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Observing strain glass transition in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)high entropy alloy with Elinvar effect

Journal of Materials Science & Technology 2024年第1期168卷 16-23页

作者： Kaichao Zhang Kai Wang Bin Wang Chao Lv Jiaxing Zheng Guanqi Li Yu Fu Wenlong Xiao qingqing cai Xutao Nie Yingfeng Shao Huilong Hou Xinqing Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China China Aerodynamics Research and Development Center Mianyang 621000China State Key Laboratory of Nonlinear Mechanics Chinese Academy of SciencesInstitute of MechanicsBeijing 100190China Tianmushan Laboratory(Zhejiang Provincial Laboratory for Aviation) Hangzhou 310000China

Exploring the phase transition of high entropy alloys(HEAs)with multiple major elements is of great importance for understanding the underlying physical *** martensitic phase tran-sition has been frequently reported in HEAs,however,nanoscale microstructural phase evolution has not been investigated to the same ***,we have prepared the Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA and investi-gated the strain glass transition and its associated properties using dynamic mechanical analysis and mi-crostructure *** have found that the elastic modulus in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA deviates from Wachtman’s equation and observed the Elinvar effect in the form of temperature-independent mod-ulus in the temperature range from 150 K to 450 K and frequency-dependence modulus around 220 *** strain glass transition has been evidenced in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HEA by the formation and growth of nano-sized domains during in-situ transmission electron microscopy(TEM)cooling,and substantiated by the broken ergodicity during zero-field-cooling/*** strain glass transition is believed to account for the Elinvar effect,where the modulus hardening of nano-sized domains compensates dynam-ically with the modulus softening of the transformable matrix.

关键词： High entropy alloys Strain glass transition Elinvar effect Microstructural evolution Nanodomains

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Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu qingqing cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

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免疫检查点抑制剂相关心脏毒性研究进展

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中国临床医学 2024年第4期31卷 531-536页

作者：蔡青青程蕾蕾复旦大学附属中山医院药剂科上海200032 复旦大学附属中山医院心脏超声诊断科上海200032

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)是一种新型肿瘤免疫治疗药物,近年来已被广泛应用于多种恶性肿瘤的治疗。但免疫系统的过度激活也会诱发免疫相关不良事件,其中ICIs诱发的心脏毒性包括心肌炎、心包疾病、动脉粥样... 详细信息

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)是一种新型肿瘤免疫治疗药物,近年来已被广泛应用于多种恶性肿瘤的治疗。但免疫系统的过度激活也会诱发免疫相关不良事件,其中ICIs诱发的心脏毒性包括心肌炎、心包疾病、动脉粥样硬化、血管炎等。ICIs相关心脏毒性虽然发生率不高,但可能导致严重的临床症状,甚至死亡。因此,临床工作中须及时识别和管理ICIs相关心脏毒性,一旦确诊,需根据疾病的严重程度及时进行治疗。ICIs相关心脏毒性的规范化防治需要多学科共同协作,为患者提供全周期个体化监测与管理。

关键词：免疫检查点抑制剂心脏毒性心肌炎监测

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Reversible regulation of enzyme-like activity of molybdenum disulfide quantum dots for colorimetric pharmaceutical analysis

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Journal of Pharmaceutical Analysis 2022年第1期12卷 113-121页

作者： Juan Tan Shiyue Wu qingqing cai Yi Wang Pu Zhang Engineering Research Center for Biotechnology of Active Substances Ministry of EducationChongqing Key Laboratory of Green Synthesis and ApplicationsCollege of ChemistryChongqing Normal UniversityChongqing401331China Chongqing Research Center for Pharmaceutical Engineering College of PharmacyChongqing Medical UniversityChongqing400016China

Regulating the catalytic activity of nanozymes is significant for their applications in various ***,we demonstrate a new strategy to achieve reversible regulation of the nanozyme’s activity for sensing *** strategy involves the use of zero-dimensional MoS;quantum dots(MQDs)as the building blocks of nanozymes which display very weak peroxidase(POD)-like ***,such POD-like activity of the MQDs largely enhances in the presence of Fe;while diminishes with the addition of captopril *** investigations identify the mechanism of Fe;-mediated aggregation-induced enhancement of the POD-like activity and the inhibitory effect of captopril on the enhancement,which is highly dependent on their *** on this finding,a colorimetric method for the detection of captopril is *** sensing approach exhibits the merits of simplicity,rapidness,reliability,and low cost,which has been successfully applied in quality control of captopril in pharmaceutical ***,the present sensing platform allows smartphone read-out,which has promising applications in point-of-care testing devices for clinical diagnosis and drug analysis.

