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未来食品学报(英文) 2023年第2期3卷 169-174页

作者： Tiantian Gao Lianghua Lu qingling wu Chenghua Wang College of Light Industry and Food Engineering Guangxi UniversityNanning 530004China

Lactobacillus fermentum 9-4 is a purine-degrading probiotic firstly isolated from traditional fermented rice-flour noodles with special characteristics of southern China's Guangxi Zhuang Autonomous Region.L.fermentum 9-4 could efficiently reduce the purine contents in foods with excellent purine-nucleoside assimilation and purine-metabolizing enzymatic activities.Crude cell lysate of L.fermentum 9-4 showed strong purine degradation abilities on nucleosides including inosine,guanosine,and purines including xanthine and uric acid,indicating a complete purine metabolic pathway to degrade purine substances to allantoin.In this study,the whole genome of L.fermentum 9-4 was sequenced.Its genome consisted of a 2085632 bp circular chromosome without plasmid.The GC content of circular chromosome was 51.25%,including 2089 coding sequences(CDs),15 rRNA operons and 59 tRNA coding genes.Genetic analysis showed that at least 5 protein coding genes were related to purine lowering ability.In addition,neither toxic virulence factor nor drug resistance gene was identified by searching the virulence factor database and drug resistance gene database,suggesting good safety of L.fermentum 9-4.The results showed that L.fermentum 9-4 has a good potential for the development and utilization as a purine-degrading probiotic for low-purine foods.

关键词： Lactobacillus fermentum Low purine food Fermented rice-floor noodles Genome

Chemical composition and pharmacological properties of Flos sophorae immaturus, Flos sophorae and Fructus sophorae: a review

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未来食品学报(英文) 2023年第4期3卷 330-339页

作者： Ping Shi Jiajun Liao Ting Duan qingling wu Xiaoni Huang Xiaodong Pei Chenghua Wang College of Light Industry and Food Engineering Guangxi UniversityNanning 530004China

The flower buds and fruits of Sophora japonica are known as Flos sophorae immaturus(Chinese Huaimi,FSI),Flos sophorae(Chinese Huaihua,FLS)and Fructus sophorae(Chinese Huaijiao,FRS)due to their different physiological forms.FSI and FLS are precious resources of homology of medicine and food,while FRS is a valuable Chinese herb,and all of which have been used for thousands of years.There are great differences in the active ingredients,functions and toxicological properties of FSI,FLS and FRS.However,they are often confused and assumed to have fairly similar validity,which is detrimental to their precision development of resources of homology of medicine and food.This review summarized the active constituents,analytical techniques and pharmacological properties of FSI,FLS and FRS,then systematically compared their differences.The article will help people better understand and distinguish the differences and characteristics of FSI,FLS and FRS in bioactive constituents,content of functional components and pharmacological properties,which can contribute to their highly efficient targeted applications in the future food and medical fields.

关键词： Flos sophorae immaturus Flos sophorae Fructus sophorae Active constituents Analytic techniques Pharmacological properties

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地方政府的竞争对我国医疗服务效率的影响

医学与社会 2024年第1期37卷 50-56页

作者：吴庆玲舒燕广州中医药大学公共卫生与管理学院广东广州510006

目的:从财政医疗卫生支出视角探究地方政府的竞争对医疗服务效率的影响,为我国医疗卫生体系的建设提供建议。方法:运用非期望产出的SBM(slacks-based measure)方法,以2010-2021年我国31个省份的面板数据为样本,对我国医疗服务效率进行测... 详细信息

