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Comparison-embedded evidence-CNN model for fuzzy assessment of wear severity using multi-dimensional surface images

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Friction 2024年第6期12卷 1098-1118页

作者： Tao SHAO Shuo WANG qinghua WANG Tonghai wu Zhifu HUANG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Wear topography is a significant indicator of tribological behavior for the inspection of machine health *** intelligent in-suit wear assessment method for random topography is here ***-dimension(3D)topography is employed to address the uncertainties in wear ***,3D topography reconstruction from a worn surface is accomplished with photometric stereo vision(PSV).Then,the wear features are identified by a contrastive learning-based extraction network(WSFE-Net)including the relative and temporal prior knowledge of wear ***,the typical wear degrees including mild,moderate,and severe are evaluated by a wear severity assessment network(WSA-Net)for the probability and its associated uncertainty based on subjective *** integrating the evidence information from 2D and 3D-damage surfaces with Dempster–Shafer(D–S)evidence,the uncertainty of severity assessment results is further *** proposed model could constrain the uncertainty below 0.066 in the wear degree evaluation of a continuous wear experiment,which reflects the high credibility of the evaluation result.

关键词： wear severity assessment contrastive learning subjective logic Dempster-Shafer(D-S)evidence theory

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不同种质白芷适宜采收期及质量评价研究

中草药 2024年第15期55卷 5245-5255页

作者：张佳旭晏宇杭吴清华黄成凤杜金雨黄旭龙郑全林裴瑾西南特色中药资源国家重点实验室四川成都611137 成都中医药大学药学院四川成都611137 四川遂宁市全泰堂药业有限公司四川遂宁629000

目的采用指纹图谱与化学模式识别方法,以香豆素为指标,探讨不同种质白芷药材Angelicae Dahuricae Radix发育过程中有效成分的含量变化规律,评价不同种质白芷的质量,为白芷药材合理采收和质量控制提供参考和依据。方法采用HPLC法测定5个... 详细信息

目的采用指纹图谱与化学模式识别方法,以香豆素为指标,探讨不同种质白芷药材Angelicae Dahuricae Radix发育过程中有效成分的含量变化规律,评价不同种质白芷的质量,为白芷药材合理采收和质量控制提供参考和依据。方法采用HPLC法测定5个种质白芷不同发育时期香豆素类成分含量,建立不同种质白芷药材化学指纹图谱,结合相似度分析、聚类分析、主成分分析对不同种质白芷进行比较和质量评价。结果建立了不同种质白芷药材的化学指纹图谱,共标定了19个共有峰,35批白芷相似度均在0.871~0.995;在各种质白芷发育过程中,总香豆素含量呈现先增加后降低的趋势,在7月中旬达到最高;5个种质白芷不同采收期样本的主成分分析结果显示:5个种质白芷的综合评分均在7月中旬最高;5个种质白芷7月中旬样本的主成分分析的综合评分结果:川白芷>南川白芷>禹白芷>祁白芷>亳白芷,且川白芷的总香豆素含量及欧前胡素含量显著高于其余种质。结论白芷香豆素类成分组成与含量既取决于种质又受发育程度的影响,各种质白芷最佳采收期为7月中旬,以川白芷质量最佳。

关键词：白芷药材香豆素种质资源采收期指纹图谱欧前胡素异欧前胡素

Research progresses and prospects of medicated oil dual-purpose crop safflower based on patent mining

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Oil Crop Science 2022年第4期7卷 209-218页

作者： Lanyu Zhou Yuhang Yan Yue Wang qinghua wu Jie Yan Jin Pei State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China Chengdu611137China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

Safflower is widely cultivated and used as a dual-purpose medicinal oil *** research used the incoPat patent database to search the global safflower patents for nearly 20 years,aiming to reveal the development process and current situation of the safflower industry in China and around the world by analyzing patent application trends,patent technology characteristics,advantageous industries and regions,patent quality,*** analysis shows that safflower patent applications are generally increasing,and the period 2010-2016 is characterized by the rapid development of patent *** technical features of global patents are mainly concentrated in pharmaceutical preparations,cosmetics,food and health care,various beverages,animal feed,safflower cultivation and harvesting equipment,and safflower seed *** the rapid development of patent applications,safflower was further developed in cosmetics,edible oil,and harvesting *** addition,patent applications in rheumatism and bone diseases have increased,with the potential for *** is the leading region for researching and developing medicinal safflower patents,especially Shandong and Henan *** patents are more focused on the value development of safflower seed oil in food and *** to the major countries and organizations that apply for safflower patents on a global scale,the quality of Chinese safflower patents is medium,and more awareness of patent protection is *** paper provides suggestions for the subsequent development of the safflower industry,summarizes and analyzes the development trend of safflower patents,and provides new ideas to obtain innovative patent results.