关键词： Nanozyme Aggregation Peroxidase Captopril Colorimetric detection Smartphone

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A New Genus of Paleonisciformes from the Early Cretaceous Longjiang Formation in Heilongjiang Province, China

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Acta Geologica Sinica(English Edition) 2018年第3期92卷 889-896页

作者： WANG Xuri TAN Kai LU Liwu LI Tao cai qingqing Key Laboratory of Paleontology and Stratigraphy Ministry of Natural Resources Beijing 100037 China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China Hebei GEO University Shijiazhuang 050031 China The Geological Museum of China Beijing 100034 China Jilin University Museum Changehun 130026 China Liaoning Province Shiyan High Scholl Shenyang 110841 China

We report a new genus and species of Paleonisciformes-Cretolepis dongbeiensis gen. et sp. nov.,from the Early Cretaceous Longjiang Formation in Qiqihar City, Heilongjiang Province. The new materials can be distinguished from other Paleonisciformes genera by possessing the following characteristics: a sclerotic ring composed of more than five small bones; three pieces of suborbitals; one dermohyomandibular;a jaw hanging apparently inclined anteriorly; long and tall horizontal branch of the preopercular, a short vertical branch, with the angle formed by the two branches slightly higher than 90°; a triangular dorsal fin in the middle point between the pelvic and anal fins. The discovery of Mesozoic Paleonisciformes in northeastern China adds to the biodiversity and geographic distribution of Paleonisciformes.

关键词： Paleonisciformes Early Cretaceous Longjiang Formation northeastern China

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智慧养老模式融入我国养老事业的机遇与挑战

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继续医学教育 2024年第9期38卷 154-157页

作者：安益强李之文蔡卿卿赵世鸿徐州医科大学卫生健康政策研究中心江苏徐州221000 徐州医科大学养老研究院江苏徐州221000

智慧养老作为一种新型的养老模式,具有精准性、便捷性、互动性、安全性、开放性和整合性等特点,显著提升了养老服务的效能与质量。文章深入剖析了智慧养老模式在推行过程中所面临的技术、人才、安全等多方面的挑战,同时也探讨了其带来... 详细信息

智慧养老作为一种新型的养老模式,具有精准性、便捷性、互动性、安全性、开放性和整合性等特点,显著提升了养老服务的效能与质量。文章深入剖析了智慧养老模式在推行过程中所面临的技术、人才、安全等多方面的挑战,同时也探讨了其带来的广阔机遇。笔者认为随着人工智能、物联网技术的快速发展,并通过加大技术研发力度、加强人才培养、完善相关规范标准以及加强文化宣传等措施,可以有效应对并解决智慧养老带来的各种挑战。在当前我国快速老龄化的背景下,智慧养老模式能够有效弥补传统养老服务供给的不足,有效减轻居家养老、社区养老和机构养老的人力成本,为老年人提供更加个性化、高质量的养老服务,因此,它成为一种可行的养老模式发展路径。

关键词：智慧养老老龄化新型养老模式优势机遇挑战

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大型低速风洞尾撑机构研制

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兵工自动化 2024年第2期43卷 35-39页

作者：张德久徐剑英谢明伟蔡清青李进学中国空气动力研究与发展中心低速所四川绵阳621000 中国空气动力研究与发展中心设备设计及测试技术研究所四川绵阳621000

尾撑机构是为大型低速风洞研制配套的多用途支撑设备,其主要用途包括:支撑战斗机模型完成大迎角状态测力、测压试验任务,迎角连续变化范围-15°~90°,侧滑角连续变化范围±35°;支撑大尺度模型(最大翼展达6 m)完成常规测力、测压、地效... 详细信息

尾撑机构是为大型低速风洞研制配套的多用途支撑设备,其主要用途包括:支撑战斗机模型完成大迎角状态测力、测压试验任务,迎角连续变化范围-15°~90°,侧滑角连续变化范围±35°;支撑大尺度模型(最大翼展达6 m)完成常规测力、测压、地效试验等任务,满足迎角连续变化范围-10°~75°;支撑特殊模型进行特种试验,包括细长体模型、螺旋桨模型、动力模拟试验模型等。标模试验验证结果表明:该机构刚性强,模型支撑牢固,运行灵活,模型姿态变化定位精确,可满足常规和大量特种模型支撑和姿态变化需要。

关键词：尾撑机构低速风洞试验设备

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Production of non-mosaic genome edited porcine embryos by injection of CRISPR/Cas9 into germinal vesicle oocytes

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Journal of Genetics and Genomics 2019年第7期46卷 335-342页

作者： Xiaohu Su Wei Chen qingqing cai Puping Liang Yaosheng Chen Peiqing Cong Junjiu Huang Key Laboratory of Reproductive Medicine of Guangdong Province First Affiliated Hospital and School of Life Sciences Sun Yat-sen University Guangzhou 510275 China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Key Laboratory of Reproductive Medicine of Guangdong Province Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China

Genetically modified pigs represent a great promise for generating models of human diseases and producing new *** of genetically edited pigs using somatic cell nuclear transfer(SCNT)or zygote cytoplasmic microinjection is a tedious process due to the low developmental rate or mosaicism of the founder(FO).Herein,we developed a method termed germinal vesicle oocyte gene editing(GVGE)to produce non-mosaic porcine embryos by editing maternal alleles during the GV to MII *** of Cas9 mRNA and X-linked Dmd gene-specific gRNA into GV oocytes did not affect their developmental *** MII oocytes edited during in vitro maturation(IVM)could develop into blastocysts after parthenogenetic activation(PA)or in vitro fertilization(IVF).Genotyping results indicated that the maternal gene X-linked Dmd could be efficiently edited during oocyte *** to81.3% of the edited IVF embryos were non-mosaic Dmd gene mutant *** conclusion,GVGE might be a valuable method for the generation of non-mosaic maternal allele edited FO embryos in a short simple step.

