition and Food Hygiene， School of Public Health， Qingdao University

This study aimed to explore the effect of Bif. Animalis F1-7 on the improvement of atherosclerotic inflammation. Arteriosclerosis model ApoE-/-mice were orally administered with Bif. Animalis F1-7 for 12 weeks. The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages， and downregulated the expression of toll-like receptor 4 (TLR4)/nuclear factor-κB (NFκB) pathway to reduce the levels of inflammatory factors. The widely-targeted metabolomics analysis showed that acetyl-L-carnitine (ALC) in the intestine of atherosclerotic mice was significantly increased after Bif. Animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response. By using ox-LDL induced macrophage foam cells， we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NFκB pathway. Finally， our results revealed that Bif. Animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses， leading to the reduction of plaque accumulation of atherosclerosis.

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城市印象管理与社会融合的新趋向:国土空间战略驱动

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上海国土资源 2024年第2期45卷 69-74页

作者：崔诣晨崔亚娟刘青玉广东技术师范大学教育科学学院广东广州510665 南京大学社会学院江苏南京210023 深圳威高集力物流有限公司广东深圳518067 上海财经大学马克思主义学院上海200433

城市印象管理是在城市所形成的内在文化环境中,城市各级政府通过推行和优化其管辖区域内各项制度和福利政策,促进城市居民普遍形成良好的城市印象,努力构建城市社会融合人类命运共同体的一种新型城市管理思路。城市社会融合的矛盾对立统... 详细信息

城市印象管理是在城市所形成的内在文化环境中,城市各级政府通过推行和优化其管辖区域内各项制度和福利政策,促进城市居民普遍形成良好的城市印象,努力构建城市社会融合人类命运共同体的一种新型城市管理思路。城市社会融合的矛盾对立统一,实质是城市居民之间的平均社会距离:这种社会距离愈大,城市各阶层离心分化的不利趋势则愈加明显。国土空间战略驱动是契合新时代居民向往美好生活的生态文明城市价值观,也是有效弥合城市居民相互之间不平衡、不充分发展的平均社会距离“空间黏结剂”。将国土空间战略驱动引入城市印象管理与城市社会融合,走出“共同但有区别的责任原则”语境主义困境,灵活选择法律法规和社会主义核心价值观,从宏观层面、中观层面、微观层面分别入手,全面优化调整城市居民之间的生产空间、生活空间、生态空间分配比例格局,建立城市居民幸福感、获得感、安全感,促进城市印象管理与城市社会融合落地生根开花结果,努力使城市社会融合人类命运共同体在国土空间战略驱动下协同进化健康发展。

关键词：城市印象管理社会融合国土空间人类命运共同体

A human comfort prediction method for indoor personnel based on time-series analysis

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Building Simulation 2023年第7期16卷 1187-1201页

作者： Wenli Zhang Guoqiang cui Yufei Wang Chao Zheng qingyu Zhu Faculty of Information Technology Beijing University of TechnologyBeijing 100124China China Construction Science&Technology Group Limited Liability Company Beijing 100070China

In buildings,the heating ventilation and air conditioning system(HVAC)creates a comfortable environment for indoor occupants by setting a temperature strategy.However,this approach leads to unreasonable indoor environmental comfort and wasted energy because it does not dynamically adjust to changes in environmental and has a long response time.In this study,a high-precision human comfort prediction method for indoor personnel based on time-series analysis is proposed as the control strategy for HVAC systems.The method includes the data pre-processing module,the class imbalance processing module,and the human comfort network model module.We propose the Human-Comfort Bi-directional Long Short-Term Memory(HC-BiLSTM)network to achieve a better human comfort prediction,and the Synthetic Minority Oversampling Technique for Time-series(SMOTE-TS)algorithm to solve the class imbalance problem in human comfort dataset.A public dataset collected in Pennsylvania,USA,was selected for this study to validate the performance of the proposed method.The experimental results show that the human comfort prediction method proposed in this study achieves 0.9482 and 0.9659 on Macro-averaging and Micro-averaging,respectively,which is the highest accuracy in the known related research.

关键词： human comfort HVAC energy efficiency buildings recurrent neural network deep learning

沙库巴曲缬沙坦治疗终末期肾病合并心力衰竭患者的疗效及安全性

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新乡医学院学报 2024年第4期41卷 333-337页

作者：姬利珂许清玉崔艳罗雨轻朱琼杰郭明好新乡医学院第一附属医院肾内科河南卫辉453100

目的探讨沙库巴曲缬沙坦治疗终末期肾病合并心力衰竭患者的疗效及安全性。方法选择2018年9月至2021年9月就诊于新乡医学院第一附属医院肾脏病医院的终末期肾病合并心力衰竭患者63例为研究对象,根据治疗方式将患者分为观察组(n=32)和对照... 详细信息

