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帕纳替尼及联合化疗治疗伴T315I突变的Ph染色体阳性急性淋巴细胞白血病4例

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中华实用诊断与治疗杂志 2019年第3期33卷 286-288页

作者：刘莹米瑞华陈琳袁芳芳尹青松魏旭东郑州大学附属肿瘤医院河南省肿瘤医院血液科郑州450008

目的探讨帕纳替尼及联合化疗治疗伴T315I突变的Ph染色体阳性急性淋巴细胞白血病(Philadelphia chromosome-positive acute lymphoblastic leukemia, Ph^+ALL)患者的临床疗效及不良反应。方法伊马替尼或达沙替尼联合化疗治疗后复发,且治... 详细信息

目的探讨帕纳替尼及联合化疗治疗伴T315I突变的Ph染色体阳性急性淋巴细胞白血病(Philadelphia chromosome-positive acute lymphoblastic leukemia, Ph^+ALL)患者的临床疗效及不良反应。方法伊马替尼或达沙替尼联合化疗治疗后复发,且治疗期间发生T315I突变Ph^+ALL患者4例,均给予帕纳替尼30 mg/d或45 mg/d,口服,视治疗情况给予联合化疗,随访观察治疗效果,记录总生存期及并发症发生情况。结果 1例应用帕纳替尼45 mg/d治疗1个月达分子生物学完全缓解,后BCR-ABL基因转阳但处于完全缓解状态;1例应用帕纳替尼30 mg/d治疗25 d后达完全缓解,复发后联合鞘内注射甲氨蝶呤+阿糖胞苷+地塞米松治疗再次达完全缓解;2例应用帕纳替尼45 mg/d治疗1个月后达完全缓解,其中1例3个月后复发,帕纳替尼联合Hyper-CVAD(环磷酰胺+表阿霉素+长春地辛+地塞米松)治疗后仍为部分缓解,后失访;末次随访时3例未失访者中位总生存期为16.4个月;4例患者均出现Ⅳ级骨髓抑制,2例出现肺部感染,1例出现心功能不全,经对症治疗后缓解,无治疗相关死亡。结论帕纳替尼及联合化疗治疗伴T315I突变的Ph^+ALL疗效确切,不良反应可耐受。

关键词：急性淋巴细胞白血病帕纳替尼 Ph染色体 T315I突变

The square rod-shaped ionic polymer-metal composite and its application in interventional surgical guide device

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International Journal of Smart and Nano Materials 2020年第2期11卷 159-172页

作者： qingsong He Kai Huo Xianrui Xu yinghao Yue Guoxiao yin Min Yu Jiangsu Provincial Key Laboratory of Bionic Functional Materials Institute of Bio-inspired Structure and Surface EngineeringCollege of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina College of Astronautics Nanjing University of Aeronautics and AstronauticsNanjingChina

Ionic polymer-metal composite(IPMC)is an electro-active polymer material,which has many advantages such as small size,light weight,low driving voltage,large strain,and good ***,the conventional sheet IPMC has the shortcoming of only bending in the two-dimensional plane,which greatly limits the application of IPMC in the field of interventional *** this work,a square rodshaped IPMC with multi-degree-of-freedom motion was fabricated,and the displacement and blocking force of the square rod-shaped IPMC in different directions are measured and analyzed under the DC voltage *** interventional catheter was designed using the square rod-shaped IPMC in order to achieve active guidance,and a simulation experiment platform and a model of human aorta were built to successfully complete the in vitro simulation experiment of interventional surgery,which preliminarily verified the feasibility of the square rod-shaped IPMC in the field of interventional surgery.

关键词： Square rod-shaped IPMC guiding device interventional surgery simulation experiment

达沙替尼治疗急性白血病致血性胸腔积液三例并文献复习

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白血病．淋巴瘤 2019年第8期28卷 490-492页

作者：米瑞华汪小姣陈琳尹青松袁芳芳熊媛媛于萍朱松涛魏旭东郑州大学附属肿瘤医院血液科 450008 郑州大学附属肿瘤医院中心实验室 450008

目的探讨达沙替尼治疗急性白血病(AL)致血性胸腔积液的临床特点及转归.方法回顾性分析3例达沙替尼治疗中发生血性胸腔积液的AL患者的临床资料,并复习相关文献.结果例1患者将达沙替尼减量后胸腔积液好转,获得持续分子学缓解;例2患者将达... 详细信息

目的探讨达沙替尼治疗急性白血病(AL)致血性胸腔积液的临床特点及转归.方法回顾性分析3例达沙替尼治疗中发生血性胸腔积液的AL患者的临床资料,并复习相关文献.结果例1患者将达沙替尼减量后胸腔积液好转,获得持续分子学缓解;例2患者将达沙替尼(商品名:依尼舒)调整为达沙替尼(商品名:施达赛),并逐渐增加剂量,获得持续分子学缓解;例3患者将达沙替尼调整为伊马替尼治疗,获得再次缓解.结论胸腔积液是达沙替尼治疗过程中较常见的不良反应,但血性胸腔积液少见,应密切监测并尽早干预,可使患者获长期满意疗效.