关键词： Porcine Germinal vesicle(GV) In vitro maturation CRISPR/Cas9 Dmd

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Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes

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Science China(Life Sciences) 2020年第7期63卷 996-1005页

作者： Xiaohu Su Wei Chen qingqing cai Puping Liang Yaosheng Chen Peiqing Cong Junjiu Huang Key Laboratory'of Reproductive Medicine of Guangdong Province the First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Key Laboratory of Reproductive Medicine of Guangdong Province the Third Affiliated Hospital of Guangzhou Medical University'Guangzhou 510150China

Cytosine and adenine base editors are promising new tools for introducing precise genetic modifications that are required to generate disease models and to improve traits in pigs. Base editors can catalyze the conversion of C→T(C>T) or A→G(A>G) in the target site through a single guide RNA. Injection of base editors into the zygote cytoplasm can result in the production of offspring with precise point mutations, but most F0 are mosaic, and breeding of F1 heterozygous pigs is time-intensive. Here, we developed a method called germinal vesicle oocyte base editing(GVBE) to produce point mutant F0 porcine embryos by editing the maternal alleles during the GV to MⅡ transition. Injection of cytosine base editor 3(BE3) mRNA and X-linked Dmdspecific guide RNAs into GVoocytes efficiently edited maternal Dmd during in vitro maturation and did not affect the maturation potential of the oocytes. The edited MⅡ oocytes developed into blastocysts after parthenogenetic activation(PA) or in vitro fertilization(IVF). However, BE3 may reduce the developmental potential of IVF blastocysts from 31.5%±0.8% to 20.4%±2.1%. There 40%–78.3% diploid PA blastocysts had no more than two different alleles, including up to 10% embryos that had only C>T mutation alleles. Genotyping of IVF blastocysts indicated that over 70% of the edited embryos had one allele or two different alleles of Dmd. Since the male embryos had only a copy of Dmd allele, all five(5/19) F0 male embryos are homozygous and three of them were Dmd precise C>T mutation. Nine(9/19) female IVF embryos had two different alleles including a WT and a C>T mutation. DNA sequencing showed that some of them might be heterozygous embryos. In conclusion, the GVBE method is a valuable method for generating F0 embryos with maternal point mutated alleles in a single step.

关键词： cytosine base editor point mutation porcine germinal vesicle oocyte maternal genome Dmd

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Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes

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Protein & Cell 2015年第8期6卷 575-588页

作者： Lin Lin qingqing cai Xiaoyan Zhang Hongwei Zhang Yang Zhong Congjian Xu Yanyun Li Department of Gynecology Obstetrics and Gynecology Hospital Fudan University Shanghai 200011 China Department of Obstetrics and Gynecology of Shanghai Medical School Fudan University Shanghai 200032 China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011 China Institute of Biomedical Sciences Fudan University Shanghai 200032 China School of Life Sciences and Technology Tongji University Shanghai 200092 China Shanghai Center for Bioinformation Technology Shanghai 200235 China School of Life Sciences Fudan University Shanghai 200433 China

Human papillomaviruses （HPVs） including *** （HR） and low-risk （LR） subtypes have distinguishable variation on both genotypes and phenotypes. The co- infection of multiple HR-HPVs, headed by HPV16, is common in cervical cancer in female. Recently accu- mulating reports have focused on the interaction be- tween virus and host, particularly the role of human microRNAs （miRNAs） in anti-viral defense by targeting viral genome. Here, we found a well-conserved target site of miRNAs in the genomes of most HR-HPVs, not LR-HPVs, by scanning all potential target sites of human miRNAs on 24 HPVs of unambiguous subtypes of risk. The site is targeted by two less common human miR- NAs, miR-875 and miR-3144, and is located in E6 onco- gene open reading frame （ORF） and overlap with the first alternative splice exon of viral early transcripts. In validation tests, miR-875 and miR-3144 were identified to suppress the target reporter activity markedly and inhibit the expression of both synthetically exogenous E6 and endogenous E6 oncogene. High level of two miRNAs can inhibit cell growth and promote apoptosisin HPV16-positive cervical cancer cells. This study pro- vides a promising common target of miRNAs for most HR-HPVs and highlights the effects of two low ex- pressed human miRNAs on tumour suppression.

关键词： human papillomavirus microRNA E6miR-875 miR-3144

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