目的探讨沙库巴曲缬沙坦治疗终末期肾病合并心力衰竭患者的疗效及安全性。方法选择2018年9月至2021年9月就诊于新乡医学院第一附属医院肾脏病医院的终末期肾病合并心力衰竭患者63例为研究对象,根据治疗方式将患者分为观察组(n=32)和对照组(n=31)。2组患者均接受持续性腹膜透析、慢性心力衰竭的常规治疗。在此基础上,观察组者给予沙库巴曲缬沙坦钠片,起始剂量50 mg,每日2次,根据患者血压每2~4周倍增1次,最高剂量200 mg;对照组患者给予缬沙坦胶囊80 mg,每日1次,根据血压调整剂量,最高剂量160 mg。分别于治疗前后采用彩色多普勒超声测量患者的左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)、每搏输出量(SV)、左心室舒张末期容积(LVEDV)等心室功能参数和左心室舒张末期内径(LVDd)、左心室收缩末期内径(LVDs)、室间隔厚度(IVS)、左心室后壁厚度(LVPW)等心室构型参数,应用美国纽约心脏病学会分级标准评估2组患者的心功能分级,比较2组患者治疗前后的收缩压(SBP)和舒张压(DBP),记录2组患者随访期间低血压、高血钾、肝功能异常、心力衰竭再住院等不良事件发生情况。结果治疗前2组患者的心室功能、心室构型参数比较差异均无统计学意义(P>0.05)。对照组患者治疗前后心室功能、心室构型参数比较差异均无统计学意义(P>0.05);观察组患者治疗后LVEF、LVFS大于治疗前,LVDd、LVDs小于治疗前(P0.05)。治疗后,观察组患者LVDs小于对照组(P0.05)。治疗前和治疗后,2组患者心功能分级比较差异均无统计学意义(P>0.05)。观察组患者治疗后心功能分级Ⅳ级患者占比显著低于治疗前(P0.05)。对照组患者治疗前后心功能分级比较差异均无统计学意义(P>0.05)。治疗前,2组患者的SBP、DBP比较差异无统计学意义(P>0.05)。对照组患者治疗前后SBP、DBP比较差异无统计学意义(P>0.05);观察组治疗后患者SBP、DBP显著低于治疗前(P0.05)。结论沙库巴曲缬沙坦可有效改善终末期肾病合并心力衰竭患者心室功能,逆转心室重构,提高心功能分级,降低血压,且安全性良好。

关键词：终末期肾病腹膜透析心力衰竭沙库巴曲缬沙坦心室功能心室重构血压

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倾斜地面3D点云快速分割算法

无线电工程 2024年第2期54卷 447-456页

作者：张清宇崔丽珍李敏超马宝良内蒙古科技大学信息工程学院内蒙古包头014010

依赖于平面拟合或局部几何特征区分地面障碍物的方法广泛应用于自动驾驶领域,但是在具有倾斜地形或稀疏数据的情况下,性能会降低。在倾斜地形场景中,利用激光雷达(LiDAR)提供的点云数据,通过地面点云的3D投影与直线拟合,利用栅格地图方... 详细信息

依赖于平面拟合或局部几何特征区分地面障碍物的方法广泛应用于自动驾驶领域,但是在具有倾斜地形或稀疏数据的情况下,性能会降低。在倾斜地形场景中,利用激光雷达(LiDAR)提供的点云数据,通过地面点云的3D投影与直线拟合,利用栅格地图方法降低计算复杂度,实现地面点云的分割。针对非地面的点云集合,利用SLR聚类算法处理,通过设定强度特征阈值在垂直方向区分地面点与非地面点,并对扫描到的障碍物地面分类。通过实验分析,提出的算法较其他地面点云分割算法,一方面在倾斜地形上具有更好的建图效果,另一方面SLR聚类算法处理后的强度特征在X、Y、Z三个方向覆盖范围更精确,如在X方向相较于快速地面分割算法平均提高了44.0%,相较于添加了栅格地图的算法平均提高了40.1%。

关键词：倾斜地面激光雷达点云分割栅格地图聚类

Digestion performance improvement of tributyrin through nano-emulsion preparation technology

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Grain & Oil Science and Technology 2022年第3期5卷 131-145页

作者： Feng Gao Yaoming cui Shijia Song Jinfeng Zhu Xinyu Liu Xuyang Ji Hao Zhu qingyu Jia Qiaohan Lin Junjun Guan College of Biological Engineering Henan University of TechnologyZhengzhou 450001China

The current research aimed to optimize the preparation technology of tributyrin nano-emulsion(TBNE)to improve its digestion properties, which were investigated through digestion models in vitro and in vivo. The content of each component of TBNE was optimized by response surface methodology(RSM) to improve the z-average particle size and stability of TBNE. The optimized TBNE was evaluated for its digestion properties by in vitro and in vivo models. The preparation conditions of TBNE optimized by RSM were as follows: 61.3% of sorbitol, 32.7% of tributyrin, and 6.0% of modified phospholipid(MP). The predicted z-average particle size of TBNE was(246.02 ± 18.10) nm. The results of the verification test showed that the z-average particle size, zeta potential, conductivity, emulsification activity index, and emulsification stability index of TBNE were(250.02 ± 7.18) nm,(-40.23 ± 0.76) m V,(31.80 ± 2.09) μS/cm,(848.00 ± 84.53) min and(1.14 ± 0.02) m^(2)/g, respectively. The in vitro digestion experiment results showed that the TBNE remained stable in the stomach and was released in the intestine, while the size of TBNE in the gastrointestinal tact was significantly smaller than that of tributyrin(P < 0.05), which made it easier to be digested and absorbed. Compared with tributyrin treatment, TBNE significantly promoted the average body weight at the 7th day, average daily feed intake,average daily gain, feed/gain, ileum weight, and organ index of ileum of Hy-Line BROWN chicks(P < 0.05), and the butyric acid content in the ileal chyme from TBNE and tributyrin treatment were172.18 mg/m L and 100.85 mg/m L(P < 0.01). Therefore, the established TBNE technology in this study could be supposed to improve the digestion properties of tributyrin.

关键词： Tributyrin Nano-emulsion Response surface methodology Digestion property Chick