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Investigation of the epidemiology,pathogenicity and immunogenicity of Bordetella bronchiseptica isolated from cats and dogs in China from 2021 to 2023

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Animal Diseases 2024年第3期4卷 156-172页

作者： qinghua Shang Wenhui Gao Xiangting Zhang Jianqing Zhao Ying Wu Haoqi Li Ming zhou Zhen F.Fu Chengguang Zhang Ling Zhao National Key Laboratory of Agricultural Microbiology Huazhong AgriculturalUniversityWuhan 430070China. Key Laboratory of Preventive VeterinaryMedicine of Hubei Province College of Veterinary MedicineHuazhongAgricultural UniversityWuhan 430070China. Hubei Hongshan Laboratory Wuhan 430070China.

Bordetella bronchiseptica(Bb)is recognized as a leading cause of respiratory diseases in dogs and ***,epidemiological data on Bb in dogs and cats in China are still limited,and there is no commercially available *** vaccines containing Bb that are widely used abroad are generally efective but can establish latency and potentially reactivate to cause illness in some immunodefcient vaccinated recipients,raising safety *** this study,34 canine-derived and two feline-derived Bb strains were isolated from 1809 canine and 113 feline nasopharyngeal swab samples collected from eight provinces in China from 2021 to *** PCR results showed that the percentage of positive Bb was 22.94%(441/1922),and more than 90%of the Bb isolates had four virulence factor-encoding genes(VFGs),namely,fhaB,prn,betA and *** the isolated strains displayed a multidrug-resistant *** virulence of 10 Bb strains isolated from dogs with respiratory symptoms was tested in mice,and we found that eight isolates were highly ***,the eight Bb isolates with high virulence were inactivated and intramuscularly injected into mice,and three Bb strains(WH1218,WH1203 and WH1224)with the best protective efcacy were *** immunized with these three strains exhibited strong protection against challenge with the Bb feld strain ***,the WH1218 strain with the greatest protection in dogs was selected as the vaccine *** and cats that received a vaccine containing 109 CFU of the inactivated WH1218 strain showed complete protection against challenge with the Bb feld strain *** study revealed that Bb is an important pathogen that causes respiratory diseases in domestic dogs and cats in China,and all the isolates exhibited multidrug *** present work contributes to the current understanding of the prevalence,antimicrobial resistance,and virulence genes of Bb in domestic dogs and ***,our results suggest

关键词： Bordetella bronchiseptica Epidemiological investigation Pathogenicity Immunogenicity Inactivated vaccine

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肺癌多学科综合诊治现状及未来方向

中国肺癌杂志 2024年第5期27卷 325-329页

作者：车国卫周清华四川大学华西医院肺癌中心/肺癌研究所成都610041 四川大学华西医院胸外科成都610041

尽管肺癌多学科诊疗(multidisciplinary team,MDT)模式能够提高患者的生活质量和生存预后,为何没有达到MDT诊疗模式所预期的目标呢?主要原因是肺癌MDT诊治模式相对滞后于各种治疗手段的进步。分析国内外肺癌MDT诊治最新研究成果,结合四... 详细信息

尽管肺癌多学科诊疗(multidisciplinary team,MDT)模式能够提高患者的生活质量和生存预后,为何没有达到MDT诊疗模式所预期的目标呢?主要原因是肺癌MDT诊治模式相对滞后于各种治疗手段的进步。分析国内外肺癌MDT诊治最新研究成果,结合四川大学华西医院肺癌中心肺癌MDT诊治经验,本文将从以下几个方面对肺癌MDT的进展及未来发展方向进行讨论和总结:(1)肺癌MDT诊治模式的内涵和外延需要转变并适应新的诊治手段;(2)肺癌MDT诊治临床决策应当从“多学科会诊(multidisciplinary consultation,MDC)”向“MDT”转变;(3)肺癌MDT诊治过程要从“消防队模式”转向“防火墙模式”,并最终实行“个体化全程管理模式”;(4)肺癌MDT诊治路径要从“临时召集模式”向“肺癌单病种中心制模式”转变。

关键词：多学科诊疗临床决策诊治模式肺肿瘤

金融科技能提升城市包容性绿色全要素生产率吗?

