检索结果-南通市图书馆

SARS-CoV-2 virus: Vaccines in development

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2021年第2期1卷 131-138页

作者： qingrui huang Jinghua Yan CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China

The ongoing COVID-19 pandemic,caused by SARS-CoV-2,is an imprecedented challenge to *** herd immunity may be necessary before resumption of normal economic and societal *** the beginning of the outbreak,the development of COVID-19 vaccines has proceeded at record speed using nearly all available platforms or strategies to maximize vaccine success.A total of 42 vaccine candidates have now entered clinical trials and encouraging data from several vaccine candidates in phase 1 or 2 clinical trials have been *** this review,we examine current COVID-19 vaccine candidates,discuss their strengths and weaknesses,summarize published clinical data and analyze future challenges.

关键词： SARS-CoV-2 COVID-19 Vaccine Clinical trial Virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于相火理论辨治雄激素性脱发

现代中医临床 2024年第4期31卷 91-94页

作者：黄清瑞郑屿萍张彦峰何翔三明市皮肤病医院三明365000 上海中医药大学附属曙光医院

雄激素性脱发(androgenetic alopecia, AGA)是最常见的脱发类型,中医学称其为“发蛀脱发”“蛀发癣”。相火理论是中医学的特色理论之一,对临床诊治疾病有重要的指导意义。生理性相火是维持人体生命活动的原动力,相火妄动即病理性相火,... 详细信息

雄激素性脱发(androgenetic alopecia, AGA)是最常见的脱发类型,中医学称其为“发蛀脱发”“蛀发癣”。相火理论是中医学的特色理论之一,对临床诊治疾病有重要的指导意义。生理性相火是维持人体生命活动的原动力,相火妄动即病理性相火,是导致疾病的贼邪,其成因主要为脏腑之火相煽、情志失调。AGA根本病机为相火妄动,主要表现在:情志过极,相火亢盛;劳欲不节,相火离位;禀赋异常,相火易亢。基于相火理论治疗AGA,包括:养心正志,相火自安;安宁君火,清降相火;滋阴固本,补水泻火;阴阳双补,引火归元。本文结合临床验案阐述基于相火理论对AGA的辨治。

关键词：相火相火妄动雄激素性脱发脱发

A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第2期7卷 372-374页

作者： Xiaomin Duan Rui Shi Pulan Liu qingrui huang Fengze Wang Xinyu Chen Hui Feng Weijin huang Junyu Xiao Jinghua Yan CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking-Tsinghua Center for Life SciencesBeijing Advanced Innovation Center for GenomicsPeking UniversityBeijing 100871China Shanghai Junshi Biosciences Co.Ltd Shanghai 200126China Division of HIV/AIDS and Sextransmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Dear Editor,The emergence of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants threatens efforts to contain the coronavirus disease 2019(COVID-19)***(B.1.1.529),the fifth novel SARS-CoV-2 variant of concern(VOC),harbors 15 mutations in the receptor-binding domain(RBD)of the spike(S)protein.1 These mutations include almost all the sites of existing VOCs(Alpha/B.1.1.7,Beta/B.1.351,Gamma/P.1,and Delta/B.1.617.2).2–4 Importantly,the key mutations directly interact with the ACE2 receptor and constitute the main target of neutralizing antibodies(NAbs),which is believed to alter the sensitivity to a large number of NAbs.

关键词： ACE2 acute neutral

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

疏肝解郁法诊治斑秃的研究进展

中国中医基础医学杂志 2024年第4期30卷 738-740,F0003,F0004页

作者：郑屿萍张慧敏黄清瑞张彦峰何翔上海中医药大学附属曙光医院上海201203

斑秃是皮肤科中较为常见的疾病之一。中医学认为斑秃的病机不外乎本虚标实,心、肝、脾、肾亏虚为本,内风、痰湿、血瘀等实邪为标。近年来发现精神情志因素导致斑秃的比重越来越高,疏肝解郁法治疗斑秃具有重要的临床价值。药理研究发现... 详细信息

