检索结果-南通市图书馆

“新工科”背景下深入融合数字化的染整专业实践模块改革与创新

在线全文

学校读者我要写书评

暂无评论

山东纺织经济 2024年第5期41卷 38-41,45页

作者：周青青吕景春李静冒海燕郭岭岭何雪梅周天池盐城工学院纺织服装学院江苏盐城224051

实践教学在高校的人才培养过程中占有十分重要的地位。根据目前盐城工学院纺织服装学院染整专业实践模块存在的课程体系单一,教学模式陈旧和学生素质能力有待提高问题,结合信息时代教育数字化转型,构建“3新”即“课程新结构、教学数字... 详细信息

实践教学在高校的人才培养过程中占有十分重要的地位。根据目前盐城工学院纺织服装学院染整专业实践模块存在的课程体系单一,教学模式陈旧和学生素质能力有待提高问题,结合信息时代教育数字化转型,构建“3新”即“课程新结构、教学数字化新模式、实践新平台”的实践创新能力培养路径,满足学生多样化成才需求,实现学生科学素养、创新、实践能力的提高。通过不断的实践锻炼,提高工程实践能力,增强创新意识,解决染整工程领域复杂问题,达到“新工科”背景下的人才培养目标,成为新时代具有中国特色社会主义的合格建设者和接班人。

关键词：染整专业实践教学数字化改革与创新

维普期刊数据库博看期刊

不同光照时长处理对柚果皮有色层香豆素代谢的影响

在线全文

学校读者我要写书评

暂无评论

天津农业科学 2024年第3期30卷 1-9页

作者：雷旭黄迪捷周青青邓志军邓仕明牟蛟琳湖北民族大学生物资源保护与利用湖北省重点实验室湖北恩施445000 湖北民族大学林学园艺学院湖北恩施445000 湖北民族大学恩施州特色植物资源种质工程技术研究中心湖北恩施445000

柚是我国南方地区重要的水果,表皮富含大量的香豆素,极易受到外界环境的影响,但其光响应效果尚不明确。为探究香豆素在柚表皮中的光响应机制,通过设置12、24、36、48 h共4个不同光照时长处理来探究光照对柚果皮有色层香豆素代谢的影响... 详细信息

柚是我国南方地区重要的水果,表皮富含大量的香豆素,极易受到外界环境的影响,但其光响应效果尚不明确。为探究香豆素在柚表皮中的光响应机制,通过设置12、24、36、48 h共4个不同光照时长处理来探究光照对柚果皮有色层香豆素代谢的影响。本研究以贡水白柚和矮晚柚为试材,采用靶向代谢组学的检测方法共检测到21种香豆素,随后对贡水白柚、矮晚柚对照组和处理组果皮有色层中香豆素的代谢差异进行比较分析。结果表明:在贡水白柚和矮晚柚果皮有色层共同积累的21种香豆素中,相对含量较高且存在显著差异的香豆素为佛手柑素、橙皮油内酯、蛇床子素。不同光照时长处理对贡水白柚果皮有色层中佛手柑素、橙皮油内酯、蛇床子素、总香豆素的积累有显著影响,对矮晚柚果皮有色层中王草酚、佛手柑素、橙皮油内酯、蛇床子素、总香豆素的积累有显著影响。通过PCA分析显示,经过不同光照时长处理的贡水白柚和矮晚柚果皮有色层中总香豆素的相对含量被明显区分开。综上,光照处理会改变贡水白柚和矮晚柚果皮有色层中香豆素的积累特征,并且矮晚油相较贡水白柚大量积累王草酚和二氢欧山芹素。以上研究结果为揭示光照对柑橘香豆素代谢的调节机制奠定了基础,为提升柑橘药用品质提供了全新的思路。