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中南财经政法大学学报 2024年第2期 67-80页

作者：宋清华周学琴中南财经政法大学金融学院湖北武汉430073

包容性绿色全要素生产率强调绿色发展、社会公平与经济增长协调并进,是判断城市经济发展质量的重要依据。本文以2011—2019年中国284个地级及以上城市的数据为样本,实证检验了金融科技对城市包容性绿色全要素生产率的影响及作用机制。... 详细信息

包容性绿色全要素生产率强调绿色发展、社会公平与经济增长协调并进,是判断城市经济发展质量的重要依据。本文以2011—2019年中国284个地级及以上城市的数据为样本,实证检验了金融科技对城市包容性绿色全要素生产率的影响及作用机制。研究发现,金融科技对城市包容性绿色全要素生产率具有明显的促进作用,主要表现在技术进步指数显著提升,这一结论在经过一系列内生性处理和稳健性检验后依然成立。机制分析显示,金融科技能够通过促进绿色创新、增加环保投资以及激发创业活力提升城市包容性绿色全要素生产率。异质性分析表明,金融科技对包容性绿色全要素生产率的提升作用在人力资本水平、金融发展水平和基础设施水平较高的城市中更为明显。本文的研究为加快实现经济绿色发展和包容性增长的“双重红利”提供了重要的经验证据。

关键词：金融科技包容性绿色全要素生产率绿色创新环保投资创业活力

塔里木盆地西北缘乌什西次凹的地层系统和构造特征

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地质科学 2024年第2期59卷 271-287页

作者：王清华杨威周慧缪卫东中国石油天然气集团有限公司超深层复杂油气藏勘探开发技术研发中心新疆库尔勒841000 中国石油天然气股份有限公司塔里木油田分公司新疆库尔勒841000 中国石油天然气股份有限公司勘探开发研究院北京100083

乌什西次凹位于塔里木盆地西北缘,隶属于库车坳陷的乌什凹陷。它位于南天山主山脉(哈尔克山)和塔里木盆地柯坪—温宿凸起之间。区域构造格局上,这里是塔里木克拉通向西北自然延伸的部分。次凹北缘的阿合奇断裂是南天山造山带和塔里木克... 详细信息

乌什西次凹位于塔里木盆地西北缘,隶属于库车坳陷的乌什凹陷。它位于南天山主山脉(哈尔克山)和塔里木盆地柯坪—温宿凸起之间。区域构造格局上,这里是塔里木克拉通向西北自然延伸的部分。次凹北缘的阿合奇断裂是南天山造山带和塔里木克拉通的分界。乌什西次凹内发育与柯坪—温宿凸起相似的晚前寒武纪—古生代地层系统,包括寒武系、奥陶系和石炭系的烃源岩。新近系—第四系碎屑岩建造直接不整合于变形的古生代被动大陆边缘碎屑岩—碳酸盐岩沉积建造之上;剖面上,向南天山方向加厚,向塔里木克拉通方向减薄,呈现典型的前陆盆地剖面结构特征。这是一个晚新生代陆内前陆盆地,叠加在晚海西期—燕山期古隆起之上。这里的构造变形主要有3期,分别是中海西期、晚海西期—印支期和晚喜山期。变形以厚皮冲断构造及其相关褶皱为主,薄皮构造不发育。平面上,主构造线走向NE-SW。剖面上,以南天山向塔里木冲断为主。

关键词：晚前寒武纪—古生代地层系统被动大陆边缘二叠纪末—三叠纪冲断和褶皱晚新生代陆内前陆盆地基底卷入型构造乌什西次凹塔里木盆地西北缘南天山造山带

地理大数据揭示中国主要城市建成环境物质存量的空间格局

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Engineering 2024年第3期34卷 143-153页

作者： zhou Huang Yi Bao Ruichang Mao Han Wang Ganmin Yin Lin Wan Houji Qi Qiaoxuan Li Hongzhao Tang Qiance Liu Linna Li Bailang Yu qinghua Guo Yu Liu Huadong Guo Gang Liu Institute of Remote Sensing and Geographical Information Systems School of Earth and Space SciencesPeking UniversityBeijing 100871China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China SDU Life Cycle Engineering Department of Green TechnologyUniversity of Southern DenmarkOdense 5230Denmark Department of Construction Management School of Civil EngineeringTsinghua UniversityBeijing 100084China School of Computer Science China University of GeosciencesWuhan 430074China School of Geographical Sciences East China Normal UniversityShanghai 200062China Land Satellite Remote Sensing Application Center Ministry of Natural ResourcesBeijing 100048China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Department of Geography California State UniversityLong BeachCA 90840USA Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

