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Aggregation-induced emission:recent applications in infectious diseases

Science China Chemistry 2023年第11期66卷 2986-3005页

作者： Meijia Gu Luojia chen Rui Hu qingrong chen Jianbo Liu Lianrong Wang Shi chen Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug DiscoveryTaiKang Center for Life and Medical SciencesZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Respiratory Diseases The Research and Application Center of Precision MedicineThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450014China

Infectious diseases are caused by various pathogenic microorganisms that break through the human immune barrier,then reproduce and mutate in human cells,thus causing invasive disease.Despite many recent scientific and technological advances in fields,such as genetics,chemistry,and protein engineering,and in the efficiency of drug research and development,the discovery and development of novel and potent anti-infectious disease agents have still lagged behind.It is often challenging to keep up with the emergence and mutation of new pathogenic microorganisms,which leads to the emergence of more resistant pathogenic microorganisms.The emergence of aggregation-induced emission(AIE)fluorogens with high luminescence yields and high reactive oxygen species(ROS)production rates provides scientists with a new strategy for the prevention and treatment of pathogenic microorganisms.Due to their advantages in terms of brightness,biocompatibility,photostability,and positive correlation,AIE fluorogens(AIEgens)have great potential in biological applications.This review presents a systemic overview of recent progress in AIEgen-based platforms for the photodynamic therapy(PDT)of infectious diseases,which has emerged as a promising noninvasive alternative to traditional antibiotics for combating the drug resistance of infectious diseases.This review is mainly divided into two parts according to the type of pathogenic microorganisms:a section on bacterial and fungal infections(e.g.,eye,skin,oral cavity,and blood infections),and a section on viral infections.The future prospects and potential clinical applications of AIEgens are also discussed in detail.In addition to motivating further interest in this field,this review is intended to promote ideas for the further exploration of AIEgens and the development of more advanced AIEgens in a broader range of biomedical and clinical applications.

关键词： aggregation-induced emission infectious diseases photosensitizers photodynamic therapy pathogenic microorganisms

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Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Engineered Regeneration

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Engineered Regeneration 2022年第1期3卷 59-72页

作者： Luojia chen Xingran Wang Yuncong Yuan Rui Hu qingrong chen Lijun Zhu Meijia Gu Chao Shen College of Life Sciences Wuhan UniversityWuhanChina Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationSchool of Pharmaceutical SciencesWuhan UniversityWuhanChina

Microorganisms and cancer have always been the fierce enemies of human beings,but the traditional methods of treating them still have many defects.Therefore,it is extremely important to develop rapid,effective and safe treatments.Photodynamic Therapy(PDT)has attracted much attention because of its advantages of non-invasive,non-drug tolerance,high selectivity and low toxicity.As a result,more and more scientists are committed to developing better photosensitizers to enhance the efficiency of PDT in the therapy of microorganisms as well as tumors.The discovery of aggregation-induced emission(AIE)phenomenon provides a novel research direction for the progress of photosensitizer and brings a broader prospect for PDT.This review focuses on the recent progress of photosensitizers(PSs)with AIE properties in PDT from two aspects of anti-microbial and anti-cancer.Among them,anti-microbial aspects were introduced from the perspectives of anti-bacterial,anti-fungal and anti-viral aspects,while anti-cancer aspects were first introduced from the perspective of different target sites of photosensitizers,and then based on the modification of their own structures.Finally,the current limitations,challenges and future development of AIE photosensitizer(AIE-PSs)are clarified in view of the existing strategies and obstacles,so as to promote the development of AIE-PSs in the future clinical applications.

关键词： Aggregation-induced emission(AIE) Photosensitizers(PSs) Photodynamic therapy(PDT) Cancer therapy Nanoparticle(NP)

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ASTM:Developing the web service for anthrax related spatiotemporal characteristics and meteorology study

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Quantitative Biology 2022年第1期10卷 67-78页

作者： Shiwei Fan Ming Xiao Boyu Sun Weizhong Zhou qingrong chen Weimin Lv Pengfei Zhang Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Gannan Center for Disease Control and Prevention Hezuo 747000China Gannan Blood Station Hezuo 747000China Department of Medical Oncology Cancer CenterWest China HospitalSichuan UniversityChengdu 610065China Med-X Center for Informatics Sichuan UniversityChengdu 610065China