关键词：柚果皮香豆素光照时间靶向代谢组学

术前血清CA125水平与子宫浆液性癌宫外转移的相关性分析

在线全文

学校读者我要写书评

暂无评论

蚌埠医学院学报 2024年第1期49卷 28-31页

作者：沈焰朱晨辰周晴晴陈双凤钱莉莉赵卫东周颖吴大保申震蚌埠医科大学安徽蚌埠233030 中国科学技术大学附属第一医院安徽省立医院妇产科安徽合肥230001

目的:探讨子宫浆液性癌病人术前血清CA125水平与子宫外转移的关系。方法:回顾性收集2015-2021年诊断为子宫浆液性癌病人的临床资料,分析术前血清CA125水平与子宫外转移的相关性。结果:病人术前血清CA125水平与输卵管、卵巢和大网膜转移... 详细信息

目的:探讨子宫浆液性癌病人术前血清CA125水平与子宫外转移的关系。方法:回顾性收集2015-2021年诊断为子宫浆液性癌病人的临床资料,分析术前血清CA125水平与子宫外转移的相关性。结果:病人术前血清CA125水平与输卵管、卵巢和大网膜转移显著相关(P0.05);CA125阳性组的3年总体生存率高于阴性组(χ^(2)=5.60,P<0.05)。结论:术前血清CA125≥41.36 U/mL是预测子宫浆液性癌子宫外转移的可靠指标。

关键词：子宫肿瘤癌胚抗原125 转移

三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后心肌灌注及短期预后的影响

在线全文

学校读者我要写书评

暂无评论

中国心血管杂志 2024年第2期29卷 143-151页

作者：晋辉郑献召沈玲曾辉王中明韩风杰杭晓阳刘静周庆庆朱艳霞王晓飞郑海军新乡医学院附属焦作市人民医院心内科 454000

目的探讨三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心肌灌注及短期预后的影响。方法前瞻性、单中心、随机对照研究。纳入2017年3月至2021年8月焦作市人民医院心内科高血栓负... 详细信息

目的探讨三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心肌灌注及短期预后的影响。方法前瞻性、单中心、随机对照研究。纳入2017年3月至2021年8月焦作市人民医院心内科高血栓负荷STEMI患者150例,按照分层区组随机化原则等分为三组各50例。A组:尼可地尔+替罗非班靶血管灌注;B组:尿激酶原+替罗非班靶血管灌注;C组:尼可地尔+尿激酶原+替罗非班靶血管灌注。于PCI术前、术后即刻检测记录梗死相关动脉(IRA)的心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正的TIMI血流帧数(CTFC);于PCI术前、术后24 h记录心电图的ST段回落幅度;记录IRA开通后24 h内Curtis-Walker评分及恶性心律失常例数;于PCI术前、术后0 h、12 h、24 h、3 d及7 d检测血清高敏肌钙蛋白I(hs-cTnI);于PCI术前、术后24 h及7 d检测丙二醛(MDA)、超氧化物歧化酶(SOD);于PCI术前、术后7 d、术后1个月、术后6个月及术后12个月检测左心室射血分数(LVEF)。随访记录患者住院期间及出院后30 d内的出血事件及术后12个月内主要不良心血管事件(MACE)。结果(1)PCI术后即刻,C组患者的TIMI血流分级、TMPG均优于A组(Z=-16.610,P=0.023;Z=-18.400,P=0.015)和B组(Z=-15.130,P=0.046;Z=16.550,P=0.035);C组患者的CTFC帧数低于A组(P<0.001)和B组(P=0.001)。(2)PCI术后,C组患者的血清hs-cTnI水平低于A组和B组(均为P<0.001)。(3)PCI术后,C组患者的MDA水平低于A组和B组(均为P<0.001),SOD水平高于A组(P=0.004)和B组(P=0.024)。(4)PCI术后24 h,C组患者的ST段回落幅度大于A组(P=0.003)和B组(P=0.012),Curtis-Walker评分及恶性心律失常发生率低于A组(P=0.008、0.015)和B组(P=0.014、0.034)。(5)PCI术后,C组患者的LVEF水平高于A组和B组(均为P<0.001)。(6)住院期间及出院后30 d内,三组患者均未发生大出血,少量出血和微量出血的发生率比较无统计学差异(χ^(2)=1.385,P=0.500);术后12个月内,C组患者的MACE发生率低于A组和B组(χ^(2)=7.400,P=0.025)。结论尼可地尔+尿激酶原+替罗非班靶血管灌注具有协同作用,可有效改善STEMI患者PCI术后的心肌灌注,减轻术后心肌损伤和氧化应激损伤,促进ST段回落,降低恶性心律失常发生率,有效促进心功能恢复,减少心血管不良事件,且不增加术后出血。

