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Acta Pharmaceutica Sinica B 2024年第7期14卷 2959-2976页

作者： Chaofan Peng Peng Yang Dongsheng Zhang Chi Jin Wen Peng Tuo Wang qingyang sun Zhihao Chen Yifei Feng Yueming sun Department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Colorectal Institute of Nanjing Medical University Nanjing 210029China The First School of Clinical Medicine Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine Nanjing 210029China

Excessive fructose diet is closely associated with colorectal cancer(CRC)***,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely ***,this study reported that the fructose absorbed by primary colorectal cancer could accelerate CRLM,and the expression of KHK-A,not KHK-C,in liver metastasis was higher than in paired primary ***,KHK-A facilitated fructose-dependent CRLM in vitro and in vivo by phosphorylating PKM2 at ***2 phosphorylated by KHK-A inhibited its tetramer formation and pyruvic acid kinase activity but promoted the nuclear accumulation of *** and aerobic glycolysis activated by nuclear PKM2 enhance CRC cells’migration ability and anoikis resistance during CRLM ***-46 treatment,targeting the phosphorylation of PKM2,inhibited the pro-metastatic effect of ***,c-myc activated by nuclear PKM2 promotes alternative splicing of KHK-A,forming a positive feedback loop.

关键词： CRC CRLM Fructose KHK-A PKM2

Mixed-decomposed convolutional network:A lightweight yet efficient convolutional neural network for ocular disease recognition

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 319-332页

作者： Xiaoqing Zhang Xiao Wu Zunjie Xiao Lingxi Hu Zhongxi Qiu qingyang sun Risa Higashita Jiang Liu Research Institute of Trustworthy Autonomous Systems and Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhenChina Tomey Corporation NagoyaJapan Guangdong Provincial Key Laboratory of Brain‐inspired Intelligent Computation Department of Computer Science and EngineeringSouthern University of Science and TechnologyShenzhenChina Singapore Eye Research Institute SingaporeSingapore

Eye health has become a global health concern and attracted broad *** the years,researchers have proposed many state-of-the-art convolutional neural networks(CNNs)to assist ophthalmologists in diagnosing ocular diseases efficiently and ***,most existing methods were dedicated to constructing sophisticated CNNs,inevitably ignoring the trade-off between performance and model *** alleviate this paradox,this paper proposes a lightweight yet efficient network architecture,mixeddecomposed convolutional network(MDNet),to recognise ocular *** MDNet,we introduce a novel mixed-decomposed depthwise convolution method,which takes advantage of depthwise convolution and depthwise dilated convolution operations to capture low-resolution and high-resolution patterns by using fewer computations and fewer *** conduct extensive experiments on the clinical anterior segment optical coherence tomography(AS-OCT),LAG,University of California San Diego,and CIFAR-100 *** results show our MDNet achieves a better trade-off between the performance and model complexity than efficient CNNs including MobileNets and ***,our MDNet outperforms MobileNets by 2.5%of accuracy by using 22%fewer parameters and 30%fewer computations on the AS-OCT dataset.

关键词： artificial intelligence deep learning deep neural networks image analysis image classification medical applications medical image processing

A semi-analytical multi-harmonic balance method on full-3D contact model for dynamic analysis of dry friction systems

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Chinese Journal of Aeronautics 2024年第2期37卷 309-329页

作者： He sun Dayi ZHANG Yaguang WU qingyang SHEN Dianyin HU Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100191China Sino-French Engineering School Beihang UniversityBeijing 100191China AECC Sichuan Gas Turbine Research Establishment Chengdu 610500China

Dry friction damping structures are widely-used in aero-engines to mitigate *** nonlinear nature of friction and the two-dimensional in-plane motion on the contact interface bring challenges to accurately and efficiently predict the forced response of frictionally damped *** state-of-the-art Multi-Harmonic Balance Method(MHBM)on quasi-3D contact model in engineering cannot precisely capture the kinematics on the friction interface although the efficiency is *** full-3D contact model can describe the constitutive relationship of the interface in a more accurate manner;however,the efficiency and convergence are not guaranteed for large-scale *** this paper,a semi-analytical MHBM on full-3D contact model is *** original Trajectory Tracking Method(TTM)for evaluating the contact force is reformulated to make the calculation more concise and the derivation of the Analytical Jacobian Matrix(AJM)*** on the chain rule of derivation,the AJM which is the core to upgrade the performance is *** a shrouded blade finite element model,the accuracy and efficiency of the proposed method are compared with both the MHBM on full-3D contact model with numerical Jacobian matrix and the MHBM on quasi-3D contact model with *** results show that the AJM improves significantly the efficiency of the MHBM on full-3D contact *** time cost of the proposed method is in the same order of magnitude as that of the MHBM on quasi-3D contact *** also confirm that the full-3D contact model is necessary for the dynamic analyses of shrouded *** one uses the quasi-3D model,the estimation relative error of damping can even reach 31.8%in some *** addition,the AJM also brings benefits for stability *** is highly recommended that engineers use the MHBM on full-3D contact model for the dynamic analysis and design of shrouded blades.