关键词：白血病,急性达沙替尼血性胸腔积液

CD56在t（8；21）成人急性髓系白血病患者中的表达及其与预后的相关性分析

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中华血液学杂志 2015年第8期36卷 676-681页

作者：刘莎魏旭东米瑞华艾昊尹青松汪萍汪小姣范瑞华胡杰英朱兴虎周健符粤文宋永平郑州大学附属肿瘤医院、河南省肿瘤医院血液科 450008

目的观察CD56在t（8；21）初治成人急性髓系白血病（AML）患者中的表达，探讨其与临床特征和预后的关系。方法回顾性分析2008年1月至2014年4月收治的82例初治t（8；21）成人AML患者的临床资料，比较CD56阳性和阴性患者的临床特征及预后... 详细信息

目的观察CD56在t（8；21）初治成人急性髓系白血病（AML）患者中的表达，探讨其与临床特征和预后的关系。方法回顾性分析2008年1月至2014年4月收治的82例初治t（8；21）成人AML患者的临床资料，比较CD56阳性和阴性患者的临床特征及预后差异。结果82例患者中CD56阳性者50例，阴性者32例。对两组患者的性别、年龄、血常规、有无髓外浸润、染色体核型、早期病死率、完全缓解率及3年总生存率进行比较，差异均无统计学意义（P值均〉0．05）；阳性组患者CD19表达率较阴性组低（30．0％对53．1％，P=0．036），3年无病生存（DFS）率也较阴性组低（25．8％对46．9％，P=0．014），差异均有统计学意义。多因素分析结果显示CD56阳性是患者DFS的独立预后不良因素（HR=4．012，95％CI1．712～9．400，P=0．001）。结论CD56阳性合并t（8；21）初治成人AML患者预后不良。

关键词：抗原,CD56 白血病,髓样,急性临床特点存活率分析

Magnetically Induced Anisotropic Interaction in Colloidal Assembly

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Precision Chemistry 2023年第5期1卷 272-298页

作者： qingsong Fan Zhiwei Li Chaolumen Wu Yadong yin Department of Chemistry University of CaliforniaRiversideCalifornia 92521United States

The wide accessibility to nanostructures with high uniformity and controllable sizes and morphologies provides great opportunities for creating complex superstructures with unique *** anisotropic nanostructures as the building blocks significantly enriches the superstructural phases,while their orientational control for obtaining long-range orders has remained a significant *** solution is to introduce magnetic components into the anisotropic nanostructures to enable precise control of their orientations and positions in the superstructures by manipulating magnetic *** the importance of magnetic anisotropy in colloidal assembly,we provide here an overview of magnetic field-guided self-assembly of magnetic nanoparticles with typical anisotropic shapes,including rods,cubes,plates,and *** Review starts with discussing the magnetic energy of nanoparticles,appreciating the vital roles of magneto-crystalline and shape anisotropies in determining the easy magnetization direction of the anisotropic *** then introduces superstructures assembled from various magnetic building blocks and summarizes their unique properties and intriguing *** concludes with a discussion of remaining challenges and an outlook of future research opportunities that the magnetic assembly strategy may offer for colloidal assembly.

关键词： colloidal self-assembly magnetic field-guided self-assembly magnetic nanoparticles magnetic anisotropy superstructures magneto-crystalline anisotropy shape anisotropy

Construction of NH2-MIL-125(Ti)/Bi2WO6 composites with accelerated charge separation for degradation of organic contaminants under visible light irradiation

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Green Energy & Environment 2020年第2期5卷 203-213页

作者： Sheng yin Yong Chen Ming Li qingsong Hu Yi Ding Yifan Shao Jun Di Jiexiang Xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang 212013China School of Ecological and Environmental Science Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

Photocatalysis is considered as an ideal strategy for water pollution ***,it remains challenging to design a highly efficient photo-catalytic system through regulating the charge flow via a precise *** this work,a novel NH2-MIL-125(Ti)/Bi2WO6 composite was constructed via self-assembly growing Bi2WO6 nanosheets on NH2-MIL-125(Ti)*** characterization results demonstrated that NH2-MIL-125(Ti)was successfully incorporated into Bi2WO6 and the photoexcited carriers could be efficiently separated and transferred between the two ***2-MIL-125(Ti)/Bi2WO6 composites displayed enhanced photocatalytic activity for the removal of rhodamine B(RhB)and tetracycline(TC)under visible light irradiation,and the optimal weight ratio of NH2-MIL-125(Ti)was determined to be 7 wt%.The introduction of NH2-MIL-125(Ti)into Bi2WO6 could raise the absorption of visible light,accelerate the separation and transfer of charge carriers,and boost photocatalytic *** research presents a wide range of possibilities for the further development of novel composites in the field of environment purification.

