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Molecular Mechanism and Molecular Design of Lubricating Oil Antioxidants

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 135-145页

作者： Su Shuo Long Jun Duan qinghua.zhou Han Zhao Yi SINOPEC Research Institute of Petroleum Processing Co.Ltd. Beijing 100083

To overcome the limitations of traditional experimental“trial and error”methods in lubricant additive design,a new molecular design method based on molecular structure parameters is established *** molecular mechanism of the antioxidant reaction of hindered phenol,diphenylamine,and alkyl sulfide are studied via molecular *** results show that the strong electron-donating ability and high hydrogen-donating activity of the antioxidant molecule and the low hydrogen-abstracting activity of free radicals formed after dehydrogenation are the internal molecular causes of the shielding of phenol and diphenylamine from scavenging peroxy free radicals,and the strong electron-donating ability is the internal molecular cause of the high activity of thioether in decomposing alkyl hydrogen *** on this antioxidant molecular mechanism,a molecular design rule of antioxidant is proposed,namely“high EHOMO,large Q(S),low bond dissociation energy BDE(O—H)and BDE(N—H)”.Two new antioxidants,PAS-I and PAS-II,are designed and prepared by chemical bonding of hindered phenol,diphenylamine,and sulfur *** results show that these antioxidants both have excellent antioxidant effects in lubricating oil,and that PAS-II is the superior antioxidant,consistent with theoretical predictions.

关键词： lubricating oil antioxidant molecular mechanism molecular design antioxidant performance

Lignocellulose-Based Optical Biofilter with High Near-Infrared Transmittance via Lignin Capturing–Fusing Approach

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Research 2024年第3期2023卷 139-149页

作者： Shixu Yu Yifang zhou Meixue Gan Lu Chen Yimin Xie Yuning Zhong qinghua Feng Chaoji Chen Hubei Provincial Key Laboratory of Green Materials for Light Industry Hubei University of TechnologyWuhan 430068China.Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key LaboratorySchool of Resource and Environmental SciencesWuhan UniversityWuhan 430079China Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory School of Resource and Environmental SciencesWuhan UniversityWuhan 430079China Hubei Open University Wuhan 430074China.

Near-infrared (NIR) transparent optical filters show great promise in night vision and receiving windows. However, NIR optical filters are generally prepared by laborious, environmentally unfriendly processes that involve metal oxides or petroleum-based polymers. We propose a lignin capturing–fusing approach to manufacturing optical biofilters based on molecular collaboration between lignin and cellulose from waste agricultural biomass. In this process, lignin is captured via self-assembly in a cellulose network;then, the lignin is fused to fill gaps and hold the cellulose fibers tightly. The resulting optical biofilter featured a dense structure and smooth surface with NIR transmittance of ~90%, ultralow haze of close to 0%, strong ultraviolet-visible light blocking (~100% at 400 nm and 57.58% to 98.59% at 550 nm). Further, the optical biofilter has comprehensive stability, including water stability, solvent stability, thermal stability, and environmental stability. Because of its unique properties, the optical biofilter demonstrates potential applications in the NIR region, such as an NIR-transmitting window, NIR night vision, and privacy protection. These applications represent a promising route to produce NIR transparent optical filters starting from lignocellulose biomass waste.

关键词： transparent starting waste

Wide hybridizations reveal the robustness of functional centromeres in Triticum-Aegilops species complex lines

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Journal of Genetics and Genomics 2024年第5期51卷 570-573页

作者： Yuhong Huang qinghua Shi Chen zhou Chunhui Wang Yang Liu Congyang Yi Handong Su Fangpu Han State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Bejing 100049China National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhanHubei430070China

The Triticum-Aegilops complex groups demonstrated high cross-affinity with each other to overcome the barriers of distant hybridization(Loureiro et al.,2023).Distant hybridization involves two distinct yet closely related events:hybridization and genome *** studies have indicated that bursts of transposable elements(TEs)can occur as a consequence or concomitant to hybridization or genome duplication(Parisod et al.,2010).This raises an important scientific question regarding how the TEs-rich centromere region copes with genomic shock(McClintock,1984).The Triticum-Aegilops species complexes,particularly in the F1,So,and subsequent early generations resulting from successive selfcrossing,offer an opportunity to investigate whether the centromere environment undergoes reconstruction and the associated mechanisms that maintain genomic stability.