关键词： Dry friction damping Multi-harmonic balance method Trajectory tracking method Jacobian matrix Shrouded blade

Comprehensive therapeutic effect of the stroke rehabilitation unit in a medium-sized comprehensive community hospital

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Neural Regeneration Research 2006年第4期1卷 375-378页

作者： Xiaohua Fu Hong Wang Jia sun Haiyan sun qingyang Song Yi Liu Hong Li Department of Neurology Beijing Longfu Hospital Beijing100010 China

BACKGROUND： Acute stroke unit （stroke care unit） is developing in some domestic large-sized hospitals, but most stroke patients need stroke rehabilitation unit therapy, so setting stroke rehabilitation unit in medium-sized comprehensive community hospital （secondary hospital）, where medical facility is relatively insufficient, is a new pathway to satisfy stroke patients. OBJECTIVE： To observe the comprehensive effect of developing stroke rehabilitation unit based on the facility of secondary hospital and its feasibility. DESIGN： Non-randomized concurrent controlled observation SETTING： Department of Neurology, Beijing Longfu Hospital PARTICIPANTS： Totally 264 stroke reconvalescents who suffered stroke for 7 days and received treatment in the Department of Neurology, Beijing Longfu Hospital during June 2003 to June 2005 were involved in the study. All the involved patients were confirmed by CT or MRI. The patients were scored by using Modified Edinbergh-Scandinavia stroke scale （SSS）〉 16 points. Written informed consents were obtained from all the patients. The patients were assigned into 2 groups according to the willing of patients and their relatives：（1）treatment group, in which, there were 134 patients, 76 males and 58 females, aged 43 to 74 years; cerebral infarction was found in 116 cases and cerebral hemorrhage in 18 cases;（2） control group, in which, there were 130 patients, 66 males and 64 females, aged 45 to 77 years, cerebral infarction was found in 115 cases and cerebral hemorrhage in 15 cases. There were significant differences in baseline data of the patients between two groups. METHODS： A same basic treatment was conducted in the patients of the two groups. （1） Patients in the treatment group admitted to stroke rehabilitation unit and received comprehensive rehabilitation treatment. The rehabilitation flow-sheet： randomization-letting the patients of treatment group go into the unit-making comprehensive assessment in the initial stage-makin

关键词： Comprehensive therapeutic effect of the stroke rehabilitation unit in a medium-sized comprehensive community hospital

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6S管理模式在食品类专业实验室中的应用

食品工业 2024年第6期45卷 169-172页

作者：张丽王萌路艺董永红孙庆扬宋丽军河北科技师范学院食品科技学院秦皇岛066600 河北科技师范学院板栗产业技术教育部工程研究中心秦皇岛066600 河北科技师范学院教务处秦皇岛066600

实验室不仅是高校开展实践教学的主要场所,更是进行科学探究、提高学生综合素质和创新能力的重要平台。从食品科技学院实验室实际管理和发展需要出发,结合高校本科食品类专业实验室运行特点及存在的问题,阐述6S管理模式在实验室管理中... 详细信息

实验室不仅是高校开展实践教学的主要场所,更是进行科学探究、提高学生综合素质和创新能力的重要平台。从食品科技学院实验室实际管理和发展需要出发,结合高校本科食品类专业实验室运行特点及存在的问题,阐述6S管理模式在实验室管理中的具体应用。采用6S管理模式后,实验室管理显著规范,实验室环境得到有效改善,实验人员的素养提高,可有效保障实验室的安全。

