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Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays

Nano Research 2024年第5期17卷 4329-4337页

作者： Yang Liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng Liu Yingyuan Liu Meng Su Keyu Wang Qiangguo Ao qingli cheng Department of Nephrology The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China Chinese PLA Medical School Beijing 100853China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China

Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of patients.In this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the point-of-care.We confirmed its efficacy in the early diagnosis of AKI using clinical urine specimens.Direct quantitative detection of uKIM-1 was achieved within 10 min.The lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal microarray.Consequently,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community settings.Rapid,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare costs.It highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions.

关键词： photonic crystal point-of-care testing urine kidney injury molecule-1(KIM-1) acute kidney injury

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Influence of meteorological factors on open biomass burning at a background site in Northeast China

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Journal of Environmental Sciences 2024年第4期138卷 1-9页

作者： Yulong Wang Linlin Liang Wanyun Xu Chang Liu Hongbing cheng Yusi Liu Gen Zhang Xiaobin Xu Dajiang Yu Peng Wang qingli Song Jiumeng Liu Yuan cheng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesBeijing 100081China Longfengshan Regional Background Station China Meteorological AdministrationHeilongjiang 150200China Heilongjiang Climate Center Heilongjiang 150030China

Biomass burning(BB)is a very important emission source that significantly adversely impacts regional air quality.BB produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,BB also provides many precursors for secondary organic aerosol(SOA)generation.In this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(OBB)events,which occurred in two representative episodes,October 13 to November 30,2020,and April1 to April 30,2021.The ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/OC.When LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of OBB to OA is crucial.According to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main fuel.The occurrence of OBB coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without rain.Meteorological factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices.

关键词： Air pollution Biomass burning Meteorological factors Organic trace Agricultural fires

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Survival outcomes in older patients with different stages of acute kidney injury defined by the addition of urine output criteria

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Chinese Medical Journal 2023年第9期136卷 1129-1131页

作者： Jiebin Hou Yabin Zhang Jie Zhang Yang Liu Xiaohua Wang Zhen Wu Jiayu Guo Xiaoli Sun qingli cheng Qiangguo Ao Department of Nephrology The Second Medical Centre&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Nephrology National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Nephrology The Second Medical CentreChinese PLA General HospitalBeijing 100853China Department of Gastroenterology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

To the Editor:Globally,acute kidney injury(AKI)is a common life-threatening condition.AKI is more prevalent in elderly patients,with increasing mortality rates.Compared with younger patients,older patients with AKI have a higher risk of persistent injury and poorer prognoses.[1]Older individuals often have comorbidities,increasing their susceptibility to AKI.Kidney Disease:Improving Global Outcomes(KDIGO)criteria define and stage AKI based on the higher stage of AKI defined by either serum creatinine(SCr)level or urine output(UO).[2]However,the record of UO is difficult to access in clinic,the data on the value of UO combined with SCr for AKI diagnosis or prognosis in elderly patients are lacking.Therefore,the objectives of this study were to investigate whether UO would influence the classification of AKI and improve the accuracy of prediction of the clinical prognosis in elderly patients.

关键词： patients urine Survival

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考虑风电出力和电价不确定性的水风联合现货市场竞价策略

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电力系统自动化 2024年第11期48卷 122-133页

作者：白庆立赵志鹏靳晓雨程春田邓志豪贾泽斌大连理工大学电子信息与电气工程学院辽宁省大连市116024 大连理工大学水电与水信息研究所辽宁省大连市116024 昆明电力交易中心有限责任公司云南省昆明市650011 华北水利水电大学水资源学院河南省郑州市450046

以风电为代表的新能源参与现货市场已是大势所趋,但出力不确定性导致其市场竞争力较弱,而电价的不确定性又进一步增大了其承担的收益风险。联合具有灵活调节能力的水电是有效的解决途径,而制定符合决策者风险意愿的竞价策略则是其中亟... 详细信息