关键词： centromere Triticum complex

High-performance and wavelength-transplantable on-chip Fourier transform spectrometer using MEMS in-plane reconfiguration

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Photonics Research 2024年第8期12卷 1730-1740页

作者： HENG CHEN HUI ZHANG JING zhou CHEN MA QIAN HUANG HANXING WANG qinghua REN NAN WANG CHENGKUO LEE YIMING MA School of Microelectronics Shanghai UniversityShanghai 201800China Shanghai Collaborative Innovation Center of Intelligent Sensing Chip Technology Shanghai UniversityShanghai 201800China Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

On-chip spectrometers with high compactness and portability enable new applications in scientific research and industrial *** transform(FT)spectrometers have the potential to realize a high signal-to-noise *** we propose and demonstrate a generalized design for high-performance on-chip FT *** spectrometer is based on the dynamic in-plane reconfiguration of a waveguide coupler enabled by an integrated comb-drive actuator *** electrostatic actuation intrinsically features ultra-low power *** coupling gap is crucial to the spectral *** in-plane reconfiguration surmounts the lithography accuracy limitation of the coupling gap,boosting the resolution to 0.2 nm for dual spectral spikes over a large bandwidth of 100 nm(1.5–1.6μm)within a compact footprint of 75μm×1000μ***,the in-plane tuning range can be large enough for arbitrary wavelengths to ensure the effectiveness of spectrum *** a result,the proposed spectrometer can be easily transplanted to other operation bands by simply scaling the structural *** a proof-of-concept,a mid-infrared spectrometer is further demonstrated with a dual-spike reconstruction resolution of 1.5 nm and a bandwidth of 300 nm(4–4.3μm).

关键词： waveguide tuning lithography

Biological function of miRNA-145-5p in angiotensin II induced renal inflammation

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BIOCELL 2024年第4期48卷 601-611页

作者： BIN LI YUCHENG SHENG XIAOYING XU SHENGCUN WANG HONGYAN SONG JINGYUAN LI HAONAN JI qinghua WANG XIAODI zhou LONGJU QI Department of Pediatrics Affiliated Hospital of Nantong UniversityNantong226001China Department of Science and Education Affiliated Nantong Hospitalof Nantong UniversityNantong226001China Laboratory Animal Center Nantong UniversityNantong226001China Department of Gynecology and Obstetrics and Department of Oncology Hai’an Hospital Affiliated to Nantong UniversityNantong226600China

Objective:Chronic kidney disease(CKD)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative ***,the therapeutic promise of miR-145-5p in addressing renal pathologies has been *** investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells(HGMCs)to stimulation with Angiotensin II(AngII).Materials and Methods:Cellular viability and the levels of inﬂammatory mediators were evaluated utilizing Cell Counting Kit-8(CCK-8),quantitative real-time polymerase chain reaction(qRT-PCR),and western blot methodologies,both in the presence of AngII incubation and in scenarios of miR-145p overexpression and ***,the cell cycle dynamics were elucidated through Fluorescence-activated Cell Sorting(FACS)***:AngII incubation induced an upregulation of miR-145-5p and inﬂammatory factors including Intercellular Adhesion Molecule 1(ICAM-1),Interleukin 6(IL-6),Interleukin 8(IL-8),and Interleukin 1β(IL-1β).Additionally,it elevated the expression of Cyclin A2,Cyclin D1,and the G2/M cell cycle ***,inhibition of miR-145-5p heightened the levels of inﬂammatory factors and cell cycle regulators induced by AngII *** expression of miR-145-5p correlated with a downregulation of Interleukin 10(IL-10)expression,concurrently promoting HGMC proliferation under AngII ***,ectopic miR-145-5p expression demonstrated a reduction in inﬂammatory factors,cell cyclin regulators,G2/M cell cycle ratio,and overall ***:MiR-145-5p exhibited inhibitory effects on the inﬂammatory response and proliferation induced by Angiotensin II in HGMCs,showcasing its potential as a therapeutic avenue for the treatment of kidney injury.

关键词： miR-145-5p Kidney Angiotensin II Cell cycle Inflammation

High-performance terahertz modulators induced by substrate field in Te-based all-2D heterojunctions

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Light(Science & Applications) 2024年第3期13卷 577-586页

作者： Pujing Zhang Qihang Liang Qingli zhou Jinyu Chen Menglei Li Yuwang Deng Wanlin Liang Liangliang Zhang qinghua Zhang Lin Gu Chen Ge Kui-juan Jin Cunlin Zhang Guozhen Yang Department of Physics Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging Theory and TechnologyCapital Normal UniversityBeijing 100048China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering Beijing National Center for Electron Microscopy and Laboratory of Advanced MaterialsTsinghua UniversityBeijing 100084China

High-performance active terahertz modulators as the indispensable core components are of great importance for the next generation communication ***,they currently suffer from the tradeoff between modulation depth and ***,we introduce two-dimensional(2D)tellurium(Te)nanofilms with the unique structure as a new class of optically controlled terahertz modulators and demonstrate their integrated heterojunctions can successfully improve the device performances to the optimal and applicable levels among the existing all-2D broadband *** photoresponse measurements confirm the significant impact of the stacking *** first clarify the direction of the substrate-induced electric field through first-principles calculations and uncover the unusual interaction mechanism in the photoexcited carrier dynamics associated with the charge transfer and interlayer exciton *** advances the fundamental and applicative research of Te nanomaterials in high-performance terahertz optoelectronics.