目的:从财政医疗卫生支出视角探究地方政府的竞争对医疗服务效率的影响,为我国医疗卫生体系的建设提供建议。方法:运用非期望产出的SBM(slacks-based measure)方法,以2010-2021年我国31个省份的面板数据为样本,对我国医疗服务效率进行测度,其后利用面板Tobit模型,以财政医疗卫生支出为中介变量,实证检验地方政府的竞争、财政医疗卫生支出与医疗服务效率之间的关联。结果:我国省级医疗服务效率整体向好,年均增长率为1.3%,但区域差异显著;地方政府的竞争对医疗服务效率具有显著负向影响,但该结果在发达地区并不显著;财政医疗卫生支出在其中起部分中介效应,中介效应占比14.2%;在全国,总抚养比、人均绿地面积、财政支出分权显著提升医疗服务效率。在发达地区,财政自给度与医疗服务效率成正比;在欠发达地区,城镇化与医疗服务效率负相关。结论:地方政府的竞争通过减少财政医疗卫生支出规模进而降低医疗服务效率。后续应建立地方政府竞争动态均衡机制、建立政府绩效考核柔性机制、健全地方政府竞争监督约束机制以及完善医疗卫生预算机制。

关键词：医疗服务效率地方政府竞争财政分权

Facile Synthesis of Porous Carbon Nitride Spheres with Hierarchical Three-Dimensional Mesostructures for CO_(2) Capture

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Nano Research 2010年第9期3卷 632-642页

作者： Qiang Li Jianping Yang Dan Feng Zhangxiong wu qingling wu Sung Soo Park Chang-Sik Ha Dongyuan Zhao Department of Chemistry and Shanghai Key Laboratory of MolecularCatalysis and Innovative Materials Laboratory of Advanced MaterialsFudan UniversityShanghai 200433China Department of Polymer Science and Engineering Pusan National UniversityGeumjeong-guBusan 609-735Korea

Porous carbon nitride(CN)spheres with partially crystalline frameworks have been successfully synthesized via a nanocasting approach by using spherical mesoporous cellular silica foams(MCFs)as a hard template,and ethylenediamine and carbon tetrachloride as precursors.The resulting spherical CN materials have uniform diameters of ca.4μm,hierarchical three-dimensional(3-D)mesostructures with small and large mesopores with pore diameters centered at ca.4.0 and 43 nm,respectively,a relatively high BET surface area of~550 m^(2)/g,and a pore volume of 0.90 cm^(3)/g.High-resolution transmission electron microscope(HRTEM)images,wide-angle X-ray diffraction(XRD)patterns,and Raman spectra demonstrate that the porous CN material has a partly graphitized structure.In addition,elemental analyses,X-ray photoelectron spectra(XPS),Fourier transform infrared spectra(FT-IR),and CO_(2) temperature-programmed desorption(CO_(2)-TPD)show that the material has a high nitrogen content(17.8 wt%)with nitrogen-containing groups and abundant basic sites.The hierarchical porous CN spheres have excellent CO_(2) capture properties with a capacity of 2.90 mmol/g at 25℃and 0.97 mmol/g at 75℃,superior to those of the pure carbon materials with analogous mesostructures.This can be mainly attributed to the abundant nitrogen-containing basic groups,hierarchical mesostructure,relatively high BET surface area and stable framework.Furthermore,the presence of a large number of micropores and small mesopores also enhance the CO_(2) capture performance,owing to the capillary condensation effect.

关键词： Mesoporous materials carbon nitride nanocasting sphere hard template CO_(2)capture

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积极老龄化视域下老年教育发展路径探究

继续教育研究 2024年第4期 32-36页

作者：伍清玲娄底开放大学湖南娄底417000

人口老龄化已成为世界性问题,老龄人口逐年递增以及随之而来的社会问题,要求我们必须将人口老龄化作为重要的议题来对待。在该视域下,老年教育的价值、功能、作用不断彰显。而积极老龄化的提出,顺应了该趋势,能够为我国老龄教育的现代... 详细信息

人口老龄化已成为世界性问题,老龄人口逐年递增以及随之而来的社会问题,要求我们必须将人口老龄化作为重要的议题来对待。在该视域下,老年教育的价值、功能、作用不断彰显。而积极老龄化的提出,顺应了该趋势,能够为我国老龄教育的现代化发展寻找到全新的切入点,推进老年教育事业健康、全面、快速、蓬勃发展。结合积极老龄化与老年教育的内涵,明确老年教育的必要性与发展问题,分别从国家、政府及教育机构的角度出发,探究老年教育的发展路径,以期应对人口老龄化问题,确保我国社会和谐、稳定地发展。