以风电为代表的新能源参与现货市场已是大势所趋,但出力不确定性导致其市场竞争力较弱,而电价的不确定性又进一步增大了其承担的收益风险。联合具有灵活调节能力的水电是有效的解决途径,而制定符合决策者风险意愿的竞价策略则是其中亟须解决的关键问题。为此,从价格接受者角度提出了水电联合风电参与现货市场的竞价模型。模型中采用笛卡尔积组合后的典型场景集描述风电出力、市场电价等多种不确定性,采用条件风险价值衡量不确定性导致的市场风险,并以风险因子作为决策者风险偏好纳入决策过程。通过引入0/1整数变量,将模型中的非线性函数转换为混合整数线性规划模型予以求解。以中国西南某省梯级水电站和风电场为背景,验证了模型的有效性,并进一步分析了风险偏好对竞价决策的影响。

关键词：水风联合竞价策略现货市场典型场景集风险偏好水电调度

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肾脏储备功能最新评估方法简介

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中国临床保健杂志 2024年第1期27卷 47-49页

作者：刘洋程庆砾中国人民解放军总医院第二医学中心肾脏病科、国家老年疾病临床研究中心北京100853

肾脏储备功能(RFR)下降可提示亚临床肾功能丧失、慢性肾脏病早期阶段以及患者对急性肾损伤(AKI)易感性。在进行有潜在的肾损害治疗(如手术、化疗等)之前,评估患者对肾脏损害的易感性可能有助于进行个体化治疗和预防AKI。目前常用口服蛋... 详细信息

肾脏储备功能(RFR)下降可提示亚临床肾功能丧失、慢性肾脏病早期阶段以及患者对急性肾损伤(AKI)易感性。在进行有潜在的肾损害治疗(如手术、化疗等)之前,评估患者对肾脏损害的易感性可能有助于进行个体化治疗和预防AKI。目前常用口服蛋白和静脉输注氨基酸的方法激发并测定RFR,此方法操作复杂、费时且有创,特别是在诊断时间有限,或需要筛查大量人群时更为不便。因此,开发简易、便捷的方法来评估RFR尤为迫切。肾实质内肾抵抗指数变异(IRRIV)与RFR有很好的相关性,应用彩色多普勒超声即可测量IRRIV,是一种安全、可重复、廉价和便捷的测量方法,可用于评估健康受试者的RFR。

关键词：肾功能状态监测,生理学诊断技术,泌尿科老年人

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玉米秸秆碱尿处理及其重金属吸附性能研究

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河南财政金融学院学报（自然科学版） 2024年第1期33卷 21-25页

作者：司璟璐马韶华舒蔚翔尹旌翔成庆利华北水利水电大学环境与市政工程学院河南郑州450046

通过正交设计降低秸秆中木质素含量,最佳实验方案为:水洗温度70℃,NaOH和尿素的添加量分别为5%和8%。处理后的秸秆纤维用于吸附Pb^(2+)、Cd^(2+)、Zn^(2+)等重金属离子,效果显著。吸附符合准二级动力学模型和Freundlich方程,表明吸附过... 详细信息

通过正交设计降低秸秆中木质素含量,最佳实验方案为:水洗温度70℃,NaOH和尿素的添加量分别为5%和8%。处理后的秸秆纤维用于吸附Pb^(2+)、Cd^(2+)、Zn^(2+)等重金属离子,效果显著。吸附符合准二级动力学模型和Freundlich方程,表明吸附过程为吸热且易于进行的化学吸附,颗粒内扩散和表面吸附共同控制吸附速率。改性后的玉米秸秆纤维去除水中重金属,吸附率高,达到变废为宝的目的。

关键词：玉米秸秆碱尿处理重金属吸附性能

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Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial

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Frontiers of Medicine 2022年第2期16卷 276-284页

作者： Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong cheng Xinyu Wang qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu Department of Gynecological Oncology Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Obstetrics and Gynecology Qilu Hospital of Shandong UniversityJinan 250012China Department of Obstetrics and Gynecology West China Second University Hospital of Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Disease of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Tianjin Central Hospital of Gynecology Obstetrics Tianjin 300052China Shengjing Hospital of China Medical University Shenyang 110021China

We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN.