关键词： performance field terahertz

Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia

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Genes & Diseases 2024年第1期11卷 95-98页

作者： Cunte Chen Yuling Zhang Dongpei Lu Zelong Zhang Jun Yang Xiaowei Chen Ming zhou Wenjian Mo Caixia Wang qinghua Cai Yumiao Li Ruiqing zhou Shilin Xu Wei zhou Tingfen Deng Shiyi Pan Yanli Xu Shunqing Wang Yuping Zhang Department of Hematology Guangzhou First People's HospitalSouth China University of TechnologyGuangzhouGuangdong 510180China Guangzhou Junruikang Biotechnology Co. LtdGuangzhouGuangdong 510700China

Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone marrow(BM)cells,putative autoantigens,and oligoclonal expansion of CD8+T cells.1 For SAA patients,the definitive therapies are immunosuppressive therapy(IST)or hematopoietic stem transplantation(HSCT).

关键词： anemia aplastic interferon

Emergent ultra-high temperature ferromagnetism in La_(2)CoO_(4±x) thin films

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Nano Research 2024年第8期17卷 7250-7255页

作者： Ziang Meng Han Yan Peixin Qin Zhuo Yin Peiheng Jiang Xiaorong zhou Xiaoning Wang Hongyu Chen Li Liu Zhiyuan Duan Guojian Zhao Weisheng Zhao Fengxia Hu qinghua Zhang Zhicheng Zhong Zhiqi Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Magnetic Materials and Devices and Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Fert Beijing Institute School of Integrated Circuit Science and EngineeringBeihang UniversityBeijing 100191China

Searching for novel ferromagnetic oxides with high Curie temperature(TC)has been one of the main goals for oxide *** well-known perovskite cobaltate LaCoO_(3) is a classical ferromagnet in its thin-film form;however,it suffers from a low TC(~85 K).Here we report a new type of ferromagnetic La-Co-O films with an ultrahigh TC of~820 *** are fabricated by pulsed laser deposition from a LaCoO_(3) target at low oxygen partial *** structural analysis indicates that they crystallize in terms of the Ruddlesden–Popper phase of La_(2)CoO_(4±x).In sharp contrast to the antiferromagnetism of bulk La_(2)CoO_(4),the strong ferromagnetism in the La_(2)CoO_(4±x) thin films is firmly demonstrated by magnetometry measurements,X-ray magnetic circular dichroism characterization,and magnetotransport *** importantly,density functional theory calculations indicate that the nonstoichiometric oxygen induces an antiferromagnetic-to-ferromagnetic phase transition,accompanied by the orbital reconstruction of Co 3d ***,our study provides an attractive strategy for designing or synthesizing exotic magnetic oxides with high ordering temperatures.

关键词： ferromagnetic oxides ultra-high Curie temperature La_(2)CoO_(4) spin current transport oxygen engineering

Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer

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Chinese Medical Journal 2024年第9期137卷 1019-1032页

作者： Lingling Zhu Xianzhe Yu Xiaojun Tang Chenggong Hu Lei Wu Yanyang Liu qinghua.zhou Lung Cancer Center Lung Cancer InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengduSichuan 610041China Department of Gastrointestinal Surgery Chengdu Second People’s HospitalChengduSichuan 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Core Facility of West China Hospital Sichuan UniversityChengduSichuan 610041China Department of Medical Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

Liver metastases(LMs)are common in lung *** substantial advances in diagnosis and treatment,the survival rate of patients with LM remains low as the immune-suppressive microenvironment of the liver allows tumor cells to evade the immune *** impact of LMs on the outcomes of immune checkpoint inhibitors in patients with solid tumors has been the main focus of recent translational and clinical *** evidence indicates that the hepatic microenvironment delivers paracrine and autocrine signals from non-parenchymal and parenchymal ***,these microenvironments create pre-and post-metastatic conditions for the progression of ***,we reviewed the epidemiology,physiology,pathology and immunology,of LMs associated with non-small cell lung cancer and the role and potential targets of the liver microenvironment in LM in each phase of ***,we reviewed the current treatment strategies and challenges that should be overcome in preclinical and clinical *** approaches target liver elements as the basis for future clinical trials,including combinatorial interventions reported to resolve hepatic immune suppression,such as immunotherapy plus chemotherapy,immunotherapy plus radiotherapy,immunotherapy plus anti-angiogenesis therapy,and surgical resection.

关键词： Non-small cell lung cancer Liver metastasis Combination therapy Immune checkpoint inhibitors Immune tolerance Immunotherapy