关键词：积极老龄化老年教育发展实践价值人才数据库

Soil temperature estimation at different depths,using remotely-sensed data

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Journal of Integrative Agriculture 2020年第1期19卷 277-290页

作者： HUANG Ran HUANG Jian-xi ZHANG Chao MA Hong-yuan ZHUO Wen CHEN Ying-yi ZHU De-hai qingling wu Lamin R.MANSARAY College of Land Science and Technology China Agricultural University/Key Laboratory of Remote Sensing for Agri-hazardsMinistry of Agriculture and Rural Affairs/Key Laboratory for Agricultural Land QualityMinistry of Natural ResourcesBeijing 100083P.R.China College of Information&Electrical Engineering China Agricultural UniversityBeijing 100083P.R.China Department of Geography University College LondonLondon WC1E 6BTUK Department of Agro-meteorology and Geo-informatics Magbosi LandWater and Environment Research Centre(MLWERC)Sierra Leone Agricultural Research Institute(SLARI)Freetown PMB 1313Sierra Leone

Soil temperatures at different depths down the soil profile are important agro-meteorological indicators which are necessary for ecological modeling and precision agricultural activities. In this paper, using time series of soil temperature(ST) measured at different depths(0, 5, 10, 20, and 40 cm) at agro-meteorological stations in northern China as reference data, ST was estimated from land surface temperature(LST) and normalized difference vegetation index(NDVI) derived from AQUA/TERRA MODIS data, and solar declination(Ds) in univariate and multivariate linear regression models. Results showed that when daytime LST is used as predictor, the coefficient of determination(R^2) values decrease from the 0 cm layer to the 40 cm layer. Additionally, with the use of nighttime LST as predictor, the R^2 values were relatively higher at 5, 10 and 15 cm depths than those at 0, 20 and 40 cm depths. It is further observed that the multiple linear regression models for soil temperature estimation outperform the univariate linear regression models based on the root mean squared errors(RMSEs) and R^2. These results have demonstrated the potential of MODIS data in tandem with the Ds parameter for soil temperature estimation at the upper layers of the soil profile where plant roots grow in. To the best of our knowledge, this is the first attempt at the synergistic use of LST, NDVI and Ds for soil temperature estimation at different depths of the upper layers of the soil profile, representing a significant contribution to soil remote sensing.

关键词： soil temperature land surface temperature normalized difference vegetation index solar declination

Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

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Cellular & Molecular Immunology 2021年第2期18卷 427-439页

作者： Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li qingling wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe wu Zhinan Yin The First Affiliated Hospital Faculty of Medical ScienceJinan UniversityGuangzhou510632GuangdongPR China Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai519000GuangdongPR China The Biomedical Translational Research Institute Jinan UniversityGuangzhou510632GuangdongPR China Department of Paediatrics and Adolescent Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongPR China Institute of Immunology Christian-Albrechts-University KielKielGermany Fuda Cancer Hospital Faculty of Medical ScienceJinan UniversityGuangzhou510665GuangdongPR China Shanghai Chest Hospital Shanghai Jiao Tong UniversityShanghaiPR China Tongji Chibi Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyChibiHubeiPR China

Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients.

关键词： Cancer immunotherapy Immunotherapy Translational immunology

A migration imaging method using CGP stacked cylindrical waves

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Applied Geophysics 2006年第2期3卷 87-91页

作者： Li Zishun Long Jiangnan wu qingling China University of Geosciences （Beijing） Beijing 100083 China Research Institute of Exploration and Development of Daqing Oilfield Co. Ltd. Daqing 163000 China China University of petroleum （East China） Dongying 257061 China

鉴于在 Songliao 盆的薄沙水库的地震探索问题，这篇论文用叠的 CGP (普通地震检波器点) 提出一个迁居成像方法圆柱的波浪。由这个工具，地震数据应该从与小射击点间距和小地震检波器间隔射击布局系统的一个中点被获得。用如此的地震数... 详细信息