关键词： NH2-MIL-125(Ti) Bi2WO6 nanosheets Charge separation Photocatalysis Visible light

Review on Improvement,Modeling,and Application of Ionic Polymer Metal Composite Artificial Muscle

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Journal of Bionic Engineering 2022年第2期19卷 279-298页

作者： qingsong He Guoxiao yin David Vokoun Qi Shen Ji Lu Xiaofang Liu Xianrui Xu Min Yu Zhendong Dai Jiangsu Provincial Key Laboratory of Bionic Functional Materials Institute of Bio-Inspired Structure and Surface EngineeringCollege of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China Institute of Physics of the Academy of Sciences of the Czech Republic Prague 18221Czech Republic Active Materials and Smart Living Laboratory Department of Mechanical EngineeringUniversity of Nevada Las VegasLas Vegas 89154-4027USA

Recently,researchers have concentrated on studying ionic polymer metal composite(IPMC)artificial muscle,which has numerous advantages including a relatively large strain under low input voltage,flexibility,high response,low noise,light weight,and high driving energy *** paper reports recent developments in IPMC artificial muscle,including improvement methods,modeling,and *** types of IPMCs are described,along with various methods for overcoming some shortcomings,including improvement of Nafion matrix membranes,surface preparation of Nafion membranes,the choice of high-performing electrodes,and new electro-active polymers for enhancing the properties of *** models are also reviewed,providing theoretical guidance for studying the performance and applications of *** applications such as bio-inspired robots,opto-mechatronic systems,and medical engineering are discussed.

关键词： Ionic polymer metal composite Artificial muscle Improvement Model Bio-inspired application

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急性白血病化疗后合并结核感染临床分析

肿瘤基础与临床 2017年第4期30卷 304-306页

作者：左文丽邓梅杨景柯尹青松朱兴虎魏旭东郑州大学附属肿瘤医院血液科河南郑州450008

目的探讨急性白血病化疗后合并结核感染的临床特点、诊断、治疗和转归。方法回顾性分析了我院198例急性白血病患者中合并结核感染的4例患者的临床资料,并进行相关文献复习。结果 198例急性白血病患者中有4例(2.02%)合并结核感染,其中急... 详细信息

目的探讨急性白血病化疗后合并结核感染的临床特点、诊断、治疗和转归。方法回顾性分析了我院198例急性白血病患者中合并结核感染的4例患者的临床资料,并进行相关文献复习。结果 198例急性白血病患者中有4例(2.02%)合并结核感染,其中急性髓系白血病及急性淋巴细胞白血病各2例,均存在应用化疗药物及化疗后骨髓抑制期白细胞减少等易感因素,临床表现为发热、咳嗽等,给予抗结核治疗后,3例病情比较稳定,目前随访均处于完全缓解中,1例因白血病复发死亡。结论急性白血病化疗后易合并结核感染,发病率高于正常人群,其临床特点不典型,抗结核治疗后疗效确切,不影响患者的长期生存。

关键词：急性白血病化疗结核

Ph-儿童急性淋巴细胞白血病远期复发为Ph＋急性淋巴细胞白血病一例

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中华血液学杂志 2017年第1期38卷 78-78页

作者：袁芳芳艾昊米瑞华陈琳尹青松魏旭东宋永平郑州大学附属肿瘤医院(河南省肿瘤医院)血液科 450008

患者，女，11岁。因＂间断发热、乏力2周，确诊急性淋巴细胞白血病（ALL）1周＂于2011年12月21日至我院就诊。12月11日当地医院查血常规示：WBC 36×109/L，HGB 110 g/L，PLT 87×109/L，淋巴细胞占0.90。骨髓象：增生极度活跃，原幼淋... 详细信息

患者，女，11岁。因＂间断发热、乏力2周，确诊急性淋巴细胞白血病（ALL）1周＂于2011年12月21日至我院就诊。12月11日当地医院查血常规示：WBC 36×109/L，HGB 110 g/L，PLT 87×109/L，淋巴细胞占0.90。骨髓象：增生极度活跃，原幼淋巴细胞占0.845，诊断为＂ALL＂，给予地塞米松7 mg/d共6 d。2011年12月21日入住我院，查外周血涂片：未见原幼淋巴细胞，成熟淋巴细胞占0.26；骨髓象：增生活跃，原幼淋巴细胞占0.515；流式细胞术免疫分型：幼稚细胞占50.6%，表达CD10、CD34、CD19、CD20、CD22、CD38、HLA-DR，符合早前B-ALL；荧光原位杂交检测BCR-ABL未见融合信号；染色体核型：46，XX[10]。2011年12月24日行VDLP（长春新碱、柔红霉素、左旋门冬酰胺酶和泼尼松）方案诱导化疗获完全缓解。

关键词：儿童急性淋巴细胞白血病远期复发 Ph+ 原幼淋巴细胞 BCR-ABL 左旋门冬酰胺酶 HLA-DR 原位杂交检测