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Chinese Medical Journal 2023年第16期136卷 2014-2016页

作者： qingxing xie Xiaohui Pan Xinyue Zhang Jinfang Ma Ge Peng Nanwei Tong Division of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengduSichuan 610041China Center for Diabetes and Metabolism Research West China Hospital of Sichuan UniversityChengduSichuan 610041China Laboratory of Diabetes and Islet Transplantation Research West China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:Non-alcoholic fatty liver disease(NAFLD)includes a spectrum of diseases:simple steatosis,nonalcoholic steatohepatitis(NASH),and the related fibrosis and cirrhosis.[1]The treatment of NAFLD should aim to reverse or prevent liver fibrosis,which is associated with liver-specific morbidity or mortality,rather than just to reduce circulating liver enzyme activities and improve NASH.

关键词： NAFLD liver mortality

Foodborne parasitic diseases in China:A scoping review on current situation,epidemiological trends,prevention and control

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Asian Pacific Journal of Tropical Medicine 2021年第9期14卷 385-400页

作者： Langui Song qingxing xie Zhiyue Lv The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhenGuangdongChina Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikouChina NHC Key Laboratory of Control of Tropical Diseases the First Affiliated HospitalHainan Medical UniversityHaikouChina Key Laboratory of Tropical Disease Control Sun Yat-sen UniversityMinistry of EducationGuangzhouChina

Objective:Foodborne parasitic diseases,although with a declining overall incidence rate,are still endangering local public safety.This review aims to describe the current situation and epidemiological trends of foodborne parasitic diseases in China in order to explore possible reasons contributors to its high prevalence in some areas,and propose strategies for prevention and control accordingly.Methods:A scoping review was conducted by searching Pub Med,CNKI,Wanfang,CQVIP,Embase,and the Cochrane Library using search formula"foodborne parasitic diseases(or foodborne parasites)"AND"China".Studies on foodborne parasitic diseases in China were considered,but only articles in English or Chinese published between January 1980 and June 2020 were retrieved.Included studies were screened according to the eligibility criteria:1)diseases consistent with the WHO definition of foodborne parasitic diseases;2)the food carriers were included in the WHO food classification;3)data related to epidemiology,pathogenicity,and prevention and control;4)Foodborne parasitic diseases cases or outbreaks in China.Results:A total of 111 out of 665 records were included and summarized.The prevalence of clonorchiasis,angiostrongyliasis,echinococcosis,trichinellosis and cysticercosis was still increasing although the infection rate of soil-transmitted nematodes has substantially decreased in recent years.Diverse eating habits,close contact with animals,and urbanization were contributing factors to the increase.Conclusions:Foodborne parasitic diseases remain an important public health issue in China with the progress of economic globalization and food diversification.We should manage to raise public awareness about the prevention and control of foodborne parasitic diseases,improve health and safety inspections,as well as public health practice.

关键词： Foodborne diseases Parasitic diseases China Preventive medicine

Electric field manipulation of multiple nonequivalent Dirac cones in the electronic structures of hexagonal CrB_4 sheet

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Chinese Physics B 2018年第9期27卷 518-523页

作者：王锦坤柯亚娇谢晴兴李艳丽王嘉赋 Department of Physics and Institute of Applied Condensed Matter Physics School of Science Wuhan University of Technology Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of Technology

Two-dimensional materials with Dirac cones have significant applications in photoelectric technology. The origin and manipulation of multiple Dirac cones need to be better understood. By first-principle calculations, we study the influence of external fields on the electronic structure of the hexagonal CrB4 sheet with double nonequivalent Dirac cones. Our results show that the two cones are not sensitive to tensile strain and out-of-plane electric field, but present obviously different behaviors under the in-plane external electric field（along the B-B direction）, i.e., one cone holds while the other vanishes with a gap opening. More interestingly, a new nonequivalent cone emerges under a proper in-plane electric field. We also discuss the origin of the cones in CrB4 sheet. Our study provides a new method on how to obtain Dirac cones by the external field manipulation, which may motivate potential applications in nanoelectronics.

关键词： borophene multiple Dirac cones electric field manipulation first-principle calculation

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors

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Protein & Cell 2023年第1期14卷 17-27页

作者： Yi Zang Mingbo Su qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Center for Excellence in Biomacromolecules Chinese Academy of SciencesBeijing 100101China Zhongshan Branch the Institute of Drug Discovery and DevelopmentChinese Academy of SciencesGuangdong 528400China

The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development.