关键词： gestational trophoblastic neoplasia(GTN) methotrexate(MTX) dactinomycin(ACTD)

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原油储罐底部油泥对Q235B碳钢腐蚀行为的影响

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电镀与涂饰 2022年第7期41卷 519-526页

作者：程庆利中石化安全工程研究院有限公司山东青岛266000

通过热重分析、电化学分析、组织结构分析等研究了油泥在原油沉积水中对Q235B碳钢腐蚀行为的影响。结果表明,油泥覆盖的Q235B碳钢在模拟沉积水中浸泡的前21 d内腐蚀速率逐渐升高,腐蚀形式以点蚀为主。浸泡21 d后Q235B碳钢的腐蚀速率下降... 详细信息

通过热重分析、电化学分析、组织结构分析等研究了油泥在原油沉积水中对Q235B碳钢腐蚀行为的影响。结果表明,油泥覆盖的Q235B碳钢在模拟沉积水中浸泡的前21 d内腐蚀速率逐渐升高,腐蚀形式以点蚀为主。浸泡21 d后Q235B碳钢的腐蚀速率下降,腐蚀形态由局部腐蚀为主转变成全面腐蚀。在腐蚀的起始阶段,油泥中含有的硫酸盐还原菌(SRB)能够诱导碳钢发生局部腐蚀。随着浸泡时间延长,腐蚀产物和油泥沉积层附着在金属表面,抑制了腐蚀反应的继续进行。

关键词：原油罐油泥碳钢硫酸盐还原菌腐蚀行为

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Systematic review of Listeria monocytogenes from food and clinical samples in Chinese mainland from 2010 to 2019

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Food Quality and Safety 2022年第3期6卷 365-374页

作者：程颖董庆利刘阳泰刘弘张红芝王翔 School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Shanghai Municipal CenterforDisease Control and Prevention ShanghaiChina

Listeria monocytogenes(L.monocytogenes),a foodborne pathogen,can cause human listeriosis.Listeriosis is a potentially fatal gastrointestinal illness,which is closely related to the spread of food to humans.We review the literature published during 2010-2019 to better understand the prevalence of L.monocytogenes in food products,incidence of human listeriosis,and their characteristics in Chinese mainland.We found the main sequence types(STs)strains from foods are similar globally,and the prevalence of L.monocytogenes from raw meat was the highest among all food products.The most common STs in food products and clinical cases were ST9(serogroup I.2)strains and ST87(serogroup Il.2)strains,respectively.The ST87 strains being the most common STs of clinical cases might be related to the existence of Listeria pathogenicity island 4 gene and Chinese eating habits for ready-to-eat foods,among which the prevalence of ST87 strain was the highest in ready-to-eat foods.Therefore,more research should be conducted to explore the reasons for the L.monocytogenes isolates differences in food and clinical sources.

关键词： Listeriosis foodborne pathogens subtype epidemiology food safety

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抗爆HSE功能材料在石油化工领域中的应用

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石油学报（石油加工） 2022年第3期38卷 512-519页

作者：杨哲杨珂程庆利王全国中国石化安全工程研究院有限公司山东青岛266000

近几年频发的化学品爆炸事故常会对附近建筑物内的人员造成重大伤亡,为了降低爆炸事故的危害,亟需提升化工企业建筑物的抗爆能力。笔者简要介绍了金属基、混凝土基和高分子基3种类型抗爆HSE功能材料的特点。着重介绍了一种阻燃抗爆聚脲... 详细信息

近几年频发的化学品爆炸事故常会对附近建筑物内的人员造成重大伤亡,为了降低爆炸事故的危害,亟需提升化工企业建筑物的抗爆能力。笔者简要介绍了金属基、混凝土基和高分子基3种类型抗爆HSE功能材料的特点。着重介绍了一种阻燃抗爆聚脲材料,通过结构型阻燃聚酯多元醇对聚脲进行阻燃改性。改性后的阻燃抗爆聚脲的燃烧性能达到B级,并且其力学性能保持较高,拉伸强度为27 MPa,断裂伸长率为320%;在气体爆炸实验中,抗爆聚脲涂层可抗1.16 MPa的爆炸超压。最后展望了抗爆HSE功能材料在石油化工行业中的作用及发展前景。

关键词：聚脲阻燃抗爆

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