斑秃是皮肤科中较为常见的疾病之一。中医学认为斑秃的病机不外乎本虚标实,心、肝、脾、肾亏虚为本,内风、痰湿、血瘀等实邪为标。近年来发现精神情志因素导致斑秃的比重越来越高,疏肝解郁法治疗斑秃具有重要的临床价值。药理研究发现疏肝解郁法治疗斑秃可能涉及中药调节下丘脑-垂体-肾上腺轴、调节免疫改善炎症、减少氧化应激、改善血流等机制。因此,本文基于疏肝解郁法诊治斑秃,从疏肝气、养肝血角度,并结合现代机制研究进行论述,为斑秃的进一步临床治疗及研究提供参考。

关键词：斑秃疏肝解郁机制研究

在线全文

学校读者我要写书评

暂无评论

ⅩⅦ型胶原蛋白在脱发中的作用机制研究进展

中国美容医学 2024年第3期33卷 175-178页

作者：郑屿萍黄清瑞张彦峰(综述) 张慧敏何翔(审校) 上海中医药大学附属曙光医院皮肤科上海201203

脱发是一种较为常见的皮肤疾病,其发病率逐年上升,并呈年轻化趋势发展,困扰着越来越多人的生活,以进行性毛囊微型化、毛发生长期缩短为特点,导致毛发附着松散容易脱落。ⅩⅦ型胶原蛋白是一种跨膜蛋白,位于表皮基底膜区的半桥粒,维持表... 详细信息

脱发是一种较为常见的皮肤疾病,其发病率逐年上升,并呈年轻化趋势发展,困扰着越来越多人的生活,以进行性毛囊微型化、毛发生长期缩短为特点,导致毛发附着松散容易脱落。ⅩⅦ型胶原蛋白是一种跨膜蛋白,位于表皮基底膜区的半桥粒,维持表皮真皮之间的紧密连接。近期研究发现,ⅩⅦ型胶原蛋白参与毛发生长,调节毛发相关细胞的静息与活化。若缺失ⅩⅦ型胶原蛋白可通过DNA损伤效应累积、表皮细胞极性失衡以及抑制干细胞竞争导致脱发。本文将对ⅩⅦ型胶原蛋白在脱发中的作用机制予以综述,为毛发再生领域研究提供方向。

关键词： ⅩⅦ型胶原蛋白毛囊干细胞衰老脱发再生

维普期刊数据库博看期刊

The identification of a CD47-blocking“hotspot”and design of a CD47/PD-L1 dual-specific antibody with limited hemagglutination

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 2227-2229页

作者： Rui Shi Yan Chai Xiaomin Duan Xiaoshan Bi qingrui huang Qihui Wang Shuguang Tan George F.Gao Jianhua Zhu Jinghua Yan CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of Sciences100101 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences100101 BeijingChina Institute of Physical Science and Information Technology Anhui University230601 HefeiChina Department of Oncology Fourth Medical Center of PLA General Hospital100048 BeijingChina

Dear Editor,By targeting the programmed cell death 1(PD-1)pathway with monoclonal antibodies(mAbs),immune checkpoint therapy(ICT)has achieved unprecedented clinical success in the treatment of multiple tumors.1,2 Cancer cells evade the host immune system via both the tolerance of T cells and functional suppression of innate immune cells.3 CD47 provides a“do not eat me”signal by binding to signal regulatory protein alpha(SIRPα)to prevent innate immune cells from attacking host cells.4 Recently,macrophages were found to restore antitumor reactivity by blocking the interaction between upregulated CD47 on tumor cells and SIRPαon innate immune cells.5 However,it remains unknown whether there are blocking“hotspots”on CD47 for mAb-based anti-CD47 therapy or additional blocking hotspot regions within CD47 for therapeutic mAb *** it is overexpressed on tumor cells,CD47 is also expressed in many normal cells,including red blood cells and platelets.6 Some validated CD47-blocking mAbs under clinical investigation induce hemagglutination and anemia.7 Thus,designing an engineered CD47-blocking antibody to exert a therapeutic effect with limited hemagglutination is needed.