关键词： high-throughput screening SARS CoV-2 main papain-like proteases

宫腔镜切除子宫内膜息肉术后四种方法预防复发临床研究

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首都食品与医药 2022年第11期29卷 34-37页

作者：张琳李清醒谢有欢广东省佛山市南海区桂城医院广东佛山528200

目的对比宫内放置曼月乐、口服短效避孕药、孕激素及单纯TCRP术对子宫内膜息肉切除术(TCRP)术后复发的预防效果.方法选择2020年1月-2020年12月期间于佛山市南海区桂城医院接受治疗的子宫内膜息肉(EP)患者175例作为研究对象,术后根据不... 详细信息

目的对比宫内放置曼月乐、口服短效避孕药、孕激素及单纯TCRP术对子宫内膜息肉切除术(TCRP)术后复发的预防效果.方法选择2020年1月-2020年12月期间于佛山市南海区桂城医院接受治疗的子宫内膜息肉(EP)患者175例作为研究对象,术后根据不同治疗方法分为A组(曼月乐,n=48)、B组(短效避孕药,n=43)、C组(孕激素,n=44)及D组(对照组,n=40).分别评价其手术治疗效果,同时于术后1、6、12个月随访四组患者的子宫内膜厚度、月经量改善情况、血红蛋白水平及术后复发情况.结果①四组患者TCRP手术疗效无显著性差异(P>0.05).②术后1、6、12个月,四组患者子宫内膜厚度均低于术前;术后12个月,A组患者子宫内膜厚度显著低于B组、C组及对照组(P0.05).③术后6、12个月,治疗组患者月经改善比例均高于对照组(P0.05).④术后12个月治疗组术后血红蛋白水平均明显高于对照组(P0.05).⑤术后12个月治疗组复发率均显著低于对照组(χ^(2)=4.351,P<0.01);治疗组间比较,差异不明显.结论TCRP术后联合曼月乐、口服短效避孕药及孕激素均能显著降低EP复发率、提高血红蛋白水平,但联合曼月乐更有助于抑制子宫内膜厚度,同时改善月经情况,具有推广价值.

关键词：子宫内膜息肉宫腔镜左炔诺孕酮宫内缓释系统息肉复发

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基于深度学习的机器视觉轴承检测方法研究

信息与电脑 2023年第6期35卷 50-52页

作者：柳清星姚虹光秦超谢广玲陈雨虹广西财经学院广西南宁530003

轴承缺陷检测是机器视觉技术中一个重要的应用领域,传统算法需针对特征设计特殊算子检测缺陷,算法比较复杂,局部算子实现困难,大大降低了算法的稳定性,开发效率不高。基于此,首先分析利用机器视觉检测缺陷的方法,其次分析深度学习在轴... 详细信息

轴承缺陷检测是机器视觉技术中一个重要的应用领域,传统算法需针对特征设计特殊算子检测缺陷,算法比较复杂,局部算子实现困难,大大降低了算法的稳定性,开发效率不高。基于此,首先分析利用机器视觉检测缺陷的方法,其次分析深度学习在轴承缺陷检测中的应用,最后分析深度学习在轴承检测应用中的未来研究方向。

关键词：缺陷检测机器视觉深度学习轴承

老年糖尿病患者结肠镜诊疗中护理干预对策与效果

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中外医疗 2023年第25期42卷 126-129,134页

作者：王素云王素琴叶清星谢晨曦福建省厦门市厦门大学附属中山医院消化内镜室福建厦门361001 厦门市海沧区海沧街道石塘社区卫生服务中心福建厦门361026 厦门大学附属中山医院消化内科福建厦门361001

目的分析老年糖尿病患者结肠镜诊疗中实施护理干预的效果。方法随机选取2021年6月—2022年6月在福建省厦门大学附属中山医院接受结肠镜检查的60例老年糖尿病患者。按照随机数表法分为观察组、对照组,每组30例。对照组常规护理,观察组综... 详细信息

目的分析老年糖尿病患者结肠镜诊疗中实施护理干预的效果。方法随机选取2021年6月—2022年6月在福建省厦门大学附属中山医院接受结肠镜检查的60例老年糖尿病患者。按照随机数表法分为观察组、对照组,每组30例。对照组常规护理,观察组综合护理,观察两组清洁质量评分、不良反应发生率、耐受性评分、护理满意度的对比效果。结果观察组右半结肠(2.87±0.19)分、横结肠(2.71±0.19)分、左半结肠肠道(2.63±0.41)分的清洁质量评分均高于对照组,差异有统计学意义(t=6.609、4.519、6.394,P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组耐受性优于对照组,差异有统计学意义(P<0.05);观察组护理满意度高于对照组,差异有统计学意义(P<0.05)。结论结肠镜诊疗期间,实施综合护理干预,可提高肠道清洁质量,降低不良反应发生率,增强患者的耐受性。