鉴于在 Songliao 盆的薄沙水库的地震探索问题，这篇论文用叠的 CGP (普通地震检波器点) 提出一个迁居成像方法圆柱的波浪。由这个工具，地震数据应该从与小射击点间距和小地震检波器间隔射击布局系统的一个中点被获得。用如此的地震数据， CGP 集合首先被叠填写圆柱的波浪节。圆柱的波浪节向下借助于光线路径被移植并且想象下面去的波浪和波浪方程的继续向下继续起来去的波浪。从在建议移植成像方法举办的 Songliao 盆表演 TK8157 地震的线处理的当模特儿的分析和数据的结果更高地震的分辨率和忠实。而且，建议方法被证明为发现小沙身体更有效，小差错， stratigraphic 拧外面等等。

关键词：松辽盆地 CMP叠加 CGP叠加偏移成像

广东省公共卫生财政支出效率及影响因素研究——基于三阶段DEA-Tobit模型

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卫生经济研究 2023年第5期40卷 34-39页

作者：吴庆玲舒燕广州中医药大学公共卫生与管理学院广东广州510006

目的:分析广东省公共卫生财政支出效率及影响因素,并提出相应的建议。方法:运用三阶段DEA方法,对2010—2020年广东省各地市公共卫生财政支出效率进行评价,运用Tobit模型分析其影响因素。结果:广东省公共卫生财政支出效率均值为0.857,且... 详细信息

目的:分析广东省公共卫生财政支出效率及影响因素,并提出相应的建议。方法:运用三阶段DEA方法,对2010—2020年广东省各地市公共卫生财政支出效率进行评价,运用Tobit模型分析其影响因素。结果:广东省公共卫生财政支出效率均值为0.857,且呈现下降趋势;财政规模、财政收入分权对公共卫生财政支出效率有负向作用,财政负担率、健康保险密度和空气质量水平对公共卫生财政支出效率有正向作用,而财政支出分权、受教育程度对纯技术效率有显著的正向作用。结论:广东省公共卫生财政支出效率整体处于中上水平,但区域间差异较大,应提高财政资金管理水平、合理控制公共卫生财政支出规模、理顺省级政府和地方政府的财政资金分配关系,并增加疾病预防支出,发挥财政对卫生健康事业的兜底作用。

关键词：公共卫生财政支出效率三阶段DEA Tobit模型财政资金

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清肺化痰平喘方治疗小儿肺炎的临床观察

中医临床研究 2022年第12期14卷 86-88页

作者：吴庆灵桂林市中西医结合医院广西桂林541004

目的:分析小儿肺炎采用清肺化痰平喘方治疗的临床效果。方法:将2019年12月-2020年5月接诊且行常规西医治疗的40例肺炎患儿作为对照组,将2020年6月-2020年11月接诊且在对照组基础上加用清肺化痰平喘方治疗的40例肺炎患儿作为观察组,对组... 详细信息

目的:分析小儿肺炎采用清肺化痰平喘方治疗的临床效果。方法:将2019年12月-2020年5月接诊且行常规西医治疗的40例肺炎患儿作为对照组,将2020年6月-2020年11月接诊且在对照组基础上加用清肺化痰平喘方治疗的40例肺炎患儿作为观察组,对组间肺功能指标、症状持续时间、治疗效果展开分析。结果:①组间第1秒用力呼吸率(FEV_(1)/FVC)、肺活量(FVC)、第1秒用力呼气量(FEV_(1))在治疗前差异无统计学意义(P>0.05);治疗1周后,两组上述指标均有所改善,且观察组更佳,P<0.05;②较之对照组,观察组症状持续时间更少,P<0.05;③治疗1周后,观察组3例无效(7.50%),对照组11例无效(27.50%),P<0.05。结论:对肺炎患儿进行清肺化痰平喘方治疗,可以增强疗效,改善患儿肺功能,尽快消除临床症状,值得推广。

关键词：清肺化痰平喘方小儿肺炎临床效果