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基于HS-SPME-GC-MS分析不同茶树品种川红工夫红茶香气差异

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食品工业科技 2024年第19期45卷 268-277页

作者：金磊练学燕杨植溢李甜李宇豪何清钰李东四川轻化工大学生物工程学院四川宜宾644000 宜宾川红茶业集团有限公司四川宜宾644000

选取宜宾境内种植的‘四川中小叶群体’‘福鼎大白’‘福云6号’‘名山131’‘青心乌龙’‘天府5号’和‘天府6号’共7个茶树品种加工制成川红工夫红茶,通过感官审评、电子鼻(E-nose)、顶空固相微萃取-气相色谱-质谱联用(headspace soli... 详细信息

选取宜宾境内种植的‘四川中小叶群体’‘福鼎大白’‘福云6号’‘名山131’‘青心乌龙’‘天府5号’和‘天府6号’共7个茶树品种加工制成川红工夫红茶,通过感官审评、电子鼻(E-nose)、顶空固相微萃取-气相色谱-质谱联用(headspace solid-phase microextraction gas chromatography-mass spectrometry,HS-SPME-GC-MS)、香气活度值(Odor activity value,OAV)和偏最小二乘判别分析(Partial least squares discrimination analysis,PLS-DA)分析不同茶树品种鲜叶所制川红工夫红茶的关键差异香气化合物。结果表明,7个茶树品种鲜叶制成的红茶均表现为甜香,‘四川中小叶群体’稍带果香,评分最高;共检出84种挥发性香气化合物,醇类29种、醛类12种、酯类15种、烯类12种、酸类7种、酮类5种和4种其它碳氢化合物;7个样品中共有的香气化合物有14种,且不同样品间香气成分含量具有显著性差异(P1);不同茶树品种红茶样本中鉴定出8个关键差异香气化合物,分别是香叶醇、芳樟醇、水杨酸甲酯、苯乙醇、苯乙烯、2-己烯醛、(E)-芳樟醇氧化物(呋喃型)和柠檬醛。综上所述,由不同茶树品种鲜叶加工制成的川红工夫红茶香气物质种类和含量相差较大,研究结果可为筛选川红工夫红茶适制茶树品种提供参考。

关键词：茶树品种川红工夫红茶香气活度值偏最小二乘判别分析

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透水型建筑固废再生水稳材料疲劳性能试验及预测模型

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铁道科学与工程学报 2024年第7期21卷 2766-2777页

作者：杨涛肖源杰陈宇亮李昀博何庆宇周震李鼎硕中南大学土木工程学院湖南长沙410075 中南大学重载铁路工程结构教育部重点实验室湖南长沙410075 湖南省交通科学研究院有限公司湖南长沙410015 广东省交通规划设计研究院集团股份有限公司广东广州510440

为探讨建筑固体废弃物再生骨料在透水型公路水泥稳定碎石基层中的应用和耐久性强化问题,以建筑固废再生骨料部分替代天然碎石制备透水型再生水泥稳定碎石试样,开展无侧限抗压和四点弯曲疲劳试验。基于能量理论分析透水型再生水泥稳定碎... 详细信息

为探讨建筑固体废弃物再生骨料在透水型公路水泥稳定碎石基层中的应用和耐久性强化问题,以建筑固废再生骨料部分替代天然碎石制备透水型再生水泥稳定碎石试样,开展无侧限抗压和四点弯曲疲劳试验。基于能量理论分析透水型再生水泥稳定碎石材料在疲劳加载过程中的耗散能变化规律,并建立基于耗散能的疲劳损伤预估模型,进而分析透水型建筑固废再生水稳碎石材料的疲劳损伤演化规律。研究结果表明:透水型建筑固废再生水稳碎石材料其抗压强度和渗透系数满足我国大多数公路基层的使用要求;试样累积耗散能随疲劳应力加载峰值的上升呈指数级增长,并且单次疲劳应力加卸载循环中产生的耗散能量与疲劳应力比具有较强关联,疲劳应力比为0.75和0.85的试样在每个疲劳加载循环中的耗散能相较于0.55的试样整体分别提高了50%和200%;随着试样中再生骨料占比的提升,试样在单次加载中产生的耗散能降低,试样疲劳损伤变量和疲劳损伤相对变化速率均有不同程度的增大。基于疲劳应力峰值和损伤演化规律提出的疲劳寿命预测模型可较好地预估不同疲劳应力水平下材料的疲劳寿命。研究结果可为建筑固体废弃物再生骨料在透水型公路水泥稳定碎石基层中的高效应用及长期服役性能提升提供理论依据和技术参考。

关键词：透水型基层建筑固废再生水泥稳定材料疲劳损伤疲劳寿命

How to discover new proteins——translatome profiling

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Science China(Life Sciences) 2014年第3期57卷 358-360页

作者： ZHANG Gong WANG Tong he qingyu College of Life Science and Technology Jinan University

According to the Central Dogma,genes in genome can be transcribed and translated into proteins to perform a variety of biological *** proteins are the actual functional molecules in almost all physiological processes,discovering new proteins is essential to understand the nature of various biological *** far,the Human Genome Project and many transcriptomic analyses have defined about 20300 genes that can be transcribed into *** genes,comprising only 2%of human genome,are considered as coding genes that may be translated into proteins.

