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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG JIANFENG cai JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu Jiao Dai Baigen cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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智慧养老模式融入我国养老事业的机遇与挑战

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继续医学教育 2024年第9期38卷 154-157页

作者：安益强李之文蔡卿卿赵世鸿徐州医科大学卫生健康政策研究中心江苏徐州221000 徐州医科大学养老研究院江苏徐州221000

智慧养老作为一种新型的养老模式,具有精准性、便捷性、互动性、安全性、开放性和整合性等特点,显著提升了养老服务的效能与质量。文章深入剖析了智慧养老模式在推行过程中所面临的技术、人才、安全等多方面的挑战,同时也探讨了其带来... 详细信息

智慧养老作为一种新型的养老模式,具有精准性、便捷性、互动性、安全性、开放性和整合性等特点,显著提升了养老服务的效能与质量。文章深入剖析了智慧养老模式在推行过程中所面临的技术、人才、安全等多方面的挑战,同时也探讨了其带来的广阔机遇。笔者认为随着人工智能、物联网技术的快速发展,并通过加大技术研发力度、加强人才培养、完善相关规范标准以及加强文化宣传等措施,可以有效应对并解决智慧养老带来的各种挑战。在当前我国快速老龄化的背景下,智慧养老模式能够有效弥补传统养老服务供给的不足,有效减轻居家养老、社区养老和机构养老的人力成本,为老年人提供更加个性化、高质量的养老服务,因此,它成为一种可行的养老模式发展路径。

关键词：智慧养老老龄化新型养老模式优势机遇挑战

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菌剂强化曝气生物滤池预处理微囊藻毒素试验

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环境化学 2017年第9期36卷 2015-2024页

作者：蔡庆庆吴旭鹏沈红池刘亮毛林强张文艺常州大学环境与安全工程学院常州213164 江苏龙环环境科技有限公司常州213127

本研究针对河湖饮用水源地因藻类爆发(水华)引起的微囊藻毒素(MC-LR)污染难以得到有效解决这一难题,采用菌剂强化曝气生物滤池(BAF)处理含藻微污染水源水.通过向BAF中投加本课题组从太湖底泥中筛选所得的藻毒素降解菌T1,考察了投加T1菌... 详细信息

本研究针对河湖饮用水源地因藻类爆发(水华)引起的微囊藻毒素(MC-LR)污染难以得到有效解决这一难题,采用菌剂强化曝气生物滤池(BAF)处理含藻微污染水源水.通过向BAF中投加本课题组从太湖底泥中筛选所得的藻毒素降解菌T1,考察了投加T1菌剂以及投加T1菌剂下水力负荷、水温等工艺参数对BAF降解MC-LR和叶绿素a的影响.结果表明,投加T1菌剂前后BAF对MC-LR的降解率分别为58.82%和79.45%;当水力负荷为0.07 m^3·(m^2·h)^(-1),平均水温为29.6℃时,出水MC-LR含量最低,仅为0.73μg·L^(-1),低于《生活饮用水水质卫生规范》(GB5749—2006)中对饮用水源中MC-LR浓度设定的1.0μg·L^(-1)基准限定值,T1菌剂对于MC-LR有较强的降解效果.投加T1菌剂前后BAF对叶绿素a的去除率分别为35.17%和40.59%,说明T1菌剂的强化"溶藻"效果一般.对BAF中的生物膜进行PCR扩增和高通量测序分析,显示其中微生物群落有14大门类43个种属,以变形菌门(Betaproteobacteria)和拟杆菌门(Bacteroidetes)占主要优势(约50%).投加T1菌剂的BAF生物膜,其所属的芽孢杆菌高达1.97%,未投加菌剂的BAF生物膜所属的芽孢杆菌仅0.16%,表明投加的T1菌剂在BAF生物膜微生物中形成了优势菌群.本研究对于生物法处理含藻微污染水源水具有一定的理论意义和实用价值.

关键词：曝气生物滤池 MC-LR 高通量测序微生物.

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大型低速风洞尾撑机构研制

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兵工自动化 2024年第2期43卷 35-39页

作者：张德久徐剑英谢明伟蔡清青李进学中国空气动力研究与发展中心低速所四川绵阳621000 中国空气动力研究与发展中心设备设计及测试技术研究所四川绵阳621000

尾撑机构是为大型低速风洞研制配套的多用途支撑设备,其主要用途包括:支撑战斗机模型完成大迎角状态测力、测压试验任务,迎角连续变化范围-15°~90°,侧滑角连续变化范围±35°;支撑大尺度模型(最大翼展达6 m)完成常规测力、测压、地效... 详细信息

尾撑机构是为大型低速风洞研制配套的多用途支撑设备,其主要用途包括:支撑战斗机模型完成大迎角状态测力、测压试验任务,迎角连续变化范围-15°~90°,侧滑角连续变化范围±35°;支撑大尺度模型(最大翼展达6 m)完成常规测力、测压、地效试验等任务,满足迎角连续变化范围-10°~75°;支撑特殊模型进行特种试验,包括细长体模型、螺旋桨模型、动力模拟试验模型等。标模试验验证结果表明:该机构刚性强,模型支撑牢固,运行灵活,模型姿态变化定位精确,可满足常规和大量特种模型支撑和姿态变化需要。

关键词：尾撑机构低速风洞试验设备

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Molecular Structure Tailoring of Organic Spacers for High‑Performance Ruddlesden–Popper Perovskite Solar Cells

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Nano-Micro Letters 2025年第2期17卷 314-357页

作者： Pengyun Liu Xuejin Li Tonghui cai Wei Xing Naitao Yang Hamidreza Arandiyan Zongping Shao Shaobin Wang Shaomin Liu School of Materials Science and Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049People’s Republic of China Centre for Applied Materials and Industrial Chemistry(CAMIC) School of ScienceRMIT UniversityMelbourneVic 3000Australia WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Engineering Great Bay UniversityDongguan 523000People’s Republic of China

Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)***,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic ***,these issues can be readily resolved by rationally designing spacer cations of *** review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic *** firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of *** we brought three aspects to attention for designing organic ***,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP *** proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.

关键词： Ruddlesden-Popper perovskites Low-dimensional perovskite solar cells Organic spacers Molecular structure Design strategies

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构建中国式辅助生活养老新业态的价值内涵和实施策略

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卫生职业教育 2024年第23期42卷 146-149页

作者：安益强李之文蔡卿卿赵世鸿徐州医科大学卫生健康政策研究中心江苏徐州221000 徐州医科大学养老研究院江苏徐州221000

系统介绍美国辅助生活养老模式的特点、优势及存在的不足,结合我国国情提出构建中国式辅助生活养老新业态的价值内涵和实施策略。通过新建辅助生活社区、改造现有社区和搭建农村辅助生活平台等,并利用“时间银行”和人工智能等方式降低... 详细信息

系统介绍美国辅助生活养老模式的特点、优势及存在的不足,结合我国国情提出构建中国式辅助生活养老新业态的价值内涵和实施策略。通过新建辅助生活社区、改造现有社区和搭建农村辅助生活平台等,并利用“时间银行”和人工智能等方式降低构建辅助生活养老新业态过程中的人工成本,确保该模式的顺利实施和可持续发展,为我国养老服务事业的发展提供可行思路和方法。

关键词：辅助生活养老模式养老服务

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

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