关键词： Safflower Patent Medicated oil dual-purpose crop Industry incoPat

Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets

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Animal Nutrition 2022年第2期9卷 269-279页

作者： Aimei Liu Yaqin Yang Jingchao Guo Yan Gao qinghua wu Ling Zhao Lv-hui Sun Xu Wang National Reference Laboratory of Veterinary Drug Residues and Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityMinistry of Agriculture(MOA)Wuhan430070China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Wuhan430070China College of Life Science Yangtze UniversityJingzhou434025China

Deoxynivalenol(DON)is an inevitable contaminant in animal feed and can lead to liver damage,then decreasing appetite and causing growth retardation in *** many molecular mechanisms are related to hepatoxicity caused by DON,few studies have been done on cytochrome P450(CYP450)enzymes and DNA *** explore the role of CYP450 enzymes and DNA methylation in DONinduced liver injury,male piglets were fed a control diet,or diet containing 1.0 or 3.0 mg/kg DON for 4 *** significantly raised the activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and glutamyl transpeptidase(GGT)(P<0.01),leading to liver *** vivo study found that DON exposure increased the expression of CYP450 enzymes(such as CYP1A1,CYP2E1,CYP3A29)(P<0.05),and disturbed the expression of nicotinamide N-methyltransferase(NNMT),galanin-like peptide(GALP)and insulin-like growth factor 1(IGF-1)(P<0.05),in which DNA methylation affected the expression of these *** vitro study(human normal hepatocytes L02)further proved that DON elevated the expression of CYP1A1,CYP2E1 and CYP3A4(P<0.05),and inhibited cell growth in a dose-dependent manner,resulting in cell *** importantly,knockdown of CYP1A1 or CYP2E1 could alleviate DON-induced growth inhibition by promoting IGF-1 *** together,increased CYP450 enzymes expression was one of the mechanisms of hepatoxicity and growth inhibition induced by DON,suggesting that the decrease of CYP450 enzymes can antagonize the hepatoxicity in animals,which provides some value for animal feed safety.

关键词： Deoxynivalenol Hepatoxicity Growth inhibition CYP450 enzyme DNA methylation Piglet

Synthesis,characterization,and tunable semiconducting properties of aza-BODIPY derived polycyclic aromatic dyes

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Science China Chemistry 2020年第9期63卷 1240-1245页

作者： Wanle Sheng Yu-Qing Zheng qinghua wu Kangkang Chen Mao Li Lijuan Jiao Erhong Hao Jie-Yu Wang Jian Pei The Key Laboratory of Functional Molecular Solids Ministry of EducationSchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Department of Chemistry BengBu Medical CollegeBengbu 233030China

Azadipyrromethene derived polycyclic aromatic complexes(HBPs)containing thirteen fused rings have been synthesized,which show highly selective intense absorption in the near infrared spectrum(NIR)region with high photo-and *** periphery alkoxy and alkyl substituents greatly affect their molecular packing structures in thin films and their thin film transistor *** the simple changes of the alkyl substituents,the packing structures changed from discrete-grain with H-aggregation type absorption to lamellar packing with J-aggregation type absorption,and the semiconducting properties were modulated from p-type to interesting ambipolar-type in solution-processed organic field effect transistors(OFETs)with hole and electron mobilities reaching to 0.42 and 0.17 cm^2 V^-1 s^-1,respectively.

关键词： aza-BODIPY polycyclic aromatic dyes near infrared field-effect transistors

A Deep Learning-Enabled Skin-Inspired Pressure Sensor for Complicated Recognition Tasks with Ultralong Life

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Research 2024年第1期2023卷 443-454页

作者： Yingxi Xie Xiaohua wu Xiangbao Huang qinghua Liang Shiping Deng Zeji wu Yunpeng Yao Longsheng Lu School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhouChina

Flexible full-textile pressure sensor is able to integrate with clothing directly,which has drawn extensive attention from scholars *** the realization of flexible full-textile pressure sensor with high sensitivity,wide detection range,and long working life remains *** recognition tasks necessitate intricate sensor arrays that require extensive data processing and are susceptible to *** human skin is capable of interpreting tactile signals,such as sliding,by encoding pressure changes and performing complex perceptual *** by the skin,we have developed a simple dip-and-dry approach to fabricate a full-textile pressure sensor with signal transmission layers,protective layers,and sensing *** sensor achieves high sensitivity(2.16 kPa^(−1)),ultrawide detection range(0 to 155.485 kPa),impressive mechanical stability of 1 million loading/unloading cycles without fatigue,and low material *** signal transmission layers that collect local signals enable real-world complicated task recognition through one single *** developed an artificial Internet of Things system utilizing a single sensor,which successfully achieved high accuracy in 4 tasks,including handwriting digit recognition and human activity *** results demonstrate that skin-inspired full-textile sensor paves a promising route toward the development of electronic textiles with important potential in real-world applications,including human–machine interaction and human activity detection.