关键词：急性ST段抬高型心肌梗死高血栓负荷经皮冠状动脉介入尼可地尔重组人尿激酶原心肌灌注

维普期刊数据库博看期刊

Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1119-1132页

作者： qingqing Wei Changning Xue Mengna Li Jianxia Wei Lemei Zheng Shipeng Chen Yumei Duan Hongyu Deng Faqing Tang Wei Xiong Ming zhou NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Cancer Research Institute and School of Basic Medical Sciences Central South UniversityChangsha 410078China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South UniversityChangsha 410078China Hunan Key Laboratory of Oncotarget Gene Hunan Key Laboratory of Cancer MetabolismHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China

Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation.It occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal function.Hence,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N^(6)-methyladenosine(m^(6)A)is a highly evolutionarily conserved epigenetic modification in mammals.The m^(6)A modification is commonly linked to tumor proliferation,progression,and therapy resistance because it is involved in RNA metabolic processes.Intriguingly,accumulating evidence suggests that dysregulated ferroptosis caused by the m^(6)A modification drives tumor development.In this review,we summarized the roles of m^(6)A regulators in ferroptosis-mediated malignant tumor progression and outlined the m^(6)A regulatory mechanism involved in ferroptosis pathways.We also analyzed the potential value and application strategies of targeting m^(6)A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

关键词： ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression

Optimization and test for structural parameters of UAV spraying rotary cup atomizer

在线全文

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2017年第3期10卷 78-86页

作者： zhou qingqing Xue Xinyu Qin Weicai Cai Chen zhou Liangfu Nanjing Research Institute for Agriculture Mechanization Ministry of AgricultureNanjing 210014China

Small unmanned aerial vehicle(UAV)pesticide application technology is developing rapidly in China.However,the spray efficiency of UAV sprayer is not stable,one important reason is that the lack of specialized aviation nozzle.Rotary cup atomizer is not easily to be blocked and has broad application foreground in UAV spray.In order to obtain good spraying quality and narrow droplet spectrum aviation spraying centrifugal nozzle,the impacts of rotary cup atomizer structural parameters on atomization property were studied.In this research,a centrifugal atomization test device was designed,on which a frequency converter was used to adjust the rotary speed,and a return valve was used to stabilize the flow rate and pressure of spray liquid.The droplet volume medium diameter(VMD)and droplet spectrum relative width(SRW)were tested by using laser particle analyzer and particle analysis system.The analysis results of variance and quadratic regression orthogonal test were used to optimize the structural parameters of rotary cup atomizer.The influences of rotary cup atomizer structural parameters on atomization property,such as groove shape,diameter,teeth number,cone angle and height were evaluated and analyzed by conducting single-factor test.The results showed that:the best optimized rotary groove shape was square,diameter and teeth number had significant effects on droplet VMD and SRW,while cone angle had no effect on the droplet VMD and SRW,height affected droplet VMDbut did not affect droplet SRW.Therefore,diameter and teeth number were selected as the variables of quadratic regression orthogonal test,droplet VMD and SRW regression model was established by using response surface analysis method.The optimized structural parameters respectively were:groove shape square,cone angle 60°,height 20 mm,diameter 61.5 mm and teeth number 149.Droplet VMD and SRW simulation value respectively were 200μm and 0.562.The differences between simulation value and test value were 0.68%and 9.90%respectively,indicating that the regression mod

关键词： rotary cup atomizer atomization droplet VMD droplet SRW optimization mathematical model response surface

Kdm2b epigenetically promotes innate IL-6 production through Brg1-mediated chromatin remodeling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kdm2b epigenetically promotes innate IL-6 production through...