Background:Anthrax is a zoonotic infectious disease caused by Bacillus anthracis.Investigating the spatiotemporal characteristics of anthrax and the impact of meteorological factors on the incidence of anthrax is helpful for the prevention and control of anthrax.Methods:At first,we applied the Granger causality test to explore the spatiotemporal characteristics of anthrax transmission between the counties and cities of Gannan Tibetan Autonomous Prefecture,Gansu Province of China.Then,we constructed three generalized linear models to analyze the impact of meteorological factors on the monthly number of anthrax cases in Gannan Tibetan Autonomous Prefecture.Finally,we developed an easy-to-use online web server that integrates the above functions.Results:This study developed an online service website(ASTM,http://www.***.online/anthrax/index.html)for the analysis and visualization of anthrax,which not only can investigate the correlation of anthrax among different regions in Gannan Tibetan Autonomous Prefecture,but also can analyze the correlation between meteorological factors and!the number of anthrax cases.Conclusions:Our study not only explored spatiotemporal characteristics of anthrax transmission,but also analyzed the impact of seven meteorological factors on the monthly number of anthrax cases.Meanwhile,the online service website which integrates the above functions is useful for the prevention and control of anthrax.

关键词： time series analysis correlation analysis visualization web service data mining

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基于大气散射模型的图像去雾及亮度增强算法

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光电子．激光 2024年第3期35卷 303-310页

作者：唐斌陈清容段春红贵州财经大学信息学院贵州贵阳550025

针对雾图能见度低和去雾图像亮度偏暗的问题,提出一种基于大气散射模型的双阶段去雾算法。首先使用线性变换估算复原图像亮度,使用拉伸方法估算复原图像饱和度,根据复原图像亮度、饱和度估算其最小通道,联合雾图最小通道获取粗糙透射率... 详细信息

针对雾图能见度低和去雾图像亮度偏暗的问题,提出一种基于大气散射模型的双阶段去雾算法。首先使用线性变换估算复原图像亮度,使用拉伸方法估算复原图像饱和度,根据复原图像亮度、饱和度估算其最小通道,联合雾图最小通道获取粗糙透射率。在不同阶段分别使用双梯度代价函数、导向滤波优化粗糙透射率,依据大气散射模型复原图像和增强亮度。实验结果表明,所提算法复原图像更清晰明亮;图像综合质量、峰值信噪比和运行时间等客观指标均值优于所有比较算法,其中图像综合质量最少提高1.55倍,运行速度最少加速1.50倍。所提算法有效地增强了雾图的能见度和明亮度。

关键词：双梯度代价函数导向滤波线性变换饱和度亮度最小通道

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Aggregation-induced emission shining in the biomedical field:From bench to bedside

Engineered Regeneration

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Engineered Regeneration 2021年第1期2卷 206-218页

作者： Yishen Liu qingrong chen Yidan Sun Luojia chen Yuncong Yuan Meijia Gu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationSchool of Pharmaceutical SciencesWuhan UniversityWuhanHubei 430071China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Type Culture Collection Wuhan UniversityWuhanHubei 430072China

Fluorogens with aggregation-induced emission characteristics(AIEgens)have been developed in an unprece-dented manner in the biomedical field over the past decade,which is ascribable to their superior fluorescence quantum yields,photosensitivities,as well as their“turn-on”characteristics in their aggregate states.By delib-erately engineering their molecular structures and nanocarriers,the input energies of AIEgens can be channeled into specific forms,thereby enabling bioimaging,phototherapy,and even synergetic therapy.Moreover,multiple targeting strategies have been tailored for nidus and pathogen localization that subsequently guide therapeutic processes.This review integrates application-oriented design strategies for AIEgens,demonstrating how microscopic imaging,bioimaging,and theranostics can be developed to combat tumors,pathogens,and other diseases,and critically discusses challenges and perspectives for clinical translation.

关键词： Aggregation-induced emission(AIE) Biomedical field Microscopic imaging Bioimaging Theranostics

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浅析大黄鱼源变形假单胞菌的流行与防控

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渔业信息与战略 2024年第2期39卷 121-125页

作者：陈庆荣宁德市蕉城区水产技术推广站福建宁德352100

变形假单胞菌(Pseudomonas plecoglossicida)是一类重要的鱼类条件致病菌,可感染多种海、淡水养殖鱼类。变形假单胞菌引起的内脏白点病是网箱养殖大黄鱼最重要的病害之一,在海水网箱养殖中,患病大黄鱼没有明显的外观症状,给疾病的诊断... 详细信息

变形假单胞菌(Pseudomonas plecoglossicida)是一类重要的鱼类条件致病菌,可感染多种海、淡水养殖鱼类。变形假单胞菌引起的内脏白点病是网箱养殖大黄鱼最重要的病害之一,在海水网箱养殖中,患病大黄鱼没有明显的外观症状,给疾病的诊断和防治工作带来了更大的挑战。从病原入侵大黄鱼的部位、发病症状、流行季节、发病地域、防治措施等方面综述变形假单胞菌的相关内容,并从养殖管理、药物防治和疫苗开发3个方面提出防治大黄鱼内脏白点病的策略,提出降低养殖密度、做好养殖管理是目前防治该病最主要的手段,期望为这一疾病的防治提供参考,推动大黄鱼养殖产业健康发展。

关键词：大黄鱼变形假单胞菌内脏白点病防控策略

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Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction

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Nano-Micro Letters 2021年第10期13卷 288-307页

作者： Yingjie Yang Yanhui Yu Jing Li qingrong chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang Peilin Deng Yijun Shen Xinlong Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikou 570228People’s Republic of China

The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy society.To establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure hydrogen.Compared with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower price.Analyzing and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is indispensable.In this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly introduced.Moreover,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are discussed.Finally,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER.