关键词：蛋白质人类基因组计划生物学功能中心法则生理过程功能分子生命现象 mRNA

Iron acquisition by Streptococcus species: An updated review

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Frontiers in Biology 2009年第4期4卷 392-401页

作者： Ruiguang GE Xuesong SUN qingyu he Laboratory of Integrative Biology College of Life SciencesSun Yat-Sen UniversityGuangzhou 510006China Institute of Life and health Engineering/Guangdong Provincial Key Laboratory of Bioengineering Pharmaceutics/National Engineering&Research Center of Genetic Medicine Jinan UniversityGuangzhou 510632China

Streptococcus is a genus of spherical Gram-positive bacteria responsible for many cases of meningitis,bacterial pneumonia, endocarditis, erysipelas, and necro-tizing fasciitis. To survive in the host environment withlimited free iron available, Streptococcus species havedeveloped various mechanisms to uptake iron as anessential nutrient. They can directly extract the metalions from host iron-containing proteins such as ferritin,transferrin, lactoferrin, and hemoproteins. Other iron-uptake strategies, which are broadly distributed in thestrains, include the employment of specialized secretedhemophores to acquire heme and the usage of smallmolecules called siderophores as high-affinity ferricchelators. This review intends to discuss the most recentdiscoveries of these iron acquisition systems and theirrelevant regulators in Streptococcus species.

关键词： Gram-positive bacteria Streptococcus spe-cies iron heme siderophore transport

Neogene subduction initiation models in the western Pacific and analysis of subduction zone parameters

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Science China Earth Sciences 2023年第3期66卷 472-491页

作者： Min LI Song HUANG Tianyao HAO Miao DONG Ya XU Jian ZHANG qingyu he Gui FANG Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

The Neogene is an important period for studying the onset of subduction,with numerous subduction zones forming in the western Pacific,including the Ryukyu,Manila,Philippine,North Sulawesi,Halmahera,New Britain,Solomon,and New hebrides subduction ***,studies on these subduction zones are relatively independent,so it is important to conduct systematic comparative *** this paper,we review the initiation models of Neogene subduction in the western Pacific,with the three typical types of subduction initiation models including polarity-reversal,induced subduction re-initiation,and noninherited subduction initiation to form new *** addition,the parameters of different subduction zones are collated to form five categories:basic features,subducting plate features,upper plate features,kinematic features,and subsequent *** regularity of the subduction processes,the specificity of the different subduction cases,and the possible constraints between the subduction initiation types and the characteristics of the subduction zone parameters are discussed and *** compiled dataset of the subduction zone parameters can provide data support for related studies.

关键词： Subduction initiation Western Pacific Neogene Subduction zone parameters

Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1271-1287页

作者： Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan he Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li qingyu he Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringJinan UniversityGuangzhou 510632China Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hong Kong-Macao Institute of CNS RegenerationKey Laboratory of CNS RegenerationMinistry of EducationJinan UniversityGuangzhou 510632China MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China

As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer *** screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of *** using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of *** could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of *** PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor ***,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent *** together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease.

关键词： Drug repurposing Metabolic reprogramming Glycolysis PFKL DARTS technology Esophageal cancer Penfluridol

A Review of Researches on Deep Learning in Remote Sensing Application

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International Journal of Geosciences 2019年第1期10卷 1-11页

作者： Ming Zhu Yongning he qingyu he Institute of Geoscience and Resources China University of Geosciences Beijing China Geographic Information Center of Guangxi Nanning China

In recent years, deep learning has been widely used in the field of image understanding and made breakthroughs research progress in image understanding. Because remote sensing application and image understanding are inseparable, researchers have carried out a lot of research on the application of deep learning in remote sensing field, and extended the deep learning method to various application fields of remote sensing. This paper summarizes the basic principles of deep learning and its research progress and typical applications in remote sensing, introduces the current main deep learning model and its development history, focuses on the analysis and elaboration of the research status of deep learning in remote sensing image classification, object detection and change detection, and on this basis, summarizes the typical applications and their application effects. Finally, according to the current application of deep learning in remote sensing, the main problems and future development directions are summarized.

关键词： Deep Learning Remote Sensing Application CNN Land Cover Classification Object Detection Change Detection

Reveal the lost entanglement for accelerated atoms in the high-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 48-57页

作者： Jiatong Yan Baocheng Zhang qingyu Cai School of Mathematics and Physics China University of GeosciencesWuhan 430074China Physics Department Brown UniversityProvidenceRhode Island 02912USA Center for Theoretical Physics Hainan UniversityHaikou 570228China School of Information and Communication Engineering Hainan UniversityHaikou 570228China Peng Huanwu Center for Fundamental Theory Hefei 230026China

When atoms are accelerated in the vacuum,entanglement among atoms will degrade compared with the initial situation before the *** this study,we propose a novel and interesting view that the lost entanglement can be recovered completely when the high-dimensional spacetime is exploited,in the case that the acceleration is not too large,since the entanglement loss rate caused by the large acceleration is faster than the recovery *** also calculate the entanglement change caused by the anti-Unruh effect and found that the lost entanglement could just be recovered part by the anti-Unruh effect,and the anti-Unruh effect could only appear for a finite range of acceleration when the interaction time scale is approximately shorter than the reciprocal of the energy gap in two dimensional *** limit case of zero acceleration is also investigated,which gives an analytical interpretation for the increase or recovery of entanglement.

关键词： entanglement acceleration high-dimensional spacetime

Exploration of human chromosomes by biomass spectrometry based proteomics with trans-omics

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Exploration of human chromosomes by biomass spectrometry bas...