关键词：糖尿病结肠镜肠道清洁护理干预对策

两个系列催化剂在4.0Mt·a^(-1)渣油加氢装置上的运行性能对比

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工业催化 2022年第12期30卷 61-69页

作者：胡永宏胡永群王一程龙庆兴谢德壮中国石油天然气股份有限公司广西石化分公司广西钦州535000 西安石油大学石油与工程学院陕西西安710065

介绍了某国外公司RM/RN系列催化剂和某国内公司RHT系列催化剂的物性以及在渣油加氢装置中的装填情况,通过RM/RN和RHT系列催化剂在4.0 Mt·a^(-1)渣油加氢装置中的实际日常运行情况,对各反应器床层平均温度、反应器床层总平均温度、反应... 详细信息

介绍了某国外公司RM/RN系列催化剂和某国内公司RHT系列催化剂的物性以及在渣油加氢装置中的装填情况,通过RM/RN和RHT系列催化剂在4.0 Mt·a^(-1)渣油加氢装置中的实际日常运行情况,对各反应器床层平均温度、反应器床层总平均温度、反应器温升、反应器压降以及氢耗进行对比研究,对产品在装置运转期间原料油和加氢常渣的硫含量、残炭值和金属Ni、V、Fe和Ca的含量变化进行分析。结果表明,RN/RM系列催化剂活性和选择性高,能耗低;RHT系列催化剂原料适应性和硬度定性好、失活率低。

关键词：石油化学工程固定床渣油加氢催化剂对比研究

多学科诊疗模式在基层医院老年髋部骨折绿色通道救治的临床研究

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基层医学论坛 2023年第8期27卷 1-4页

作者：彭庆星欧阳凯谢小兰陈科明黄从伍丘鹏程深圳市宝安区福永人民医院广东深圳518103

目的探讨多学科诊疗模式在基层医院老年髋部骨折绿色通道救治中的临床效果。方法选择深圳市宝安区福永人民医院2020-2021年期间60例老年髋部骨折绿色通道救治的患者作为试验组,纳入多学科诊疗围手术期管理;2019年前进行常规围手术期处理... 详细信息

目的探讨多学科诊疗模式在基层医院老年髋部骨折绿色通道救治中的临床效果。方法选择深圳市宝安区福永人民医院2020-2021年期间60例老年髋部骨折绿色通道救治的患者作为试验组,纳入多学科诊疗围手术期管理;2019年前进行常规围手术期处理的60例老年髋部骨折患者作为对照组,统计其围手术期并发症发生率、患者满意度、末次随访时髋关节功能Harris评分。结果试验组围手术期并发症发生率显著低于对照组,患者满意度显著高于对照组,末次随访时髋关节功能Harris评分显著高于对照组,差异均显著(P<0.05)。结论将多学科协作诊疗模式应用于基层医院老年髋部骨折绿色通道救治中,可降低围手术期并发症发生率,促进患者髋关节功能恢复,提高满意度,其作为一种高效管理模式,应用于基层医院可提高救治水平,符合我国大力发展基层医疗的国情。

关键词：基层医院老年髋部骨折绿色通道救治多学科诊疗模式临床效果

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清洁压裂液返排液渗吸驱油效果影响因素评价

断块油气田 2020年第5期27卷 666-670页

作者：刘煜杨建民王丹廖庆星杜光辉谢岩长江大学地球科学学院湖北武汉430100 中国石油长庆油田分公司第七采油厂陕西西安710000 中国石油青海油田分公司采油三厂青海茫崖816400

致密砂岩油藏通常需要采用水力压裂进行开采,压裂液返排液的处理及回收利用成为制约此类油藏开发的重要因素,而渗吸驱油是致密砂岩油藏开发的一种重要技术手段。清洁压裂液返排液中通常含有较多的表面活性剂,具备渗吸驱油的有利条件。因... 详细信息

致密砂岩油藏通常需要采用水力压裂进行开采,压裂液返排液的处理及回收利用成为制约此类油藏开发的重要因素,而渗吸驱油是致密砂岩油藏开发的一种重要技术手段。清洁压裂液返排液中通常含有较多的表面活性剂,具备渗吸驱油的有利条件。因此,室内以致密砂岩油藏天然岩心和现场清洁压裂液返排液为研究对象,开展了清洁压裂液返排液渗吸驱油效果影响因素研究。结果表明:随着压裂液返排液界面张力的下降、岩心渗透率的升高,渗吸采收率呈现出先上升后下降的趋势,存在一个最佳的界面张力值和渗透率范围,使得渗吸采收率达到最大;而随着岩石表面亲水性的增强、温度的升高以及原油黏度的降低,渗吸采收率逐渐增大。矿场试验结果表明,实施清洁压裂液返排液渗吸驱油措施后,油井的产油量得到明显提高,含水率明显下降,取得了显著的增油效果。

关键词：致密砂岩油藏压裂液返排液渗吸作用采收率影响因素