Optimization and test for spraying parameters of cotton defoliant sprayer

第十三届全国免疫学学术大会

作者： Zhenzhen Zhan qingqing zhou Yunkai Zhang Bo Wang Institute of Heart Failure Shanghai East HospitalTongji University School of Medicine National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

Interleukin-6(IL-6) plays important and pleiotropic roles in infection and inflammatory diseases, and its production needs to be tightly regulated. However, the epigenetic mechanism underlying Il6 gene transcription remains to be fully elucidated. Here, we reported that deficiency of lysine-specific demethylase 2 b(Kdm2 b), a demethylase of H3 K36 me2 and H3 K4 me3, preferentially inhibited innate IL-6 production triggered by Toll-like receptors(TLRs) in macrophages and dendritic cells, but not the production of TNF-α and IFN-β. Kdm2 b-deficient mice were more resistant to LPS-or poly(I:C)-triggered endotoxin shock and dextran-sulfate-sodium(DSS)-induced colitis with a decreased IL-6 production and less severe inflammatory pathogenesis phenotype. Kdm2 b selectively bound the Il6 promoter, but did not alter the histone demethylation;instead, Kdm2 b interacted with Brg1, the core ATPase subunit of SWI/SNF chromatin remodeling complexes, to facilitate the chromatin accessibility of Il6 promoter. Furthermore, Kdm2 b directly recruited RNA Polymerase II(Pol II)(RNAP II) to Il6 promoter. In all, Kdm2 b contributed to increased Il6 transcription upon innate stimuli. Our finding elucidated a crucial role of Kdm2 b in the gene-specific transcription initiation and enhancement of Il6 independent of its demethylase activity, and added a mechanic insight into the epigenetic modification of inflammatory immune responses.

关键词： KDM2B epigenetic regulation IL-6 macrophages inflammation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2016年第4期9卷 63-72页

作者： Qin Weicai Xue Xinyu Cui Longfei zhou qingqing Xu Zhufeng Chang Feilong Key Laboratory of Modern Agricultural Equipment and Technology Ministry of EducationJiangsu UniversityZhenjiang 212013China Nanjing Research Institute for Agricultural Mechanization Ministry of AgricultureNanjing 210014China

Boom sprayer is widely used in large farm crops because of its high working efficiency and favorable spraying effect.But there are still some problems in cotton defoliant spraying in Xinjiang,China.Cotton is planted in a high density in Xinjiang,the row space is(10+66)cm,leaves in two adjacent rows are seriously overlapped,the lower leavers are poorly sprayed,so the defoliation effect is poor,and the cotton quality is degraded.To solve this problem and improve the defoliant droplets coverage on the cotton canopy,the original boom spraying was modified,and the spraying pardameters was optimized by the central combination test and design concept of Box-Behnken based on a single-factor test.A quadratic polynomial model of droplets coverage was created by using working parameters including horizontal spraying boom height,hang boom height and nozzles angle as the influential factors and the mean droplets coverage on cotton canopy as the target function,and the effectiveness of mode and interaction of factors were analyzed.The model was optimized and analyzed using the regression analysis method and response surface analysis method of software Design-Expert 7.0.0,and the optimal combination of spraying parameters was obtained.The results showed that the droplets coverage on cotton canopy were influenced by boom height,sprayer height and angled nozzles sequentially from large to small,and the optimal combination of spraying parameters was under horizontal spraying boom height of 134 cm,hang spraying boom height of 27.5 cm and nozzles angle of 21°.The mean droplets coverage of experimental value and predicted value on cotton canopy were 19.6%and 20.43%respectively in such conditions,and the relative error to the estimated value on the model was–4.25%.The research result can provide a reference for further optimizing the spraying parameters of cotton defoliant sprayer.

关键词： pesticide sprayer cotton spraying parameter optimization mathematical model response surface

Reactive orange 5 removal from aqueous solution using Hydroxyl Ammonium Ionic Liquids/layered double hydroxides intercalation composites

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reactive orange 5 removal from aqueous solution using Hydrox...