关键词： CD47 hemagglutination blocking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

加强绿色建筑的全寿命期成本管理

建筑技术 2009年第5期40卷 464-466页

作者：黄庆瑞长江大学城市建设学院湖北荆州434023

绿色建筑的成本是影响其实施和推广的关键因素之一。对绿色建筑的成本进行分析,应站在全寿命期的角度,尤其关注设计和运营阶段的费用。针对影响绿色建筑全寿命期成本的主要因素,采取相应的措施加强管理,对绿色建筑相关理论的逐步完善及... 详细信息

绿色建筑的成本是影响其实施和推广的关键因素之一。对绿色建筑的成本进行分析,应站在全寿命期的角度,尤其关注设计和运营阶段的费用。针对影响绿色建筑全寿命期成本的主要因素,采取相应的措施加强管理,对绿色建筑相关理论的逐步完善及其实施具有重要的现实意义。

关键词：绿色建筑全寿命期成本管理

A novel variant associated with refractory lymphopenia in systemic lupus erythematosus:Dedicator of cytokinesis 2 gene c.2883_2886dup

在线全文

学校读者我要写书评

暂无评论

Rheumatology & Autoimmunity 2024年第3期4卷 180-182页

作者： Minghua huang Yaqi Zhao Wei Xu Zhenzhen Ma Yanyan Bai qingrui Yang Department of Respiratory Medicine Shandong Provincial Third HospitalShandong UniversityJinanShandongChina Department of Rheumatology and Immunology Shandong Province Hospital of Shandong First Medical UniversityJinanShandongChina Department of Rheumatology and Immunology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina

To the Editor,Genetic and phenotypic heterogeneity present challenges for the diagnosis and personalized treatment of systemic lupus erythematosus(SLE).1 Leukopenia,a common clinical presentation of SLE,can vary in severity from mild to *** thinking often attributes the pathogenesis of leukopenia to immune-mediated damage,infections,or iatrogenic factors(azathioprine and cyclophosphamide).2 However,the gene defects associated with leukopenia have only gained limited ***,we report a novel dedicator of cytokinesis 2(DOCK2)gene mutation that played a nonautoimmune pathogenic role in a woman with SLE who developed refractory lymphopenia.

关键词： erythematosus lupus diagnosis

Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosafety and Health 2023年第2期5卷 89-100页

作者： Qian Chen Pei Du Yuxuan Han Xuehui Ma Rong Zhang Xiaoyu Rong Xu Zhao Renyi Ma Huiting Yang Anqi Zheng qingrui huang Jinghua Yan Hui Wang Xin Zhao Lianpan Dai George F.Gao Qihui Wang Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China Beijing Institute of Biological Products Company Limited Beijing 100176China

With continuous mutations of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the severe immune escape of Omicron sub-variants urges the development of next-generation broad-spectrum vaccines,especially as booster jabs after high-level vaccination coverage of inactivated vaccines in China and many other ***,we developed a coronavirus disease 2019(COVID-19)protein subunit vaccine ZF2001?based on the tandem homo-prototype receptor-binding domain(RBD)-dimer of the SARS-CoV-2 spike *** upgraded the antigen into a hetero-chimeric prototype(PT)-Beta or Delta-BA.1 RBD-dimer to broaden the cross-protection efficacy and prove its efficiency with protein subunit and mRNA vaccine ***,we further explored the hetero-chimeric RBD-dimer mRNA vaccines and evaluated their broad-spectrum activities as booster jabs following two doses of inactivated vaccine(Ⅳ)in *** data demonstrated that the chi-meric vaccines significantly boosted neutralizing antibody levels and specific T-cell responses against the vari-ants,and PT-Beta was superior to Delta-BA.1 RBD as a booster in mice,shedding light on the antigen design for the next-generation COVID-19 vaccines.

关键词： SARS-CoV-2 RBD-dimer mRNA Vaccine Broad-spectrum Omicron BA.5