关键词： Deep Skin utilizing

LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

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Chinese Medical Journal 2024年第2期137卷 190-199页

作者： Muchen wu Jing wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan wu qinghua Meng Department of Liver Disease Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of General Surgery Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex *** hypoglycemia is common in patients with ACLF and often predicts a worse *** evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of *** protease-1(LONP1)is a novel mediator of energy and glucose ***,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains ***:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl 4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury ***1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis *** histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ***:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver ***,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histopathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF ***,mitochondrial morphology was improved upon overexpression of ***,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 ***,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis ***

关键词： Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction Metabolism

探讨IL-34在小鼠慢性根尖周炎模型中的动态表达

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淮海医药 2024年第2期42卷 120-124页

作者：王敏徐丽朱永娜张伟健武庆华刘茜蚌埠医科大学第二附属医院/上海市第一人民医院蚌埠医院口腔科安徽蚌埠233000 蚌埠医科大学第一附属医院安徽蚌埠233000

目的:探讨白介素-34(IL-34)在小鼠慢性根尖周炎模型中的表达及变化情况。方法:选择35只SD小鼠,对其下颌第一磨牙开髓制造根尖周炎的模型,并在0、7、14、21、28 d随机脱颈处死,解剖分离含有第一磨牙的下颌骨,进行影像学检查,了解模型中... 详细信息

目的:探讨白介素-34(IL-34)在小鼠慢性根尖周炎模型中的表达及变化情况。方法:选择35只SD小鼠,对其下颌第一磨牙开髓制造根尖周炎的模型,并在0、7、14、21、28 d随机脱颈处死,解剖分离含有第一磨牙的下颌骨,进行影像学检查,了解模型中根尖周的破坏情况。将下颌骨标本制备切片,进行HE染色观察根尖周组织病理学改变以及抗酒石酸酸性磷酸酶(TRAP)染色检测破骨细胞,实时荧光定量PCR(RT-qPCR)检测IL-34与肿瘤坏死因子-α(TNF-α)在根尖周炎模型中的动态表达。结果:影像学检查显示,0~7 d根尖无明显异常,14~21 d开始出现轻度根尖破坏,28 d根尖阴影变大,范围增宽。HE染色显示,0 d根尖周组织正常未见明显改变,7 d炎性因子浸润开始增多,14 d出现明显的骨质破坏以及坏死中心,21 d炎性渗出减少,小范围的骨质破坏区域增多,28 d炎性细胞浸润趋于稳定,小范围的骨质破坏连接成片,大范围的骨质破坏形成。TRAP染色显示,0 d几乎看不到破骨细胞,7~14 d破骨细胞数目明显增加,在21 d时到达高峰,28 d时轻微下降,但7、14、21、28 d时均高于0 d(P<0.05)。RT-qPCR检测显示,7~28 d的IL-34及TNF-α的mRNA表达量均逐渐增高,且在14 d到达顶峰,在21 d呈现下降的趋势,28 d又呈现上升趋势,在7~28 d的表达量均高于0 d(P<0.05),并且呈现正相关关系。结论:IL-34的mRNA表达量随着根尖周炎病变程度发展而改变,尤其是与骨质破坏的程度相关,并与TNF-α有着密切的联系,出现短暂的表达量下降说明其表达受到了抑制,有助于为临床治疗提供方向。

关键词：根尖周炎白介素-34(IL-34) 肿瘤坏死因子-α(TNF-α)

基因沉默番木瓜环斑病毒复制酶基因(PRSV-Nib)获得抗病毒病番木瓜的研究

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热带作物学报 2024年第4期45卷 837-846页

作者：吴清铧贾瑞宗郭静远杨牧之胡玉娟郝志刚赵辉郭安平海南大学热带作物学院海南海口570228 海南省南繁生物安全与分子育种重点实验室/中国热带农业科学院三亚研究院/中国热带农业科学院热带生物技术研究所海南三亚572024

番木瓜是重要的热带经济水果。番木瓜环斑病毒(Papaya ringspot virus,PRSV)是番木瓜的重要病毒病,经常导致严重的产量损失和质量恶化。自从1998年第一例转基因番木瓜问世以来,使得基于“致病菌衍生的抗病性(pathogen-derived resistanc... 详细信息

番木瓜是重要的热带经济水果。番木瓜环斑病毒(Papaya ringspot virus,PRSV)是番木瓜的重要病毒病,经常导致严重的产量损失和质量恶化。自从1998年第一例转基因番木瓜问世以来,使得基于“致病菌衍生的抗病性(pathogen-derived resistance,PDR)”的抗病育种策略获得成功广泛应用。然而依赖于序列同源性的抗病性与病毒突变导致多样性增加之间的矛盾成为番木瓜育种科学家的新挑战。本研究拟采用RNAi策略针对复制酶(nuclear inclusion ***)获得广谱抗PRSV番木瓜新种质。通过团队已建立的胚性愈伤诱导-农杆菌介导转化-再生苗诱导的番木瓜遗传转化体系,共获得经过抗性筛选的再生苗52株,通过特异性PCR进行筛选共计获得24株转基因阳性植株。通过对T0代田间自然发病试验中,转基因番木瓜株系抗病性明显高于非转基因对照,其中NibB5-2田间抗病性最优。通过hiTAIL-PCR方法确定NibB5-2插入位点位于第2号染色体supercontig_30的1976766的位置。T1代接种试验中,无病毒积累且无发病症状,初步确认具有良好的病毒抗性,为番木瓜抗病育种提供新思路。

关键词：番木瓜番木瓜环斑病毒 Nib基因 RNA介导的病毒抗性