The patterns of material accumulation in buildings and infrastructure accompanied by rapid urbanization offer an important,yet hitherto largely missing stock perspective for facilitating urban system engineering and informing urban resources,waste,and climate ***,our existing knowledge on the patterns of built environment stocks across and particularly within cities is limited,largely owing to the lack of sufficient high spatial resolution *** study leveraged multi-source big geodata,machine learning,and bottom-up stock accounting to characterize the built environment stocks of 50 cities in China at 500 m fine-grained *** per capita built environment stock of many cities(261 tonnes per capita on average)is close to that in western cities,despite considerable disparities across cities owing to their varying socioeconomic,geomorphology,and urban form *** is mainly owing to the construction boom and the building and infrastructure-driven economy of China in the past ***’s urban expansion tends to be more“vertical”(with high-rise buildings)than“horizontal”(with expanded road networks).It trades skylines for space,and reflects a concentration-dispersion-concentration pathway for spatialized built environment stocks development within cities in *** results shed light on future urbanization in developing cities,inform spatial planning,and support circular and low-carbon transitions in cities.

关键词： Urban system engineering Built environment stock Spatial pattern Urban sustainability Big geodata

基于改进YOLOv8的露天矿区行车障碍物检测

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黄金科学技术 2024年第2期32卷 345-355页

作者：顾清华周琼王丹西安建筑科技大学资源工程学院陕西西安710055 西安建筑科技大学西安市智慧工业感知计算与决策重点实验室陕西西安710055

露天矿区场景复杂,行车障碍物检测受扬尘和颗粒物等粉尘噪声干扰严重,难以准确识别障碍物,尤其是光线较差的夜间,不利于做出正确决策,从而影响无人作业的安全性和整体效率。针对以上问题,提出了一种基于YOLOv8n模型的露天矿区行车障碍... 详细信息

露天矿区场景复杂,行车障碍物检测受扬尘和颗粒物等粉尘噪声干扰严重,难以准确识别障碍物,尤其是光线较差的夜间,不利于做出正确决策,从而影响无人作业的安全性和整体效率。针对以上问题,提出了一种基于YOLOv8n模型的露天矿区行车障碍物检测算法YOLOv8n-Enhanced。该算法主要从3个方面进行了改进,具体包括:首先,针对受粉尘噪声干扰严重和夜间光线不足的问题,提出了C2fCA模块结构,提高了模型特征提取能力;其次,使用轻量级卷积技术GSConv和VoV-GSCSP模块,减轻模型复杂性,实现检测器更高的计算成本效益;最后,使用WIOU损失函数,提高了模型泛化能力。试验结果表明:改进算法在保持实时性的前提下,可将YOLOv8n的平均精度(mean Average Precision,mAP)分别提高1.8%和2.6%,实现白天与夜间场景下不同尺度的障碍物识别。

关键词：露天矿区无人驾驶障碍物检测 YOLOv8检测模型矿区复杂场景

An interpretability model for syndrome differentiation of HBV-ACLF in traditional Chinese medicine using small-sample imbalanced data

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Digital Chinese Medicine 2024年第2期7卷 137-147页

作者： zhou Zhan PENG qinghua XIAO Xiaoxia ZOU Beiji LIU Bin GUO Shuixia School of Informatics Hunan University of Chinese MedicineChangshaHunan 410208China School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangshaHunan 410208China School of Mathematics and Statistics Hunan Normal UniversityChangshaHunan 410081China

Objective Clinical medical record data associated with hepatitis B-related acute-on-chronic liver failure(HBV-ACLF)generally have small sample sizes and a class ***,most machine learning models are designed based on balanced data and lack *** study aimed to propose a traditional Chinese medicine(TCM)diagnostic model for HBV-ACLF based on the TCM syndrome differentiation and treatment theory,which is clinically interpretable and highly *** We collected medical records from 261 patients diagnosed with HBV-ACLF,including three syndromes:Yang jaundice(214 cases),Yang-Yin jaundice(41 cases),and Yin jaundice(6 cases).To avoid overfitting of the machine learning model,we excluded the cases of Yin *** data standardization and cleaning,we obtained 255 relevant medical records of Yang jaundice and Yang-Yin *** address the class imbalance issue,we employed the oversampling method and five machine learning methods,including logistic regression(LR),support vector machine(SVM),decision tree(DT),random forest(RF),and extreme gradient boosting(XGBoost)to construct the syndrome diagnosis *** study used precision,F1 score,the area under the receiver operating characteristic(ROC)curve(AUC),and accuracy as model evaluation *** model with the best classification performance was selected to extract the diagnostic rule,and its clinical significance was thoroughly ***,we proposed a novel multiple-round stable rule extraction(MRSRE)method to obtain a stable rule set of features that can exhibit the model’s clinical *** The precision of the five machine learning models built using oversampled balanced data exceeded *** these models,the accuracy of RF classification of syndrome types was 0.92,and the mean F1 scores of the two categories of Yang jaundice and Yang-Yin jaundice were 0.93 and 0.94,***,the AUC was *** extraction rules of the RF syn