关键词： Hydrogen evolution reaction Ruthenium-based catalysts Performance Electrochemical water splitting

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带输入饱和的双摆桥式起重机神经网络滑模控制

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控制工程 2024年第4期31卷 687-694页

作者：刘佳辉程文明谌庆荣杜润西南交通大学机械工程学院四川成都610031

针对现代工业中输入饱和受限的双摆桥式起重机防摇摆控制问题,设计了一种基于神经网络的非奇异终端滑模控制器。首先,分析起重机的非线性动力学系统,并引入抗饱和模块将系统所需的控制力限制在驱动电机能提供的最大驱动力内;然后,采用... 详细信息

针对现代工业中输入饱和受限的双摆桥式起重机防摇摆控制问题,设计了一种基于神经网络的非奇异终端滑模控制器。首先,分析起重机的非线性动力学系统,并引入抗饱和模块将系统所需的控制力限制在驱动电机能提供的最大驱动力内;然后,采用部分状态信息反馈控制设计控制器,该控制器只需起重机小车位置、速度的反馈信息,无须实时测量吊重和摆角;之后,利用所提控制器跟踪经过规划的S形平滑函数,并用神经网络逼近起重机系统中复杂未知的非线性函数部分;最后,通过李雅普诺夫稳定性理论对系统状态的稳定性进行分析。仿真结果表明,所提控制器能在保证起重机小车准确定位的同时,有效抑制吊钩和重物的残余摆动,并且对外界干扰具有较强的鲁棒性。

关键词：输入饱和部分状态反馈控制神经网络双摆起重机李雅普诺夫稳定性理论

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音乐学习对语言韵律加工的影响及其作用机制

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心理科学 2024年第1期47卷 21-27页

作者：张晶晶薛亚楠冯银高攀科陈庆荣南京师范大学心理学院南京210097

语言和音乐在结构与功能上均具有密切的联系,语言中的韵律和音乐尤其如此。因此,音乐学习是否以及如何影响语言韵律加工受到了研究者们的广泛关注。本文从言语韵律和情感韵律出发,系统论述了音乐学习对正常人群和语言加工障碍人群韵律... 详细信息

语言和音乐在结构与功能上均具有密切的联系,语言中的韵律和音乐尤其如此。因此,音乐学习是否以及如何影响语言韵律加工受到了研究者们的广泛关注。本文从言语韵律和情感韵律出发,系统论述了音乐学习对正常人群和语言加工障碍人群韵律感知的影响,探讨了音乐学习影响韵律加工的内在机制。未来研究应在现有研究基础上进一步深入思考,挖掘其中的影响因素,并且区分先天音乐能力和后天音乐学习在促进语言韵律加工中的分别作用。

关键词：音乐学习言语韵律情感韵律作用机制

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Journal of Intelligent Learning Systems and Applications 2018年第3期10卷 104-119页

作者： Tianquan Feng qingrong chen Ming Yi College of Teacher Education Nanjing Normal University Nanjing China School of Psychology Nanjing Normal University Nanjing China College of Sciences Huazhong Agricultural University Wuhan China

We theoretically investigate the collective response of an ensemble of leaky integrate-and-fire neuron units to a noisy periodic signal by including local spatially correlated noise. By using the linear response theory, we obtained the analytic expression of signal-to-noise ratio (SNR). Numerical simulation results show that the rms amplitude of internal noise can be increased up to?an optimal value where the output SNR reaches a maximum value. Due to the existence of the local spatially correlated noise in the units of the ensemble, the SNR gain of the collective ensemble response can exceed unity and can be optimized when the nearest-neighborhood correlation is negative. This nonlinear collective phenomenon of SNR gain amplification in an ensemble of leaky integrate-and-fire neuron units can be related to the array stochastic resonance (SR) phenomenon. Furthermore, we also show that the SNR gain can also be optimized by tuning the number of neuron units, frequency and?amplitude of the weak periodic signal. The present study illustrates the potential to utilize the local spatially correlation noise and the number of ensemble units for optimizing the collective response of the neuron to inputs, as well as a guidance in the design of information processing devices to weak signal detection.

关键词： Array Stochastic Resonance Signal-to-Noise Ratio Local Correlation Noisy Neurons

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