关键词： 6S管理模式食品专业实验室应用

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超高层核心筒结构模板体系施工技术

施工技术 2015年第7期44卷 11-13,16页

作者：王宁孙清杨张绚上海建科工程咨询有限公司上海200032

目前国内超高层核心筒施工常用的模板体系有自爬模和顶升钢平台系统。结合工程实例,针对超高层核心筒混凝土结构模板体系的搭设、使用、爬升等过程进行多角度探讨,对常用的自爬模和整体顶升钢平台系统在技术、安全、造价、进度等方面进... 详细信息

目前国内超高层核心筒施工常用的模板体系有自爬模和顶升钢平台系统。结合工程实例,针对超高层核心筒混凝土结构模板体系的搭设、使用、爬升等过程进行多角度探讨,对常用的自爬模和整体顶升钢平台系统在技术、安全、造价、进度等方面进行对比,总结各模板体系的优缺点,为超高层核心筒模板施工给出建议。

关键词：高层建筑核心筒模板自爬模顶升钢平台施工技术

PPP模式下市政综合管廊建设中BIM技术的应用研究

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土工基础 2018年第2期32卷 178-181页

作者：孙清杨上海建筑科学研究院(集团)有限公司上海建科工程咨询有限公司

PPP模式是一种新型的项目建设融资模式,旨在引入社会资本进行城市大型基础设施项目的建设,能够合理地对各个参建方的风险进行分担,并且能够有效地提高市政综合管廊项目建设及运营的质量。但是目前在市政综合管廊的建设过程当中还存在诸... 详细信息

PPP模式是一种新型的项目建设融资模式,旨在引入社会资本进行城市大型基础设施项目的建设,能够合理地对各个参建方的风险进行分担,并且能够有效地提高市政综合管廊项目建设及运营的质量。但是目前在市政综合管廊的建设过程当中还存在诸多困难,通过对某工程实例的应用分析,对BIM技术在PPP模式下市政综合管廊建设中能够起到的作用进行研究和总结。

关键词： PPP模式市政综合管廊 BIM技术

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邻近历史保护建筑的基坑施工应对措施

建筑施工 2018年第6期40卷 842-843页

作者：孙清杨上海市建筑科学研究院集团有限公司上海200032 上海建科工程咨询有限公司上海200032

随着城市建设的发展,城市中心可建造空间越来越局促,而城市中心往往保留着大量优秀历史保护建筑,甚至是文物保护建筑,在满足城市开发和发展的同时,如何做好对历史建筑的保护更是重中之重。以上海地区为例,针对邻近历史保护建筑开挖基坑... 详细信息

随着城市建设的发展,城市中心可建造空间越来越局促,而城市中心往往保留着大量优秀历史保护建筑,甚至是文物保护建筑,在满足城市开发和发展的同时,如何做好对历史建筑的保护更是重中之重。以上海地区为例,针对邻近历史保护建筑开挖基坑的案例,探讨对保护建筑加固、基坑围护设计、施工方案优化等方面的技术,通过预应力静压桩加固、MJS、轴力自动补偿系统钢支撑、合理分区开挖、加强监测等技术措施,在顺利完成基坑施工的同时,保证了历史保护建筑的安全,为后续类似项目的实施提供了一定的技术参考。

关键词：保护建筑基坑开挖保护措施基础托换

星载SAR欺骗式干扰信号的实时产生技术研究

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现代雷达 2016年第7期38卷 78-82页

作者：丁宸聪孙清洋舒汀海军装备研究院上海200436 上海交通大学上海市智能探测与识别重点实验室上海200240

为了在电子战系统中对敌方星载合成孔径雷达(SAR)雷达进行有效干扰,文中提出了一种新颖的星载SAR欺骗式干扰信号的实时产生技术。该技术首先通过对分布式大场景的干扰调制函数的离线及分块并行计算,降低了干扰信号产生的复杂度和计算量... 详细信息

为了在电子战系统中对敌方星载合成孔径雷达(SAR)雷达进行有效干扰,文中提出了一种新颖的星载SAR欺骗式干扰信号的实时产生技术。该技术首先通过对分布式大场景的干扰调制函数的离线及分块并行计算,降低了干扰信号产生的复杂度和计算量;然后,通过实时卷积产生欺骗干扰信号,从而实现对敌方星载SAR系统的实时欺骗干扰的目的;最后,试验干扰机的测试数据和仿真结果说明了方法的有效性。结果表明:该方法不但可以提供可信赖的干扰效果,而且在实践应用中具有一定的实时性。

关键词：星载合成孔径雷达干扰调制函数欺骗式干扰实时产生

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