关键词： Traditional Chinese medicine(TCM) Hepatitis B-related acute-on-chronic liver failure(HBV-ACLF) Imbalanced data Random forest(RF) Interpretability

深入学习贯彻习近平总书记考察宁夏重要讲话精神凝心聚力加快建设美丽新宁夏

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宁夏党校学报 2024年第5期26卷 14-22页

作者：周庆华宁夏回族自治区党委宣传部宁夏银川750001

2024年6月,习近平总书记时隔四年再次亲临宁夏考察指导并发表重要讲话,为宁夏指明了现代化之路、高质量发展之路、改革开放之路、人民共同富裕之路。习近平总书记考察宁夏重要讲话,从中国式现代化全局的战略高度,对事关宁夏长远发展的... 详细信息

2024年6月,习近平总书记时隔四年再次亲临宁夏考察指导并发表重要讲话,为宁夏指明了现代化之路、高质量发展之路、改革开放之路、人民共同富裕之路。习近平总书记考察宁夏重要讲话,从中国式现代化全局的战略高度,对事关宁夏长远发展的重大问题精准把脉、开出良方,为建设美丽新宁夏擘画了宏伟蓝图,为各项事业发展指明了前进方向、提供了根本遵循。我们要以高度的政治自觉、饱满的政治热情、笃定的政治行动,深入学习贯彻习近平总书记考察宁夏重要讲话精神,把学习成效转化为加快建设美丽新宁夏的强大动力,转化为积极干事创业的务实行动,为奋力谱写中国式现代化宁夏篇章贡献力量。

关键词：习近平新时代中国特色社会主义思想中国式现代化美丽新宁夏

面向多目标状态感知的自适应云边协同调度研究

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计算机科学 2024年第9期51卷 319-330页

作者：周文晖彭清桦谢磊南京大学软件新技术全国重点实验室南京210000

随着智能城市和工业智能制造的蓬勃发展,从监控摄像头获取详尽信息以进行多目标视觉分析的需求日益突出。现有研究主要关注在服务器上进行资源调度以及改良视觉模型,往往不能很好地应对设备资源状态和任务状态的动态变化。随着边缘端硬... 详细信息

随着智能城市和工业智能制造的蓬勃发展,从监控摄像头获取详尽信息以进行多目标视觉分析的需求日益突出。现有研究主要关注在服务器上进行资源调度以及改良视觉模型,往往不能很好地应对设备资源状态和任务状态的动态变化。随着边缘端硬件资源的升级和任务处理模型的改进,设计一个自适应的云边协同调度模型来满足任务的实时用户需求成为优化多目标状态感知任务的重要方式。因此,在深入分析云边场景下多目标状态感知任务特性的基础上,提出了一种基于深度强化学习的自适应云边协同调度模型ATS-SAC。ATS-SAC通过实时解析多目标状态感知任务的运行时状态,动态给出任务执行的视频流配置、模型部署配置等调度决策,从而显著优化环境不稳定的云边场景下多目标状态感知任务的精度、时延的综合性能质量。同时,还引入了一种基于用户体验极限阈值的动作筛选方法,有助于去除冗余的决策动作,进一步优化模型的决策空间。针对用户对多目标状态感知任务性能结果的不同需求,ATS-SAC模型能提供包括极速模式、均衡模式和精度模式在内的多种灵活的调度策略。实验结果表明,相比其他的任务执行方式,在ATS-SAC模型的调度策略下,多目标状态感知任务在精度质量和处理时延上更能满足用户的体验需求。同时,当实时运行状态变化时,ATS-SAC模型能够动态调整其调度策略,以保持稳定的任务处理效果。

关键词：边缘计算云边协同调度策略多目标状态感知深度强化学习